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B. Higgs · SciRah

Researcher profile · Semantic Scholar

B. Higgs

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B. Higgs — researcher profile on SciRah

h-index: 40
Works: 148
Citations: 6,921

Most-cited papers

Durvalumab With or Without Tremelimumab vs Standard Chemotherapy in First-line Treatment of Metastatic Non–Small Cell Lung Cancer
N. Rizvi, B. Cho, N. Reinmuth, K. Lee +26 more
2020JAMA Oncology553 citations Open access
Semantic Scholar
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction
Daniel K. Wells, M. Buuren, Kristen K. Dang, Vanessa M. Hubbard-Lucey +141 more
2020Cell495 citations Open access
Semantic Scholar
Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery
Suzanne Mosely, J. Prime, R. Sainson, J. Koopmann +20 more
2016Cancer immunology research352 citations Open access
Semantic Scholar
Prognostic and Predictive Impact of Circulating Tumor DNA in Patients with Advanced Cancers Treated with Immune Checkpoint Blockade
Qu Zhang, Jia Luo, Song Wu, H. Si +11 more
2020Cancer Discovery263 citations Open access
Semantic Scholar
Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab
R. Raja, M. Kuziora, Philip Z. Brohawn, B. Higgs +3 more
2018Clinical Cancer Research224 citations Open access
Semantic Scholar
Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer
Li-Yan Jiang, Jiaqi Huang, B. Higgs, Zhi-Bin Hu +35 more
2016PLoS Genetics199 citations Open access
Semantic Scholar
Tumor mutational burden and immune infiltration as independent predictors of response to neoadjuvant immune checkpoint inhibition in early TNBC in GeparNuevo.
T. Karn, C. Denkert, K. Weber, U. Holtrich +20 more
2020Annals of Oncology193 citations Open access
Semantic Scholar
Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non–Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab
B. Higgs, C. Morehouse, K. Streicher, Philip Z. Brohawn +3 more
2018Clinical Cancer Research183 citations
Semantic Scholar
The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity
S. Gautam, J. Fioravanti, Wei Zhu, J. L. Le Gall +17 more
2019Nature Immunology167 citations Open access
Semantic Scholar
A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality
Wei Zhu, C. Germain, Zheng Liu, Y. Sebastian +11 more
2015Oncoimmunology113 citations Open access
Semantic Scholar
Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.
Stephanie Sungalee, E. Mamessier, Ester Morgado, E. Gregoire +28 more
2014Journal of Clinical Investigation104 citations Open access
Semantic Scholar
A Blood-based Assay for Assessment of Tumor Mutational Burden in First-line Metastatic NSCLC Treatment: Results from the MYSTIC Study
H. Si, M. Kuziora, K. Quinn, E. Helman +11 more
2020Clinical Cancer Research94 citations
Semantic Scholar
Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy
Sonja Althammer, Tze-Heng Tan, A. Spitzmüller, L. Rognoni +13 more
2019Journal of Immunotherapy for Cancer92 citations Open access
Semantic Scholar
Suppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis.
Xiang Guo, B. Higgs, A. Bay-Jensen, M. Karsdal +3 more
2015Journal of Investigative Dermatology81 citations Open access
Semantic Scholar
MicroRNA‐206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D
R. Georgantas, K. Streicher, Xiao-Bing Luo, L. Greenlees +9 more
2014Pigment Cell & Melanoma Research77 citations
Semantic Scholar
In Vivo Therapeutic Success of MicroRNA‐155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage
Shiyu Zhou, Yan Wang, Y. Meng, Chun-Yuan Xiao +11 more
2016Arthritis & Rheumatology64 citations
Semantic Scholar
The Role of ARF6 in Biliary Atresia
M. Ningappa, Juhoon So, J. Glessner, Chethan Ashokkumar +16 more
2015PLoS ONE60 citations Open access
Semantic Scholar
Population Modeling of Tumor Kinetics and Overall Survival to Identify Prognostic and Predictive Biomarkers of Efficacy for Durvalumab in Patients With Urothelial Carcinoma
Yanan Zheng, R. Narwal, C. Jin, P. Baverel +7 more
2018Clinical pharmacology and therapy50 citations Open access
Semantic Scholar
Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations.
G. Jin, Meng Zhu, R. Yin, W. Shen +18 more
2015American Journal of Human Genetics46 citations Open access
Semantic Scholar
Prognostic Significance of Liver Metastasis in Durvalumab-Treated Lung Cancer Patients.
S. Sridhar, L. Paz-Ares, Hao Liu, Kui Shen +12 more
2019Clinical Lung Cancer43 citations Open access
Semantic Scholar
Increased CD73 and reduced IFNG signature expression in relation to response rates to anti-PD-1(L1) therapies in EGFR-mutant NSCLC.
K. Streicher, B. Higgs, Song Wu, K. Coffman +7 more
201740 citations
Semantic Scholar
Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis
Xiang Guo, B. Higgs, A. Bay-Jensen, Yu-Ling Wu +7 more
2018Rheumatology37 citations
Semantic Scholar
15LBA High tumoral IFNγ mRNA, PD-L1 protein, and combined IFNγ mRNA/PD-L1 protein expression associates with response to durvalumab (anti-PD-L1) monotherapy in NSCLC patients
B. Higgs, P. Robbins, J. A. Blake-Haskins, Wei Zhu +7 more
201537 citations
Semantic Scholar
Predicting cellular rejection with a cell-based assay: Pre-clinical evaluation in children
Chethan Ashokkumar, K. Soltys, G. Mazariegos, G. Bond +21 more
2017Transplantation36 citations Open access
Semantic Scholar
Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes
J. Glessner, M. Ningappa, Kim Ngo, M. Zahid +31 more
2023Journal of Hepatology34 citations Open access
Semantic Scholar
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control
J. Dreyfuss, Yixing Yuchi, Xue-hong Dong, V. Efthymiou +17 more
2021Nature Communications33 citations Open access
Semantic Scholar
HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma
Feng Xue, B. Higgs, Jiaqi Huang, C. Morehouse +15 more
2015Journal of Translational Medicine32 citations Open access
Semantic Scholar
Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma
Li-Yan Jiang, Wei Zhu, K. Streicher, C. Morehouse +10 more
2014BMC Cancer32 citations Open access
Semantic Scholar
Type I interferon gene signature test–low and –high patients with systemic lupus erythematosus have distinct gene expression signatures
P. Brohawn, K. Streicher, B. Higgs, Christopher A. Morehouse +3 more
2019Lupus31 citations
Semantic Scholar
Relationship of baseline tumoral IFNγ mRNA and PD-L1 protein expression to overall survival in durvalumab-treated NSCLC patients.
B. Higgs, C. Morehouse, K. Streicher, M. Rebelatto +7 more
201626 citations
Semantic Scholar
Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality
Juhoon So, M. Ningappa, J. Glessner, J. Min +30 more
2020Frontiers in Physiology25 citations Open access
Semantic Scholar
Somatic STK11/LKB1 mutations to confer resistance to immune checkpoint inhibitors as monotherapy or in combination in advanced NSCLC.
M. Jure-Kunkel, Song Wu, Feng Xiao, S. Abdullah +8 more
201825 citations
Semantic Scholar
Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma
S. Ranganathan, M. Ningappa, Chethan Ashokkumar, B. Higgs +6 more
2016Scientific Reports22 citations Open access
Semantic Scholar
Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition
H. Zhong, Cui Chen, R. Tammali, S. Breen +11 more
2018Molecular Cancer Therapeutics21 citations
Semantic Scholar
Profile of the Pleximmune blood test for transplant rejection risk prediction
R. Sindhi, Chethan Ashokkumar, B. Higgs, Samantha Levy +5 more
2016Expert Review of Molecular Diagnostics19 citations Open access
Semantic Scholar
InVivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors
N. Pore, Sanjoo Jalla, Zheng Liu, B. Higgs +5 more
2015Neoplasia18 citations Open access
Semantic Scholar
Anti-thymocyte globulin facilitates alloreactive T-cell apoptosis via caspase-3: potential implications for monitoring rejection-free outcomes
Chethan Ashokkumar, Qing Sun, M. Ningappa, B. Higgs +3 more
2015Transplantation16 citations Open access
Semantic Scholar
A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation
M. Ningappa, Syed A. Rahman, B. Higgs, Chethan Ashokkumar +3 more
2022Cell Reports Medicine15 citations Open access
Semantic Scholar
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts
Sonja Althammer, K. Steele, M. Rebelatto, Tze-Heng Tan +431 more
2016Journal for ImmunoTherapy of Cancer15 citations Open access
Semantic Scholar
High-throughput RNA sequencing reveals distinct gene signatures in active IgG4-related disease
B. Higgs, Yan-Ying Liu, Jian-Ping Guo, Y. Sebastian +13 more
2017Scientific Reports12 citations Open access
Semantic Scholar
Mutually exclusive expression of CD73 and PDL1 in tumors from patients (pt) with NSCLC, gastroesophageal (GE) and urothelial bladder carcinoma (UBC).
Philip Martin, A. Spitzmueller, Song Wu, M. Widmaier +6 more
201712 citations
Semantic Scholar
Chronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation CD 4 + T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate COPD Phenotypes
M. Roberts, B. Higgs, P. Brohawn, F. Pilataxi +4 more
201512 citations
Semantic Scholar
CD154‐expressing CMV‐specific T cells associate with freedom from DNAemia and may be protective in seronegative recipients after liver or intestine transplantation
Chethan Ashokkumar, Michael R. Green, K. Soltys, M. Michaels +23 more
2020Pediatric Transplantation11 citations Open access
Semantic Scholar
Exome analysis of oncogenic pathways and tumor mutational burden (TMB) in triple-negative breast cancer (TNBC): Results of the translational biomarker program of the neoadjuvant double-blind placebo controlled GeparNuevo trial.
S. Loibl, B. Sinn, T. Karn, M. Untch +16 more
2019Journal of Clinical Oncology11 citations
Semantic Scholar
Biologic and clinical relevance of an IFNG mRNA signature (IFNGS) and PD-L1 protein expression in tumor and immune cells in urothelial cancer (UC) patients (pts) treated with durvalumab (D).
C. Bais, M. Kuziora, C. Morehouse, B. Higgs +12 more
201711 citations
Semantic Scholar
Association of early reduction in circulating tumor DNA (ctDNA) with improved progression-free survival (PFS) and overall survival (OS) of patients (pts) with urothelial bladder cancer (UBC) treated with durvalumab (D).
M. Kuziora, B. Higgs, Philip Z. Brohawn, R. Raja +2 more
201711 citations
Semantic Scholar
BubbleTree: an intuitive visualization to elucidate tumoral aneuploidy and clonality using next generation sequencing data
Wei Zhu, M. Kuziora, T. Creasy, Z. Lai +10 more
2015Nucleic Acids Research11 citations Open access
Semantic Scholar
A New Pipeline to Predict and Confirm Tumor Neoantigens Predict Better Response to Immune Checkpoint Blockade
Yelena Lazdun, H. Si, T. Creasy, K. Ranade +3 more
2020Molecular Cancer Research10 citations Open access
Semantic Scholar
Association of liver metastases (LM) with survival in NSCLC patients treated with durvalumab (D) in two independent clinical trials.
L. Paz-Ares, Kui Shen, B. Higgs, C. Morehouse +9 more
201710 citations
Semantic Scholar
Abstract 1773: A baseline IFNG gene expression signature correlates with clinical outcomes in durvalumab-treated advanced NSCLC cancer patients
B. Higgs, C. Morehouse, K. Streicher, P. Brohawn +9 more
20179 citations
Semantic Scholar

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