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J. Fiorito · SciRah

Researcher profile · Semantic Scholar

J. Fiorito

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J. Fiorito — researcher profile on SciRah

h-index: 10
Works: 28
Citations: 644

Most-cited papers

Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach
A. Teich, Russell E Nicholls, D. Puzzo, J. Fiorito +3 more
2015Neurotherapeutics145 citations Open access
Semantic Scholar
Synthesis of Quinoline Derivatives: Discovery of a Potent and Selective Phosphodiesterase 5 Inhibitor for the Treatment of Alzheimer's disease
J. Fiorito, F. Saeed, Hong Zhang, Agnieszka Staniszewski +7 more
2012European journal of medicinal chemistry111 citations Open access
Semantic Scholar
DEVELOPMENT OF NOVEL PHOSPHODIESTERASE 5 INHIBITORS FOR THE THERAPY OF ALZHEIMER’S DISEASE.
Elisa Zuccarello, Erica Acquarone, Elisa Calcagno, Elentina K. Argyrousi +4 more
2020Biochemical Pharmacology70 citations Open access
Semantic Scholar
Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
Erica Acquarone, Elentina K. Argyrousi, M. V. D. van den Berg, Walter Gulisano +9 more
2019Molecular Neurodegeneration58 citations Open access
Semantic Scholar
PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease
A. Teich, Mikako Sakurai, Mitesh Patel, C. M. Holman +3 more
2016Journal of Alzheimer's Disease51 citations Open access
Semantic Scholar
Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer’s Disease
J. Fiorito, Jeremie Vendome, F. Saeed, Agnieszka Staniszewski +5 more
2017Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells.
P. Sozio, J. Fiorito, V. di Giacomo, A. Di Stefano +8 more
2015European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells.
M. Olivieri, E. Amata, S. Vinciguerra, J. Fiorito +10 more
2016Journal of Medicinal Chemistry37 citations Open access
Semantic Scholar
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.
A. Marrazzo, J. Fiorito, Laura Zappalà, O. Prezzavento +5 more
2011European journal of medicinal chemistry34 citations Open access
Semantic Scholar
MRJF4, a novel histone deacetylase inhibitor, induces p21 mediated autophagy in PC3 prostate cancer cells.
V. di Giacomo, V. Di Valerio, M. Rapino, Domenico Bosco +6 more
2015Cellular and Molecular Biology13 citations
Semantic Scholar
Optimizing metabolic stability of phosphodiesterase 5 inhibitors: discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity
Elisa Zuccarello, Hong Zhang, Erica Acquarone, D. Pham +5 more
2023Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
Targeting the NO/cGMP/CREB Phosphorylation Signaling Pathway in Alzheimer’s Disease
J. Fiorito, Shi-Xian Deng, D. Landry, O. Arancio
2018Neurochemical Basis of Brain Function and Dysfunction6 citations Open access
Semantic Scholar
Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration.
S. Pacella, J. Fiorito, I. Cacciatore, V. di Giacomo +8 more
2017Central Nervous System Agents in Medicinal Chemistry6 citations
Semantic Scholar
Molecular Mechanisms of Learning and Memory
D. Puzzo, J. Fiorito, Rosa Purgatorio, Walter Gulisano +3 more
20164 citations
Semantic Scholar
HDAC/σ1R Dual-Ligand as a Targeted Melanoma Therapeutic
C. Leotta, Carla Barbaraci, J. Fiorito, Alessandro Coco +4 more
2025Pharmaceuticals3 citations Open access
Semantic Scholar
Discovery of Indole-Based PDE5 Inhibitors: Synthesis and Pharmacological Evaluation
S. Park, D. Pham, Param Shukla, J. Edward +7 more
2025ACS Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators
Yuxuan Liu, J. Fiorito, Yulissa Gonzalez, B. Estrella +9 more
2019Blood2 citations Open access
Semantic Scholar
FOCUS ON ... SESSION : NON-CLINICAL NEW DRUGS 079 FIRST-IN-CLASS HAT ACTIVATOR HIGHLY SYNERGISTIC WITH PAN-HDAC INHIBITOR ROMIDEPSIN LEADING TO PROFOUND HISTONE ACETYLATION CYTOTOXICITY
Y. Liu, J. Fiorito, Y. Gonzale, E. Calcagno +8 more
20192 citations
Semantic Scholar
Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma
Yuxuan Liu, J. Fiorito, Yulissa Gonzalez, Elisa Zuccarello +13 more
2018Blood2 citations Open access
Semantic Scholar
Design and Synthesis of Potent First-in-Class Histones Acetyltransferase Modulators
Elisa Zuccarello, Mattia Mori, Elisa Calcagno, Rosa Purgatorio +12 more
2025bioRxiv1 citations
Semantic Scholar
Unlocking the synergistic potential of HAT activation and HDAC inhibition for rescuing memory deficits in Alzheimer’s Disease
Elisa Calcagno, Elisa Zuccarello, Anna Staniszewski, Jonhatan van de Loo +8 more
2024Alzheimer's & Dementia1 citations Open access
Semantic Scholar
Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
Erica Acquarone, Elentina K. Argyrousi, M. V. D. van den Berg, Walter Gulisano +9 more
2024Molecular Neurodegeneration1 citations Open access
Semantic Scholar
PDE5 inhibitors against synaptic and cognitive impairment in Alzheimer’s disease and related dementia
O. Arancio, Elisa Zuccarello, J. Fiorito, Erica Acquarone +6 more
2022Alzheimer's & Dementia1 citations
Semantic Scholar
Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N‐(pyridin‐3‐ylmethyl)quinoline derivative targeting synaptic plasticity
Elisa Zuccarello, Hong Zhang, Erica Acquarone, Shi-Xian Deng +3 more
2024Alzheimer's & Dementia0 citations Open access
Semantic Scholar
Structure-Metabolic Stability Relationship of Quinoline-Based Phosphodiesterase 5 Inhibitors
Elisa Zuccarello, Erica Acquarone, D. Pham, Shi-Xiang Deng +3 more
2022Social Science Research Network0 citations Open access
Semantic Scholar
Histone Acetyltransferase (HAT) Activator, YF2, Modulates the p53:BCL6 Axis and Antigen Presentation in Diffuse Large B-Cell Lymphomas
B. Estrella, Yuxuan Liu, Edd Ricker, Manuel A. Pazos +6 more
2021Blood0 citations Open access
Semantic Scholar
Antiproliferative Activity of Phenylbutyrate Ester of Haloperidol Metabolite II [(.+‐.)‐MRJF4] in Prostate Cancer Cells.
A. Marrazzo, J. Fiorito, Laura Zappalà, O. Prezzavento +5 more
20110 citations
Semantic Scholar
Modulateurs de l'histone acétyltransférase et leurs utilisations
Yitshak Francis, Mauro Fa, Ottavio Arancio, J. Fiorito +4 more
20110 citations
Semantic Scholar

Frequent co-authors

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O. Arancio×20
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O. Arancio — researcher profile on SciRah
Elisa Zuccarello×13
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Elisa Zuccarello — researcher profile on SciRah
Erica Acquarone×9
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Erica Acquarone — researcher profile on SciRah
Elisa Calcagno×9
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Elisa Calcagno — researcher profile on SciRah

×8

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Shi-Xian Deng — researcher profile on SciRah

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A. Marrazzo — researcher profile on SciRah

Agnieszka Staniszewski×6

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Agnieszka Staniszewski — researcher profile on SciRah

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D. Landry — researcher profile on SciRah

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D. Puzzo — researcher profile on SciRah

Elentina K. Argyrousi×5

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Elentina K. Argyrousi — researcher profile on SciRah

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M. Fa' — researcher profile on SciRah

V. di Giacomo×4

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V. di Giacomo — researcher profile on SciRah