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M. Kowala · SciRah

Researcher profile · Semantic Scholar

M. Kowala

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M. Kowala — researcher profile on SciRah

h-index: 27
Works: 83
Citations: 2,626

Most-cited papers

Identification and Characterization of a Major Liver Lysophosphatidylcholine Acyltransferase*
Yang Zhao, Yan-Qun Chen, T. M. Bonacci, D. Bredt +6 more
2008Journal of Biological Chemistry182 citations Open access
Semantic Scholar
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis.
Q. Xiao, M. J. Danton, D. Witte, M. Kowala +3 more
1997Proceedings of the National Academy of Sciences of the United States of America157 citations Open access
Semantic Scholar
Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors.
P. Kiener, P. M. Davis, J. Murray, Sonia Youssef +2 more
2001International Immunopharmacology149 citations
Semantic Scholar
Selective blockade of the endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol.
M. Kowala, P. Rose, P. D. Stein, N. L. Goller +5 more
1995American Journal of Pathology134 citations
Semantic Scholar
Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.
R. Schmidt, Thomas P. Beyer, W. Bensch, Yuewei Qian +5 more
2008Biochemical and Biophysical Research Communications - BBRC117 citations
Semantic Scholar
Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice.
Tae-Sik Park, W. Rosebury, Erick K. Kindt, M. Kowala +1 more
2008Pharmacological Research116 citations
Semantic Scholar
Effect of dietary fat saturation and cholesterol on LDL composition and metabolism. In vivo studies of receptor and nonreceptor-mediated catabolism of LDL in cebus monkeys.
R. Nicolosi, A. Stucchi, M. Kowala, L. Hennessy +2 more
1990Arteriosclerosis113 citations Open access
Semantic Scholar
Prospective identification of biologically active structures by topomer shape similarity searching.
R. Cramer, Michaël Poss, Mark A. Hermsmeier, Thomas J. Caulfield +2 more
1999Journal of Medicinal Chemistry99 citations
Semantic Scholar
Doxazosin and cholestyramine similarly decrease fatty streak formation in the aortic arch of hyperlipidemic hamsters.
M. Kowala, John J. Nunnari, S. Durham, R. Nicolosi
1991Atherosclerosis96 citations
Semantic Scholar
Characterization of atherosclerosis in LDL receptor knockout mice: macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE.
M. Kowala, R. Recce, S. Beyer, C. Gu +1 more
2000Atherosclerosis95 citations
Semantic Scholar
Inhibitors of angiotensin converting enzyme decrease early atherosclerosis in hyperlipidemic hamsters. Fosinopril reduces plasma cholesterol and captopril inhibits macrophage-foam cell accumulation independently of blood pressure and plasma lipids.
M. Kowala, R. Grove, G. Åberg
1994Atherosclerosis95 citations
Semantic Scholar
Fibrinogen deficiency is compatible with the development of atherosclerosis in mice.
Xiao Qing, M. J. Danton, David P. Witte, M. Kowala +2 more
1998Journal of Clinical Investigation90 citations Open access
Semantic Scholar
Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
N. Murugesan, Zheng-Xiang Gu, Leena Fadnis, John E. Tellew +13 more
2005Journal of Medicinal Chemistry83 citations
Semantic Scholar
Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats.
B. Cummings, A. Bettaieb, J. Graham, K. Stanhope +4 more
2012Endocrinology82 citations Open access
Semantic Scholar
Increased severity of glomerulonephritis in C-C chemokine receptor 2 knockout mice.
J. Bird, Mary R. Giancarli, Takao Kurihara, M. Kowala +5 more
2000Kidney International68 citations Open access
Semantic Scholar
Novel Dual Action AT1 and ETA Receptor Antagonists Reduce Blood Pressure in Experimental Hypertension
M. Kowala, N. Murugesan, John E. Tellew, K. Carlson +20 more
2004Journal of Pharmacology and Experimental Therapeutics62 citations
Semantic Scholar
Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats
B. Cummings, A. Bettaieb, J. Graham, Jaehyoung Kim +11 more
2012Disease Models & Mechanisms60 citations Open access
Semantic Scholar
Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.
J. Pawlowski, D. S. Taylor, M. Valentine, M. Hail +3 more
1997Journal of Clinical Investigation60 citations Open access
Semantic Scholar
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia.
J. Pfefferkorn, Chulho Choi, S. Larsen, B. Auerbach +15 more
2008Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists.
N. Murugesan, John E. Tellew, Zheng-Xiang Gu, Bridgette L. Kunst +17 more
2002Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
W. Park, R. Kennedy, S. Larsen, S. Miller +15 more
2008Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Prostacyclin agonists reduce early atherosclerosis in hyperlipidemic hamsters. Octimibate and BMY 42393 suppress monocyte chemotaxis, macrophage cholesteryl ester accumulation, scavenger receptor activity, and tumor necrosis factor production.
M. Kowala, C. Mazzucco, K. Hartl, S. Seiler +3 more
1993Arteriosclerosis and Thrombosis A Journal of Vascular Biology46 citations Open access
Semantic Scholar
The popliteal lymph node of the mouse: internal architecture, vascular distribution and lymphatic supply.
M. Kowala, G. Schoefl
1986Journal of Anatomy41 citations
Semantic Scholar
The Guinea Pig as a Preclinical Model for Demonstrating the Efficacy and Safety of Statins
C. S. Madsen, E. Janovitz, Rong-An Zhang, Vân T. B. Nguyen-Tran +21 more
2008Journal of Pharmacology and Experimental Therapeutics39 citations
Semantic Scholar
The role of endothelin in the pathogenesis of atherosclerosis.
M. Kowala
1997Advances in Pharmacology39 citations
Semantic Scholar
Enhanced reduction of atherosclerosis in hamsters treated with pravastatin and captopril: ACE in atheromas provides cellular targets for captopril.
M. Kowala, M. Valentine, Ron Recce, S. Beyer +3 more
1998Journal of Cardiovascular Pharmacology36 citations Open access
Semantic Scholar
Cellular changes during hypertension: a quantitative study of the rat aorta.
M. Kowala, H. Cuénoud, I. Joris, Guido Majno
1986Experimental and molecular pathology (Print)35 citations
Semantic Scholar
The need for adjusting experimental models to meet clinical reality.
F. Lezoualc'h, L. Badimón, H. Baker, M. Bernard +10 more
2022Cardiovascular Research27 citations Open access
Semantic Scholar
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
J. Pfefferkorn, John E. Litchfield, R. Hutchings, Xue-Min Cheng +37 more
2011Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Proteolytic cleavage of antigen extends the durability of an anti-PCSK9 monoclonal antibody[S]
K. Schroeder, Thomas P. Beyer, R. Hansen, Bomie Han +4 more
2015Journal of Lipid Research24 citations Open access
Semantic Scholar
Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway[S]
Nicholas B. Blackburn, Laura F. Michael, P. Meikle, J. Peralta +19 more
2019Journal of Lipid Research23 citations Open access
Semantic Scholar
Salt-dependent Blood Pressure in Human Aldosterone Synthase-Transgenic Mice
H. Gu, Zhi-Zhong Ma, Jian Wang, T. Zhu +5 more
2017Scientific Reports23 citations Open access
Semantic Scholar
Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease.
G. Cao, Yuewei Qian, M. Kowala, R. Konrad
2008Endocrine, Metabolic & Immune Disorders - Drug Targets22 citations
Semantic Scholar
Acute SGLT-2i treatment improves cardiac efficiency during myocardial ischemia independent of Na+/H+ exchanger-1.
Hana E. Baker, J. Tune, K. Mather, Bianca S. Blaettner +6 more
2022International Journal of Cardiology21 citations
Semantic Scholar
The T- and L-Type Calcium Channel Blocker (CCB) Mibefradil Attenuates Leg Edema Induced by the L-Type CCB Nifedipine in the Spontaneously Hypertensive Rat: A Novel Differentiating Assay
T. Major, S. Dhamija, N. Black, S. Liachenko +6 more
2008Journal of Pharmacology and Experimental Therapeutics21 citations
Semantic Scholar
Regression of Early Atherosclerosis in Hyperlipidemic Hamsters Induced by Fosinopril and Captopril
M. Kowala, R. Recce, S. Beyer, G. Åberg
1995Journal of Cardiovascular Pharmacology21 citations Open access
Semantic Scholar
Effect of Doxazosin on Plasma Lipids and Atherogenesis: A Preliminary Report
M. Kowala, R. Nicolosi
1989Journal of Cardiovascular Pharmacology17 citations Open access
Semantic Scholar
Leukotriene B4 Levels in Human Atherosclerotic Plaques and Abdominal Aortic Aneurysms
P. van den Borne, S. W. van der Laan, S. Bovens, D. Koole +12 more
2014PLoS ONE16 citations Open access
Semantic Scholar
Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists.
John E. Tellew, R. Baska, S. Beyer, K. Carlson +11 more
2003Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
A Novel Aldosterone Antagonist Limits Renal Injury in 5/6 Nephrectomy
C. Fujihara, M. Kowala, M. Breyer, Claudia R. Sena +8 more
2017Scientific Reports14 citations Open access
Semantic Scholar
Genome-wide Screen for Modulation of Hepatic Apolipoprotein A-I (ApoA-I) Secretion
R. Miles, William L. Perry, Joseph V. Haas, M. Mosior +12 more
2013Journal of Biological Chemistry13 citations Open access
Semantic Scholar
Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.
S. Larsen, T. Poel, K. J. Filipski, J. Kohrt +11 more
2007Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes
T. Major, B. Olszewski, W. Rosebury, C. Okerberg +5 more
2008Cardiovascular Drugs and Therapy10 citations
Semantic Scholar
Effects of prazosin on hemodynamics, hemostasis, and serum lipid and lipoprotein levels in normal and hypercholesterolemic monkeys.
William H. Karge, E. Weiner, M. Kowala, Robert M. Graham +1 more
1989American Journal of Medicine9 citations
Semantic Scholar
Selective Phosphodiesterase 1 Inhibitor BTTQ Reduces Blood Pressure in Spontaneously Hypertensive and Dahl Salt Sensitive Rats: Role of Peripheral Vasodilation
A. Dey, S. Khedr, J. Bean, Leah L. Porras +12 more
2020Frontiers in Physiology7 citations Open access
Semantic Scholar
Captopril decreases accelerated atherosclerosis in hypertensive one kidney one clip rats fed cholesterol
M. Kowala
19937 citations
Semantic Scholar
Serum Lipids, Lipoproteins, Hemodynamics, and Hemostasis in Doxazosin‐Treated Monkeys
W. Karge, M. Kowala, E. Weiner, R. Nicolosi
1989Journal of Cardiovascular Pharmacology7 citations Open access
Semantic Scholar
Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models
Xiaojun Wang, Yan-Ping Xu, Xiaohong Yu, A. Dey +12 more
2022Pharmacology Research & Perspectives5 citations Open access
Semantic Scholar
Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet–Induced Obese Rats
Thomas B. Estridge, A. Dey, C. Reidy, Xiaohong Yu +10 more
2017Journal of Pharmacology and Experimental Therapeutics5 citations
Semantic Scholar
Intimal Responses to Shear Stress, Hypercholesterolemia, and Hypertension
C. Majno, T. Zand, John J. Nunnari, M. Kowala +1 more
19885 citations
Semantic Scholar

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