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V. Sayin · SciRah

Researcher profile · Semantic Scholar

V. Sayin

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V. Sayin — researcher profile on SciRah

h-index: 22
Works: 80
Citations: 4,669

Most-cited papers

Antioxidants Accelerate Lung Cancer Progression in Mice
V. Sayin, Mohamed X Ibrahim, E. Larsson, J. Nilsson +2 more
2014Science Translational Medicine841 citations
Semantic Scholar
Antioxidants can increase melanoma metastasis in mice
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, V. Sayin +7 more
2015Science Translational Medicine610 citations
Semantic Scholar
Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis
Rodrigo Romero, V. Sayin, Shawn M. Davidson, M. Bauer +24 more
2017Nature Medicine591 citations Open access
Semantic Scholar
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis.
Clotilde Wiel, Kristell Le Gal, Mohamed X Ibrahim, C. Jahangir +10 more
2019Cell511 citations Open access
Semantic Scholar
Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
Luca Lignitto, Sarah E. Leboeuf, Harrison Homer, Shao-Wen Jiang +9 more
2019Cell510 citations Open access
Semantic Scholar
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
V. Sayin, Sarah E. Leboeuf, Simranjit X. Singh, Shawn M. Davidson +14 more
2017eLife203 citations Open access
Semantic Scholar
The pleiotropic functions of reactive oxygen species in cancer
Katherine Wu, A. E. El Zowalaty, V. Sayin, T. Papagiannakopoulos
2024Nature Cancer191 citations
Semantic Scholar
Activation of oxidative stress response in cancer generates a druggable dependency on exogenous non-essential amino acids
Sarah E. Leboeuf, Warren L. Wu, Triantafyllia Karakousi, Burcu Karadal +6 more
2019Cell Metabolism138 citations Open access
Semantic Scholar
Cellular Redox Homeostasis
Kristell Le Gal, E. Schmidt, V. Sayin
2021Antioxidants132 citations Open access
Semantic Scholar
Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria
Mohamed X Ibrahim, V. Sayin, Murali K. Akula, Meng-Ru Liu +3 more
2013Science112 citations Open access
Semantic Scholar
Oncogene-induced senescence underlies the mutual exclusive nature of oncogenic KRAS and BRAF
Jaroslaw Cisowski, V. Sayin, Meng-Ru Liu, Christin Karlsson +1 more
2016Oncogene105 citations Open access
Semantic Scholar
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
Michael McLoughlin, D. Orlicky, J. R. Prigge, P. Krishna +15 more
2019Proceedings of the National Academy of Sciences of the United States of America93 citations Open access
Semantic Scholar
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Murali K. Akula, Mohamed X Ibrahim, Emil Ivarsson, Omar M. Khan +10 more
2019Nature Communications75 citations Open access
Semantic Scholar
Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events
A. Ashouri, V. Sayin, J. Van den Eynden, Simranjit X. Singh +2 more
2016Nature Communications57 citations Open access
Semantic Scholar
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer
R. Pillai, Sarah E. Leboeuf, Yuan Hao, Connie New +24 more
2024Science Advances55 citations Open access
Semantic Scholar
Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P
Maria Schwarz, Caroline E Meyer, Alexander Löser, Kristina Lossow +21 more
2023Nature Communications42 citations Open access
Semantic Scholar
Loss of One Copy of Zfp148 Reduces Lesional Macrophage Proliferation and Atherosclerosis in Mice by Activating p53
V. Sayin, Omar M. Khan, Lara E Pehlivanoglu, A. Staffas +8 more
2014Circulation Research37 citations Open access
Semantic Scholar
Antioxidants Promote Intestinal Tumor Progression in Mice
Zhiyuan Zou, Kristell Le Gal, A. E. El Zowalaty, Lara E Pehlivanoglu +10 more
2021Antioxidants31 citations Open access
Semantic Scholar
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer
R. Pillai, Sarah E. Leboeuf, Yuan Hao, Connie New +24 more
2023bioRxiv27 citations Open access
Semantic Scholar
The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity
Laura Casares, R. Moreno, K. Ali, M. Higgins +13 more
2022Redox Biology27 citations Open access
Semantic Scholar
KRAS Mutations Impact Clinical Outcome in Metastatic Non-Small Cell Lung Cancer
E. Eklund, C. Wiel, H. Fagman, Levent M. Akyürek +4 more
2022Cancers26 citations Open access
Semantic Scholar
Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in Mice
Kristell Le Gal, Clotilde Wiel, Mohamed X Ibrahim, Marcus Henricsson +2 more
2021Antioxidants26 citations Open access
Semantic Scholar
Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1.
R. Moreno, Laura Casares, M. Higgins, K. Ali +5 more
2022Free Radical Biology & Medicine17 citations Open access
Semantic Scholar
Zfp148 Deficiency Causes Lung Maturation Defects and Lethality in Newborn Mice That Are Rescued by Deletion of p53 or Antioxidant Treatment
V. Sayin, Anna Nilton, Mohamed X Ibrahim, P. Ågren +7 more
2013PLoS ONE17 citations Open access
Semantic Scholar
The integrated stress response promotes immune evasion through lipocalin 2
Jozef P Bossowski, R. Pillai, J. Kilian, Angela Wong Lau +32 more
2026Nature16 citations Open access
Semantic Scholar
Targeting Metabolic Bottlenecks in Lung Cancer.
V. Sayin, Sarah E. Leboeuf, T. Papagiannakopoulos
2019Trends in Cancer16 citations
Semantic Scholar
Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice
D. Petersen, L. Saba, V. Sayin, T. Papagiannakopoulos +4 more
2018PLoS ONE15 citations Open access
Semantic Scholar
Application of CRISPR-mediated genome engineering in cancer research.
V. Sayin, T. Papagiannakopoulos
2017Cancer Letters15 citations
Semantic Scholar
Ageing promotes metastasis via activation of the integrated stress response
Angana A. H. Patel, Jozefina J. Dzanan, K. Ali, E. Eklund +25 more
2026Nature14 citations Open access
Semantic Scholar
Targeting Zfp148 activates p53 and reduces tumor initiation in the gut
Anna Nilton, V. Sayin, Zhiyuan Zou, S. Sayin +7 more
2016OncoTarget12 citations Open access
Semantic Scholar
Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway
Zhiyuan Zou, Nadia Gul, M. Lindberg, Abdulmalik A. Bokhari +14 more
2020Scientific Reports11 citations Open access
Semantic Scholar
High baseline PD-1+ CD8 T Cells and TIGIT+ CD8 T Cells in circulation associated with response to PD-1 blockade in patients with non-small cell lung cancer
Nikita Dutta, Johanna Svensson, G. Saad, M. Mello +8 more
2025Cancer Immunology and Immunotherapy10 citations Open access
Semantic Scholar
Identification of a BACH1 lung cancer signature: A novel tool for understanding BACH1 biology and identifying new inhibitors
Donika Klenja-Skudrinja, K. Ali, David J. Walker, Maureen Higgins +10 more
2025bioRxiv10 citations Open access
Semantic Scholar
Comprehensive genetic variant analysis reveals combination of KRAS and LRP1B as a predictive biomarker of response to immunotherapy in patients with non-small cell lung cancer
E. Eklund, Johanna Svensson, L. Näslund, Maria Yhr +8 more
2025Journal of experimental & clinical cancer research : CR9 citations Open access
Semantic Scholar
A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis.
Hai-Dong Yao, Xue Chen, Ting Wang, Muhammad Kashif +7 more
2023Cell Reports9 citations Open access
Semantic Scholar
Bibliometric Analysis of Studies Conducted between 2015-2019 on the Flipped Classroom Model
R. Çakır, V. Sayin, S. Bektaş
2020International Journal of Research in Education and Science8 citations Open access
Semantic Scholar
Zinc Finger Protein 148 Is Dispensable for Primitive and Definitive Hematopoiesis in Mice
Anna Nilton, V. Sayin, A. Staffas, E. Larsson +6 more
2013PLoS ONE6 citations Open access
Semantic Scholar
Involvement of KEAP1/NRF2 pathway in non‐BRAF mutated squamous cell carcinoma of the thyroid
E. Schoultz, Jakob Dahlberg, Lisa M. Nilsson, Jozefina J. Dzanan +10 more
2025Journal of Pathology5 citations Open access
Semantic Scholar
Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes arthritis.
E. Malmhäll-Bah, K. Andersson, M. Erlandsson, Murali K. Akula +6 more
2022Journal of Autoimmunity5 citations Open access
Semantic Scholar
Monotherapy With Immune Checkpoint Blockade Improves Survival Outcomes in KRAS-Mutant but Not KRAS Wild-Type Metastatic Lung Adenocarcinoma: Validation From an Extended Swedish Cohort
E. Eklund, S. Sayin, J. S. Jonsson, Hannes van Renswoude +4 more
2025JTO Clinical and Research Reports4 citations
Semantic Scholar
Combinatory analysis of immune cell subsets and tumor-specific genetic variants predict clinical response to PD-1 blockade in patients with non-small cell lung cancer
Nikita Dutta, A. Rohlin, E. Eklund, M. Magnusson +7 more
2023Frontiers in Oncology4 citations Open access
Semantic Scholar
Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b
C. Karlsson, Murali K. Akula, A. Staffas, J. Cisowski +4 more
2020Leukemia4 citations
Semantic Scholar
Author response: Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
V. Sayin, Sarah E. Leboeuf, Simranjit X. Singh, Shawn M. Davidson +14 more
20174 citations Open access
Semantic Scholar
Nuclear AGO2 supports influenza A virus replication through type-I interferon regulation
Hsiang-Chi Huang, Michelle Fong, Iwona Nowak, E. Shcherbinina +12 more
2025Nucleic Acids Research3 citations Open access
Semantic Scholar
Equalizing prognostic disparities in KRAS-mutated stage III NSCLC patients: addition of durvalumab to combined chemoradiotherapy improves survival.
E. Eklund, Mathilda Orgard, Delice Wallin, S. Sayin +8 more
2025Lung Cancer3 citations Open access
Semantic Scholar
Assessing the prognostic value of KRAS mutation combined with tumor size in stage I-II non-small cell lung cancer: a retrospective analysis
E. Eklund, A. Mourad, C. Wiel, S. Sayin +3 more
2024Frontiers in Oncology3 citations Open access
Semantic Scholar
STING-dependent peripheral inflammaging drives neurodegeneration via extracellular vesicles.
Maria Öberg, Caitlyn Myers, Najmeh Saffarzadeh, Ivana Maric +18 more
2026Cell Reports2 citations Open access
Semantic Scholar
Amino acid restriction sensitizes lung cancer cells to ferroptosis via GCN2-dependent activation of the integrated stress response
Viktor Garellick, Nadia Gul, Parvin Horrieh, D. Mustafa +11 more
2025bioRxiv2 citations Open access
Semantic Scholar
Distinct metastatic organotropism shapes prognosis in lung adenocarcinoma with brain metastasis
S. Sayin, E. Eklund, K. Ali, Jozefina J. Dzanan +6 more
2025medRxiv2 citations Open access
Semantic Scholar
Aging promotes lung cancer metastasis through epigenetic ATF4 induction
Angana A. H. Patel, Jozefina J. Dzanan, K. Ali, E. Eklund +16 more
2024bioRxiv2 citations
Semantic Scholar

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