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Sebastiano Intagliata · SciRah

Researcher profile · Semantic Scholar

Sebastiano Intagliata

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Sebastiano Intagliata — researcher profile on SciRah

h-index: 21
Works: 60
Citations: 1,177

Most-cited papers

Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update
Sebastiano Intagliata, M. Modica, L. M. Santagati, L. Montenegro
2019Antioxidants121 citations Open access
Semantic Scholar
Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective
A. N. Fallica, V. Pittalà, M. Modica, L. Salerno +4 more
2021Journal of Medicinal Chemistry56 citations Open access
Semantic Scholar
Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells
Valeria Consoli, V. Sorrenti, V. Pittalà, K. Greish +5 more
2022International Journal of Molecular Sciences55 citations Open access
Semantic Scholar
Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs
Valeria Ciaffaglione, M. Modica, V. Pittalà, G. Romeo +2 more
2021ChemMedChem55 citations Open access
Semantic Scholar
Heme Oxygenase-2 (HO-2) as a therapeutic target: Activators and inhibitors.
Sebastiano Intagliata, L. Salerno, Valeria Ciaffaglione, C. Leonardi +6 more
2019European journal of medicinal chemistry53 citations Open access
Semantic Scholar
The analgesic potential of glycosides derived from medicinal plants
H. Khan, Aini Pervaiz, Sebastiano Intagliata, N. Das +7 more
2020DARU Journal of Pharmaceutical Sciences49 citations Open access
Semantic Scholar
Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation
K. Greish, L. Salerno, Reem Al Zahrani, E. Amata +9 more
2018Molecules47 citations Open access
Semantic Scholar
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update.
M. Modica, E. Lacivita, Sebastiano Intagliata, L. Salerno +3 more
2018Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo
Sebastiano Intagliata, Abhisheak Sharma, Tamara I. King, C. Mesangeau +7 more
2020AAPS Journal46 citations
Semantic Scholar
Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats
V. Sorrenti, Marco Raffaele, L. Vanella, R. Acquaviva +4 more
2019International Journal of Molecular Sciences46 citations Open access
Semantic Scholar
Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain
Thomas J. Cirino, S. Eans, Jessica M. Medina, L. Wilson +4 more
2019Frontiers in Pharmacology42 citations Open access
Semantic Scholar
Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines.
V. Sorrenti, V. Pittalà, G. Romeo, E. Amata +12 more
2018European journal of medicinal chemistry40 citations Open access
Semantic Scholar
Lipid Nanoparticles Traverse Non-Corneal Path to Reach the Posterior Eye Segment: In Vivo Evidence
C. Puglia, Debora Santonocito, G. Romeo, Sebastiano Intagliata +8 more
2021Molecules37 citations Open access
Semantic Scholar
Solid Lipid Nanoparticles Loading Idebenone Ester with Pyroglutamic Acid: In Vitro Antioxidant Activity and In Vivo Topical Efficacy
L. Montenegro, A. Panico, L. M. Santagati, E. A. Siciliano +2 more
2018Nanomaterials33 citations Open access
Semantic Scholar
Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands.
L. Salerno, V. Pittalà, M. Modica, M. Siracusa +6 more
2014European journal of medicinal chemistry33 citations Open access
Semantic Scholar
Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents
A. N. Fallica, Carla Barbaraci, E. Amata, L. Pasquinucci +12 more
2021Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain
L. Wilson, Amy R. Alleyne, S. Eans, Thomas J. Cirino +5 more
2022Molecules23 citations Open access
Semantic Scholar
New Arylethanolimidazole Derivatives as HO-1 Inhibitors with Cytotoxicity against MCF-7 Breast Cancer Cells
Valeria Ciaffaglione, Sebastiano Intagliata, V. Pittalà, A. Marrazzo +7 more
2020International Journal of Molecular Sciences23 citations Open access
Semantic Scholar
Benzimidazolone-based selective σ2 receptor ligands: synthesis and pharmacological evaluation
Sebastiano Intagliata, Walid Alsharif, C. Mesangeau, N. Fazio +4 more
2019European journal of medicinal chemistry23 citations Open access
Semantic Scholar
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands.
G. Romeo, O. Prezzavento, Sebastiano Intagliata, V. Pittalà +9 more
2019European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives
H. E. Nicholson, Walid Alsharif, Anthony B. Comeau, C. Mesangeau +4 more
2018Journal of Pharmacology and Experimental Therapeutics21 citations Open access
Semantic Scholar
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.
M. Modica, Sebastiano Intagliata, V. Pittalà, L. Salerno +4 more
2015Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox
Sebastiano Intagliata, A. Spadaro, M. Lorenti, A. Panico +6 more
2020Antioxidants20 citations Open access
Semantic Scholar
New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HT7 and 5-HT1A receptor ligands: Synthesis, structure-activity relationships, and molecular modeling studies.
Sebastiano Intagliata, M. Modica, V. Pittalà, L. Salerno +5 more
2017Bioorganic & Medicinal Chemistry20 citations Open access
Semantic Scholar
Ginseng and heme oxygenase-1: The link between an old herb and a new protective system.
G. Carota, Marco Raffaele, V. Sorrenti, L. Salerno +2 more
2019Fitoterapia19 citations
Semantic Scholar
Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.
Sebastiano Intagliata, M. Modica, V. Pittalà, L. Salerno +4 more
2016Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents.
V. Pittalà, L. Vanella, Chiara Bianca Maria Platania, L. Salerno +9 more
2019Future Medicinal Chemistry15 citations
Semantic Scholar
Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation
L. Salerno, L. Vanella, V. Sorrenti, Valeria Consoli +6 more
2021Journal of Enzyme Inhibition and Medicinal Chemistry14 citations Open access
Semantic Scholar
Glucose-Impaired Corneal Re-Epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate
Giovanni Giurdanella, A. Longo, L. Salerno, G. Romeo +8 more
2021Antioxidants13 citations Open access
Semantic Scholar
The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers: Mechanisms Implicated
Irene Suárez-Rojas, Montse Pérez-Fernández, X. Bai, Ignacio Martínez-Martel +4 more
2023Antioxidants12 citations Open access
Semantic Scholar
Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity
G. Romeo, Valeria Ciaffaglione, E. Amata, Maria Dichiara +8 more
2021Molecules12 citations Open access
Semantic Scholar
Novel Tyrosine Kinase Inhibitors to Target Chronic Myeloid Leukemia
Valeria Ciaffaglione, Valeria Consoli, Sebastiano Intagliata, A. Marrazzo +8 more
2022Molecules11 citations Open access
Semantic Scholar
Development of New Benzylpiperazine Derivatives as σ1 Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects
G. Romeo, Federica Bonanno, L. Wilson, Emanuela Arena +6 more
2021ACS Chemical Neuroscience11 citations Open access
Semantic Scholar
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells
L. Salerno, V. Sorrenti, V. Pittalà, Valeria Consoli +7 more
2023ChemMedChem10 citations Open access
Semantic Scholar
Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use
L. Wilson, S. Eans, Insitar Ramadan-Siraj, M. Modica +3 more
2022International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Chromatograpic resolution of phenylethanolic-azole racemic compounds highlighted stereoselective inhibition of heme oxygenase-1 by (R)-enantiomers.
G. Floresta, A. Carotti, F. Ianni, V. Sorrenti +6 more
2020Bioorganic chemistry (Print)8 citations
Semantic Scholar
Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand.
Raluca Popa, Shyam H Kamble, Raju S Kanumuri, Tamara I. King +4 more
2020Journal of Pharmaceutical and Biomedical Analysis8 citations Open access
Semantic Scholar
Evaluation of the anticancer effects exerted by 5-fluorouracil and heme oxygenase-1 inhibitor hybrids in HTC116 colorectal cancer cells
L. Salerno, A. Notaro, Valeria Consoli, Federica Affranchi +5 more
2024Journal of Enzyme Inhibition and Medicinal Chemistry7 citations Open access
Semantic Scholar
Discovery of 3‐(2‐aminoethyl)‐thiazolidine‐2,4‐diones as a novel chemotype of sigma‐1 receptor ligands
Nada Elkholy, Ahmad Abdelwaly, K. Mohamed, E. Amata +4 more
2022Chemical Biology and Drug Design7 citations
Semantic Scholar
Haloperidol drug repurposing unveils ferroptosis involvement in breast cancer cells
Valeria Consoli, V. Sorrenti, Salvatore Saccone, Concetta Federico +5 more
2025Scientific Reports6 citations Open access
Semantic Scholar
Structure-activity relationships of mixed σ1R/σ2R ligands with antiproliferative and anticancer effects.
A. N. Fallica, Valeria Ciaffaglione, M. Modica, V. Pittalà +5 more
2022Bioorganic & Medicinal Chemistry6 citations Open access
Semantic Scholar
Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands
Sebastiano Intagliata, Hebaalla Agha, T. Kopajtic, J. Katz +4 more
2020Medicinal Chemistry Research6 citations Open access
Semantic Scholar
Synthesis and in Vitro Evaluation of CAPE Derivatives as Ferroptosis Inducers in Triple Negative Breast Cancer.
Valeria Consoli, A. N. Fallica, N. Virzì, L. Salerno +6 more
2024ACS Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
In vitro and in silico analysis of imatinib analogues as anti-Trypanosoma cruzi drug candidates
Luca S. F. Nesic de Freitas, C. F. da Silva, Sebastiano Intagliata, E. Amata +2 more
2023Parasitology5 citations Open access
Semantic Scholar
A computer-aided approach to identify novel Leishmania major protein disulfide isomerase inhibitors for treatment of leishmaniasis
Noureddine Ben Khalaf, Susie Pham, G. Romeo, S. Abdelghany +8 more
2021Journal of Computer-Aided Molecular Design4 citations
Semantic Scholar
Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma
Maha AliAlghamdi, Mohamed Haider, Sebastiano Intagliata, V. Pittalà +4 more
2024Journal of drug targeting (Print)3 citations Open access
Semantic Scholar
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity
A. N. Fallica, V. Sorrenti, A. G. D'Amico, L. Salerno +8 more
2021Journal of Medicinal Chemistry3 citations Open access
Semantic Scholar
Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands
Sebastiano Intagliata, Mohamed A. Helal, L. Materia, V. Pittalà +6 more
2020Molecules3 citations Open access
Semantic Scholar
UPLC-MS/MS method for the quantification of MCI-77, a novel sigma-1 receptor ligand, and its application to pharmacokinetic studies
Raluca Popa, Shyam H Kamble, Raju S Kanumuri, Tamara I. King +4 more
2022Journal of chromatography. B, Analytical technologies in the biomedical and life sciences2 citations Open access
Semantic Scholar
The Sigma1 Receptor Antagonist CM304 Potentiates the Antinociceptive but not the Discriminative Stimulus Effects of the Cannabinoid Receptor Agonist THC in Rats
Samuel Obeng, Avi Patel, Mallory Burns, Sebastiano Intagliata +10 more
2020The FASEB Journal2 citations
Semantic Scholar

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L. Salerno×31
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L. Salerno — researcher profile on SciRah
V. Pittalà×30
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V. Pittalà — researcher profile on SciRah
G. Romeo×24
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G. Romeo — researcher profile on SciRah
M. Modica×17
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M. Modica — researcher profile on SciRah

×16

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V. Sorrenti — researcher profile on SciRah

A. Marrazzo×12

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A. Marrazzo — researcher profile on SciRah

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L. Vanella — researcher profile on SciRah

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E. Amata — researcher profile on SciRah

Valeria Consoli×8

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Valeria Consoli — researcher profile on SciRah

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C. McCurdy — researcher profile on SciRah

A. N. Fallica×7

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A. N. Fallica — researcher profile on SciRah

Valeria Ciaffaglione×7

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Valeria Ciaffaglione — researcher profile on SciRah