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Zheng-Xiang Gu · SciRah

Researcher profile · Semantic Scholar

Zheng-Xiang Gu

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Zheng-Xiang Gu — researcher profile on SciRah

h-index: 21
Works: 61
Citations: 1,226

Most-cited papers

A mild and efficient method for the preparation of guanidines
M. Poss, E. Iwanowicz, J. Reid, James Lin +1 more
1992124 citations
Semantic Scholar
Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability
Bing Bai, Alexandr Belovodskiy, Mostofa A Hena, Appan Srinivas Kandadai +22 more
2021Journal of Medicinal Chemistry88 citations Open access
Semantic Scholar
Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
N. Murugesan, Zheng-Xiang Gu, Leena Fadnis, John E. Tellew +13 more
2005Journal of Medicinal Chemistry83 citations
Semantic Scholar
Novel Dual Action AT1 and ETA Receptor Antagonists Reduce Blood Pressure in Experimental Hypertension
M. Kowala, N. Murugesan, John E. Tellew, K. Carlson +20 more
2004Journal of Pharmacology and Experimental Therapeutics62 citations
Semantic Scholar
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
D. S. Weinstein, Wen Liu, Zheng-Xiang Gu, C. Langevine +14 more
2005Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.
N. Murugesan, Zheng-Xiang Gu, S. Spergel, M. Young +17 more
2003Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
A Highly Concise Synthesis of Lavendamycin Methyl Ester
M. Behforouz, Zheng-Xiang Gu, Wen Cai, M. A. Horn +1 more
199354 citations
Semantic Scholar
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.
N. Murugesan, John E. Tellew, Zheng-Xiang Gu, Bridgette L. Kunst +17 more
2002Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Discovery and Assessment of Atropisomers of (±)-Lesinurad.
JianFei Wang, Wenqin Zeng, Shao-hua Li, Liang Shen +5 more
2017ACS Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor*
Sofiya N. Micheva-Viteva, Y. Kobayashi, L. Edelstein, Annmarie L. Pacchia +10 more
2011Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones.
M. Behforouz, Wen Cai, Farahnaz Mohammadi, M. Stocksdale +9 more
2007Bioorganic & Medicinal Chemistry38 citations Open access
Semantic Scholar
Structure-activity relationship (SAR) optimization of 6-(indol-2-yl)pyridine-3-sulfonamides: identification of potent, selective, and orally bioavailable small molecules targeting hepatitis C (HCV) NS4B.
Nan-Jing Zhang, Xiaoyan Zhang, Jin Zhu, A. Turpoff +23 more
2014Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Discovery of 3,3'-Spiro[Azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection.
Wei-Hua Shi, Zhigan Jiang, Haiying He, Fubiao Xiao +14 more
2018ACS Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
BMS‐180560, an insurmountable inhibitor of angiotensin II‐stimulated responses: comparison with losartan and EXP3174
K. Dickinson, R. Cohen, S. Skwish, C. Delaney +6 more
1994British Journal of Pharmacology35 citations Open access
Semantic Scholar
Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.
Xiaoyan Zhang, Nan-Jing Zhang, Guang-Ming Chen, A. Turpoff +21 more
2013Bioorganic & Medicinal Chemistry Letters32 citations
Semantic Scholar
Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).
N. Murugesan, Zheng-Xiang Gu, P. Stein, Sharon Bisaha +23 more
1998Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Chemistry of Quinoline-5,8-diones
M. Behforouz, J. Haddad, Wen Cai, Zheng-Xiang Gu
199831 citations
Semantic Scholar
Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.
N. Murugesan, Zheng-Xiang Gu, P. Stein, S. Spergel +11 more
2000Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Diels-Alder reactions of N-silyloxy 1-azadienes
M. Behforouz, Zheng-Xiang Gu, L. S. Stelzer, M. Ahmadian +2 more
199723 citations
Semantic Scholar
Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein
Zheng-Xiang Gu, Jason D Graci, F. Lahser, Jamie J. Breslin +15 more
2013Antimicrobial Agents and Chemotherapy22 citations Open access
Semantic Scholar
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.
Jun Shi, Zheng-Xiang Gu, Elizabeth A. Jurica, Xi-Mao Wu +35 more
2018Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD.
Peng Li, Jun Yu, F. Hao, Haiying He +20 more
2017ACS Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Orally active prodrugs of quinoline-4-carboxylic acid angiotensin II receptor antagonists
D. Ryono, J. Lloyd, M. Poss, J. Bird +13 more
199419 citations
Semantic Scholar
Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment.
Xiaolin Li, Kai-Xuan Zhou, Haiying He, Qiong Zhou +18 more
2017ACS Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Discovery of N-(4'-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication.
Guang-Ming Chen, Hong-Yu Ren, A. Turpoff, A. Arefolov +12 more
2013Bioorganic & Medicinal Chemistry Letters17 citations
Semantic Scholar
Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.
John E. Tellew, R. Baska, S. Beyer, K. Carlson +11 more
2003Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B.
Guang-Ming Chen, Hong-Yu Ren, Nan-Jing Zhang, W. Lennox +14 more
2015Bioorganic & Medicinal Chemistry Letters15 citations
Semantic Scholar
Reduction of Site-Specific CYP3A-Mediated Metabolism for Dual Angiotensin and Endothelin Receptor Antagonists in Various in Vitro Systems and in Cynomolgus Monkeys
Hong-Jiang Zhang, Donglu Zhang, Wenying Li, Ming Yao +8 more
2007Drug Metabolism And Disposition15 citations
Semantic Scholar
Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B.
Nan-Jing Zhang, A. Turpoff, Xiaoyan Zhang, Song Huang +13 more
2016Bioorganic & Medicinal Chemistry Letters14 citations
Semantic Scholar
Design, synthesis, and biological evaluation of anti-EV71 agents.
Peng Li, Bailing Yang, F. Hao, Ping Wang +22 more
2016Bioorganic & Medicinal Chemistry Letters12 citations
Semantic Scholar
Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent.
Peng Li, Siqi Wu, Tianyichen Xiao, Yunlong Li +11 more
2020Bioorganic & Medicinal Chemistry11 citations
Semantic Scholar
Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.
B. Ellsworth, P. M. Sher, Xi-Mao Wu, Gang Wu +29 more
2013Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
1,4-substituted indoles: a potent and selective class of angiostensin II receptor antagonists
M. Poss, Zheng-Xiang Gu, D. Ryono, J. Reid +12 more
199411 citations
Semantic Scholar
Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infection.
Yanbin Hu, Fei Sun, Q. Yuan, Jinhua Du +18 more
2022Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.
N. Murugesan, Zheng-Xiang Gu, P. Stein, S. Spergel +6 more
2002Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Design and synthesis of nonpeptidal endothelin receptor antagonists based on the structure of a cyclic pentapeptide
N. Murugesan, Zheng-Xiang Gu, V. Lee, M. Webb +3 more
19958 citations
Semantic Scholar
HIV Type-1 Latency: Targeted Induction of Proviral Reservoirs
Jason D Graci, J. Colacino, S. Peltz, J. Dougherty +1 more
2009Antiviral Chemistry & Chemotherapy6 citations Open access
Semantic Scholar
Preclinical Evaluation of Amphihevir, a First-in-Class Clinical Hepatitis C Virus NS4B Inhibitor
Xin Tao, Ning-Yu Wang, JianFei Wang, Z. Fu +5 more
2019Antimicrobial Agents and Chemotherapy5 citations Open access
Semantic Scholar
Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.
Yifan Yang, K. Miller, Yeheng Zhu, Yang Hong +11 more
2011Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Targeting HIV reverse transcriptase in novel ways
M. Wainberg, Zheng-Xiang Gu
1995Nature Medicine4 citations
Semantic Scholar
Structure-activity relationship study of a series of caspase inhibitors containing γ-amino acid moiety for treatment of cholestatic liver disease.
Jian-Feng Mou, Song-Liang Wu, Zhi Luo, Feng Guo +17 more
2018Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Identification of benzazole compounds that induce HIV-1 transcription
Jason D Graci, Daniel Michaels, Guang-Ming Chen, Gillian M. Schiralli Lester +6 more
2017PLoS ONE3 citations Open access
Semantic Scholar
A Mild and Efficient Method for the Preparation of Guanidines.
M. Poss, E. Iwanowicz, J. Reid, James Lin +1 more
19933 citations
Semantic Scholar
PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally
Jason D Graci, Stephen Jung, J. Pichardo, F. Lahser +3 more
2016Antimicrobial Agents and Chemotherapy2 citations Open access
Semantic Scholar
Chemistry of Quinoline-5,8-diones.
M. Behforouz, J. Haddad, Wen Cai, Zheng-Xiang Gu
20102 citations
Semantic Scholar
Correction to "The Discovery of 3,3'-Spiro[azetidine]-2-oxo-indoline Derivatives as Fusion Inhibitors for Treatment of RSV Infection".
Wei-Hua Shi, Zhigan Jiang, Haiying He, Fubiao Xiao +14 more
2018ACS Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
HIV Drug Resistance: Molecular Basis and Clinical Significance
M. Wainberg, MarilynA Smith, J. Montaner, K. Nagai +3 more
19951 citations
Semantic Scholar
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.
Appan Srinivas Kandadai, Bing Bai, M. Rahim, F. Lin +7 more
2023Bioorganic & Medicinal Chemistry0 citations Open access
Semantic Scholar
Inhibition of the HERG Potassium Ion Channel by Different Non-Nucleoside Human Cytomegalovirus Polymerase Antiviral Templates and the Exploration of Variations of a Pyrroloquinoline Series to Reduce Cardiotoxicity Potential
Appan Srinivas Kandadai, Bing Bai, M. Rahim, F. Lin +7 more
2023Social Science Research Network0 citations
Semantic Scholar
Modulateurs dihydropyrazoles de gpr40
B. Ellsworth, Jun Shi, W. Ewing, Elizabeth A. Jurica +5 more
20130 citations
Semantic Scholar

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J. Colacino×10
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Jason D Graci — researcher profile on SciRah

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