C. Bethune

Most-cited papers

1. Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

   H. Büller, C. Bethune, S. Bhanot, D. Gailani +5 more

   2014New England Journal of Medicine578 citations Open access

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2. Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXIRx in Patients With ESRD

   M. Walsh, C. Bethune, A. Smyth, J. Tyrwhitt +6 more

   2021Kidney International Reports71 citations Open access

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3. Accumulation and elimination of dietary arsenobetaine in two species of fish, Atlantic salmon (Salmo salar L.) and Atlantic cod (Gadus morhua L.)

   H. Amlund, K. Francesconi, C. Bethune, A. Lundebye +1 more

   2006Environmental Toxicology and Chemistry52 citations

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4. ISIS-FXIRx, A Novel and Specific Antisense Inhibitor of Factor XI, Caused Significant Reduction in FXI Antigen and Activity and Increased aPTT without Causing Bleeding in Healthy Volunteers

   Que Liu, C. Bethune, Esmat Dessouki, J. Grundy +2 more

   201147 citations

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5. A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

   N. Jones, Melissa A. Pegues, M. McCrory, W. Singleton +6 more

   2012Molecular Therapy: Nucleic Acids45 citations Open access

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6. PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients

   S. Willmann, Eleonora Marostica, N. Snelder, A. Solms +10 more

   2021CPT: Pharmacometrics & Systems Pharmacology35 citations Open access

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7. A preliminary comparison of polybrominated diphenyl ether concentrations relative to lipid content and to levels of dioxins and dioxin‐like polychlorinated biphenyls in Norwegian farmed Atlantic salmon (Salmo salar)

   C. Bethune, K. Julshamn, A. Lundebye

   200523 citations

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8. The Role of Drug-Lipid Interactions on the Disposition of Liposome-Formulated Opioid Analgesics In Vitro and In Vivo

   C. Bethune, C. Bernards, Tot Bui-Nguyen, D. Shen +1 more

   2001Anesthesia and Analgesia17 citations Open access

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9. Pharmacokinetics and Pharmacodynamics of Ionis-FXIRx, an Antisense Inhibitor of Factor XI, in Patients with End-Stage Renal Disease on Hemodialysis

   C. Bethune, Michael Walsh, Michael Walsh, M. Walsh +4 more

   201716 citations

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10. Phase I study of XMT-1001 given IV every 3 weeks to patients with advanced solid tumors.

    E. Sausville, L. Garbo, G. Weiss, D. Shkolny +4 more

    201015 citations

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11. Lipid association improves the therapeutic index of lomustine [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea] to suppress 36B-10 tumor growth in rats.

    C. Bethune, R. Geyer, Alexander M. Spence, R. Ho

    2001Cancer Research14 citations

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12. Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model

    K. Luu, Erin S. Morgan, S. Bhanot, R. Geary +5 more

    2017Journal of Pharmacokinetics and Pharmacodynamics13 citations

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13. Current Levels of Primary Polybrominated Diphenyl Ethers (PBDEs) in Norwegian Seafood

    C. Bethune, John Nielsen, 1. KareJulshamn

    7 citations

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14. Abstract B52: Phase 1 study of XMT‐1001, a novel water soluble camptothecin conjugate, given as an intravenous infusion once every three weeks to patients with advanced solid tumors

    E. Sausville, L. Garbo, G. Weiss, D. Shkolny +4 more

    20096 citations

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15. Comment on "Contaminant levels in Norwegian farmed Atlantic salmon (Salmo salar) in the 13-year period from 1999 to 2011" by Nøstbakken et al.

    J. Ruzzin, C. Bethune, Anders Goksøyr, K. Hylland +3 more

    2015Environment International5 citations

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16. A phase I study of the safety, tolerability, and pharmacokinetics of intravenous XMT-1001 in patients with advanced solid tumors.

    E. Sausville, S. Anthony, L. Garbo, D. Shkolny +4 more

    20075 citations

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17. Current levels (2003-2004) of brominated flame retardants in feed and selected Norwegian seafood

    C. Bethune, J. Nielsen, A. Lundebye, K. Julshamn

    20055 citations

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18. Lipid Association Increases the Potency Against Primary Medulloblastoma Cells and Systemic Exposure of l-(2-Chloroethyl)-3-Cyclohexyl-1-Nitrosourea (CCNU) in Rats

    C. Bethune, A. Blum, J. Geyer, J. Silber +1 more

    1999Pharmaceutical Research4 citations

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19. 570 Phase 1 study of XMT-1001, a novel water soluble camptothecin conjugate, given as an IV infusion every 3 weeks to patients with advanced solid tumors

    R. Fram, L. Garbo, G. Weiss, D. Shkolny +5 more

    20103 citations

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20. Development of a high-performance liquid chromatographic assay for G418 sulfate (Geneticin)

    C. Bethune, T. Bui, M.-L. Liu, M. Kay +1 more

    1997Antimicrobial Agents and Chemotherapy3 citations Open access

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21. A phase I study of the safety and pharmacokinetics (PK) of XMT-1001 given as an intravenous (IV) infusion once every three weeks to patients with advanced solid tumors.

    E. Sausville, L. Garbo, G. Weiss, S. Anthony +4 more

    2009Journal of Clinical Oncology1 citations

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22. A phase I study of the safety and pharmacokinetics (PK) of XMT-1001 given as an intravenous (IV) infusion once every three weeks to patients with advanced solid tumors

    E. Sausville, L. Garbo, G. Weiss, S. Anthony +4 more

    20160 citations

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23. A SERVING OF FARMED SALMON: HOW THE RISKS OUTWEIGH THE BENEFITS FOR NORWEGIANS

    C. Bethune

    20060 citations

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24. The role of drug-lipid interactions in biodistribution and therapeutic effects for drugs incorporated into liposomes

    C. Bethune

    19990 citations

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