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J. Paulsen · SciRah

Researcher profile · Semantic Scholar

J. Paulsen

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J. Paulsen — researcher profile on SciRah

h-index: 16
Works: 38
Citations: 658

Most-cited papers

Citrullination of NF-kB p65 enhances its nuclear localization and TLR-induced expression of IL-1β and TNFα
Bo Sun, N. Dwivedi, Tyler J. Bechtel, J. Paulsen +8 more
2017Science immunology115 citations Open access
Semantic Scholar
Drug design strategies to avoid resistance in direct-acting antivirals and beyond
A. N. Matthew, F. Leidner, G. J. Lockbaum, M. Henes +13 more
2021Chemical Reviews69 citations Open access
Semantic Scholar
CRISPR-Cas9–mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy
Le-Yuan Ma, J. Boucher, J. Paulsen, Sebastian Matuszewski +12 more
2017Proceedings of the National Academy of Sciences of the United States of America55 citations Open access
Semantic Scholar
Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans.
J. Paulsen, E. Capowski, S. Strome
1995Genetics53 citations
Semantic Scholar
Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata
Narendran G-Dayanandan, J. Paulsen, Kishore Viswanathan, Santosh Keshipeddy +8 more
2014Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
Yufeng Cai, W. Myint, J. Paulsen, C. Schiffer +2 more
2014Journal of Chemical Theory and Computation39 citations Open access
Semantic Scholar
Scoring Ensembles of Docked Protein:Ligand Interactions for Virtual Lead Optimization
J. Paulsen, A. Anderson
2009Journal of Chemical Information and Modeling38 citations Open access
Semantic Scholar
α-S-GalCer: Synthesis and Evaluation for iNKT Cell Stimulation
Marisa L. Blauvelt, M. Khalili, Weonjoo Jaung, J. Paulsen +3 more
2008Bioorganic & Medicinal Chemistry Letters36 citations Open access
Semantic Scholar
Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease
F. Leidner, N. K. Yilmaz, J. Paulsen, Y. Muller +1 more
2018Journal of Chemical Theory and Computation32 citations Open access
Semantic Scholar
Interdependence of Inhibitor Recognition in HIV-1 Protease
J. Paulsen, F. Leidner, Debra Ragland, Nese Kurt Yilmaz +1 more
2017Journal of Chemical Theory and Computation30 citations Open access
Semantic Scholar
Structure-guided design of a high affinity inhibitor to human CtBP
B. Hilbert, B. Morris, K. C. Ellis, J. Paulsen +3 more
2015ACS Chemical Biology26 citations Open access
Semantic Scholar
Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity
J. Paulsen, S. Bendel, A. Anderson
2011Chemical Biology and Drug Design19 citations Open access
Semantic Scholar
Evaluation of Free Energy Calculations for the Prioritization of Macrocycle Synthesis
J. Paulsen, Haoyu S Yu, Daniel J. Sindhikara, Ling-Le Wang +4 more
2020Journal of Chemical Information and Modeling18 citations Open access
Semantic Scholar
2,4-Diamino-5-(2′-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition
Oztekin Algul, J. Paulsen, A. Anderson
2010Journal of Molecular Graphics and Modelling17 citations Open access
Semantic Scholar
In Vitro Biological Activity and Structural Analysis of 2,4-Diamino-5-(2’-arylpropargyl)pyrimidine Inhibitors of Candida albicans
J. Paulsen, Jie-Ying Liu, David B. Bolstad, Adrienne E. Smith +3 more
2009Bioorganic & Medicinal Chemistry17 citations Open access
Semantic Scholar
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species
J. Paulsen, Kishore Viswanathan, D. Wright, A. Anderson
2013Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by NMR
S. N. Khan, J. Persons, J. Paulsen, Michel Guerrero +3 more
2018Biochemistry13 citations Open access
Semantic Scholar
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention
Zhe Nie, Roger Bonnert, Jet Tsien, Xiao-Yi Deng +40 more
2024Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
ToxBench: A Binding Affinity Prediction Benchmark with AB-FEP-Calculated Labels for Human Estrogen Receptor Alpha
Meng Liu, K. Leswing, Simon K. S. Chu, F. Ramezanghorbani +18 more
2025arXiv.org2 citations
Semantic Scholar
Abstract 7133: Phenomics-enabled discovery and optimization of small-molecule RBM39 degraders as an alternative to CDK12 targeting in high-grade serous ovarian cancer (HGSOC)
Chase Neumann, Harish Shankaran, K. Nadella, Kelly Biette +18 more
2024Cancer Research2 citations
Semantic Scholar
Abstract LB071: A phenomics platform combining imaging and artificial intelligence for rapid validation and advancement of novel oncology targets
J. Rudnick, K. Nadella, Chase Neumann, Shane D. Rowley +34 more
2023Cancer Research0 citations
Semantic Scholar
Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: tert-butyl [(2S)-1-{[(3S,17S)-2,16-dioxo-10,15-dioxa-1,21-diazatricyclo[15.3.1.1~5,9~]docosa-5(22),6,8-trien-3-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate (compound 3)
T. Appleby, J. Paulsen, U. Schmitz, D. Shivakumar
20200 citations
Semantic Scholar
Expanding the domain of applicability of structure-based drug design with IFD-MD
Kai-Di Zhu, J. Paulsen, E. Miller, K. Borrelli +2 more
20200 citations Open access
Semantic Scholar
Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-3-oxa-9,12,15,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 24)
T. Appleby, J. Paulsen, U. Schmitz, D. Shivakumar
20200 citations
Semantic Scholar
Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11,17,17-tetramethyl-14-(propan-2-yl)-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 28)
T. C. Appleby, J. Paulsen, U. Schmitz, D. Shivakumar
20200 citations
Semantic Scholar
Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-14-cyclobutyl-2,11,17,17-tetramethyl-15-oxa-3,9,12,26,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(25),18,20(28),21,23,26-hexaene-4,10,13,16-tetrone (compound 33)
T. Appleby, J. Paulsen, U. Schmitz, D. Shivakumar
20200 citations
Semantic Scholar
Human cyclophilin A bound to a series of acylcic and macrocyclic inhibitors: (2R,5S,11S,14S,18E)-2,11-dimethyl-14-(propan-2-yl)-3-oxa-9,12,15,21,29-pentaazatetracyclo[18.5.3.1~5,9~.0~23,27~]nonacosa-1(26),18,20,22,24,27-hexaene-4,10,13,16-tetrone (compound 21)
T. Appleby, J. Paulsen, U. Schmitz, D. Shivakumar
20200 citations
Semantic Scholar
CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid
B. Hilbert, B. Morris, K. C. Ellis, J. Paulsen +3 more
20150 citations
Semantic Scholar
CtBP1 in complex with substrate phenylpyruvate
B. Hilbert, B. Morris, K. C. Ellis, J. Paulsen +3 more
20150 citations
Semantic Scholar
Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111H)
J. Paulsen, A. Anderson
20140 citations
Semantic Scholar
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)
J. Paulsen, A. Anderson
20140 citations
Semantic Scholar
Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(4-methylphenyl)phenyl]but-1-yn-1-yl}-6-methylpyrimidine-2,4-diamine (UCP111D4M)
J. Paulsen, A. Anderson
20130 citations
Semantic Scholar
Candida albicans dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)
J. Paulsen, A. Anderson
20130 citations
Semantic Scholar
Candida glabrata dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3R)-3-[3-methoxy-5-(morpholin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1004)
J. Paulsen, A. Anderson
20120 citations
Semantic Scholar
A Structure-Based Drug Design Approach to Develop Dual Action Antimycotics against Candida albicans and Candida glabrata Dihydrofolate Reductase
J. Paulsen
20120 citations
Semantic Scholar
Candida glabrata dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-propylpyrimidine-2,4-diamine (UCP130B)
J. Paulsen, S. Bendel, A. Anderson
20110 citations
Semantic Scholar
Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A)
J. Paulsen, S. Bendel, A. Anderson
20110 citations
Semantic Scholar
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)
J. Paulsen, S. Bendel, A. Anderson
20110 citations
Semantic Scholar

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