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D. Wright · SciRah

Researcher profile · Semantic Scholar

D. Wright

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D. Wright — researcher profile on SciRah

h-index: 35
Works: 153
Citations: 3,985

Most-cited papers

The application of cathodic reductions and anodic oxidations in the synthesis of complex molecules.
Jeffrey B. Sperry, D. Wright
2006Chemical Society Reviews487 citations
Semantic Scholar
The cycloaddition strategy for the synthesis of natural products containing carbocyclic seven-membered rings.
M. Battiste, Phillip M. Pelphrey, D. Wright
2006Chemistry198 citations
Semantic Scholar
Selective inhibitor of proteasome’s caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites
M. Britton, M. Lucas, Sondra L. Downey, M. Screen +9 more
2009Chemistry and Biology163 citations Open access
Semantic Scholar
USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms.
A. Pozhidaeva, Gabrielle J. Valles, Feng Wang, Jian Wu +7 more
2017Cell Chemical Biology104 citations Open access
Semantic Scholar
Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
Sophia N. Ononye, Michael D. VanHeyst, E. Oblak, Wangda Zhou +3 more
2013ACS Medicinal Chemistry Letters91 citations Open access
Semantic Scholar
Antibacterial Antifolates: From Development through Resistance to the Next Generation
Alexavier Estrada, D. Wright, A. Anderson
2016Cold Spring Harbor Perspectives in Medicine76 citations Open access
Semantic Scholar
Targeting the pregnane X receptor using microbial metabolite mimicry
Z. Dvořák, F. Kopp, Cait M. Costello, Jazmin S. Kemp +38 more
2019bioRxiv74 citations Open access
Semantic Scholar
Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis.
Phillip M. Pelphrey, V. Popov, Tammy M. Joska, J. Beierlein +4 more
2007Journal of Medicinal Chemistry69 citations Open access
Semantic Scholar
Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternative Conformation of NADPH that may be Linked to Trimethoprim Resistance
K. Frey, Jie-Ying Liu, M. Lombardo, David B. Bolstad +2 more
2009Journal of Molecular Biology63 citations Open access
Semantic Scholar
Drugging the Folate Pathway in Mycobacterium Tuberculosis: The Role of Multi-Targeting Agents
B. Hajian, Eric Scocchera, Carolyn Shoen, J. Krucinska +8 more
2019Cell Chemical Biology55 citations Open access
Semantic Scholar
Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase
K. Frey, M. Lombardo, D. Wright, A. Anderson
2009Journal of Structural Biology53 citations Open access
Semantic Scholar
Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata
Narendran G-Dayanandan, J. Paulsen, Kishore Viswanathan, Santosh Keshipeddy +8 more
2014Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Cyclopropene cycloadditions with annulated furans: total synthesis of (+)- and (-)-frondosin B and (+)-frondosin A.
E. Oblak, Michael D. VanHeyst, Jin Li, Andrew J. Wiemer +1 more
2014Journal of the American Chemical Society49 citations
Semantic Scholar
Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase
J. Beierlein, K. Frey, David B. Bolstad, Phillip M. Pelphrey +5 more
2008Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.
T. Sundstrom, A. Anderson, D. Wright
2009Organic and biomolecular chemistry46 citations
Semantic Scholar
Structure‐based approach to pharmacophore identification, in silico screening, and three‐dimensional quantitative structure–activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function
Norbert Schormann, Olga Senkovich, Kiera Walker, D. Wright +6 more
2008Proteins: Structure, Function, and Bioinformatics46 citations
Semantic Scholar
Development of intestinal organoids as tissue surrogates: Cell composition and the Epigenetic control of differentiation
Lishuang Cao, Anton Kuratnik, W. Xu, J. Gibson +7 more
2015Molecular Carcinogenesis44 citations
Semantic Scholar
Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase
K. Lamb, Narendran G-Dayanandan, D. Wright, A. Anderson
2013Biochemistry43 citations Open access
Semantic Scholar
The crystal structure of Candida glabrata dihydrofolate reductase drives new inhibitor design toward efficacious antifungal agents
Jie-Ying Liu, David B. Bolstad, Adrienne E. Smith, N. Priestley +2 more
2008Chemistry and Biology41 citations Open access
Semantic Scholar
Crystal structures of trimethoprim-resistant DfrA1 rationalize potent inhibition by propargyl-linked antifolates
M. Lombardo, Narendran G-Dayanandan, D. Wright, A. Anderson
2016ACS Infectious Diseases39 citations Open access
Semantic Scholar
Structure-Based Approach to the Development of Potent and Selective Inhibitors of Dihydrofolate Reductase from Cryptosporidium
David B. Bolstad, Erin S. Bolstad, K. Frey, D. Wright +1 more
2008Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus
Lorry M. Grady, R. Szczepaniak, R. P. Murelli, T. Masaoka +3 more
2017Journal of Virology36 citations Open access
Semantic Scholar
Z-Phe-Ala-diazomethylketone (PADK) Disrupts and Remodels Early Oligomer States of the Alzheimer Disease Aβ42 Protein*
Xue-Yun Zheng, M. Gessel, Meagan L. Wisniewski, Kishore Viswanathan +3 more
2012Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Non-racemic Antifolates Stereo-selectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus
Santosh Keshipeddy, S. Reeve, A. Anderson, D. Wright
2015Journal of the American Chemical Society35 citations Open access
Semantic Scholar
Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance
K. Frey, Kishore Viswanathan, D. Wright, A. Anderson
2012Antimicrobial Agents and Chemotherapy35 citations Open access
Semantic Scholar
Antifolate Agents: A Patent Review (2006–2010)
D. Wright, A. Anderson
2011Expert Opinion on Therapeutic Patents34 citations Open access
Semantic Scholar
Structural and Functional Studies of Bacterial Enolase, a Potential Target Against Gram-Negative Pathogens.
J. Krucinska, Eric R. Falcone, H. Erlandsen, Akram Hazeen +5 more
2019Biochemistry30 citations Open access
Semantic Scholar
Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens.
Eric Scocchera, S. Reeve, Santosh Keshipeddy, M. Lombardo +6 more
2016ACS Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity
K. Lamb, M. Lombardo, Jeremy B. Alverson, N. Priestley +2 more
2014Antimicrobial Agents and Chemotherapy30 citations Open access
Semantic Scholar
Highly substituted oxabicyclic derivatives from furan: synthesis of (±)-platensimycin.
E. Oblak, D. Wright
2011Organic Letters30 citations
Semantic Scholar
Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens
J. Krucinska, M. Lombardo, H. Erlandsen, Alexavier Estrada +3 more
2022Communications Biology28 citations Open access
Semantic Scholar
Toward isozyme-selective inhibitors of histone deacetylase as therapeutic agents for the treatment of cancer
Sophia N. Ononye, Michael van Heyst, Eric M Falcone, A. Anderson +1 more
2012Pharmaceutical Patent Analyst28 citations Open access
Semantic Scholar
High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells
Yulan Zhao, Zhi-Hong Yang, Jian-Guo Wu, Raymond Wu +3 more
2017Hepatology Communications27 citations Open access
Semantic Scholar
Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis
B. Hajian, Eric Scocchera, Santosh Keshipeddy, Narendran G-Dayanandan +6 more
2016PLoS ONE27 citations Open access
Semantic Scholar
Antifolates as effective antimicrobial agents: new generations of trimethoprim analogs
Wangda Zhou, Eric Scocchera, D. Wright, A. Anderson
201326 citations
Semantic Scholar
Charged propargyl-linked antifolates reveal mechanisms of antifolate resistance and inhibit trimethoprim-resistant MRSA strains possessing clinically relevant mutations
S. Reeve, Eric Scocchera, Jacob J Ferreira, Narendran G-Dayanandan +3 more
2016Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.
E. Oblak, Erin S. Bolstad, Sophia N. Ononye, N. Priestley +2 more
2012Organic and biomolecular chemistry25 citations
Semantic Scholar
Tandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine.
E. Oblak, Narendran G-Dayanandan, D. Wright
2011Organic Letters25 citations
Semantic Scholar
Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.
V. Popov, D. Chan, Yale A. Fillingham, W. Yee +2 more
2006Bioorganic & Medicinal Chemistry Letters24 citations
Semantic Scholar
Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells
Staci L Haney, Cheryl L. Allen, Michelle Varney, Kaitlyn M. Dykstra +7 more
2017OncoTarget23 citations Open access
Semantic Scholar
Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis
Jin Li, Eric R. Falcone, S. Holstein, A. Anderson +2 more
2016Pharmacological Research23 citations Open access
Semantic Scholar
MRSA isolates from the United States hospitals carry dfrG and dfrK resistance genes and succumb to propargyl-linked antifolates
S. Reeve, Eric Scocchera, Narendran G-Dayanadan, Santosh Keshipeddy +7 more
2016Cell Chemical Biology23 citations Open access
Semantic Scholar
Towards New Antifolates Targeting Eukaryotic Opportunistic Infections
Jie-Ying Liu, David B. Bolstad, Erin S. Bolstad, D. Wright +1 more
2009Eukaryotic Cell22 citations Open access
Semantic Scholar
Nonpeptidic lysosomal modulators derived from z-phe-ala-diazomethylketone for treating protein accumulation diseases.
Kishore Viswanathan, D. Hoover, Jeannie Hwang, Meagan L. Wisniewski +3 more
2012ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Identification of novel compounds that enhance colon cancer cell sensitivity to inflammatory apoptotic ligands
A. Chopra, Anton Kuratnik, Eric Scocchera, D. Wright +1 more
2013Cancer Biology & Therapy17 citations Open access
Semantic Scholar
In Vitro Biological Activity and Structural Analysis of 2,4-Diamino-5-(2’-arylpropargyl)pyrimidine Inhibitors of Candida albicans
J. Paulsen, Jie-Ying Liu, David B. Bolstad, Adrienne E. Smith +3 more
2009Bioorganic & Medicinal Chemistry17 citations Open access
Semantic Scholar
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species
J. Paulsen, Kishore Viswanathan, D. Wright, A. Anderson
2013Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.
Jasmina Nikodinovic, Jennifer M. Dinges, S. Bergmeier, M. McMills +2 more
2006Organic Letters16 citations
Semantic Scholar
Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate
J. Krucinska, M. Lombardo, H. Erlandsen, Akram Hazeen +5 more
2019Scientific Reports15 citations Open access
Semantic Scholar
Antifolate agents: a patent review (2010 – 2013)
A. Anderson, D. Wright
2014Expert Opinion on Therapeutic Patents15 citations
Semantic Scholar

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N. Priestley×8
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Eric Scocchera×7
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Kishore Viswanathan

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Narendran G-Dayanandan×7

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J. Krucinska×6

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K. Frey — researcher profile on SciRah

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S. Reeve — researcher profile on SciRah