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Doree Sitkoff · SciRah

Researcher profile · Semantic Scholar

Doree Sitkoff

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Doree Sitkoff — researcher profile on SciRah

h-index: 15
Works: 29
Citations: 817

Most-cited papers

A comparative study of available software for high‐accuracy homology modeling: From sequence alignments to structural models
Akbar Nayeem, Doree Sitkoff, S. Krystek
2006Protein Science159 citations Open access
Semantic Scholar
Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering
Tracy S. Mitchell, G. Chao, Doree Sitkoff, Fred Lo +14 more
2014Journal of Pharmacology and Experimental Therapeutics122 citations Open access
Semantic Scholar
Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors.
D. Magnin, J. Robl, R. Sulsky, D. Augeri +18 more
2004Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
D. S. Weinstein, Wen Liu, Zheng-Xiang Gu, C. Langevine +14 more
2005Bioorganic & Medicinal Chemistry Letters54 citations Open access
Semantic Scholar
Analysis and optimization of structure-based virtual screening protocols. 2. Examination of docked ligand orientation sampling methodology: mapping a pharmacophore for success.
A. Good, D. Cheney, Doree Sitkoff, J. Tokarski +6 more
2003Journal of Molecular Graphics and Modelling48 citations
Semantic Scholar
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.
Saleem Ahmad, C. S. Madsen, P. Stein, E. Janovitz +28 more
2008Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Design, structure-activity relationships, X-ray crystal structure, and energetic contributions of a critical P1 pharmacophore: 3-chloroindole-7-yl-based factor Xa inhibitors.
Yan Shi, Doree Sitkoff, J. Zhang, H. Klei +16 more
2008Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors.
L. Harikrishnan, Heather J. Finlay, Jennifer X. Qiao, Muthoni G. Kamau +22 more
2012Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.
Elizabeth A. Jurica, Xi-Mao Wu, Kristin N Williams, Andrés S. Hernández +34 more
2017Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.
Yan Shi, Chi Li, Stephen P. O'connor, J. Zhang +16 more
2009Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.
S. Nara, S. Jogi, Srinivas Cheruku, Sarkunam Kandhasamy +24 more
2022Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors.
Guo-Hua Zhao, P. Taunk, D. Magnin, L. Simpkins +8 more
2005Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.
Yan Shi, J. Zhang, P. Stein, Mengxiao Shi +18 more
2005Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
The influence of a solvent environment on direct non-covalent interactions between two molecules: A symmetry-adapted perturbation theory study of polarization tuning of π-π interactions by water.
Dominic A. Sirianni, Xiao Zhu, Doree Sitkoff, D. Cheney +1 more
2022Journal of Chemical Physics15 citations
Semantic Scholar
Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.
Yan Shi, Stephen P. O'connor, Doree Sitkoff, J. Zhang +17 more
2011Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.
Yan Shi, J. Zhang, Mengxiao Shi, Stephen P. O'connor +15 more
2009Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Theoretical calculations of the permeability of monensin-cation complexes in model bio-membranes.
N. Ben-Tal, Doree Sitkoff, Sharron Bransburg-Zabary, E. Nachliel +1 more
2000Biochimica et Biophysica Acta15 citations Open access
Semantic Scholar
Identification of 5H-Chromeno[3,4-c]pyridine and 6H-Isochromeno[3,4-c]pyridine Derivatives as Potent and Selective Dual ROCK Inhibitors.
Zi-Lun Hu, Cai-Lan Wang, Doree Sitkoff, Nathan L Cheadle +5 more
2020Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383.
Doree Sitkoff, N. Lee, B. Ellsworth, Qi Huang +12 more
2011European Journal of Pharmacology14 citations
Semantic Scholar
Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
Joseph Carpenter, Gang Wu, Ying Wang, E. Cook +12 more
2021ACS Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Optimized damping parameters for empirical dispersion corrections to symmetry-adapted perturbation theory.
Jeffrey B. Schriber, Dominic A. Sirianni, Daniel G. A. Smith, L. A. Burns +3 more
2021Journal of Chemical Physics11 citations Open access
Semantic Scholar
Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.
B. Ellsworth, P. M. Sher, Xi-Mao Wu, Gang Wu +29 more
2013Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Discovery of a Phenylpyrazole Amide ROCK Inhibitor as a Tool Molecule for in vivo Studies.
Zi-Lun Hu, Cai-Lan Wang, P. Glunz, Julia P. Li +17 more
2020Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.
Yan Shi, Doree Sitkoff, J. Zhang, W. Han +13 more
2007Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Initial Structure-Activity Relationships for a Caprolactam-based Series of Neutral Factor Xa Inhibitors: Lead Identification
G. Bisacchi, P. Stein, J. Gougoutas, K. Hartl +9 more
20056 citations
Semantic Scholar
Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.
Zi-Lun Hu, Doree Sitkoff, P. Glunz, Yan Zou +5 more
2023Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for LDL Lowering
Tracy S. Mitchell, G. Chao, Doree Sitkoff, Fred Lo +13 more
20142 citations
Semantic Scholar
Erratum to ''Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors'' (Bioorg. Med. Chem. Lett. 15 (2005) 5453-5458)
Yan Shi, J. Zhang, P. Stein, Mengxiao Shi +18 more
20061 citations
Semantic Scholar
models homology modeling : From sequence alignments to structural A comparative study of available software for high-accuracy
Doree Sitkoff, Stanley Krystek
20050 citations
Semantic Scholar

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