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M. Staufenbiel · SciRah

Researcher profile · Semantic Scholar

M. Staufenbiel

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M. Staufenbiel — researcher profile on SciRah

h-index: 96
Works: 286
Citations: 33K

Most-cited papers

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models.
L. Ittner, Ya-Zi D. Ke, Fabien Delerue, Mian Bi +10 more
2010Cell1,874 citations Open access
Semantic Scholar
Innate immune memory in the brain shapes neurological disease hallmarks
Ann-Christin Wendeln, Karoline Degenhardt, Lalit Kaurani, Michael Gertig +20 more
2018Nature872 citations Open access
Semantic Scholar
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
F. Clavaguera, H. Akatsu, G. Fraser, R. Crowther +9 more
2013Proceedings of the National Academy of Sciences of the United States of America723 citations Open access
Semantic Scholar
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease
M. Busche, Xiaowei Chen, Horst A. Henning, Julia Reichwald +3 more
2012Proceedings of the National Academy of Sciences of the United States of America706 citations Open access
Semantic Scholar
Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis
Yvonne S. Eisele, Ulrike Obermüller, Goetz Heilbronner, F. Baumann +6 more
2010Science516 citations Open access
Semantic Scholar
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.
M. Bacioglu, L. Maia, O. Preische, J. Schelle +14 more
2016Neuron399 citations Open access
Semantic Scholar
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].
S. Sirko, Gwendolyn Behrendt, P. Johansson, P. Tripathi +17 more
2013Cell Stem Cell372 citations Open access
Semantic Scholar
Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study.
B. Winblad, N. Andreasen, L. Minthon, A. Floesser +8 more
2012Lancet Neurology279 citations
Semantic Scholar
Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia
Stefan A. Grathwohl, R. Kälin, T. Bolmont, S. Prokop +12 more
2010262 citations Open access
Semantic Scholar
Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
Yvonne S. Eisele, T. Bolmont, M. Heikenwalder, Franziska Langer +7 more
2009Proceedings of the National Academy of Sciences of the United States of America240 citations Open access
Semantic Scholar
Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β
N. Schonrock, Ya-Zi D. Ke, D. Humphreys, M. Staufenbiel +3 more
2010PLoS ONE217 citations Open access
Semantic Scholar
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease
Jay Rasmussen, J. Mahler, N. Beschorner, Stephan A. Kaeser +16 more
2017Proceedings of the National Academy of Sciences of the United States of America214 citations Open access
Semantic Scholar
Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition
Franziska Langer, Yvonne S. Eisele, Sarah K. Fritschi, M. Staufenbiel +2 more
2011Journal of Neuroscience213 citations Open access
Semantic Scholar
Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein
L. Maia, Stephan A. Kaeser, Julia Reichwald, Michael Hruscha +3 more
2013Science Translational Medicine193 citations
Semantic Scholar
The Second-Generation Active Aβ Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects
C. Wiessner, K. Wiederhold, Alain C. Tissot, P. Frey +10 more
2011Journal of Neuroscience178 citations Open access
Semantic Scholar
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Yasuhiko Kizuka, S. Kitazume, Reiko Fujinawa, T. Saito +11 more
2015EMBO Molecular Medicine172 citations Open access
Semantic Scholar
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
B. Melchior, Angie Garcia, Bor-Kai Hsiung, K. M. Lo +6 more
2010ASN Neuro164 citations Open access
Semantic Scholar
The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease
U. Neumann, M. Ufer, L. Jacobson, Marie‐Laure Rouzade‐Dominguez +28 more
2018EMBO Molecular Medicine150 citations Open access
Semantic Scholar
Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease
Christine Grienberger, Nathalie L Rochefort, H. Adelsberger, Horst A. Henning +4 more
2012Nature Communications144 citations Open access
Semantic Scholar
Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
M. Busche, Christine Grienberger, Aylin D Keskin, Beomjong Song +4 more
2015Nature Neuroscience142 citations
Semantic Scholar
In vivo positron emission tomographic imaging of glial responses to amyloid-β and tau pathologies in mouse models of Alzheimer's disease and related disorders
J. Maeda, Ming-Rong Zhang, T. Okauchi, Bin Ji +13 more
2011Journal of Neuroscience130 citations Open access
Semantic Scholar
Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing
M. Dinamarca, Adi Raveh, A. Schneider, Thorsten Fritzius +14 more
2019Nature Communications119 citations Open access
Semantic Scholar
BACE inhibition-dependent repair of Alzheimer’s pathophysiology
Aylin D Keskin, Maja Kekuš, H. Adelsberger, U. Neumann +10 more
2017Proceedings of the National Academy of Sciences of the United States of America113 citations Open access
Semantic Scholar
Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein
L. A. Gomes, Silvia Andrea Hipp, Ajeet Rijal Upadhaya, K. Balakrishnan +14 more
2019Acta Neuropathologica110 citations Open access
Semantic Scholar
A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice
U. Neumann, H. Rueeger, R. Machauer, S. Veenstra +10 more
2015Molecular Neurodegeneration102 citations Open access
Semantic Scholar
Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathology
M. Higuchi, N. Iwata, Y. Matsuba, Jiro Takano +7 more
2012The FASEB Journal100 citations Open access
Semantic Scholar
Amyloid‐β protein (Aβ) Glu11 is the major β‐secretase site of β‐site amyloid‐β precursor protein‐cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis
Yu Deng, Zhe Wang, Ruitao Wang, Xiaozhu Zhang +5 more
2013European Journal of Neuroscience99 citations
Semantic Scholar
Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice
N. Iwata, Misaki Sekiguchi, Yoshino Hattori, A. Takahashi +6 more
2013Scientific Reports99 citations Open access
Semantic Scholar
Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment
Carrie E. McAllister, J. Long, A. Bowers, Aaron Walker +6 more
2010Journal of Neuroscience99 citations Open access
Semantic Scholar
Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides.
H. Rueeger, R. Lueoend, Olivier Rogel, J. Rondeau +6 more
2012Journal of Medicinal Chemistry98 citations Open access
Semantic Scholar
Multiple Factors Contribute to the Peripheral Induction of Cerebral β-Amyloidosis
Yvonne S. Eisele, Sarah K. Fritschi, T. Hamaguchi, Ulrike Obermüller +7 more
2014Journal of Neuroscience91 citations Open access
Semantic Scholar
Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer’s transgenic mice
Re-Na Li, P. He, Jie Cui, M. Staufenbiel +2 more
2012Molecular Neurobiology86 citations Open access
Semantic Scholar
Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life
Ruth E. Uhlmann, Christine Rother, Jay Rasmussen, J. Schelle +22 more
2020Nature Neuroscience80 citations Open access
Semantic Scholar
Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid
Sarah K. Fritschi, Franziska Langer, Stephan A. Kaeser, L. Maia +12 more
2014Brain : a journal of neurology77 citations Open access
Semantic Scholar
Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of β-Secretase in a Mouse Model of Alzheimer’s Disease
P. He, Xin Cheng, M. Staufenbiel, Re-Na Li +1 more
2013PLoS ONE69 citations Open access
Semantic Scholar
Noninvasive Magnetic Resonance Imaging Detection of Cerebral Amyloid Angiopathy-Related Microvascular Alterations Using Superparamagnetic Iron Oxide Particles in APP Transgenic Mouse Models of Alzheimer's Disease: Application to Passive Aβ Immunotherapy
N. Beckmann, C. Gérard, D. Abramowski, C. Cannet +1 more
2011Journal of Neuroscience65 citations Open access
Semantic Scholar
Persistence of Aβ seeds in APP null mouse brain
L. Ye, Sarah K. Fritschi, J. Schelle, Ulrike Obermüller +7 more
2015Nature Neuroscience59 citations
Semantic Scholar
Exposure to 56Fe-Particle Radiation Accelerates Electrophysiological Alterations in the Hippocampus of APP23 Transgenic Mice
R. Vlkolinský, E. Titova, T. Krucker, B.-B. Chi +3 more
2010Radiation Research56 citations
Semantic Scholar
Increased CSF Aβ during the very early phase of cerebral Aβ deposition in mouse models
L. Maia, Stephan A. Kaeser, Julia Reichwald, Marius Lambert +6 more
2015EMBO Molecular Medicine55 citations Open access
Semantic Scholar
Early‐onset axonal pathology in a novel P301S‐Tau transgenic mouse model of frontotemporal lobar degeneration
J. van Eersel, C. Stevens, Magdalena Przybyla, Amadeus Gladbach +10 more
2015Neuropathology and Applied Neurobiology53 citations Open access
Semantic Scholar
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
A. Lerchner, R. Machauer, C. Betschart, S. Veenstra +11 more
2010Bioorganic & Medicinal Chemistry Letters51 citations Open access
Semantic Scholar
Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition
J. Schelle, Lisa M. Häsler, J. Göpfert, T. Joos +8 more
2017Alzheimer's & Dementia50 citations
Semantic Scholar
Transgenic Expression of Intraneuronal Aβ42 But Not Aβ40 Leads to Cellular Aβ Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology
D. Abramowski, Sabine Rabe, A. Upadhaya, Julia Reichwald +8 more
2012Journal of Neuroscience50 citations Open access
Semantic Scholar
Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice.
Ajeet Rijal Upadhaya, E. Capetillo-Zárate, I. Kosterin, D. Abramowski +6 more
2012Neurobiology of Aging49 citations
Semantic Scholar
Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model
Renata Novotny, Franziska Langer, J. Mahler, Angelos A. Skodras +11 more
2016Journal of Neuroscience47 citations Open access
Semantic Scholar
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
R. Machauer, K. Laumen, S. Veenstra, J. Rondeau +8 more
2009Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Aβ seeding potency peaks in the early stages of cerebral β‐amyloidosis
L. Ye, Jay Rasmussen, Stephan A. Kaeser, A. Marzesco +10 more
2017EMBO Reports43 citations Open access
Semantic Scholar
β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice
H. Schieb, H. Kratzin, Olaf Jahn, Wiebke Möbius +4 more
2011Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer’s disease
Jie Cui, Balaji Jothishankar, P. He, M. Staufenbiel +2 more
2013Molecular Neurobiology37 citations Open access
Semantic Scholar
Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.
Hong Jiang, P. He, Jun-Xia Xie, M. Staufenbiel +2 more
2014Human Molecular Genetics36 citations Open access
Semantic Scholar

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M. Jucker×16
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M. Jucker — researcher profile on SciRah
Stephan A. Kaeser×12
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Stephan A. Kaeser — researcher profile on SciRah
U. Neumann×9
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U. Neumann — researcher profile on SciRah
Julia Reichwald×8
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Julia Reichwald — researcher profile on SciRah

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L. Walker — researcher profile on SciRah

Yvonne S. Eisele×6

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Yvonne S. Eisele — researcher profile on SciRah

Ulrike Obermüller×6

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Ulrike Obermüller — researcher profile on SciRah

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J. Schelle — researcher profile on SciRah

Sarah K. Fritschi×6

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Sarah K. Fritschi — researcher profile on SciRah

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F. Baumann — researcher profile on SciRah

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