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G. J. Lockbaum · SciRah

Researcher profile · Semantic Scholar

G. J. Lockbaum

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G. J. Lockbaum — researcher profile on SciRah

h-index: 15
Works: 64
Citations: 609

Most-cited papers

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
Ala M. Shaqra, Sarah N. Zvornicanin, Q. Huang, G. J. Lockbaum +9 more
2022Nature Communications114 citations Open access
Semantic Scholar
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188
G. J. Lockbaum, A. Reyes, Jeong Min Lee, R. Tilvawala +5 more
2021Viruses102 citations Open access
Semantic Scholar
Drug design strategies to avoid resistance in direct-acting antivirals and beyond
A. N. Matthew, F. Leidner, G. J. Lockbaum, M. Henes +13 more
2021Chemical Reviews69 citations Open access
Semantic Scholar
Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2
S. Mondal, Yong-Zhi Chen, G. J. Lockbaum, Sudeshna Sen +10 more
2022Journal of the American Chemical Society52 citations Open access
Semantic Scholar
Structural Adaptation of Darunavir Analogs Against Primary Mutations in HIV-1 Protease
G. J. Lockbaum, F. Leidner, L. Rusere, M. Henes +7 more
2018ACS Infectious Diseases34 citations Open access
Semantic Scholar
pM to μM - Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance
M. Henes, G. J. Lockbaum, K. Kosovrasti, F. Leidner +9 more
2019ACS Chemical Biology32 citations Open access
Semantic Scholar
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode
G. J. Lockbaum, M. Henes, Jeong Min Lee, J. Timm +4 more
2021Biochemistry28 citations Open access
Semantic Scholar
HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2′ Ligands to Optimize Hydrogen Bonding in the Substrate Envelope
L. Rusere, G. J. Lockbaum, Sook-Kyung Lee, M. Henes +7 more
2019Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Inhibiting HTLV-1 Protease: A Viable Antiviral Target
G. J. Lockbaum, M. Henes, Nathaniel Talledge, L. Rusere +7 more
2021ACS Chemical Biology24 citations Open access
Semantic Scholar
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors
A. N. Matthew, J. Zephyr, Desaboini Nageswara Rao, M. Henes +8 more
2020mBio19 citations Open access
Semantic Scholar
Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants.
L. Rusere, A. N. Matthew, G. J. Lockbaum, M. Jahangir +6 more
2018ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Molecular determinants of epistasis in HIV-1 protease: Elucidating the interdependence of L89V and L90M mutations in resistance
M. Henes, K. Kosovrasti, G. J. Lockbaum, F. Leidner +6 more
2019Biochemistry17 citations Open access
Semantic Scholar
Picomolar to Micromolar: Elucidating the Role of Distal Mutations in HIV ‑ 1 Protease in Conferring Drug Resistance
M. Henes, G. J. Lockbaum, K. Kosovrasti, F. Leidner +10 more
201917 citations Open access
Semantic Scholar
Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses
W. Harshbarger, D. Deming, G. J. Lockbaum, N. Attatippaholkun +8 more
2021Nature Communications16 citations Open access
Semantic Scholar
Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance
E. Spielvogel, Sook-Kyung Lee, Shuntai Zhou, G. J. Lockbaum +8 more
2019bioRxiv16 citations Open access
Semantic Scholar
HIV-1 Protease Inhibitors with a P1 Phosphonate Modification Maintain Potency against Drug-Resistant Variants by Increased Interactions with Flap Residues
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +8 more
2023European journal of medicinal chemistry13 citations Open access
Semantic Scholar
Structural Analysis of Potent Hybrid HIV-1 Protease Inhibitors Containing Bis-Tetrahydrofuran in a Pseudo-Symmetric Dipeptide Isostere
L. Rusere, G. J. Lockbaum, M. Henes, Sook-Kyung Lee +8 more
2020Journal of Medicinal Chemistry6 citations Open access
Semantic Scholar
Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2′ ligands with potent activity against drug-resistant variants
Jagroop Kaur, E. Spielvogel, Desaboini Nageswara Rao, L. Rusere +7 more
2025European journal of medicinal chemistry2 citations Open access
Semantic Scholar
Selection of HIV-1 for Resistance to Fourth Generation Protease Inhibitors Reveals Two 1 Independent Pathways to High-Level Resistance 2 3
E. Spielvogel, Sook-kyung Lee, Shun-Tai Zhou, G. J. Lockbaum +9 more
20192 citations
Semantic Scholar
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures.
G. J. Lockbaum, F. Leidner, W. Royer, Nese Kurt Yilmaz +1 more
2020Acta Crystallographica Section D: Structural Biology1 citations Open access
Semantic Scholar
pM to μM-Elucidating the Role of Distal Mutations in HIV-1 Protease in Conferring Drug Resistance
M. Henes, G. J. Lockbaum, K. Kosovrasti, F. Leidner +11 more
20201 citations
Semantic Scholar
Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
G. J. Lockbaum, F. Leidner, L. Rusere, M. Henes +7 more
2019ACS Infectious Diseases1 citations Open access
Semantic Scholar
SARS-CoV-2 Main Protease (Mpro) in Complex with Rupintrivir (P21212)
G. J. Lockbaum, M. Henes, J. M. Lee, J. Timm +4 more
20210 citations
Semantic Scholar
WT HTLV-1 Protease in Complex with UMass6 (UM6)
G. J. Lockbaum, M. Henes, K. Kosovrasti, E. Nalivaika +3 more
20210 citations
Semantic Scholar
SARS-CoV-2 Main Protease (Mpro) in Complex with ML188
G. J. Lockbaum, J. M. Lee, A. Reyes, E. Nalivaika +4 more
20210 citations
Semantic Scholar
EV68 3C protease (3Cpro) in Complex with Rupintrivir
G. J. Lockbaum, M. Henes, J. M. Lee, J. Timm +4 more
20210 citations
Semantic Scholar
WT HTLV-1 Protease in Complex with Phosphonated UMass6 (PU6)
G. J. Lockbaum, M. Henes, K. Kosovrasti, E. Nalivaika +3 more
20210 citations
Semantic Scholar
WT HTLV-1 Protease in Complex with Darunavir (DRV)
G. J. Lockbaum, M. Henes, K. Kosovrasti, E. Nalivaika +3 more
20210 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR3-43
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with Lopinavir
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
Molecular Mechanisms of Resistance and Structure-Based Drug Design in Homodimeric Viral Proteases
G. J. Lockbaum
20200 citations
Semantic Scholar
Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H3 Hemagglutinin
W. Harshbarger, G. J. Lockbaum, D. Deming, N. Attatippaholkun +2 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR4-41
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-43
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-32
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-41
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-42
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR3-95
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR3-28
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-35
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR3-29
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-44
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR3-97
G. J. Lockbaum, L. Rusere, M. Henes, K. Kosovrasti +7 more
20200 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in complex with darunavir
G. J. Lockbaum, M. Henes, K. Kosovrasti, F. Leidner +5 more
20190 citations
Semantic Scholar
Crystal structure of HIV-1 Protease NL4-3 L89V Mutant in complex with darunavir
M. Henes, K. Kosovrasti, G. J. Lockbaum, F. Leidner +6 more
20190 citations
Semantic Scholar
HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, V82F, I84V Mutant in complex with darunavir
G. J. Lockbaum, M. Henes, K. Kosovrasti, F. Leidner +5 more
20190 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-19
G. J. Lockbaum, L. Rusere, S. K. Lee, M. Henes +7 more
20190 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR-82
G. J. Lockbaum, L. Rusere, S. K. Lee, M. Henes +7 more
20190 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-18
G. J. Lockbaum, L. Rusere, S. K. Lee, M. Henes +7 more
20190 citations
Semantic Scholar
HIV-1 Protease NL4-3 WT in Complex with LR2-20
G. J. Lockbaum, L. Rusere, S. K. Lee, M. Henes +7 more
20190 citations
Semantic Scholar

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