K. Laumen

Most-cited papers

1. Enzymatic esterification of glycerol I. Lipase-catalyzed synthesis of regioisomerically pure 1,3-sn-diacylglycerols

   M. Berger, K. Laumen, M. Schneider

   1992196 citations

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2. Enzymatic hydrolysis of prochiral -1,4-diacyl-2-cyc-lopentenediols: preparation of (1,4)-and (1,4)-4-hydroxy-2-cyclopentenylderivatives, versatile building blocks for cyclopentanoid natural products.

   K. Laumen, M. Schneider

   198493 citations

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3. Enantioselective hydrolysis of cis-1,2-diacetoxycycloalkanedimethanols: enzymatic preparation of chiral building blocks from prochiral meso-substrates

   K. Laumen, M. Schneider

   198565 citations

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4. A highly selective ester hydrolase from Pseudomonas sp. for the enzymatic preparation of enantiomerically pure secondary alcohols; chiral auxiliaries in organic synthesis

   K. Laumen, M. Schneider

   198855 citations

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5. Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.

   P. Furet, P. Imbach, Maria Noorani, J. Koeppler +7 more

   2004Journal of Medicinal Chemistry54 citations Open access

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6. Enzymatic ester hydrolysis and synthesis - two approaches to cycloalkane derivatives of high enantiomeric purity

   U. Ader, D. Breitgoff, P. Klein, K. Laumen +1 more

   198953 citations

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7. Immobilized porcine liver esterase: a convenient reagent for the preparation of chiral building blocks.

   K. Laumen, E. Reimerdes, M. Schneider, H. Gorisch

   198553 citations

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8. Enzymic preparation of enantiomerically pure secondary alcohols. Ester synthesis by irreversible acyl transfer using a highly selective ester hydrolase from Pseudomonas sp.; an attractive alternative to ester hydrolysis

   K. Laumen, D. Breitgoff, M. Schneider

   198852 citations

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9. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.

   R. Machauer, K. Laumen, S. Veenstra, J. Rondeau +8 more

   2009Bioorganic & Medicinal Chemistry Letters47 citations Open access

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10. Preparative-scale Chemo-enzymatic Synthesis of Optically Pure D-myo-Inositol-1-phosphate

    K. Laumen, O. Ghisalba

    199445 citations

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11. A facile chemoenzymatic route to optically pure building blocks for cyclopentanoid natural products

    K. Laumen, M. Schneider

    198641 citations

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12. Enzymatic differentiation of the enantiotopic hydroxymethyl groups of glycerol; synthesis of chiral building blocks

    D. Breitgoff, K. Laumen, M. Schneider

    198638 citations

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13. Enzymatic preparation of optically active cyanohydrin acetates

    Andreas van Almsick, J. Buddrus, Petra Hönicke-Schmidt, K. Laumen +1 more

    198930 citations

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14. Enzymatic hydrolysis of (±)-trans-1,2-diacetozycycloalkanes. A facile route to optically-active cycloalkane-1,2-diols

    D. Crout, V. S. B. Gaudet, K. Laumen, M. Schneider

    198626 citations

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15. Chemo-enzymatic approaches for the creation of novel chiral building blocks and reagents for pharmaceutical applications

    K. Laumen, M. Kittelmann, O. Ghisalba

    200223 citations

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16. The development of a practical synthesis of the potent and selective somatostatin sst3 receptor antagonist [4-(3,4-difluoro-phenyl)-piperazine-1-yl]-{(4S,4aS,8aR)-2[(S)-3-(6-methoxy-pyridin-3-yl)-2-methyl-propyl]-decahydroisoquinoline-4-yl}-methanone (NVP-ACQ090)

    M. Bänziger, J. Cercus, Hans-Dieter Hirt, K. Laumen +4 more

    200322 citations

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17. Enantiomerically pure cyclohexanols and cyclohexane-1,2-diol derivatives; chiral auxiliaries and substitutes for (–)-8-phenylmenthol. A facile enzymatic route

    K. Laumen, D. Breitgoff, R. Seemayer, M. Schneider

    198922 citations

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18. Optimized Synthesis of l-m-Tyrosine Suitable for Chemical Scale-Up

    Cara E. Humphrey, Markus Furegati, K. Laumen, L. La Vecchia +3 more

    200720 citations

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19. Enzyme-assisted Preparation of D-tert.-Leucine

    K. Laumen, O. Ghisalba, K. Auer

    2001Bioscience, biotechnology and biochemistry18 citations

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20. Lipase-catalyzed esterification of hydrophilic diols in organic solvents

    M. Berger, K. Laumen, M. Schneider

    1992Biotechnology Letters18 citations

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21. Enzymic preparation of enantiomerically pure cyclohexanols: ester synthesis by irreversible acyl transfer

    K. Laumen, R. Seemayer, M. Schneider

    199018 citations

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22. Biocatalysis in the Fine Chemical and Pharmaceutical Industries

    P. W. Sutton, Joseph P. Adams, I. Archer, D. Auriol +30 more

    201216 citations

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23. Chemo-enzymatic Synthesis of both Enantiomers of myo-Inositol 1,3,4,5-tetrakisphosphate.

    K. Laumen, O. Ghisalba

    1999Bioscience, biotechnology and biochemistry16 citations

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24. Enzymatic preparation of optically active bicyclo[2.2.1]heptene derivatives, building blocks for terpenoid natural products. An attractive alternative to enantioselective Diels–Alder syntheses

    J. Van der Eycken, M. Vandewalle, G. Heinemann, K. Laumen +3 more

    198916 citations

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25. [17] Screening techniques for lipase catalyst selection

    U. Ader, P. Andersch, M. Berger, U. Goergens +6 more

    199715 citations

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26. Diastereoisomeric Salt Formation and Enzyme-Catalyzed Kinetic Resolution as Complementary Methods for the Chiral Separation of cis-/trans-Enantiomers of 3-Aminocyclohexanol

    C. Brocklehurst, K. Laumen, L. La Vecchia, D. Shaw +1 more

    201113 citations

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27. [19] Ester synthesis via acyl transfer (Transesterification)

    P. Andersch, M. Berger, J. Hermann, K. Laumen +4 more

    199713 citations

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28. Production, purification, and characterization of a highly enantioselective (S )-N-acetyl-1-phenylethylamine amidohydrolase from Rhodococcus equi Ac6

    A. Brunella, M. Graf, M. Kittelmann, K. Laumen +1 more

    1997Applied Microbiology and Biotechnology8 citations

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29. Easy Access to Enantiomerically Pure Nonproteinogenic Amino Acids

    K. Laumen, O. Ghisalba, NovartisPharmaAG, E. LifeSci

    20067 citations

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30. Isolation and characterization of highly (R)-specific N-acetyl-1-phenylethylamine amidohydrolase, a new enzyme from Arthrobacter aurescens AcR5b

    M. Graf, A. Brunella, M. Kittelmann, K. Laumen +1 more

    1997Applied Microbiology and Biotechnology7 citations

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31. Lipid modification of amino acids, carbohydrates and polyols

    H. Altenbach, M. Berger, B. Jakob, R. Ihizane +5 more

    20103 citations

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32. New Biocatalytic Approaches for the Synthesis of Chiral Drugs, Intermediates, and Substrates

    K. Laumen, A. Brunella, M. Graf, M. Kittelmann +2 more

    19983 citations

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33. Methyl Jasmonate: A Short Synthesis of Naturally Occurring Methyl Jasmonate and Its Unnatural Enantiomer via Enantiodivergent Alkylation of Cyclopent-2-ene-1,3-diol Derivatives by Palladium(0)-Induced Reactions.

    F. Montforts, I. Gesing-Zibulak, W. Grammenos, M. Schneider +1 more

    19902 citations

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34. Enzymic Preparation of Enantiomerically Pure Secondary Alcohols. Ester Synthesis by Irreversible Acyl Transfer Using a Highly Selective Ester Hydrolase from Pseudomonas sp., an Attractive Alternative to Ester Hydrolysis.

    K. Laumen, D. Breitgoff, M. Schneider

    19892 citations

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35. Hydrolytic Enzymes in Organic Synthesis: Chiral Building Blocks from Prochiral Substrates

    D. Breitgoff, T. Essert, K. Laumen, M. Schneider

    19891 citations

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36. Enzymes in organic synthesis - chiral building blocks from racemic and prochiral substrates

    M. Schneider, K. Laumen

    19881 citations

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37. Enzymatic Hydrolysis of (±)-trans-1,2-Diacetoxycycloalkanes. A Facile Route to Optically-Active Cycloalkane-1,2-diols.

    D. Crout, V. S. B. Gaudet, K. Laumen, M. Schneider

    19861 citations

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38. Enzymatic Preparation of Enantiomerically Pure Cyclohexanols: Ester Synthesis by Irreversible Acyl Transfer.

    K. Laumen, R. Seemayer, M. Schneider

    19900 citations

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39. Enzymes in Organic Synthesis. Part 15. Enzymatic Preparation of Optically Active Cyanohydrin Acetates.

    A. Van Almsick, J. Buddrus, P. Hönicke-Schmidt, K. Laumen +1 more

    19900 citations

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40. Enzymatic Preparation of Optically Active Bicyclo(2.2.1)heptene Derivatives, Building Blocks for Terpenoid Natural Products. An Attractive Alternative to Enantioselective Diels-Alder Syntheses.

    J. Van der Eycken, M. Vandewalle, G. Heinemann, K. Laumen +3 more

    19890 citations

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41. A Highly Selective Ester Hydrolase from Pseudomonas Sp. for the Enzymatic Preparation of Enantiomerically Pure Secondary Alcohols. Chiral Auxiliaries in Organic Synthesis.

    K. Laumen, M. Schneider

    19880 citations

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42. Chiral synthesis building blocks of prochiral glycerol and procedure for their production

    M. Schneider, K. Laumen, D. Breitgoff, D. Wullbrandt +2 more

    19870 citations

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43. Chiral synthesis building blocks from prochiral glycerol

    M. Schneider, K. Laumen, D. Breitgoff, D. Wullbrandt +2 more

    19860 citations

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44. HYDROLYTIC ENZYMES IN ORGANIC SYNTHESIS. 6. ENANTIOSELECTIVE HYDROLYSIS OF CIS-1,2-DIACETOXYCYCLOALKANEDIMETHANOLS: ENZYMIC PREPARATION OF CHIRAL BUILDING BLOCKS FROM PROCHIRAL MESO-SUBSTRATES

    K. Laumen, M. Schneider

    19850 citations

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45. HYDROLYTIC ENZYMES IN ORGANIC SYNTHESIS. 4. ENZYMIC HYDROLYSIS OF PROCHIRAL CIS-1,4-DIACYL-2-CYCLOPENTENEDIOLS: PREPARATION OF (1S,4R)- AND (1R,4S)-4-HYDROXY-2-CYCLOPENTENYL DERIVATIVES, VERSATILE BUILDING BLOCKS FOR CYCLOPENTANOID NA

    K. Laumen, M. Schneider

    19850 citations

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46. Hydrolytic Enzymes in Organic Synthesis. Part 5. Immobilized Porcine Liver Esterase: A Convenient Reagent for the Preparation of Chiral Building Blocks.

    K. Laumen, E. Reimerdes, M. Schneider, H. Goerisch

    19850 citations

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47. REACTIONS OF TRANS-CYCLOOCTENE AND OF 7-METHOXY-1,3-DIOXA-5(E)-CYCLOOCTENE WITH ALLENES AND CHLOROSULFONYL ISOCYANATE. FORMATION OF THE FIRST TRANS-ANNULATED METHYLENECYCLOBUTANES. REACTION OF ALLENE AS AN ENE-COMPONENT

    H. Jendralla, K. Laumen

    19830 citations

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