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C. Betschart · SciRah

Researcher profile · Semantic Scholar

C. Betschart

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C. Betschart — researcher profile on SciRah

h-index: 17
Works: 43
Citations: 829

Most-cited papers

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.
C. Betschart, S. Hintermann, Dirk Behnke, S. Cotesta +10 more
2013Journal of Medicinal Chemistry93 citations Open access
Semantic Scholar
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
Jonathan H. Fox, Teal Connor, V. Chopra, Kathryn Dorsey +8 more
2010Molecular Neurodegeneration83 citations Open access
Semantic Scholar
Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.
S. Hanessian, H. Yun, Yihua Hou, Gao-Qiang Yang +13 more
2005Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE).
S. Hanessian, Gao-Qiang Yang, J. Rondeau, U. Neumann +2 more
2006Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
A. Lerchner, R. Machauer, C. Betschart, S. Veenstra +11 more
2010Bioorganic & Medicinal Chemistry Letters51 citations Open access
Semantic Scholar
Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo.
R. Machauer, K. Laumen, S. Veenstra, J. Rondeau +8 more
2009Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Synthesis of azapenams, diazepinones, and dioxocyclams via the photolytic reaction of chromium alkoxycarbene complexes with imidazolines
C. Betschart, L. Hegedus
199245 citations
Semantic Scholar
Kinetic properties of “dual” orexin receptor antagonists at OX1R and OX2R orexin receptors
Gabrielle E. Callander, Morenike Olorunda, Dominique Monna, Edi Schuepbach +12 more
2013Frontiers in Neuroscience40 citations Open access
Semantic Scholar
Distinct effects of IPSU and suvorexant on mouse sleep architecture
D. Hoyer, Thomas Dürst, M. Fendt, L. Jacobson +8 more
2013Frontiers in Neuroscience36 citations Open access
Semantic Scholar
Novel scaffold for cathepsin K inhibitors.
N. Teno, T. Miyake, T. Ehara, O. Irie +18 more
2007Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy
S. Hawtin, C. Andre, Géraldine Collignon-Zipfel, S. Appenzeller +26 more
2023Cell Reports Medicine33 citations Open access
Semantic Scholar
2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.
E. Altmann, R. Aichholz, C. Betschart, T. Buhl +6 more
2007Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.
R. Machauer, S. Veenstra, J. Rondeau, M. Tintelnot‐Blomley +3 more
2009Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Structure-based design and synthesis of novel P2/P3 modified, non-peptidic beta-secretase (BACE-1) inhibitors.
S. Hanessian, Z. Shao, C. Betschart, J. Rondeau +2 more
2010Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.
T. Knoepfel, Pierre Nimsgern, Sébastien Jacquier, Marjorie Bourrel +17 more
2020Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
K. Kegel, E. Sapp, J. Alexander, P. Reeves +14 more
2010Molecular Neurodegeneration22 citations Open access
Semantic Scholar
Dipeptide nitrile inhibitors of cathepsin K.
E. Altmann, R. Aichholz, C. Betschart, T. Buhl +3 more
2006Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).
Dirk Behnke, S. Cotesta, S. Hintermann, M. Fendt +11 more
2015Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
New chemotypes for cathepsin K inhibitors.
N. Teno, O. Irie, T. Miyake, K. Gohda +6 more
2008Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.
C. Betschart, M. Faller, F. Zink, R. Hemmig +20 more
2022ACS Medicinal Chemistry Letters12 citations Open access
Semantic Scholar
Structure-based and property-driven optimization of N-aryl imidazoles towards potent and selective oral RORγt inhibitors.
Klemens Hoegenauer, J. Kallen, E. Jiménez-Núñez, R. Strang +17 more
2019Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
SAR of 2-benzyl-4-aminopiperidines NK1 antagonists. Part 21. synthesis of CGP 49823
S. Veenstra, K. Hauser, W. Schilling, C. Betschart +1 more
199611 citations
Semantic Scholar
Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.
Philip B. Alper, C. Betschart, C. Andre, T. Boulay +21 more
2023ACS Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway.
Philip B. Alper, J. Deane, C. Betschart, D. Buffet +20 more
2020Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Studies on the active conformation of NK1 antagonist CGP 49823. Part 1. Synthesis of conformationally restricted analogs.
S. Veenstra, K. Hauser, C. Betschart
19978 citations
Semantic Scholar
Corrigendum to “Structure-based design and synthesis of macrocyclic peptidomimetic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 1361–1365]
R. Machauer, S. Veenstra, J. Rondeau, M. Tintelnot‐Blomley +3 more
20094 citations Open access
Semantic Scholar
Synthesis of Azapenams, Diazepinones, and Dioxocyclams via the Photolytic Reaction of Chromium Alkoxycarbene Complexes with Imidazolines.
C. Betschart, L. Hegedus
19922 citations
Semantic Scholar
Preparation of 1,2-Diarylethylenediamines by Aminative Reductive Coupling of Aromatic Aldehydes with Low-Valent Titanium Reagents.
C. Betschart, D. Seebach
19882 citations
Semantic Scholar
POS1140 A NOVEL TLR7/8 ANTAGONIST BLOCKS PRO-INFLAMMATORY FUNCTION OF IMMUNE COMPLEXES FROM LUPUS PATIENTS AND ABROGATES LUPUS-LIKE DISEASE IN MICE
S. Hawtin, C. Andre, G. Zipfel, S. Appenzeller +26 more
2023Annals of the Rheumatic Diseases1 citations Open access
Semantic Scholar
Corrigendum to “Structure-based design and synthesis of novel P2/P3 modified, non-peptidic β-secretase (BACE-1) inhibitors” [Bioorg. Med. Chem. Lett. 20 (2010) 1924–1927]
S. Hanessian, Z. Shao, C. Betschart, J. Rondeau +2 more
20131 citations
Semantic Scholar
Anti-Proteus activity of some South African medicinal plants : their potential for the prevention of rheumatoid arthritis
D. Hoyer, C. Gee, G. Mang, M. Fendt +15 more
20131 citations
Semantic Scholar
Distinct effects of orexin 2 receptor antagonism and dual orexin 1,2 receptor antagonism on sleep architecture in mice.
D. Hoyer, T. Duerst, M. Fendt, L. Jacobson +8 more
20131 citations
Semantic Scholar
SAR of 2‐Benzyl‐4‐aminopiperidines NK1 Antagonists. Part 2. Synthesis of CGP 49823.
S. Veenstra, K. Hauser, W. Schilling, C. Betschart +1 more
19971 citations
Semantic Scholar
Application of Low-Valent Titanium Reagents in Organic Synthesis
C. Betschart, D. Seebach
19891 citations
Semantic Scholar
A0019 Transurethral injection of autologous muscle precursor cells in collagen solution for the treatment of female stress urinary incontinence – results from a blinded, prospective and randomised phase II clinical trial (SUISSE MPC2 Study)
F. Schmid, T. S. Schmidli, J. Prange, L. Leitner +12 more
2026European Urology0 citations
Semantic Scholar
Derivatives of heteroarylnitrilverbindungen
E. Altmann, C. Betschart, K. Hayakawa, O. Irie +5 more
20030 citations
Semantic Scholar
Pyrrolopyrimidines an agent for inhibiting cysteine proteases
C. Betschart, K. Hayakawa, O. Irie, G. Iwasaki +4 more
20020 citations
Semantic Scholar
1-aryl-2-acylammo-etanföreningar och användning därav som neurokininantagonister, särskilt som neurokinin 1 antagonister
Marc Gerspacher, Sprecher Andreas Von, Silvio Roggo, R. Mah +5 more
19970 citations
Semantic Scholar
1-aryl-2-asyyliammo-etaaniyhdisteitä and their use as neurokinin antagonists, especially as antagonists of the neurokinin 1
M. Gerspacher, Sprecher Andreas Von, S. Roggo, R. Mah +5 more
19970 citations
Semantic Scholar
10-Aminoaliphatyl-dibenz [b, f] oxepines with antineurodegenerativ effect
Kaspar Zimmermann, C. Betschart
19960 citations
Semantic Scholar
Synthesis of New Heterocyclic Systems by Photochemical Reactions of Chromium Carbene Complexes with Imidazolines
C. Betschart, L. Hegedus
19940 citations
Semantic Scholar
Scope and Limitations of the Reductive Coupling of Aromatic Aldimine Derivatives with Formation of 1,2-Diarylethylenediamine Units, Using Low-Valent Titanium Reagents.
C. Betschart, B. Schmidt, D. Seebach
19890 citations
Semantic Scholar
Open Access Research Article
Jonathan H. Fox, Teal Connor, V. Chopra, Kathryn Dorsey +8 more
0 citations
Semantic Scholar

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