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Federico Falchi · SciRah

Researcher profile · Semantic Scholar

Federico Falchi

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Federico Falchi — researcher profile on SciRah

h-index: 22
Works: 51
Citations: 1,377

Most-cited papers

Toward the Discovery of Novel Anti‐HIV Drugs. Second‐Generation Inhibitors of the Cellular ATPase DDX3 with Improved Anti‐HIV Activity: Synthesis, Structure–Activity Relationship Analysis, Cytotoxicity Studies, and Target Validation
G. Maga, Federico Falchi, M. Radi, L. Botta +15 more
2011ChemMedChem102 citations
Semantic Scholar
Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.
M. Radi, Federico Falchi, A. Garbelli, A. Samuele +7 more
2012Bioorganic & Medicinal Chemistry Letters86 citations Open access
Semantic Scholar
Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.
G. Maga, Federico Falchi, A. Garbelli, Amalia Belfiore +3 more
2008Journal of Medicinal Chemistry85 citations Open access
Semantic Scholar
Fyn kinase in brain diseases and cancer: the search for inhibitors.
S. Schenone, C. Brullo, Francesca Musumeci, M. Biava +2 more
2011Current Medicinal Chemistry75 citations
Semantic Scholar
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia.
E. Sondo, Federico Falchi, E. Caci, L. Ferrera +9 more
2018Cell Chemical Biology63 citations Open access
Semantic Scholar
Targeting the human DEAD-box polypeptide 3 (DDX3) RNA helicase as a novel strategy to inhibit viral replication.
Anna Garbelli, M. Radi, Federico Falchi, S. Beermann +5 more
2011Current Medicinal Chemistry62 citations
Semantic Scholar
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents.
M. Radi, Emmanuele Crespan, G. Botta, Federico Falchi +7 more
2008Bioorganic & Medicinal Chemistry Letters52 citations Open access
Semantic Scholar
Structure-based design of small-molecule protein-protein interaction modulators: the story so far.
Federico Falchi, F. Caporuscio, M. Recanatini
2014Future Medicinal Chemistry51 citations
Semantic Scholar
2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile.
Federica Prati, C. Bergamini, M. Molina, Federico Falchi +5 more
2015Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
Greta Bagnolini, D. Milano, Marcella Manerba, F. Schipani +15 more
2020Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Kernel-Based, Partial Least Squares Quantitative Structure-Retention Relationship Model for UPLC Retention Time Prediction: A Useful Tool for Metabolite Identification.
Federico Falchi, S. M. Bertozzi, G. Ottonello, G. F. Ruda +8 more
2016Analytical Chemistry45 citations Open access
Semantic Scholar
Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.
M. Roberti, F. Schipani, Greta Bagnolini, D. Milano +13 more
2019European journal of medicinal chemistry44 citations Open access
Semantic Scholar
Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case.
V. Corradi, M. Mancini, M. Santucci, T. Carlomagno +7 more
2011Bioorganic & Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
N‐[2‐Methyl‐5‐(triazol‐1‐yl)phenyl]pyrimidin‐2‐amine as a Scaffold for the Synthesis of Inhibitors of Bcr‐Abl
Federica Arioli, Stella Borrelli, F. Colombo, Federico Falchi +9 more
2011ChemMedChem41 citations
Semantic Scholar
From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.
A. Rampa, F. Mancini, A. De Simone, Federico Falchi +8 more
2015Bioorganic & Medicinal Chemistry Letters34 citations Open access
Semantic Scholar
Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.
Federico Falchi, E. Giacomini, T. Masini, N. Boutard +11 more
2017ACS Chemical Biology33 citations Open access
Semantic Scholar
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.
C. Tintori, Giuseppina La Sala, G. Vignaroli, L. Botta +21 more
2015Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin‐Based Derivatives
S. Montanari, M. Bartolini, P. Neviani, Federica Belluti +10 more
2016ChemMedChem30 citations Open access
Semantic Scholar
Chalcone-based carbamates for Alzheimer's disease treatment.
A. Rampa, S. Montanari, L. Pruccoli, M. Bartolini +7 more
2017Future Medicinal Chemistry28 citations
Semantic Scholar
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.
Elisa Uliassi, G. Fiorani, R. Krauth-Siegel, C. Bergamini +16 more
2017European journal of medicinal chemistry28 citations Open access
Semantic Scholar
Protein Tunnels: The Case of Urease Accessory Proteins.
F. Musiani, D. Gioia, Matteo Masetti, Federico Falchi +3 more
2017Journal of Chemical Theory and Computation26 citations Open access
Semantic Scholar
Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.
Sebastiano Rupiani, R. Buonfiglio, Marcella Manerba, Lorenza Di Ianni +7 more
2015European journal of medicinal chemistry26 citations Open access
Semantic Scholar
Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti‐HIV Agents
C. Tintori, I. Laurenzana, F. La Rocca, Federico Falchi +10 more
2013ChemMedChem22 citations
Semantic Scholar
Structure-Based Virtual Screening Allows the Identification of Efficient Modulators of E-Cadherin-Mediated Cell–Cell Adhesion
Andrea Dalle Vedove, Federico Falchi, S. Donini, Aurélie Dobric +9 more
2019International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation.
M. Radi, Lasse Evensen, E. Dreassi, Claudio Zamperini +6 more
2012Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr‐Abl T315I Mutant: from Docking False Positives to ATP‐Noncompetitive Inhibitors
M. Radi, Emmanuele Crespan, Federico Falchi, V. Bernardo +5 more
2010ChemMedChem21 citations
Semantic Scholar
Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
Irene Brusa, E. Sondo, Federico Falchi, N. Pedemonte +2 more
2022Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Targeting the Protein Tunnels of the Urease Accessory Complex: A Theoretical Investigation
Matteo Masetti, Federico Falchi, D. Gioia, M. Recanatini +2 more
2020Molecules20 citations Open access
Semantic Scholar
Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data.
E. Dreassi, A. Zizzari, Federico Falchi, S. Schenone +3 more
2009European journal of medicinal chemistry19 citations Open access
Semantic Scholar
Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases.
S. Tassini, Liang Sun, Kristina Lanko, Emmanuele Crespan +14 more
2017Journal of Medicinal Chemistry18 citations
Semantic Scholar
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds.
F. Manetti, Federico Falchi, Emmanuele Crespan, S. Schenone +2 more
2008Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A.
Sebastiano Rupiani, Laura Guidotti, Marcella Manerba, Lorenza Di Ianni +5 more
2016Organic and biomolecular chemistry15 citations
Semantic Scholar
3D QSAR Models Built on Structure‐Based Alignments of Abl Tyrosine Kinase Inhibitors
Federico Falchi, F. Manetti, F. Carraro, A. Naldini +6 more
2009ChemMedChem15 citations
Semantic Scholar
Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.
E. Giacomini, A. Nebbioso, Alfonso Ciotta, Cristina Ianni +8 more
2014ACS Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Collecting and Assessing Human Lactate Dehydrogenase-A Conformations for Structure-Based Virtual Screening
R. Buonfiglio, Mariarosaria Ferraro, Federico Falchi, A. Cavalli +2 more
2013Journal of Chemical Information and Modeling14 citations
Semantic Scholar
Protein Dynamics of the HIF-2α PAS-B Domain upon Heterodimerization and Ligand Binding
Matteo Masetti, Federico Falchi, M. Recanatini
2014PLoS ONE13 citations Open access
Semantic Scholar
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5
Irene Brusa, E. Sondo, E. Pesce, Valeria Tomati +12 more
2023Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Searching for New Microbiome-Targeted Therapeutics through a Drug Repurposing Approach.
M. Barone, S. Rampelli, E. Biagi, S. M. Bertozzi +6 more
2021Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Radial access for percutaneous coronary procedure: relationship between operator expertise and complications
Simona Susanu, M. Angelillis, C. Giannini, Rossella Binella +7 more
2018Clinical and Experimental Emergency Medicine9 citations Open access
Semantic Scholar
Development of a multisite model for Ni(II) ion in solution from thermodynamic and kinetic data
Matteo Masetti, F. Musiani, M. Bernetti, Federico Falchi +3 more
2017Journal of Computational Chemistry9 citations
Semantic Scholar
Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication
Hanieh Ghassabian, Federico Falchi, Martina Timmoneri, B. Mercorelli +3 more
2020Viruses4 citations Open access
Semantic Scholar
COVID-19 Repurposed Therapeutics Targeting the Viral Protease and Spike-protein:ACE2 Interface using MD-based Pharmacophore and Consensus Virtual Screening
Brady D. Garabato, Federico Falchi, A. Cavalli
20202 citations Open access
Semantic Scholar
Divide et Impera: Identification of Small-Molecule Inhibitors of HCMV Replication Interfering with Dimerization of DNA Polymerase Processivity Factor UL44
Hanieh Ghassabian, Federico Falchi, Veronica Di Antonio, Martina Timmoneri +4 more
2020bioRxiv1 citations Open access
Semantic Scholar
COVID-19 Repurposed Therapeutics Targeting the Viral Protease and Spike-protein:ACE2 Interface using MD-based Pharmacophore and Consensus Virtual Screening
B. Garabato, Federico Falchi, A. Cavalli
20201 citations Open access
Semantic Scholar
Correction to "Novel Antiproliferative Chimeric Compounds with Marked Histone Deacetylase Inhibitory Activity".
E. Giacomini, A. Nebbioso, Alfonso Ciotta, Cristina Ianni +8 more
2024ACS Medicinal Chemistry Letters0 citations Open access
Semantic Scholar
Review Special FocuS: computational chemiStRy
Federico Falchi
20140 citations
Semantic Scholar
Structure-based design of small-molecule protein – protein interaction modulators : the story
Federico Falchi
20140 citations
Semantic Scholar
Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach
G. Maga, A. Garbelli, M. Radi, Federico Falchi +7 more
2012Retrovirology0 citations Open access
Semantic Scholar
Next generation of antiretroviral agents targeting the RNA binding site of the HIV-1 cellular cofactor DDX3: an innovative therapeutic approach
G. Maga, A. Garbelli, M. Radi, Federico Falchi +7 more
2012Retrovirology0 citations Open access
Semantic Scholar
Composés ayant une activité inhibitrice et utilisations de ceux-ci
M. Radi, Maurizio Botta, Federico Falchi, G. Maga +2 more
20100 citations
Semantic Scholar

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G. Maga×15
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M. Botta×15
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M. Radi×12
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