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K. Eggan · SciRah

Researcher profile · Semantic Scholar

K. Eggan

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K. Eggan — researcher profile on SciRah

h-index: 72
Works: 207
Citations: 28K

Most-cited papers

ALS IMPLICATED PROTEIN TDP-43 SUSTAINS LEVELS OF STMN2 A MEDIATOR OF MOTOR NEURON GROWTH AND REPAIR
Joseph R. Klim, Luis A. Williams, Francesco Limone, Irune Guerra San Juan +12 more
2019Nature Neuroscience593 citations Open access
Semantic Scholar
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
F. Merkle, Sulagna Dia Ghosh, Nolan Kamitaki, Jana M. Mitchell +13 more
2017Nature496 citations Open access
Semantic Scholar
Modeling ALS using motor neurons derived from human induced pluripotent stem cells
S. Sances, L. Bruijn, S. Chandran, K. Eggan +11 more
2016Nature Neuroscience266 citations Open access
Semantic Scholar
Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.
Michael F. Wells, M. Salick, Ole Wiskow, D. Ho +10 more
2016Cell Stem Cell255 citations Open access
Semantic Scholar
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria
Aaron Burberry, Michael F. Wells, Francesco Limone, Alexander Couto +13 more
2020Nature251 citations Open access
Semantic Scholar
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
R. Nehme, Emanuela Zuccaro, Sulagna Dia Ghosh, Chen-Chen Li +17 more
2018Cell Reports251 citations Open access
Semantic Scholar
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
Aaron Burberry, Naoki Suzuki, Jin-Yuan Wang, R. Moccia +13 more
2016Science Translational Medicine251 citations Open access
Semantic Scholar
Evaluating the state of the science for adeno-associated virus integration: An integrated perspective
D. Sabatino, Frederic D. Bushman, R. Chandler, R. Crystal +10 more
2022Molecular Therapy180 citations Open access
Semantic Scholar
Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues
Mian Wang, Wan-Lu Li, Jin Hao, Arthur A. Gonzales +15 more
2022Nature Communications136 citations Open access
Semantic Scholar
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath +20 more
2023Nature Immunology134 citations Open access
Semantic Scholar
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage
S. Hill, Daniel A. Mordes, L. Cameron, D. Neuberg +3 more
2016Proceedings of the National Academy of Sciences of the United States of America134 citations Open access
Semantic Scholar
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
B. Wainger, E. Macklin, S. Vucic, C. McIlduff +45 more
2020JAMA Neurology125 citations Open access
Semantic Scholar
Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium
Stephan J Sanders, B. Neale, Hai-Liang Huang, D. Werling +24 more
2017Nature Neuroscience125 citations Open access
Semantic Scholar
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7 encoding a heat-shock protein
S. Farhan, D. Howrigan, L. Abbott, Joseph R. Klim +31 more
2019Nature Neuroscience122 citations Open access
Semantic Scholar
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.
P. Andrews, Uri Ben-David, N. Benvenisty, P. Coffey +7 more
2017Stem Cell Reports122 citations Open access
Semantic Scholar
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1
P. Tripathi, N. Rodriguez-Muela, Joseph R. Klim, A. D. de Boer +9 more
2017Stem Cell Reports121 citations Open access
Semantic Scholar
Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons
J. Kawada, S. Kaneda, T. Kirihara, A. Maroof +4 more
2017Stem Cell Reports99 citations Open access
Semantic Scholar
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
Michael F. Wells, J. Nemesh, Sulagna Dia Ghosh, Jana M. Mitchell +23 more
2023Cell Stem Cell94 citations Open access
Semantic Scholar
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
Feng Tian, Wenlong Yang, Daniel A. Mordes, Jin-Yuan Wang +17 more
2016Nature Communications86 citations Open access
Semantic Scholar
Dysregulated protocadherin-pathway activity as an intrinsic defect in iPSC-derived cortical interneurons from patients with schizophrenia
Zhicheng Shao, H. Noh, Woong Bin Kim, Pei-Yan Ni +33 more
2019Nature Neuroscience77 citations Open access
Semantic Scholar
Mapping genetic effects on cellular phenotypes with “cell villages”
Jana M. Mitchell, J. Nemesh, Sulagna Dia Ghosh, R. Handsaker +10 more
2020bioRxiv73 citations Open access
Semantic Scholar
Loss of mouse Stmn2 function causes motor neuropathy
Irune Guerra San Juan, L. Nash, K. S. Smith, Marcel F Leyton-Jaimes +15 more
2022Neuron70 citations Open access
Semantic Scholar
Connecting TDP-43 Pathology with Neuropathy.
Joseph R. Klim, G. Pintacuda, L. Nash, Irune Guerra San Juan +1 more
2021Trends in Neurosciences65 citations Open access
Semantic Scholar
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis
Yingying Zhang, Aaron Burberry, Jin-Yuan Wang, Jackson Sandoe +9 more
2018Genes & Development65 citations Open access
Semantic Scholar
All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS
E. Kiskinis, Joel M. Kralj, Peng Zou, Eli N. Weinstein +6 more
2018bioRxiv60 citations Open access
Semantic Scholar
Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS
Akshata A Almad, A. Taga, J. Joseph, Sarah K Gross +12 more
2022Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons
M. Vogt, Zahra Ehsaei, P. Knuckles, A. Higginbottom +9 more
2018Scientific Reports55 citations Open access
Semantic Scholar
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
R. Nehme, O. Pietiläinen, M. Artomov, M. Tegtmeyer +41 more
2021Nature Communications54 citations Open access
Semantic Scholar
Motoneurons Derived from Induced Pluripotent Stem Cells Develop Mature Phenotypes Typical of Endogenous Spinal Motoneurons
Jeremy S. Toma, Basavaraj C Shettar, P. Chipman, Devanand M. Pinto +6 more
2015Journal of Neuroscience51 citations Open access
Semantic Scholar
Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development
D. McPhie, R. Nehme, C. Ravichandran, S. M. Babb +10 more
2018Translational Psychiatry50 citations Open access
Semantic Scholar
Absence of Survival and Motor Deficits in 500 Repeat C9ORF72 BAC Mice.
Daniel A. Mordes, Brett M. Morrison, X. H. Ament, C. Cantrell +6 more
2020Neuron49 citations Open access
Semantic Scholar
Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues
Francesco Limone, Irune Guerra San Juan, Jana M. Mitchell, Janell L. M. Smith +15 more
2022bioRxiv48 citations Open access
Semantic Scholar
Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation
Xuan Huang, K. Roet, Liying Zhang, Amy L. Brault +20 more
2021Cell Reports47 citations Open access
Semantic Scholar
A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.
Sebastian Thams, Emily R. Lowry, Marie-Hélène Larraufie, Krista J. Spiller +12 more
2019Molecular Therapy46 citations Open access
Semantic Scholar
Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation
F. Merkle, Sulagna Dia Ghosh, G. Genovese, R. Handsaker +9 more
2022Cell Stem Cell45 citations Open access
Semantic Scholar
High-dimensional phenotyping to define the genetic basis of cellular morphology
M. Tegtmeyer, Jatin Arora, Samira Asgari, B. Cimini +15 more
2023bioRxiv44 citations Open access
Semantic Scholar
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition
Linlin Z. Fan, R. Nehme, Yoav Adam, Eun Sun Jung +4 more
2018Nature Methods44 citations Open access
Semantic Scholar
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders
G. Pintacuda, Yu-Han H. Hsu, K. Tsafou, Ka-Wan Li +12 more
2023Cell Genomics43 citations Open access
Semantic Scholar
The genetic architecture of DNA replication timing in human pluripotent stem cells
Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu +14 more
2020Nature Communications42 citations Open access
Semantic Scholar
RNA-seq as a tool for evaluating human embryo competence
A. Groff, N. Resetkova, Francesca Di Domenico, D. Sakkas +3 more
2019Genome Research41 citations Open access
Semantic Scholar
Comprehensive protocols for CRISPR/Cas9-based gene editing in human pluripotent stem cells
David P. Santos, E. Kiskinis, K. Eggan, F. Merkle
2016Current protocols in stem cell biology39 citations Open access
Semantic Scholar
Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9
H. Oh, W. Neuhausser, P. Eggan, Magdalena Angelova +3 more
2019eLife38 citations Open access
Semantic Scholar
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
Evgeny Shlevkov, Himanish Basu, M. Bray, Zhenquan Sun +12 more
2019Cell Reports38 citations Open access
Semantic Scholar
A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells
D. Hazelbaker, A. Beccard, G. Angelini, P. Mazzucato +4 more
2020Scientific Reports37 citations Open access
Semantic Scholar
Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophrenia
Kristina Dobrindt, Han-Wen Zhang, Debamitra Das, S. Abdollahi +12 more
2020bioRxiv37 citations Open access
Semantic Scholar
Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells.
Y. Avior, Elyad Lezmi, K. Eggan, N. Benvenisty
2020Cell Stem Cell36 citations Open access
Semantic Scholar
Modelling Zika Virus Infection of the Developing Human Brain In Vitro Using Stem Cell Derived Cerebral Organoids
M. Salick, Michael F. Wells, K. Eggan, A. Kaykas
2017Journal of Visualized Experiments36 citations Open access
Semantic Scholar
CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development *
Mridula K. Ray, Ole Wiskow, Matthew J. King, Nidha Ismail +11 more
2016Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder
Bipasha Mukherjee-Clavin, R. Mi, Barbara Kern, In-Young Choi +16 more
2019Nature Biomedical Engineering34 citations Open access
Semantic Scholar
Hippo signaling in the ovary and polycystic ovarian syndrome
K. Maas, S. Mirabal, A. Penzias, P. Sweetnam +2 more
2018Journal of Assisted Reproduction and Genetics34 citations Open access
Semantic Scholar

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Sulagna Dia Ghosh×13
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R. Nehme×8
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