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R. Zahler · SciRah

Researcher profile · Semantic Scholar

R. Zahler

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R. Zahler — researcher profile on SciRah

h-index: 27
Works: 116
Citations: 2,310

Most-cited papers

Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
W. Meng, B. Ellsworth, A. Nirschl, P. McCann +24 more
2008Journal of Medicinal Chemistry594 citations Open access
Semantic Scholar
BMS-200475, a novel carbocyclic 2′-deoxyguanosine analog with potent and selective anti-hepatitis B virus activity in vitro
G. Bisacchi, Sam T. Chao, C. Bachard, J. Daris +11 more
1997121 citations
Semantic Scholar
Metabolic Studies on BMS-200475, a New Antiviral Compound Active against Hepatitis B Virus
G. Yamanaka, Todd Wilson, S. Innaimo, Gregory S. Bisacchi +4 more
1999Antimicrobial Agents and Chemotherapy100 citations Open access
Semantic Scholar
Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.
N. Murugesan, Zheng-Xiang Gu, Leena Fadnis, John E. Tellew +13 more
2005Journal of Medicinal Chemistry83 citations
Semantic Scholar
Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
James C. Sutton, Scott A. Bolton, Malcolm E. Davis, K. Hartl +7 more
2004Bioorganic & Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
James C. Sutton, Scott A. Bolton, K. Hartl, Ming Huang +11 more
2002Bioorganic & Medicinal Chemistry Letters61 citations Open access
Semantic Scholar
Discovery of potent and muscle selective androgen receptor modulators through scaffold modifications.
James J. Li, James C. Sutton, A. Nirschl, Yan Zou +18 more
2007Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
D. S. Weinstein, Wen Liu, Zheng-Xiang Gu, C. Langevine +14 more
2005Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
Trade and Financial Liberalization Given External Shocks and Inconsistent Domestic Policies
Mohsin S. Khan, R. Zahler
198551 citations
Semantic Scholar
(±)-(1α,2β,3α)-9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine [(±)-BHCG or SQ 33 054]: A potent and selective inhibitor of herpesviruses
A. Field, A. Tuomari, B. McGeever-Rubin, B. Terry +8 more
199050 citations
Semantic Scholar
Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes.
R. Brigance, W. Meng, A. Fura, T. Harrity +4 more
2010Bioorganic & Medicinal Chemistry Letters49 citations Open access
Semantic Scholar
Synthesis of SQ-33,054, a novel cyclobutane nucleoside with potent antiviral activity
W. Slusarchyk, M. Young, G. Bisacchi, D. R. Hockstein +1 more
198949 citations
Semantic Scholar
Synthesis of potent and highly selective inhibitors of human tryptase.
W. Slusarchyk, Scott A. Bolton, K. Hartl, Ming Huang +11 more
2002Bioorganic & Medicinal Chemistry Letters46 citations Open access
Semantic Scholar
Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.
W. Meng, R. Brigance, Hannguang J. Chao, A. Fura +14 more
2010Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Synthesis of SQ-32,829, a new nucleoside antiviral agent
G. Jacobs, J. Tino, R. Zahler
198944 citations
Semantic Scholar
Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778).
P. Devasthale, Ying Wang, Wen Wang, J. Fevig +17 more
2013Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).
Jun Li, L. J. Kennedy, Yan Shi, Shiwei Tao +43 more
2010Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.
Saleem Ahmad, C. S. Madsen, P. Stein, E. Janovitz +28 more
2008Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.
K. Atwal, S. O'Neil, Saleem Ahmad, L. Doweyko +6 more
2006Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids
Ping Chen, Peter T. W. Cheng, S. Spergel, R. Zahler +4 more
199739 citations
Semantic Scholar
Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance
D. Maura, S. Drees, A. Bandyopadhaya, T. Kitao +11 more
2017ACS Chemical Biology36 citations Open access
Semantic Scholar
Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.
G. Bisacchi, W. Slusarchyk, Scott A. Bolton, K. Hartl +10 more
2004Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Hao Zhang, D. Ryono, P. Devasthale, Wen Wang +24 more
2009Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Broad-spectrum antiviral activity of the acyclic guanosine phosphonate (R,S)-HPMPG.
B. Terry, Kathryn E. Mazina, A. Tuomari, M. L. Haffey +6 more
1988Antiviral Research33 citations
Semantic Scholar
N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.
A. Nirschl, Yan Zou, S. Krystek, James C. Sutton +21 more
2009Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators.
L. Hamann, M. Manfredi, Chong-Qing Sun, S. Krystek +18 more
2007Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Regioselective Coupling of Tetraalkylammonium Salts of 6-Iodo-2-aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS-180,194, a Potent Antiviral Carbocyclic Nucleoside
G. Bisacchi, Janak Singh, J. D. Godfrey, T. P. Kissick +6 more
199527 citations
Semantic Scholar
Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Haixia Wang, Zheming Ruan, James J. Li, L. Simpkins +21 more
2008Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Chile's Rapid Growth in the 1990s Good Policies, Good Luck, or Political Change?
Esteban Jadresic, R. Zahler
2000Social Science Research Network24 citations Open access
Semantic Scholar
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.
L. Simpkins, Scott A. Bolton, Z. Pi, James C. Sutton +18 more
2007Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
β-Lactam synthesis: Chemospecific sulfonation and cyclization of the β-hydroxyvaline nucleus
W. Slusarchyk, T. Dejneka, J. Gougoutas, W. H. Koster +10 more
198619 citations
Semantic Scholar
European economic and monetary union: Recent progress and possible implications for Latin America and the Caribbean
Rainer Schweickert, R. Zahler, A. Jessen
199717 citations
Semantic Scholar
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.
Yan Shi, J. Zhang, P. Stein, Mengxiao Shi +18 more
2005Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site.
Wei Wang, P. Devasthale, Aiying Wang, T. Harrity +13 more
2011Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC‐MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition
Paul Turnpenny, A. Padfield, P. Barton, J. Teague +4 more
2017Journal of Pharmaceutical and Biomedical Analysis14 citations
Semantic Scholar
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
Scott A. Bolton, James C. Sutton, R. Anumula, G. Bisacchi +16 more
2013Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
The Central Bank and Chilean macroeconomic policy in the 1990s
R. Zahler
199814 citations
Semantic Scholar
Differences in antiviral activities for isomers of a fluorinated cyclobutane nucleoside analog
G. Vite, J. Tino, R. Zahler, V. Goodfellow +3 more
199312 citations
Semantic Scholar
Synthesis and biological evaluation of novel pyrrolidine acid analogs as potent dual PPARα/γ agonists.
Hao Zhang, Charles Z. Ding, Zhi-Yang Lai, Sean S Chen +31 more
2015Bioorganic & Medicinal Chemistry Letters10 citations Open access
Semantic Scholar
Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.
Yan Shi, Doree Sitkoff, J. Zhang, W. Han +13 more
2007Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Macroeconomic stability and investment allocation of domestic pension funds in emerging economies: the case of Chile
R. Zahler
20069 citations
Semantic Scholar
Chapter 14. Antiviral Agents
J. Barrish, R. Zahler
19939 citations
Semantic Scholar
Monetary policy and an open capital account
R. Zahler
19929 citations
Semantic Scholar
α-hydroxyamide derived aminodiols as potent inhibitors of hiv protease
Saleem Ahmad, A. Ashfaq, Masud Alam, G. Bisacchi +15 more
19958 citations
Semantic Scholar
Regioselective Coupling of Tetraalkylammonium Salts of 6‐Iodo‐2‐ aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS‐180,194, a Potent Antiviral Carbocyclic Nucleoside.
G. Bisacchi, Janak Singh, J. D. Jun. Godfrey, T. P. Kissick +6 more
19958 citations
Semantic Scholar
Designing financial regulatory policies that work for Latin America: the role of markets and institutions
P. Guidotti, L. Rojas-Suárez, R. Zahler
20047 citations
Semantic Scholar
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
Yan Shi, Ying Wang, Wei Meng, R. Brigance +59 more
2022Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.
Yan Shi, Jun Li, L. J. Kennedy, Shiwei Tao +35 more
2016ACS Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
Xiang-Yang Ye, Yi-Xin Li, Dennis Farrelly, Neil Flynn +10 more
2008Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Discovery and Development of Entecavir
Richard R. Wilber, B. Kreter, M. Bifano, S. Danetz +5 more
20115 citations
Semantic Scholar

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W. Slusarchyk — researcher profile on SciRah
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James C. Sutton — researcher profile on SciRah
L. Hamann×9
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Aiying Wang — researcher profile on SciRah

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S. Krystek — researcher profile on SciRah

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