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A. Marrazzo · SciRah

Researcher profile · Semantic Scholar

A. Marrazzo

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A. Marrazzo — researcher profile on SciRah

h-index: 32
Works: 165
Citations: 2,876

Most-cited papers

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.
G. Floresta, V. Pistarà, E. Amata, Maria Dichiara +3 more
2017European journal of medicinal chemistry98 citations Open access
Semantic Scholar
Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents.
Maria Dichiara, O. Prezzavento, A. Marrazzo, V. Pittalà +3 more
2017European journal of medicinal chemistry76 citations
Semantic Scholar
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries.
E. Amata, V. Pittalà, A. Marrazzo, C. Parenti +4 more
2017Clinical science73 citations Open access
Semantic Scholar
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective
A. N. Fallica, V. Pittalà, M. Modica, L. Salerno +4 more
2021Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines.
L. Salerno, V. Pittalà, G. Romeo, M. Modica +7 more
2015European journal of medicinal chemistry56 citations Open access
Semantic Scholar
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.
Sebastiano Intagliata, L. Salerno, Valeria Ciaffaglione, C. Leonardi +6 more
2019European journal of medicinal chemistry53 citations Open access
Semantic Scholar
Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.
V. Pittalà, L. Vanella, L. Salerno, G. Romeo +3 more
2017Current Medicinal Chemistry53 citations
Semantic Scholar
Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation
K. Greish, L. Salerno, Reem Al Zahrani, E. Amata +9 more
2018Molecules47 citations Open access
Semantic Scholar
Development of a Sigma‐2 Receptor affinity filter through a Monte Carlo based QSAR analysis
A. Rescifina, G. Floresta, A. Marrazzo, C. Parenti +4 more
2017European Journal of Pharmaceutical Sciences47 citations
Semantic Scholar
Potholing of the hydrophobic heme oxygenase-1 western region for the search of potent and selective imidazole-based inhibitors.
L. Salerno, E. Amata, G. Romeo, A. Marrazzo +6 more
2018European journal of medicinal chemistry46 citations Open access
Semantic Scholar
(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects.
O. Prezzavento, Emanuela Arena, C. Sánchez-Fernández, R. Turnaturi +6 more
2017European journal of medicinal chemistry43 citations Open access
Semantic Scholar
Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands.
G. Floresta, A. Rescifina, A. Marrazzo, Maria Dichiara +4 more
2017European journal of medicinal chemistry41 citations
Semantic Scholar
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines.
V. Sorrenti, V. Pittalà, G. Romeo, E. Amata +12 more
2018European journal of medicinal chemistry40 citations Open access
Semantic Scholar
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.
P. Sozio, J. Fiorito, V. di Giacomo, A. Di Stefano +8 more
2015European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties
K. Szczepańska, Sabina Podlewska, Maria Dichiara, Davide Gentile +15 more
2021ACS Chemical Neuroscience37 citations Open access
Semantic Scholar
Tuning Properties for Blood-Brain Barrier (BBB) Permeation: A Statistics-Based Analysis.
Maria Dichiara, B. Amata, R. Turnaturi, A. Marrazzo +1 more
2019ACS Chemical Neuroscience37 citations
Semantic Scholar
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.
M. Olivieri, E. Amata, S. Vinciguerra, J. Fiorito +10 more
2016Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors
E. Amata, A. Marrazzo, Maria Dichiara, M. Modica +6 more
2017ChemMedChem36 citations
Semantic Scholar
Sigma-2 receptor ligands QSAR model dataset
A. Rescifina, G. Floresta, A. Marrazzo, C. Parenti +4 more
2017Data in Brief34 citations Open access
Semantic Scholar
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors
E. Amata, A. Marrazzo, Maria Dichiara, M. Modica +6 more
2017Data in Brief34 citations Open access
Semantic Scholar
Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D‐QSAR Coupled to Scaffold‐Hopping Analysis
G. Floresta, E. Amata, Maria Dichiara, A. Marrazzo +5 more
2018ChemMedChem32 citations
Semantic Scholar
A Structure- and Ligand-Based Virtual Screening of a Database of “Small” Marine Natural Products for the Identification of “Blue” Sigma-2 Receptor Ligands
G. Floresta, E. Amata, Carla Barbaraci, Davide Gentile +3 more
2018Marine Drugs31 citations Open access
Semantic Scholar
Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products
G. Floresta, E. Amata, Davide Gentile, G. Romeo +4 more
2019Marine Drugs30 citations Open access
Semantic Scholar
S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands
Giovanni Nastasi, Carla Miceli, V. Pittalà, M. Modica +5 more
2017Journal of Cheminformatics30 citations Open access
Semantic Scholar
Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases
Maria Dichiara, A. Marrazzo, O. Prezzavento, S. Collina +2 more
2017ChemMedChem30 citations Open access
Semantic Scholar
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain
C. Parenti, A. Marrazzo, G. Aricò, G. Cantarella +4 more
2014Inflammation28 citations
Semantic Scholar
Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?
Emanuela Arena, Maria Dichiara, G. Floresta, C. Parenti +4 more
2018Future Medicinal Chemistry27 citations
Semantic Scholar
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents
A. N. Fallica, Carla Barbaraci, E. Amata, L. Pasquinucci +12 more
2021Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review.
R. Turnaturi, A. Marrazzo, C. Parenti, L. Pasquinucci
2018European journal of medicinal chemistry24 citations Open access
Semantic Scholar
In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal melanoma.
C. Cimino, Elena H. Sánchez López, A. Bonaccorso, Lorena Bonilla +8 more
2024International journal of pharmaceutics23 citations Open access
Semantic Scholar
New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells
Valeria Ciaffaglione, Sebastiano Intagliata, V. Pittalà, A. Marrazzo +7 more
2020International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Sigma-1 and Sigma-2 receptor ligands induce apoptosis and autophagy but have opposite effect on cell proliferation in uveal melanoma
L. Longhitano, C. C. Castracani, D. Tibullo, R. Avola +10 more
2017OncoTarget23 citations Open access
Semantic Scholar
Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain
K. Szczepańska, T. Karcz, Maria Dichiara, S. Mogilski +21 more
2023Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.
Maria Dichiara, Antonia Artacho-Cordón, R. Turnaturi, Miriam Santos-Caballero +8 more
2022European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands.
G. Romeo, O. Prezzavento, Sebastiano Intagliata, V. Pittalà +9 more
2019European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain
N. Vicario, S. Denaro, R. Turnaturi, L. Longhitano +10 more
2022International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes
Barbara Schininà, A. Martorana, N. Colabufo, M. Contino +10 more
201520 citations
Semantic Scholar
Nanoencapsulation strategies for the delivery of novel bifunctional antioxidant/σ1 selective ligands.
C. Carbone, Emanuela Arena, V. Pepe, O. Prezzavento +5 more
2017Colloids and Surfaces B: Biointerfaces19 citations
Semantic Scholar
Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5ʹ‐monophosphate glycosidase
G. Floresta, V. Pistarà, E. Amata, Maria Dichiara +5 more
2018Chemical Biology and Drug Design18 citations
Semantic Scholar
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.
E. Amata, A. Rescifina, O. Prezzavento, Emanuela Arena +7 more
2018Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Mechanisms of the Antineoplastic Effects of New Fluoroquinolones in 2D and 3D Human Breast and Bladder Cancer Cell Lines
Nicole Ferrario, Emanuela Marras, Veronica Vivona, Federica Randisi +4 more
2024Cancers16 citations Open access
Semantic Scholar
Novel Sigma Receptor Ligand-Nitric Oxide Photodonors: Molecular Hybrids for Double-Targeted Antiproliferative Effect.
E. Amata, Maria Dichiara, Emanuela Arena, V. Pittalà +7 more
2017Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
(+)-Pentazocine reduces oxidative stress and apoptosis in microglia following hypoxia/reoxygenation injury.
Kathrin Heiss, L. Vanella, P. Murabito, O. Prezzavento +8 more
2016Neuroscience Letters16 citations
Semantic Scholar
Sigma-1 receptor targeting inhibits connexin 43 based intercellular communication in chronic neuropathic pain
S. Denaro, S. D'Aprile, F. Torrisi, A. Zappalà +6 more
2024Inflammation Research15 citations Open access
Semantic Scholar
Designing drugs optimized for both blood–brain barrier permeation and intra-cerebral partition
Maria Dichiara, Giuseppe Cosentino, G. Giordano, L. Pasquinucci +3 more
2023Expert Opinion on Drug Discovery15 citations
Semantic Scholar
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling
A. Fidilio, M. Grasso, R. Turnaturi, Giuseppe Caruso +10 more
2021Frontiers in Pharmacology15 citations Open access
Semantic Scholar
Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents.
V. Pittalà, L. Vanella, Chiara Bianca Maria Platania, L. Salerno +9 more
2019Future Medicinal Chemistry15 citations
Semantic Scholar
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review.
R. Turnaturi, L. Montenegro, A. Marrazzo, R. Parenti +2 more
2018European journal of medicinal chemistry15 citations Open access
Semantic Scholar
Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation.
E. Amata, Maria Dichiara, Davide Gentile, A. Marrazzo +8 more
2020ACS Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders.
Giuliana Costanzo, Rocco Buccheri, Giuseppe Cosentino, Carlo Reale +5 more
2025European journal of medicinal chemistry13 citations Open access
Semantic Scholar

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E. Amata×34
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E. Amata — researcher profile on SciRah
O. Prezzavento×27
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O. Prezzavento — researcher profile on SciRah
A. Rescifina×25
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A. Rescifina — researcher profile on SciRah
Maria Dichiara×21
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Maria Dichiara — researcher profile on SciRah

×21

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V. Pittalà — researcher profile on SciRah

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L. Salerno — researcher profile on SciRah

G. Floresta×14

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G. Floresta — researcher profile on SciRah

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G. Romeo — researcher profile on SciRah

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C. Parenti — researcher profile on SciRah

R. Turnaturi×12

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R. Turnaturi — researcher profile on SciRah

Emanuela Arena×10

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Emanuela Arena — researcher profile on SciRah

L. Pasquinucci×10

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L. Pasquinucci — researcher profile on SciRah