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A. J. Roecker · SciRah

Researcher profile · Semantic Scholar

A. J. Roecker

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A. J. Roecker — researcher profile on SciRah

h-index: 29
Works: 62
Citations: 3,120

Most-cited papers

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans
K. Nicolaou, J. Pfefferkorn, A. J. Roecker, Guo-Qiang Cao +2 more
2000593 citations
Semantic Scholar
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR.
M. Downes, Mark A. Verdecia, A. J. Roecker, Robert Hughes +11 more
2003Molecules and Cells378 citations Open access
Semantic Scholar
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Christopher D. Cox, M. J. Breslin, D. B. Whitman, John D. Schreier +24 more
2010Journal of Medicinal Chemistry353 citations Open access
Semantic Scholar
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.
Chalet Tan, R. D. de Noronha, A. J. Roecker, B. Pyrzynska +11 more
2005Cancer Research162 citations Open access
Semantic Scholar
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
Jie Yin, K. Babaoglu, C. Brautigam, L. Clark +9 more
2016Nature Structural &Molecular Biology149 citations
Semantic Scholar
Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.
A. J. Roecker, Christopher D. Cox, Paul J. Coleman
2016Journal of Medicinal Chemistry111 citations Open access
Semantic Scholar
Orexin receptors as therapeutic drug targets.
Anthony L. Gotter, A. J. Roecker, R. Hargreaves, Paul J. Coleman +2 more
2012Progress in Brain Research99 citations
Semantic Scholar
Orexin receptor antagonists: medicinal chemistry and therapeutic potential.
A. J. Roecker, Paul J. Coleman
2008Current Topics in Medicinal Chemistry92 citations
Semantic Scholar
A Novel Strategy for the Solid-Phase Synthesis of Substituted Indolines
K. Nicolaou, A. J. Roecker, J. Pfefferkorn, Gou-Qiang Cao
200084 citations
Semantic Scholar
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man
Anthony L. Gotter, M. Forman, C. M. Harrell, J. Stevens +15 more
2016Scientific Reports81 citations Open access
Semantic Scholar
Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure.
C. Winrow, K. Tanis, D. Reiss, Alison M. Rigby +11 more
2010Neuropharmacology80 citations
Semantic Scholar
Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.
K. C. Nicolaou, R. Evans, A. J. Roecker, Robert Hughes +2 more
2003Organic and biomolecular chemistry76 citations
Semantic Scholar
Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).
K. Nicolaou, Robert Hughes, J. Pfefferkorn, Sofia Barluenga +1 more
2001Chemistry70 citations
Semantic Scholar
Proline bis-amides as potent dual orexin receptor antagonists.
J. Bergman, A. J. Roecker, Swati P. Mercer, R. A. Bednar +13 more
2008Bioorganic & Medicinal Chemistry Letters68 citations Open access
Semantic Scholar
Discovery of 5′′‐Chloro‐N‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia
A. J. Roecker, Swati P. Mercer, John D. Schreier, Christopher D. Cox +19 more
2014ChemMedChem65 citations
Semantic Scholar
Continuous Flow-Enabled Synthesis of Bench-Stable Bicyclo[1.1.1]pentane Trifluoroborate Salts and Their Utilization in Metallaphotoredox Cross-Couplings.
Michael D VanHeyst, J. Qi, A. J. Roecker, J. Hughes +3 more
2020Organic Letters53 citations Open access
Semantic Scholar
Discovery of dual orexin receptor antagonists (DORAs) for the treatment of insomnia.
Paul J. Coleman, Christopher D. Cox, A. J. Roecker
2011Current Topics in Medicinal Chemistry42 citations
Semantic Scholar
Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice.
A. J. Roecker, M. Egbertson, Kristen L. G. Jones, R. Gomez +26 more
2017Bioorganic & Medicinal Chemistry Letters40 citations Open access
Semantic Scholar
Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain.
K. Nicolaou, Pradip Sasmal, A. J. Roecker, Xiao-Wen Sun +2 more
2005Angewandte Chemie40 citations Open access
Semantic Scholar
Novel strategies for the solid phase synthesis of substituted indolines and indoles.
K. Nicolaou, A. J. Roecker, Robert Hughes, R. V. van Summeren +2 more
2003Bioorganic & Medicinal Chemistry40 citations Open access
Semantic Scholar
Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement.
Jason M. Uslaner, C. Winrow, Anthony L. Gotter, A. J. Roecker +4 more
2014Behavioural Brain Research38 citations
Semantic Scholar
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
A. J. Roecker, Paul J. Coleman, Swati P. Mercer, John D. Schreier +16 more
2007Bioorganic & Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects.
K. Nicolaou, Pradip Sasmal, Theocharis V. Koftis, A. Converso +6 more
2005Angewandte Chemie36 citations
Semantic Scholar
Discovery of Novel Antibacterial Agents Active Against Methicillin‐Resistant Staphylococcus aureus from Combinatorial Benzopyran Libraries
K. Nicolaou, A. J. Roecker, S. Barluenga, J. Pfefferkorn +1 more
2001ChemBioChem36 citations
Semantic Scholar
Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions.
K. C. Nicolaou, A. J. Roecker, Holger Monenschein, Prasuna Guntupalli +1 more
2003Angewandte Chemie33 citations
Semantic Scholar
Model studies towards azadirachtin: part 2. Construction of the crowded C8-C14 bond by transition metal chemistry.
K. Nicolaou, A. J. Roecker, M. Follmann, Rachid Baati
2002Angewandte Chemie33 citations
Semantic Scholar
Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
A. J. Roecker, Thomas S. Reger, M. Mattern, Swati P. Mercer +22 more
2014Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry.
K. Nicolaou, M. Follmann, A. J. Roecker, Kevin W. Hunt
2002Angewandte Chemie30 citations
Semantic Scholar
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Valerie W Shurtleff, Mark E. Layton, Craig A. Parish, James J. Perkins +44 more
2024Journal of Medicinal Chemistry29 citations
Semantic Scholar
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.
Paul J. Coleman, John D. Schreier, A. J. Roecker, Swati P. Mercer +12 more
2010Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Swati P. Mercer, A. J. Roecker, Susan L. Garson, D. Reiss +14 more
2013Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
A. J. Roecker, Kathy M Schirripa, H. M. Loughran, Ling Tong +26 more
2023ACS Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
A. J. Roecker, Swati P. Mercer, J. Bergman, Kevin F. Gilbert +13 more
2015Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile.
A. J. Roecker, M. E. Layton, Joseph E. Pero, M. Kelly +16 more
2021ACS Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
A. J. Roecker, Swati P. Mercer, C. M. Harrell, Susan L. Garson +9 more
2014Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists.
Jason W. Skudlarek, C. Dimarco, K. Babaoglu, A. J. Roecker +17 more
2017Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
The dual orexin receptor antagonist, DORA‐22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine
Lihang Yao, Andres D. Ramirez, A. J. Roecker, Steven V. Fox +7 more
2017Journal of Neurochemistry7 citations
Semantic Scholar
Discovery of 5′′-Chloro-N- [(5,6-dimethoxypyridin-2-yl)methyl] -2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia.
A. J. Roecker
20146 citations
Semantic Scholar
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.
H. M. Loughran, Kathy M Schirripa, A. J. Roecker, M. J. Breslin +22 more
2023ACS Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators.
J. Perkins, P. Mcquade, C. J. Bungard, Tracy L. Diamond +16 more
2023ACS Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Building a Culture of Medicinal Chemistry Knowledge Sharing.
D. Beshore, Andrew M Haidle, A. Arasappan, Yeon-Hee Lim +4 more
2022Journal of Medicinal Chemistry3 citations
Semantic Scholar
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Rebecca M Klein, M. E. Layton, H. Regan, C. Regan +18 more
2022Channels3 citations Open access
Semantic Scholar
To Market, to Market—2018: Small Molecules
Erika M. V. Araujo, Marie-Gabrielle Braun, P. Dragovich, A. Converso +7 more
20193 citations
Semantic Scholar
Discovery and Optimization of Non‐steroidal FXR Agonists from Natural Product‐Like Libraries.
K. Nicolaou, R. Evans, A. J. Roecker, Robert Hughes +2 more
20032 citations
Semantic Scholar
Model Studies Towards Azadirachtin. Part 1. Construction of the Crowded C8—C14 Bond by Radical Chemistry.
K. Nicolaou, M. Follmann, A. J. Roecker, Kevin W. Hunt
20022 citations
Semantic Scholar
Kinesin Spindle Protein (KSP) Inhibitors. Part 8. Design and Synthesis of 1,4-Diaryl-4,5-dihydropyrazoles as Potent Inhibitors of the Mitotic Kinesin KSP.
A. J. Roecker, et al.
20081 citations
Semantic Scholar
Hydroformylation and Late-Stage Diversification on Densely Functionalized Cores of Influenza Endonuclease Inhibitors
Marion H. Emmert, Tao Liang, Alan M. Hyde, J. Liao +9 more
2024Organic Process Research & Development0 citations
Semantic Scholar
Progress in imaging by α‐synuclein Positron Emission Tomography
Idriss Bennacef, Zhizhen Zeng, Patricia J. Miller, Kerry Riffel +15 more
2023Alzheimer's & Dementia0 citations Open access
Semantic Scholar
To Market, to Market—2020: Small Molecules
Marie-Gabrielle Braun, G. Castanedo, Samantha A. Green, Mingshuo Zeng +12 more
20212021 Medicinal Chemistry Reviews0 citations
Semantic Scholar
To Market, to Market—2019: Small Molecules
Erika M. V. Araujo, C. Bolger, Marie-Gabrielle Braun, G. Castanedo +10 more
20202020 Medicinal Chemistry Reviews0 citations
Semantic Scholar

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