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E. Freinkman · SciRah

Researcher profile · Semantic Scholar

E. Freinkman

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E. Freinkman — researcher profile on SciRah

h-index: 39
Works: 60
Citations: 11K

Most-cited papers

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
Kıvanç Birsoy, Tim X. Wang, Walter W. Chen, E. Freinkman +2 more
2015Cell1,320 citations Open access
Semantic Scholar
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5’ sites
S. Schwartz, Maxwell R. Mumbach, M. Jovanović, Tim X. Wang +16 more
2014Cell Reports1,125 citations Open access
Semantic Scholar
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
Lucas B. Sullivan, Dan Y. Gui, Aaron M. Hosios, Lauren N. Bush +2 more
2015Cell1,098 citations Open access
Semantic Scholar
Lysosomal metabolomics reveals V-ATPase and mTOR-dependent regulation of amino acid efflux from lysosomes
Monther Abu-Remaileh, G. Wyant, Choah Kim, N. Laqtom +4 more
2017Science638 citations Open access
Semantic Scholar
Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase
J. Cantor, Monther Abu-Remaileh, N. Kanarek, E. Freinkman +4 more
2017Cell562 citations Open access
Semantic Scholar
Tissue-of-origin Dictates Branched-Chain Amino Acid Metabolism in Mutant Kras-driven Cancers
Jared R. Mayers, M. Torrence, Laura V. Danai, T. Papagiannakopoulos +13 more
2016Science549 citations Open access
Semantic Scholar
Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism
Walter W. Chen, E. Freinkman, Tim X. Wang, Kıvanç Birsoy +1 more
2016Cell480 citations Open access
Semantic Scholar
A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate
M. Pacold, K. Brimacombe, Sze Ham Chan, Jason M. Rohde +28 more
2016Nature Chemical Biology471 citations Open access
Semantic Scholar
mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient
G. Wyant, Monther Abu-Remaileh, Rachel L. Wolfson, Walter W. Chen +4 more
2017Cell432 citations Open access
Semantic Scholar
Fasting activates Fatty Acid Oxidation to enhance intestinal stem cell function during homeostasis and aging
M. Mihaylova, Chia-Wei Cheng, Amanda Q. Cao, Surya Tripathi +16 more
2018Cell Stem Cell403 citations Open access
Semantic Scholar
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death
J. Garcia-Bermudez, Lou Baudrier, Erol C. Bayraktar, Yi-Hui Shen +12 more
2019Nature388 citations Open access
Semantic Scholar
Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin
Dan Y. Gui, Lucas B. Sullivan, Alba Luengo, Aaron M. Hosios +6 more
2016Cell Metabolism307 citations Open access
Semantic Scholar
SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance
Dohoon Kim, Brian P. Fiske, Kıvanç Birsoy, E. Freinkman +15 more
2015Nature294 citations Open access
Semantic Scholar
Histidine catabolism is a major determinant of methotrexate sensitivity
N. Kanarek, Heather R. Keys, J. Cantor, Caroline A. Lewis +6 more
2018Nature283 citations Open access
Semantic Scholar
Store-operated Ca2+ entry controls clonal expansion of T cells through metabolic reprogramming
M. Vaeth, Mate Maus, S. Klein-Hessling, E. Freinkman +8 more
2017Immunity253 citations Open access
Semantic Scholar
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
Y. Shaul, E. Freinkman, William C. Comb, J. Cantor +12 more
2014Cell208 citations Open access
Semantic Scholar
Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli
Suguru Okuda, E. Freinkman, D. Kahne
2012Science197 citations Open access
Semantic Scholar
The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel
E. Freinkman, Shu-Sin Chng, D. Kahne
2011Proceedings of the National Academy of Sciences of the United States of America192 citations Open access
Semantic Scholar
Metabolic re-programming of pancreatic cancer mediated by CDK4/6 inhibition elicits unique vulnerabilities
Jorge Franco, U. Balaji, E. Freinkman, A. Witkiewicz +1 more
2016Cell Reports187 citations Open access
Semantic Scholar
LACTB is a tumour suppressor that modulates lipid metabolism and cell state
Z. Keckesova, Joana Liu Donaher, J. De Cock, E. Freinkman +11 more
2017Nature177 citations Open access
Semantic Scholar
Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export
E. Freinkman, Suguru Okuda, N. Ruiz, D. Kahne
2012Biochemistry137 citations Open access
Semantic Scholar
Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis
Tsutomu Endo, E. Freinkman, D. de Rooij, D. Page
2017Proceedings of the National Academy of Sciences of the United States of America132 citations Open access
Semantic Scholar
Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites
Walter W. Chen, E. Freinkman, D. Sabatini
2017Nature Protocols116 citations Open access
Semantic Scholar
Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates
Arielle Woznica, Alexandra M. Cantley, Christine Beemelmanns, E. Freinkman +2 more
2016Proceedings of the National Academy of Sciences of the United States of America111 citations Open access
Semantic Scholar
Critical role for arginase 2 in obesity-associated pancreatic cancer
Tamara Zaytouni, Pei-Yun Tsai, D. Hitchcock, Cory D. DuBois +10 more
2017Nature Communications91 citations Open access
Semantic Scholar
Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes
Ravi V. Shah, Venkatesh L. Murthy, M. Pacold, Kirsty M. Danielson +13 more
2017Diabetes Care88 citations Open access
Semantic Scholar
mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold
S. Labbé, Mathilde Mouchiroud, Alexandre Caron, Blandine Secco +9 more
2016Scientific Reports76 citations Open access
Semantic Scholar
The Protein Synthesis Inhibitor Blasticidin S Enters Mammalian Cells via Leucine-rich Repeat-containing Protein 8D
Clarissa C. Lee, E. Freinkman, D. Sabatini, H. Ploegh
2014Journal of Biological Chemistry74 citations Open access
Semantic Scholar
JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition
A. McKenney, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, B. Spitzer +19 more
2018Journal of Clinical Investigation73 citations Open access
Semantic Scholar
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
Alba Luengo, Keene L. Abbott, Shawn M. Davidson, Aaron M. Hosios +9 more
2019Nature Communications67 citations Open access
Semantic Scholar
Targeting Tumor Phenotypic Plasticity and Metabolic Remodeling in Adaptive Cross-Drug Tolerance
Aaron Goldman, Sachin K. Khiste, E. Freinkman, A. Dhawan +12 more
2019Science Signaling62 citations Open access
Semantic Scholar
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
M. Pacold, K. Brimacombe, Sze Ham Chan, Jason M. Rohde +28 more
2016Nature Chemical Biology61 citations Open access
Semantic Scholar
Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential
E. Knudsen, U. Balaji, E. Freinkman, P. Mccue +1 more
2016OncoTarget57 citations Open access
Semantic Scholar
Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans
F. Tafesse, A. Rashidfarrokhi, F. Schmidt, E. Freinkman +6 more
2015PLoS Pathogens57 citations Open access
Semantic Scholar
Cholesterol-independent SREBP-1 maturation is linked to ARF1 inactivation
Lorissa J. Smulan, Wei Ding, E. Freinkman, Sharvari Gujja +2 more
2016Cell Reports56 citations Open access
Semantic Scholar
Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.
Nai-Jia Huang, Ying-Cing Lin, Chung-Yueh Lin, Novalia Pishesha +5 more
2018Blood53 citations Open access
Semantic Scholar
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase
Nina Ilic, Kıvanç Birsoy, Andrew J. Aguirre, Nora Kory +15 more
2017Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes
Boryana Petrova, Ke-Ke Liu, Cai-Ping Tian, Maiko Kitaoka +3 more
2018Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Sequence variation in G-protein-coupled receptors: analysis of single nucleotide polymorphisms
S. Balasubramanian, Yu Xia, E. Freinkman, M. Gerstein
2005Nucleic Acids Research45 citations Open access
Semantic Scholar
Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum
E. Freinkman, D. Oh, J. Scott, C. Currie +1 more
2009Tetrahedron Letters27 citations Open access
Semantic Scholar
Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma
Shawn M. Davidson, D. R. Schmidt, Julia Heyman, James P. O’Brien +20 more
2021bioRxiv25 citations Open access
Semantic Scholar
An ambient-temperature storage and stabilization device performs comparably to flash-frozen collection for stool metabolomics in infants
S. Ramamoorthy, S. Levy, Masouma Mohamed, Alaa A. Abdelghani +6 more
2021BMC Microbiology25 citations Open access
Semantic Scholar
6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels
Hao-Xin Li, M. Ericsson, Bokang Rabasha, B. Budnik +7 more
2019Cell Chemical Biology25 citations Open access
Semantic Scholar
Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis
He Xu, Min-Sik Lee, Pei-Yun Tsai, Ashley Adler +11 more
2018Proceedings of the National Academy of Sciences of the United States of America24 citations Open access
Semantic Scholar
Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities
Jorge Franco, U. Balaji, E. Freinkman, A. Witkiewicz +1 more
2020Cell Reports23 citations Open access
Semantic Scholar
37th International Symposium on Intensive Care and Emergency Medicine (part 3 of 3)
M. von Seth, L. Hillered, A. Otterbeck, K. Hanslin +496 more
2017Critical Care21 citations Open access
Semantic Scholar
JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.
A. McKenney, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, B. Spitzer +19 more
2018Journal of Clinical Investigation6 citations Open access
Semantic Scholar
Author Correction: Histidine catabolism is a major determinant of methotrexate sensitivity
N. Kanarek, Heather R. Keys, J. Cantor, Caroline A. Lewis +6 more
2022Nature4 citations Open access
Semantic Scholar
Bacteria regulate choanoflagellate development with lipid activators, inhibitors, and synergists
Arielle Woznica, Alexandra M. Cantley, Christine Beemelmanns, E. Freinkman +2 more
2016bioRxiv1 citations Open access
Semantic Scholar
OMNImet™•GUT enables at-home collection and ambient temperature transport of fecal samples for metabolomics
Olle M. de Bruin, E. Freinkman, Heloise A. Breton, A. M. Evans +4 more
1 citations
Semantic Scholar

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