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R. Possemato · SciRah

Researcher profile · Semantic Scholar

R. Possemato

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R. Possemato — researcher profile on SciRah

h-index: 30
Works: 72
Citations: 8,522

Most-cited papers

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer
R. Possemato, K. Marks, Y. Shaul, M. Pacold +23 more
2011Nature949 citations Open access
Semantic Scholar
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
L. Jackson‐Grusby, C. Beard, R. Possemato, Matthew Tudor +7 more
2001Nature Genetics741 citations
Semantic Scholar
NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Samantha W. Alvarez, Vladislav O. Sviderskiy, E. Terzi, T. Papagiannakopoulos +5 more
2017Nature700 citations Open access
Semantic Scholar
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
Kıvanç Birsoy, R. Possemato, Franziska K. Lorbeer, Erol C. Bayraktar +6 more
2014Nature692 citations Open access
Semantic Scholar
A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate
M. Pacold, K. Brimacombe, Sze Ham Chan, Jason M. Rohde +28 more
2016Nature Chemical Biology471 citations Open access
Semantic Scholar
A diverse array of cancer-associated mTOR mutations are hyperactivating and can predict rapamycin sensitivity
B. Grabiner, V. Nardi, Kıvanç Birsoy, R. Possemato +5 more
2014Cancer Discovery416 citations Open access
Semantic Scholar
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors
J. Garcia-Bermudez, Lou Baudrier, K. La, Xiphias Ge Zhu +8 more
2018Nature Cell Biology411 citations Open access
Semantic Scholar
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
Kenkichi Masutomi, R. Possemato, Judy M. Y. Wong, Jennifer L. Currier +6 more
2005Proceedings of the National Academy of Sciences of the United States of America389 citations Open access
Semantic Scholar
Identification of specific PP2A complexes involved in human cell transformation.
Wen Chen, R. Possemato, K. Campbell, Courtney A. Plattner +2 more
2004Cancer Cell351 citations Open access
Semantic Scholar
T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells
G. Lugo-Villarino, R. Maldonado-López, R. Possemato, C. Penaranda +1 more
2003Proceedings of the National Academy of Sciences of the United States of America316 citations Open access
Semantic Scholar
SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance
Dohoon Kim, Brian P. Fiske, Kıvanç Birsoy, E. Freinkman +15 more
2015Nature294 citations Open access
Semantic Scholar
Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming
M. Vaeth, Mate Maus, S. Klein-Hessling, E. Freinkman +8 more
2017Immunity253 citations Open access
Semantic Scholar
MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
Kıvanç Birsoy, Tim X. Wang, R. Possemato, Omer H. Yilmaz +9 more
2012Nature Genetics224 citations Open access
Semantic Scholar
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
Y. Shaul, E. Freinkman, William C. Comb, J. Cantor +12 more
2014Cell208 citations Open access
Semantic Scholar
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
V. Sayin, Sarah E. Leboeuf, Simranjit X. Singh, Shawn M. Davidson +14 more
2017eLife203 citations Open access
Semantic Scholar
An RNA dependent RNA polymerase formed by hTERT and the RNase MRP RNA
Yoshiko Maida, Mami Yasukawa, Miho Furuuchi, T. Lassmann +6 more
2009Nature196 citations Open access
Semantic Scholar
Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs
Denise R. Minton, Minwoo Nam, Daniel J. McLaughlin, Jong Shin +7 more
2018Molecules and Cells189 citations Open access
Semantic Scholar
KRAS4A Directly Regulates Hexokinase 1
Caroline R. Amendola, J. Mahaffey, Seth J. Parker, Ian M. Ahearn +14 more
2019Nature182 citations Open access
Semantic Scholar
Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5
E. Terzi, Vladislav O. Sviderskiy, Samantha W. Alvarez, Gabrielle C Whiten +1 more
2021SciAdv178 citations Open access
Semantic Scholar
Cancer-Associated PP2A Aα Subunits Induce Functional Haploinsufficiency and Tumorigenicity
Wen Chen, Jason D. Arroyo, J. Timmons, R. Possemato +1 more
2005166 citations Open access
Semantic Scholar
Autoregulatory control of mitochondrial glutathione homeostasis
Yu-Yang Liu, Shanshan Liu, Anju Tomar, Frederick S. Yen +20 more
2023Science128 citations Open access
Semantic Scholar
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy
Lin Wu, Kate E. R. Hollinshead, Yu-Han Hao, Christy Au +13 more
2019bioRxiv110 citations Open access
Semantic Scholar
Amino acid management in cancer
Z. Tsun, R. Possemato
2015Seminars in Cell and Developmental Biology104 citations Open access
Semantic Scholar
Maintenance of tumor initiating cells of defined genetic composition by nucleostemin
Naoko Okamoto, Mami Yasukawa, Christine L. Nguyen, Vivi Kasim +7 more
2011Proceedings of the National Academy of Sciences of the United States of America104 citations Open access
Semantic Scholar
Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson
Kıvanç Birsoy, D. Sabatini, R. Possemato
2012Nature Medicine65 citations
Semantic Scholar
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
M. Pacold, K. Brimacombe, Sze Ham Chan, Jason M. Rohde +28 more
2016Nature Chemical Biology61 citations Open access
Semantic Scholar
Nek4 Regulates Entry into Replicative Senescence and the Response to DNA Damage in Human Fibroblasts
Christine L. Nguyen, R. Possemato, E. Bauerlein, Anyong Xie +2 more
2012Molecular and Cellular Biology60 citations Open access
Semantic Scholar
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB4) as a Novel Autophagy Regulator by High Content shRNA Screening
A. Strohecker, Shilpy Joshi, R. Possemato, R. Abraham +2 more
2015Oncogene54 citations Open access
Semantic Scholar
Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase Epsilon
Vladislav O. Sviderskiy, L. Blumenberg, E. Gorodetsky, Triantafyllia Karakousi +13 more
2020Molecules and Cells48 citations Open access
Semantic Scholar
Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle
Jong Shin, Hannan Mir, Maaz Khurram, Kenji M. Fujihara +3 more
2023Nature Metabolism31 citations Open access
Semantic Scholar
Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition
Minwoo Nam, Wen-Xin Xia, Abdul Hannan Mir, Alexandra E. Jerrett +3 more
2024Nature Metabolism30 citations
Semantic Scholar
The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
Niklas Ravn-Boess, Nainita Roy, T. Hattori, Devin Bready +29 more
2023bioRxiv27 citations Open access
Semantic Scholar
Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer
Fei Li, Wai-Lung Ng, T. Luster, Hai Hu +26 more
2020Cancer Research27 citations Open access
Semantic Scholar
Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4.
Rebecca L. McIntyre, M. Molenaars, B. Schomakers, Arwen W. Gao +7 more
2022Cell Reports20 citations Open access
Semantic Scholar
Mitochondrial glutathione import enables breast cancer metastasis via integrated stress response signaling
Hsi-Wen Yeh, N. DelGaudio, Beste Uygur, Alon Millet +15 more
2025Cancer Discovery18 citations Open access
Semantic Scholar
EXTH-42. H3 K27M MUTANT GLIOMAS ARE SELECTIVELY KILLED BY ONC201, A SMALL MOLECULE INHIBITOR OF DOPAMINE RECEPTOR D2
Andrew Chi, J. Stafford, Namita Sen, R. Possemato +13 more
201713 citations Open access
Semantic Scholar
Flp recombinase regulated lacZ expression at the ROSA26 locus
R. Possemato, K. Eggan, B. Moeller, R. Jaenisch +1 more
2002Genesis13 citations Open access
Semantic Scholar
Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
J. Garcia-Bermudez, Lou Baudrier, K. La, Xiphias Ge Zhu +8 more
2018Nature Cell Biology12 citations Open access
Semantic Scholar
Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Samantha W. Alvarez, Vladislav O. Sviderskiy, E. Terzi, T. Papagiannakopoulos +5 more
2022Nature10 citations Open access
Semantic Scholar
Iron–Sulfur Cluster Metabolism Impacts Iron Homeostasis, Ferroptosis Sensitivity, and Human Disease
Vladislav O. Sviderskiy, E. Terzi, R. Possemato
2019Ferroptosis in Health and Disease10 citations
Semantic Scholar
Leveraging the iron-starvation response to promote ferroptosis
Samantha W. Alvarez, R. Possemato
2018OncoTarget10 citations Open access
Semantic Scholar
Suppression of hPOT1 in diploid human cells results in an hTERT dependant alteration of telomere length dynamics
R. Possemato, J. Timmons, E. Bauerlein, N. Wada +3 more
2008Molecular Cancer Research10 citations Open access
Semantic Scholar
Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma
E. Liu, V. Vasudevaraja, Vladislav O. Sviderskiy, Yang Feng +10 more
2022Neuro-Oncology Advances8 citations Open access
Semantic Scholar
Iron, Copper, and Selenium: Cancer's Thing for Redox Bling.
E. Terzi, R. Possemato
2023Cold Spring Harbor Perspectives in Medicine7 citations Open access
Semantic Scholar
A A Subunits Induce Functional Haploinsufficiency and
Wen Chen, Jason D. Arroyo, J. Timmons, R. Possemato +1 more
20057 citations
Semantic Scholar
Author response: Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
V. Sayin, Sarah E. Leboeuf, Simranjit X. Singh, Shawn M. Davidson +14 more
20174 citations Open access
Semantic Scholar
PhosphoDisco: A Toolkit for Co-regulated Phosphorylation Module Discovery in Phosphoproteomic Data
Tobias Schraink, L. Blumenberg, Grant A. Hussey, S. George +8 more
2023Molecular & Cellular Proteomics2 citations Open access
Semantic Scholar
Acute inhibition of iron-sulfur cluster biosynthesis disrupts metabolic flexibility in mice
M. Molenaars, Hannan Mir, Samantha W. Alvarez, Lakshmi Arivazhagan +6 more
2024bioRxiv1 citations Open access
Semantic Scholar
THE THERAPEUTIC VALUE OF LYSINE AGAINST CANCER: A COMPREHENSIVE REVIEW
S. Debnath, A. Mukherjee, S. Karan, T. Chatterjee +253 more
2020International Journal of Biology Pharmacy and Allied Sciences1 citations Open access
Semantic Scholar
Damage in Human Fibroblasts Senescence and the Response to DNA Nek4 Regulates Entry into Replicative
Anyong Xie, R. Scully, W. Hahn, Christine L. Nguyen +2 more
20141 citations
Semantic Scholar

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