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S. Schenone · SciRah

Researcher profile · Semantic Scholar

S. Schenone

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S. Schenone — researcher profile on SciRah

h-index: 46
Works: 250
Citations: 6,393

Most-cited papers

Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies.
S. Schenone, M. Radi, Francesca Musumeci, C. Brullo +1 more
2014Chemical Reviews123 citations
Semantic Scholar
SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition
C. Talarico, Vincenzo Dattilo, L. D'Antona, Miranda Menniti +6 more
2016Cellular Physiology and Biochemistry78 citations Open access
Semantic Scholar
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
Claudio Battilocchio, Giovanna Poce, S. Alfonso, G. C. Porretta +11 more
2013Bioorganic & Medicinal Chemistry74 citations Open access
Semantic Scholar
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.
C. Tintori, A. L. Fallacara, M. Radi, Claudio Zamperini +13 more
2015Journal of Medicinal Chemistry65 citations Open access
Semantic Scholar
SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells
C. Talarico, Vincenzo Dattilo, L. D'Antona, A. Barone +13 more
2016OncoTarget64 citations Open access
Semantic Scholar
Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses
Valeria Francesconi, E. Cichero, S. Schenone, L. Naesens +1 more
2020Molecules63 citations Open access
Semantic Scholar
Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy
C. Talarico, L. D'Antona, D. Scumaci, A. Barone +16 more
2015OncoTarget61 citations Open access
Semantic Scholar
Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer’s Disease
Marta Campora, Valeria Francesconi, S. Schenone, B. Tasso +1 more
2021Pharmaceuticals59 citations Open access
Semantic Scholar
The SGK1 inhibitor SI113 induces autophagy, apoptosis, and endoplasmic reticulum stress in endometrial cancer cells
D. Conza, P. Mirra, G. Calì, Teresa Tortora +7 more
2017Journal of Cellular Physiology55 citations
Semantic Scholar
SI113, a Specific Inhibitor of the Sgk1 Kinase Activity that Counteracts Cancer Cell Proliferation
L. D'Antona, R. Amato, C. Talarico, F. Ortuso +14 more
2015Cellular Physiology and Biochemistry55 citations Open access
Semantic Scholar
Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy
M. C. Pismataro, Andrea Astolfi, M. L. Barreca, Martina Pacetti +4 more
2023Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia
Francesca Musumeci, C. Greco, G. Grossi, A. Molinari +1 more
2018Cancers41 citations Open access
Semantic Scholar
A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor
A. L. Fallacara, Claudio Zamperini, A. Podolski-Renić, J. Dinić +16 more
2019Cancers39 citations Open access
Semantic Scholar
Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line
F. Cammarata, F. Torrisi, G. Forte, L. Minafra +13 more
2019International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.
M. Radi, C. Tintori, Francesca Musumeci, C. Brullo +12 more
2013Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives
F. Barbieri, A. Bosio, A. Pattarozzi, M. Tonelli +17 more
2022Journal of experimental & clinical cancer research : CR37 citations Open access
Semantic Scholar
SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation
Vincenzo Dattilo, L. D'Antona, C. Talarico, M. Capula +7 more
2017Scientific Reports37 citations Open access
Semantic Scholar
In Silico Identification and Biological Evaluation of Novel Selective Serum/Glucocorticoid-Inducible Kinase 1 Inhibitors Based on the Pyrazolo-Pyrimidine Scaffold
F. Ortuso, R. Amato, A. Artese, L. D'Antona +10 more
2014Journal of Chemical Information and Modeling36 citations
Semantic Scholar
The SGK1 Kinase Inhibitor SI113 Sensitizes Theranostic Effects of the 64CuCl2 in Human Glioblastoma Multiforme Cells
Giada Catalogna, C. Talarico, Vincenzo Dattilo, Vincenzo Gangemi +8 more
2017Cellular Physiology and Biochemistry35 citations Open access
Semantic Scholar
Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.
C. Tintori, Giuseppina La Sala, G. Vignaroli, L. Botta +21 more
2015Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.
G. Vignaroli, G. Iovenitti, Claudio Zamperini, F. Coniglio +15 more
2017Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Probing In Silico the Benzimidazole Privileged Scaffold for the Development of Drug-like Anti-RSV Agents
E. Cichero, Alessio Calautti, Valeria Francesconi, M. Tonelli +2 more
2021Pharmaceuticals29 citations Open access
Semantic Scholar
Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells
Alessia Calgani, G. Vignaroli, Claudio Zamperini, F. Coniglio +8 more
2016Molecular Cancer Therapeutics28 citations
Semantic Scholar
An Update on JAK Inhibitors.
Francesca Musumeci, C. Greco, Ilaria Giacchello, A. L. Fallacara +4 more
2019Current Medicinal Chemistry27 citations
Semantic Scholar
In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity
L. D'Antona, Vincenzo Dattilo, Giada Catalogna, D. Scumaci +11 more
2019Translational Oncology27 citations Open access
Semantic Scholar
SRC Family Kinase Inhibition Through a New Pyrazolo[3,4‐d]Pyrimidine Derivative as a Feasible Approach for Glioblastoma Treatment
Elisa Ceccherini, P. Indovina, Claudio Zamperini, E. Dreassi +9 more
2015Journal of Cellular Biochemistry27 citations
Semantic Scholar
Click chemistry, a potent tool in medicinal sciences.
Francesca Musumeci, S. Schenone, Andrea Desogus, E. Nieddu +2 more
2015Current Medicinal Chemistry27 citations
Semantic Scholar
The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells
S. Matteoni, C. Abbruzzese, P. Matarrese, G. D. De Luca +11 more
2019Journal of experimental & clinical cancer research : CR26 citations Open access
Semantic Scholar
The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme
C. Abbruzzese, Giada Catalogna, Enzo Gallo, S. di Martino +9 more
2017OncoTarget26 citations Open access
Semantic Scholar
Protein-protein interactions and human cellular cofactors as new targets for HIV therapy.
C. Tintori, A. Brai, A. L. Fallacara, R. Fazi +2 more
2014Current opinion in pharmacology (Print)26 citations
Semantic Scholar
Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment.
A. Molinari, A. L. Fallacara, S. Di Maria, Claudio Zamperini +9 more
2018Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Pyrazolo[3,4-d]pyrimidines-loaded human serum albumin (HSA) nanoparticles: Preparation, characterization and cytotoxicity evaluation against neuroblastoma cell line.
A. L. Fallacara, Arianna Mancini, Claudio Zamperini, E. Dreassi +6 more
2017Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Improvement of pyrazolo[3,4-d]pyrimidines pharmacokinetic properties: nanosystem approaches for drug delivery
G. Vignaroli, P. Calandro, Claudio Zamperini, F. Coniglio +8 more
2016Scientific Reports25 citations Open access
Semantic Scholar
Synthesis and biological evaluation of a library of hybrid derivatives as inhibitors of influenza virus PA-PB1 interaction.
I. D'Agostino, Ilaria Giacchello, Giulio Nannetti, A. L. Fallacara +9 more
2018European journal of medicinal chemistry24 citations Open access
Semantic Scholar
SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation
N. Casini, I. Forte, Gianmarco Mastrogiovanni, F. Pentimalli +9 more
2015OncoTarget24 citations Open access
Semantic Scholar
Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma.
G. Bernardini, Marcella Laschi, T. Serchi, A. Spreafico +9 more
2014Molecular Biosystems24 citations
Semantic Scholar
Pyrazolo[3,4-d]pyrimidine Tyrosine Kinase Inhibitors Induce Oxidative Stress in Patient-Derived Glioblastoma Cells
A. Kostić, Sofija Jovanović Stojanov, A. Podolski-Renić, Marija Nešović +6 more
2021Brain Science23 citations Open access
Semantic Scholar
Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors.
M. Massaro, G. Barone, V. Barra, P. Cancemi +6 more
2021International journal of pharmaceutics22 citations Open access
Semantic Scholar
Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
C. Greco, Rosa Catania, D. L. Balacco, Vincenzo Taresco +4 more
2020Molecules22 citations Open access
Semantic Scholar
Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma.
Francesca Musumeci, A. L. Fallacara, C. Brullo, G. Grossi +7 more
2017European journal of medicinal chemistry22 citations Open access
Semantic Scholar
Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors.
Francesca Musumeci, M. Sanna, G. Grossi, C. Brullo +2 more
2017Current Medicinal Chemistry22 citations
Semantic Scholar
Identification of Hck Inhibitors As Hits for the Development of Antileukemia and Anti‐HIV Agents
C. Tintori, I. Laurenzana, F. La Rocca, Federico Falchi +10 more
2013ChemMedChem22 citations
Semantic Scholar
Identification of New Fyn Kinase Inhibitors Using a FLAP-Based Approach
G. Poli, T. Tuccinardi, F. Rizzolio, Isabella Caligiuri +6 more
2013Journal of Chemical Information and Modeling22 citations
Semantic Scholar
Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo
Marija Nešović, Aleksandra Divac Rankov, A. Podolski-Renić, I. Nikolic +5 more
2020Cancers19 citations Open access
Semantic Scholar
Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme.
C. Greco, Vincenzo Taresco, Amanda K. Pearce, Catherine E. Vasey +6 more
2020ACS Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Insight into the Allosteric Inhibition of Abl Kinase
A. L. Fallacara, C. Tintori, M. Radi, S. Schenone +1 more
2014Journal of Chemical Information and Modeling19 citations
Semantic Scholar
A Combination Strategy to Inhibit Pim‐1: Synergism between Noncompetitive and ATP‐Competitive Inhibitors
M. Mori, C. Tintori, Robert Christopher, M. Radi +10 more
2013ChemMedChem19 citations
Semantic Scholar
The small molecule SI113 hinders epithelial‐to‐mesenchymal transition and subverts cytoskeletal organization in human cancer cells
C. Abbruzzese, S. Matteoni, M. Persico, B. Ascione +6 more
2019Journal of Cellular Physiology18 citations
Semantic Scholar
SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase‐Mediated Cytotoxicity and Reduces Cell Migration
P. Indovina, N. Casini, Iris Maria Forte, T. Garofano +9 more
2017Journal of Cellular Physiology18 citations
Semantic Scholar
A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia
I. Laurenzana, A. Caivano, S. Trino, L. De Luca +13 more
2016OncoTarget18 citations Open access
Semantic Scholar

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Francesca Musumeci×23
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M. Botta×21
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A. L. Fallacara×14
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