Researcher profile · Semantic Scholar

D. Fairman

h-index: 14
Works: 31
Citations: 1,232

Most-cited papers

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Akram Khan, Cody Benthin, B. Zeno, T. Albertson +14 more
2017Critical Care550 citations Open access
Semantic Scholar
The Antianginal Agent Trimetazidine Does Not Exert Its Functional Benefit via Inhibition of Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase
A. Macinnes, D. Fairman, P. Binding, Jo Ann Rhodes +4 more
2003Circulation Research130 citations Open access
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Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
D. Millan, Mark E. Bunnage, J. Burrows, K. Butcher +14 more
2011Journal of Medicinal Chemistry94 citations Open access
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Free Drug Theory – No Longer Just a Hypothesis?
S. Summerfield, J. Yates, D. Fairman
2022Pharmaceutical Research79 citations
Semantic Scholar
Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants
C. Maden, D. Fairman, M. Chalker, M. J. Costa +9 more
2018European Journal of Clinical Pharmacology60 citations Open access
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A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor
Toby M. Maher, J. Simpson, Joanna C. Porter, Frederick J Wilson +20 more
2020Respiratory Research58 citations Open access
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Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling
B. Kojonazarov, A. Sydykov, S. Pullamsetti, H. Luitel +16 more
2013Journal of Inflammation40 citations
Semantic Scholar
Progress Curve Analysis of CYP1A2 Inhibition: A More Informative Approach to the Assessment of Mechanism-Based Inactivation?
D. Fairman, C. Collins, Sarah Chapple
2007Drug Metabolism And Disposition32 citations
Semantic Scholar
Inhalation by design: novel tertiary amine muscarinic M₃ receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.
P. Glossop, Christine A L Watson, David A. Price, Mark E. Bunnage +21 more
2011Journal of Medicinal Chemistry29 citations Open access
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Acidic triazoles as soluble guanylate cyclase stimulators.
Lee R. Roberts, P. Bradley, Mark E. Bunnage, K. England +10 more
2011Bioorganic & Medicinal Chemistry Letters29 citations
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Pharmacokinetics of MEDI4736, a fully human anti-PDL1 monoclonal antibody, in patients with advanced solid tumors.
D. Fairman, R. Narwal, M. Liang, P. Robbins +9 more
201428 citations
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Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment
Matthieu Chodorge, A. Celeste, J. Grimsby, A. Konkar +18 more
2018Scientific Reports25 citations Open access
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Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.
L. Jones, Helen Baldock, Mark E. Bunnage, J. Burrows +19 more
2011Bioorganic & Medicinal Chemistry Letters19 citations Open access
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Small, non-peptide C5a receptor antagonists: part 1.
J. Blagg, C. Mowbray, D. Pryde, G. Salmon +3 more
2008Bioorganic & Medicinal Chemistry Letters18 citations Open access
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Best Practices in mAb and Soluble Target Assay Selection for Quantitative Modelling and Qualitative Interpretation
D. Fairman, Hua-Ping Tang
2023AAPS Journal12 citations
Semantic Scholar
Small, non-peptide C5a receptor antagonists: part 2.
J. Blagg, C. Mowbray, D. Pryde, G. Salmon +3 more
2008Bioorganic & Medicinal Chemistry Letters11 citations Open access
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Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD
L. Hilton, Rachel Osborne, Amy S Kenyon, Helen Baldock +23 more
20117 citations
Semantic Scholar
How translational modeling in oncology needs to get the mechanism just right
J. Yates, D. Fairman
2021Clinical and Translational Science6 citations Open access
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Late Breaking Abstract - A PET imaging study to confirm target engagement in the lungs of patients with IPF following a single dose of a novel inhaled avß6 integrin inhibitor
Toby M. Maher, J. Simpson, Joanna C. Porter, Robert H Chan +16 more
2019Idiopathic interstitial pneumonias2 citations
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Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling
B. Kojonazarov, A. Sydykov, S. Pullamsetti, H. Luitel +16 more
2013Journal of Inflammation2 citations Open access
Semantic Scholar
Therapies for type 2 diabetes: modulating the incretin pathway using small molecule peptidase inhibitors or peptide mimetics
M. Coghlan, D. Fairman
20132 citations
Semantic Scholar
Using a selective avß6 PET ligand to optimise early phase IPF clinical trials
J. Simpson, A. Kang'ombe, Maria Costa, Frederick J Wilson +8 more
2019Idiopathic interstitial pneumonias1 citations
Semantic Scholar
Reversal Of Experimental Pulmonary Hypertension By The Multi-kinase Inhibitor Sunitinib
B. Kojonazarov, D. Kosanovic, S. Pullamsetti, A. Sydykov +15 more
2010Asian Test Symposium1 citations
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Corrigendum to "Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling" [International Journal of Cardiology 167 (2013) 2630-2637].
B. Kojonazarov, A. Sydykov, S. Pullamsetti, H. Luitel +16 more
2022International Journal of Cardiology0 citations Open access
Semantic Scholar
Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants
C. Maden, D. Fairman, M. Chalker, M. J. Costa +9 more
2018European Journal of Clinical Pharmacology0 citations Open access
Semantic Scholar
Title A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Akram Khan, Cody Benthin, B. Zeno, T. Albertson +14 more
20170 citations
Semantic Scholar
Triazolopyridine Inhibitors of p38
D. Millan, M. Anderson, Mark E. Bunnage, J. Burrows +18 more
20110 citations
Semantic Scholar
triazolopyridine inhibitors of p38 kinase.
D. Millan, M. Anderson, R. Bazin, M. E. Bunnage +17 more
20110 citations
Semantic Scholar
Abstract 17755: Effects of Multikinase Inhibitors on Right Ventricular Remodeling
B. Kojonazarov, A. Sydykov, H. Luitel, D. Kosanovic +15 more
20100 citations
Semantic Scholar
Temporal Characterisation And Modelling Of Fluticasone Propionate-mediated 24 Hour AUC Corticosterone Suppression In Rats
D. Lamb, D. Fairman, Radha Desai, Stephen Chappell +4 more
2010Asian Test Symposium0 citations
Semantic Scholar
Effects Of The Multikinase Inhibitor Sunitinib On Right Ventricular Remodeling In An Experimental Model Of Right Heart Hypertrophy
S. Pullamsetti, B. Kojonazarov, A. Sydykov, H. Luitel +15 more
2010Asian Test Symposium0 citations
Semantic Scholar

J. Burrows

×6

B. Kojonazarov×6

A. Sydykov×6

H. Luitel×6

D. Kosanovic×6

X. Tian×6

C. Baumann×6

N. Weissmann×6