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J. Barrow · SciRah

Researcher profile · Semantic Scholar

J. Barrow

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J. Barrow — researcher profile on SciRah

h-index: 33
Works: 111
Citations: 3,156

Most-cited papers

Classics in chemical neuroscience: diazepam (valium).
Nicholas E. Calcaterra, J. Barrow
2014ACS Chemical Neuroscience246 citations Open access
Semantic Scholar
In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia
J. Barrow, P. Nantermet, H. Selnick, K. L. Glass +19 more
2000193 citations Open access
Semantic Scholar
Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
Emily E. Burke, J. Chenoweth, J. Shin, L. Collado-Torres +33 more
2020Nature Communications134 citations Open access
Semantic Scholar
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
W. Shipe, J. Barrow, Zhi-Qiang Yang, C. Lindsley +26 more
2008Journal of Medicinal Chemistry130 citations Open access
Semantic Scholar
In Vitro Characterization of T-Type Calcium Channel Antagonist TTA-A2 and In Vivo Effects on Arousal in Mice
R. Kraus, Yuxing Li, Yun Gregan, Anthony L. Gotter +8 more
2010Journal of Pharmacology and Experimental Therapeutics118 citations
Semantic Scholar
Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.
C. Burgey, K. A. Robinson, T. Lyle, P. Sanderson +31 more
2003Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response
Laureen C. Colis, K. Peltonen, P. Sirajuddin, Hester Liu +4 more
2014OncoTarget93 citations Open access
Semantic Scholar
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Zhi-Qiang Yang, J. Barrow, W. Shipe, Kelly-Ann S. Schlegel +28 more
2008Journal of Medicinal Chemistry91 citations Open access
Semantic Scholar
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1
Feng Rao, Jing Xu, Cheng-Lai Fu, Jiyoung Y. Cha +4 more
2015Proceedings of the National Academy of Sciences of the United States of America87 citations Open access
Semantic Scholar
Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors.
M. Young, J. Barrow, K. L. Glass, G. F. Lundell +22 more
2004Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice.
V. Uebele, Anthony L. Gotter, C. Nuss, R. Kraus +13 more
2009Journal of Clinical Investigation81 citations Open access
Semantic Scholar
Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.
Qingzhang Zhu, Sarbani Ghoshal, A. Rodrigues, Su Gao +4 more
2016Journal of Clinical Investigation75 citations Open access
Semantic Scholar
TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
Sarbani Ghoshal, Qingzhang Zhu, Alice Asteian, Hua Lin +7 more
2016Molecular Metabolism59 citations Open access
Semantic Scholar
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.
S. Stauffer, Matthew G. Stanton, Alison R. Gregro, Melissa A. Steinbeiser +16 more
2007Bioorganic & Medicinal Chemistry Letters58 citations Open access
Semantic Scholar
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
V. Uebele, C. Nuss, Steven V. Fox, Susan L. Garson +19 more
2009Cell Biochemistry and Biophysics57 citations
Semantic Scholar
Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.
J. Barrow, S. Stauffer, K. E. Rittle, Phung L. Ngo +21 more
2008Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group.
P. Nantermet, J. Barrow, Stacey Lindsley, M. Young +8 more
2004Bioorganic & Medicinal Chemistry Letters55 citations Open access
Semantic Scholar
Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis.
W. Shipe, Steven S. Sharik, J. Barrow, G. McGaughey +7 more
2015Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function
Paul C. Scherer, Yan Ding, Zhi-Qing Liu, Jing Xu +6 more
2016Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators.
Feng V. Yang, William D. Shipe, Jaime Lynn Bunda, M. Brad Nolt +10 more
2010Bioorganic & Medicinal Chemistry Letters44 citations
Semantic Scholar
A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide
J. Barrow, Phung L. Ngo, J. M. Pellicore, H. Selnick +1 more
200144 citations
Semantic Scholar
Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
Scott T. Harrison, M. Poslusney, James Mulhearn, Zhi-Jian Zhao +14 more
2015ACS Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics.
J. Barrow, P. Nantermet, S. Stauffer, Phung L. Ngo +15 more
2003Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Design, Synthesis, and Structure−Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors
Laureen C. Colis, Glen E. Ernst, S. Sanders, Hester Liu +5 more
201435 citations
Semantic Scholar
Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).
P. Nantermet, J. Barrow, G. F. Lundell, J. M. Pellicore +11 more
2002Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones.
P. Nantermet, J. Barrow, H. Selnick, Carl F. Homnick +9 more
2000Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates.
R. Robinson, Sean M. Smith, S. Wolkenberg, M. Kandebo +21 more
2012ACS Chemical Neuroscience34 citations Open access
Semantic Scholar
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats.
Jason M. Uslaner, Sean M. Smith, Sarah L. Huszar, Rashida Pachmerhiwala +10 more
2012Neuropharmacology34 citations
Semantic Scholar
Pyridyl amides as potent inhibitors of T-type calcium channels.
Thomas S. Reger, Zhi-Qiang Yang, Kelly-Ann S. Schlegel, Youheng Shu +18 more
2011Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.
J. Barrow, K. E. Rittle, Thomas S. Reger, Zhi-Qiang Yang +18 more
2010ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Design and Synthesis of 2,3,5‐Substituted Imidazolidin‐4‐one Inhibitors of BACE‐1
J. Barrow, K. E. Rittle, Phung L. Ngo, H. Selnick +11 more
2007ChemMedChem32 citations
Semantic Scholar
KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia
Gregory V. Carr, Jing-Shan Chen, Feng Yang, M. Ren +13 more
2016Molecular Psychiatry31 citations Open access
Semantic Scholar
Evaluation and Implementation of a Commercially Available Mass-Guided SFC Purification Platform in a High Throughput Purification Laboratory in Drug Discovery
R. McClain, A. Dudkina, J. Barrow, G. D. Hartman +1 more
200929 citations
Semantic Scholar
Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening.
Gangling Liao, Wenjuan Ye, Tyler Heitmann, Glen E. Ernst +9 more
2021ACS Pharmacology & Translational Science28 citations Open access
Semantic Scholar
[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.
E. Hostetler, S. Sanabria-Bohórquez, H. Fan, Zhi-Zhen Zeng +12 more
2011Nuclear Medicine and Biology26 citations Open access
Semantic Scholar
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists.
Kelly-Ann S. Schlegel, Zhi-Qiang Yang, Thomas S. Reger, Youheng Shu +18 more
2010Bioorganic & Medicinal Chemistry Letters26 citations
Semantic Scholar
Design and synthesis of potent and selective macrocyclic thrombin inhibitors.
P. Nantermet, J. Barrow, C. L. Newton, J. M. Pellicore +9 more
2003Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors
Gongliang Zhang, I. Buchler, M. Depasquale, Michael M Wormald +4 more
2019ACS Chemical Neuroscience23 citations Open access
Semantic Scholar
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency.
M. Egbertson, G. McGaughey, S. Pitzenberger, S. Stauffer +28 more
2015Bioorganic & Medicinal Chemistry Letters23 citations
Semantic Scholar
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position.
K. E. Rittle, J. Barrow, Kellie J. Cutrona, K. L. Glass +12 more
2003Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.
Hemaka A. Rajapakse, P. Nantermet, H. Selnick, J. Barrow +20 more
2010Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening
Nicholas E. Calcaterra, Daniel J. Hoeppner, Huijun Wei, A. Jaffe +2 more
2016Scientific Reports21 citations Open access
Semantic Scholar
Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase
I. Buchler, D. Akuma, Vinh Au, Gregory S. Carr +15 more
2018Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
Michael M Wormald, Gangling Liao, M. Kimos, J. Barrow +1 more
2017PLoS ONE20 citations Open access
Semantic Scholar
High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors.
S. Wolkenberg, Zhi-Jian Zhao, James Mulhearn, Scott T. Harrison +9 more
2011Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing
P. Nantermet, Hemaka A. Rajapakse, Mathew G. Stanton, Shaun R. Stauffer +17 more
2009ChemMedChem20 citations
Semantic Scholar
The Importance of PK-PD.
J. Barrow, C. Lindsley
2023Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
T-type calcium channels regulate cortical plasticity in-vivo
V. Uebele, C. Nuss, V. Santarelli, Susan L. Garson +11 more
2009NeuroReport19 citations Open access
Semantic Scholar
Development of an HTRF Assay for the Detection and Characterization of Inhibitors of Catechol-O-Methyltransferase
M. Kimos, Maggi Burton, D. Urbain, Didier Caudron +5 more
2016Journal of biomolecular screening18 citations Open access
Semantic Scholar
Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328.
Scott T. Harrison, James Mulhearn, S. Wolkenberg, Patricia Miller +13 more
2011ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar

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