S. Linse

Most-cited papers

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
A. Boza-Serrano, R. Ruiz, Raquel Sanchez-Varo, Juan García-Revilla +23 more
2019Acta Neuropathologica304 citations Open access
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Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide
T. Michaels, A. Šarić, Samo Curk, K. Bernfur +8 more
2020bioRxiv302 citations Open access
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Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J. Habchi, Sean Chia, Céline Galvagnion, T. Michaels +10 more
2018Nature Chemistry211 citations Open access
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Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
S. Linse, T. Scheidt, K. Bernfur, M. Vendruscolo +13 more
2020Nature Structural & Molecular Biology167 citations
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Kinetic diversity of amyloid oligomers
A. Dear, T. Michaels, G. Meisl, D. Klenerman +5 more
2020Proceedings of the National Academy of Sciences of the United States of America158 citations Open access
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Amyloid formation as a protein phase transition
T. Michaels, Daoyuan Qian, A. Šarić, M. Vendruscolo +2 more
2023Nature Reviews Physics155 citations
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Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Ryan Limbocker, Sean Chia, F. Ruggeri, Michele Perni +21 more
2019Nature Communications139 citations Open access
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Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
T. Scheidt, Urszula Łapińska, J. Kumita, Daniel R. Whiten +8 more
2019Science Advances138 citations Open access
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On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
Xiaoting Yang, G. Meisl, B. Frohm, E. Thulin +2 more
2018Proceedings of the National Academy of Sciences of the United States of America110 citations Open access
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The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
D. Thacker, Kalyani Sanagavarapu, B. Frohm, G. Meisl +2 more
2020Proceedings of the National Academy of Sciences of the United States of America84 citations Open access
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Mechanism of amyloid protein aggregation and the role of inhibitors
S. Linse
2019Pure and Applied Chemistry76 citations Open access
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Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
T. Michaels, A. Šarić, G. Meisl, Gabriella T. Heller +6 more
2020Proceedings of the National Academy of Sciences of the United States of America68 citations Open access
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Identification of on- and off-pathway oligomers in amyloid fibril formation
A. Dear, G. Meisl, A. Šarić, T. Michaels +3 more
2020Chemical Science66 citations Open access
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Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation.
Manuela R Zimmermann, S. Bera, G. Meisl, Sourav Dasadhikari +4 more
2021Journal of the American Chemical Society64 citations Open access
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Proliferation of Tau 304–380 Fragment Aggregates through Autocatalytic Secondary Nucleation
D. C. Rodriguez Camargo, Eimantas Šileikis, Sean Chia, Emil Axell +8 more
2021ACS Chemical Neuroscience62 citations Open access
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α-Synuclein oligomers form by secondary nucleation
Catherine K. Xu, G. Meisl, E. Andrzejewska, G. Krainer +11 more
2024bioRxiv61 citations Open access
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Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
Rebecca Frankel, Mattias Törnquist, G. Meisl, O. Hansson +8 more
2019Communications Biology60 citations Open access
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Uncovering the universality of self-replication in protein aggregation and its link to disease
G. Meisl, Catherine K. Xu, Jonathan D. Taylor, T. Michaels +7 more
2022bioRxiv56 citations Open access
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The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain.
Alessia Peduzzo, S. Linse, A. Buell
2019ACS Chemical Neuroscience54 citations Open access
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Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
Patrick Flagmeier, S. De, T. Michaels, Xiaoting Yang +7 more
2020Nature Structural & Molecular Biology53 citations
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Charge Regulation during Amyloid Formation of α-Synuclein
Tinna Pálmadóttir, A. Malmendal, Thom Leiding, Mikael Lund +1 more
2021Journal of the American Chemical Society51 citations Open access
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Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils
Céline Galvagnion, D. Topgaard, K. Makasewicz, A. Buell +3 more
2019Journal of Physical Chemistry Letters47 citations Open access
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Direct observation of secondary nucleation along the fibril surface of the amyloid β 42 peptide
D. Thacker, Mohammad Barghouth, Mara Bless, Enming Zhang +1 more
2023Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
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Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
Roxine Staats, T. Michaels, Patrick Flagmeier, Sean Chia +6 more
2020Communications Chemistry46 citations Open access
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A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
Rodrigo Cataldi, Sean Chia, Katarina Pisani, F. Ruggeri +12 more
2021Communications Biology44 citations Open access
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Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation
Gabriel A. Braun, A. Dear, Kalyani Sanagavarapu, H. Zetterberg +1 more
2022Chemical Science42 citations Open access
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Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates
D. C. Rodriguez Camargo, Sean Chia, Joseph Menzies, B. Mannini +10 more
2021Frontiers in Molecular Biosciences41 citations Open access
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Amyloid β 42 fibril structure based on small-angle scattering
V. Lattanzi, I. André, U. Gasser, Marija Dubackic +2 more
2021Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
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On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide.
Gabriel A. Braun, Beatrice Ary, A. Dear, M. Rohn +7 more
2020Biomacromolecules40 citations
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Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils
Mattias Törnquist, Risto Cukalevski, U. Weininger, G. Meisl +5 more
2020Proceedings of the National Academy of Sciences of the United States of America40 citations Open access
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The catalytic nature of protein aggregation
A. Dear, G. Meisl, T. Michaels, Manuela R Zimmermann +2 more
2020Journal of Chemical Physics40 citations Open access
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Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates
Sean Chia, Z. F. Brotzakis, Robert I. Horne, A. Possenti +8 more
2021bioRxiv38 citations Open access
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Anomalous Salt Dependence Reveals an Interplay of Attractive and Repulsive Electrostatic Interactions in α-synuclein Fibril Formation
Ricardo Gaspar, Mikael Lund, E. Sparr, S. Linse
2020QRB Discovery38 citations Open access
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1H detection and dynamic nuclear polarization–enhanced NMR of Aβ1-42 fibrils
Salima Bahri, R. Silvers, Brian Michael, K. Jaudzems +7 more
2021Proceedings of the National Academy of Sciences of the United States of America36 citations Open access
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Cooperativity of α-Synuclein Binding to Lipid Membranes
K. Makasewicz, S. Wennmalm, B. Stenqvist, Marco Fornasier +4 more
2021ACS Chemical Neuroscience35 citations Open access
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pH-Responsive Capsules with a Fibril Scaffold Shell Assembled from an Amyloidogenic Peptide.
U. Shimanovich, A. Levin, D. Eliaz, T. Michaels +6 more
2021Small23 citations
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Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils
Tinna Pálmadóttir, C. Waudby, K. Bernfur, J. Christodoulou +2 more
2023International Journal of Molecular Sciences22 citations Open access
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The unhappy chaperone
S. Linse, K. Thalberg, T. Knowles
2021QRB Discovery20 citations Open access
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Expression and Purification of Intrinsically Disordered Aβ Peptide and Setup of Reproducible Aggregation Kinetics Experiment.
S. Linse
2020Methods in molecular biology20 citations
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Charting a course for chemistry
Alán Aspuru-Guzik, Mu-Hyun Baik, S. Balasubramanian, R. Banerjee +54 more
2019Nature Chemistry18 citations Open access
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Fibril Charge Affects α-Synuclein Hydrogel Rheological Properties.
Brett H. Pogostin, S. Linse, U. Olsson
2019Langmuir18 citations
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The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation
C. Haikal, Lei Ortigosa-Pascual, Zahra Najarzadeh, K. Bernfur +4 more
2021bioRxiv17 citations Open access
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Transient Lipid-Protein Structures and Selective Ganglioside Uptake During α-Synuclein-Lipid Co-aggregation
Ricardo Gaspar, Ilaria Idini, Göran Carlström, S. Linse +1 more
2021Frontiers in Cell and Developmental Biology17 citations Open access
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Lipid-protein interactions in amyloid formation.
E. Sparr, S. Linse
2019Biochimica et Biophysica Acta - Proteins and Proteomics17 citations
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A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation
Kevin N. Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M. Schneider +7 more
2022ACS Chemical Neuroscience16 citations Open access
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Solubility of Aβ40 peptide
V. Lattanzi, K. Bernfur, E. Sparr, U. Olsson +1 more
2021JCIS Open16 citations Open access
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Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
Tanja Weiffert, G. Meisl, Patrick Flagmeier, S. De +9 more
2019ACS Chemical Neuroscience16 citations Open access
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Ganglioside GM3 stimulates lipid-protein co-assembly in α-synuclein amyloid formation.
Simon Fridolf, Q. D. Pham, Jon Pallbo, K. Bernfur +3 more
2022Biophysical Chemistry15 citations Open access
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Chiral Selectivity of Secondary Nucleation in Amyloid Fibril Propagation
Mattias Törnquist, S. Linse
2021Angewandte Chemie15 citations Open access
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Toward the equilibrium and kinetics of amyloid peptide self-assembly.
S. Linse
2021Current Opinion in Structural Biology14 citations Open access
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