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S. Spergel · SciRah

Researcher profile · Semantic Scholar

S. Spergel

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S. Spergel — researcher profile on SciRah

h-index: 23
Works: 59
Citations: 1,819

Most-cited papers

Practical olefin hydroamination with nitroarenes
Jing-Han Gui, Chung-Mao Pan, Ying Jin, Tian Qin +10 more
2015Science390 citations
Semantic Scholar
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
Stephen T. Wrobleski, R. Moslin, S. Lin, Yanlei Zhang +28 more
2019Journal of Medicinal Chemistry318 citations Open access
Semantic Scholar
Selective Itk inhibitors block T-cell activation and murine lung inflammation.
Tai-An Lin, K. McIntyre, J. Das, Chun-Jian Liu +22 more
2004Biochemistry117 citations Open access
Semantic Scholar
Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist.
N. Murugesan, Zheng-Xiang Gu, S. Spergel, M. Young +17 more
2003Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors.
J. Das, Chun-Jian Liu, R. Moquin, James Lin +13 more
2006Bioorganic & Medicinal Chemistry Letters51 citations
Semantic Scholar
Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117.
J. Das, James Lin, R. Moquin, Zhong-Qi Shen +10 more
2003Bioorganic & Medicinal Chemistry Letters51 citations Open access
Semantic Scholar
Synthesis and antiviral activity of novel isonucleoside analogs.
J. Tino, J. Clark, A. Field, G. Jacobs +6 more
1993Journal of Medicinal Chemistry51 citations
Semantic Scholar
Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties.
Stephen T. Wrobleski, Ping Chen, J. Hynes, S. Lin +14 more
2003Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.
Ping Chen, A. Doweyko, Derek J. Norris, Henry H. Gu +21 more
2004Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Cupric bromide mediated oxidation of 4-carboxyoxazolines to the corresponding oxazoles
J. Barrish, Janak Singh, S. Spergel, W. Han +3 more
199347 citations
Semantic Scholar
Synthesis of benzazepinone and 3-methylbenzothiazepinone analogs of diltiazem
D. Floyd, R. Moquin, K. Atwal, Sayed Ahmed +3 more
199040 citations
Semantic Scholar
CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH Compound_5 AKA 4-[(2-CARBAMOYLPHEN YL)AMINO]-6-[(5-FLUOROPYRIDIN-2-YL)AMINO]-N-METHYLPYRIDINE -3-CARBOXAMIDE
R. Moslin, Yanlei Zhang, Stephen T. Wrobleski, S. Lin +25 more
201939 citations
Semantic Scholar
A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids
Ping Chen, Peter T. W. Cheng, S. Spergel, R. Zahler +4 more
199739 citations
Semantic Scholar
Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
R. Moslin, Yanlei Zhang, Stephen T. Wrobleski, S. Lin +25 more
2019Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors.
J. Das, J. A. Furch, Chun-Jian Liu, R. Moquin +16 more
2006Bioorganic & Medicinal Chemistry Letters38 citations
Semantic Scholar
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Qing Shi, A. Tebben, A. Dyckman, He Li +17 more
2014Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
One-pot synthesis of azaindoles via palladium-catalyzed alpha-heteroarylation of ketone enolates.
S. Spergel, Danielle R. Okoro, W. Pitts
2010Journal of Organic Chemistry32 citations
Semantic Scholar
Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308).
N. Murugesan, Zheng-Xiang Gu, P. Stein, Sharon Bisaha +23 more
1998Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.
Ping Chen, Peter T. W. Cheng, Masud Alam, Barbara D. Beyer +20 more
1996Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).
Ping Chen, Derek J. Norris, E. Iwanowicz, S. Spergel +16 more
2002Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Discovery of highly potent, selective, covalent inhibitors of JAK3.
J. Kempson, Damaso Ovalle, Jun-Qing Guo, Stephen T. Wrobleski +20 more
2017Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.
Ping Chen, Derek J. Norris, J. Das, S. Spergel +15 more
2004Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists.
N. Murugesan, Zheng-Xiang Gu, P. Stein, S. Spergel +11 more
2000Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
Discovery and structure-based design of 4,6-diaminonicotinamides as potent and selective IRAK4 inhibitors.
R. Bhide, Alec E. Keon, Carolyn A. Weigelt, J. Sack +8 more
2017Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Novel tricyclic inhibitors of IkappaB kinase.
J. Kempson, S. Spergel, Jun-Qing Guo, C. Quesnelle +26 more
2009Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
Scott H. Watterson, Jun-Qing Guo, S. Spergel, C. Langevine +24 more
2016Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
A. Balog, R. Rampulla, G. S. Martin, S. Krystek +18 more
2015ACS Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
J. Kempson, Jun-Qing Guo, J. Das, R. Moquin +14 more
2009Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency.
Ping Chen, E. Iwanowicz, Derek J. Norris, Henry H. Gu +11 more
2002Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
1-Benzazepin-2-one calcium channel blockers--VI. Receptor-binding model and possible relationship to desmethoxyverapamil.
S. Kimball, J. T. Hunt, J. Barrish, J. Das +9 more
1993Bioorganic & Medicinal Chemistry12 citations
Semantic Scholar
Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis.
S. Spergel, Michael E. Mertzman, J. Kempson, Jun-Qing Guo +21 more
2019ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Stereoelectronic effects in nucleophilic addition to a bicyclic ketone: an interpretation
A. Pudzianowski, J. Barrish, S. Spergel
199211 citations
Semantic Scholar
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
A. Dyckman, C. Langevine, C. Quesnelle, J. Kempson +15 more
2011Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.
N. Murugesan, Zheng-Xiang Gu, P. Stein, S. Spergel +6 more
2002Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease
Saleem Ahmad, A. Ashfaq, Masud Alam, G. Bisacchi +15 more
19958 citations
Semantic Scholar
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).
Scott H. Watterson, C. Langevine, Katy van Kirk, J. Kempson +21 more
2011Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Corrigendum to ''Discovery and SAR of 2-amino-5-((thiomethyl)aryl)thiazoles as potent and selective Itk inhibitors'' (Bioorg. Med. Chem. Lett. 16 (2006) 2411-2415)
J. Das, Chun-Jian Liu, R. Moquin, James Lin +13 more
20066 citations
Semantic Scholar
Conformationally constrained calcium channel blockers: novel mimics of 1-benzazepin-2-ones.
J. Barrish, S. Spergel, Suzanne Moreland, Gary J. Grover +4 more
1993Bioorganic & Medicinal Chemistry5 citations
Semantic Scholar
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Jun-Qing Guo, Scott H. Watterson, S. Spergel, J. Kempson +23 more
2016Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
The synthesis of a conformationally rigid calcium channel blocker
J. Barrish, S. Spergel, S. Moreland, S. Hedberg
19924 citations
Semantic Scholar
Synthesis of Benzazepinone and 3‐Methylbenzothiazepinone Analogues of Diltiazem.
D. Floyd, R. Moquin, K. Atwal, S. Z. Ahmed +3 more
19914 citations
Semantic Scholar
Aminodiol HIV Protease Inhibitors. Synthesis and Structure-Activity Relationships of P1/P1′ Compounds: Correlation Between Lipophilicity and Cytotoxicity.
Ping Chen, Peter T. W. Cheng, M. Alam, B. Beyer +18 more
19962 citations
Semantic Scholar
Synthesis and absolute configuration of (+)-2,3,3-trimethyl-2-hydroxybutanoic acid
Saleem Ahmad, S. Spergel, J. Barrish, J. Dimarco +1 more
19952 citations
Semantic Scholar
Aminodiol HIV protease inhibitors. 2. 1,1-Dimethyl-2-hydroxyethyl carbamate derivatives with enhanced potency
G. Bisacchi, Saleem Ahmad, M. Alam, A. Ashfaq +9 more
19952 citations
Semantic Scholar
Aminodiol HIV Protease Inhibitors. Part 1. Design, Synthesis, and Preliminary SAR.
J. Barrish, E. Gordon, M. Alam, P. Lin +17 more
19942 citations
Semantic Scholar
The design and synthesis of a novel series of androgen receptor antagonists leading to the discovery of the clinical candidate BMS-641988
A. Balog, M. Salvati, R. Rampulla, Sören Giese +26 more
20081 citations
Semantic Scholar
Cupric Bromide Mediated Oxidation of 4-Carboxyoxazolines to the Corresponding Oxazoles.
J. Barrish, Janak Singh, S. Spergel, W. Han +3 more
19931 citations
Semantic Scholar
IMIDAZOPYRIDAZINE MODULATORS OF IL-12, IL-23 AND/OR IFN-ALPHA
D. S. Weinstein, J. Duncia, S. Spergel
20180 citations
Semantic Scholar
One-Pot Synthesis of Azaindoles via Palladium-Catalyzed α-Heteroarylation of Ketone Enolates.
S. Spergel, Danielle R. Okoro, W. Pitts
20100 citations
Semantic Scholar
The Synthesis of a Conformationally Rigid Calcium Channel Blocker.
J. Barrish, S. Spergel, S. Moreland, S. Hedberg
20100 citations
Semantic Scholar

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J. Barrish — researcher profile on SciRah
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