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E. Caci · SciRah

Researcher profile · Semantic Scholar

E. Caci

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E. Caci — researcher profile on SciRah

h-index: 33
Works: 74
Citations: 4,381

Most-cited papers

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
A. Caputo, E. Caci, L. Ferrera, N. Pedemonte +6 more
2008Science1,266 citations
Semantic Scholar
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.
N. Pedemonte, G. Lukács, Kai Du, E. Caci +3 more
2005Journal of Clinical Investigation558 citations Open access
Semantic Scholar
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
P. Scudieri, E. Caci, Silvia Bruno, L. Ferrera +9 more
2012Journal of Physiology166 citations Open access
Semantic Scholar
IL-4 Is a Potent Modulator of Ion Transport in the Human Bronchial Epithelium In Vitro1
L. Galietta, P. Pagesy, C. Folli, E. Caci +7 more
2002Journal of Immunology154 citations Open access
Semantic Scholar
Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway
L. Petecchia, F. Sabatini, C. Usai, E. Caci +2 more
2012Laboratory Investigation148 citations Open access
Semantic Scholar
Thiocyanate Transport in Resting and IL-4-Stimulated Human Bronchial Epithelial Cells: Role of Pendrin and Anion Channels1
N. Pedemonte, E. Caci, E. Sondo, A. Caputo +7 more
2007Journal of Immunology134 citations Open access
Semantic Scholar
Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis.
E. Caci, A. Caputo, A. Hinzpeter, N. Arous +6 more
2008Biochemical Journal100 citations Open access
Semantic Scholar
Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
P. Scudieri, E. Caci, Arianna Venturini, E. Sondo +5 more
2015Journal of Physiology94 citations Open access
Semantic Scholar
RESCUE OF THE MUTANT CFTR CHLORIDE CHANNEL BY PHARMACOLOGICAL CORRECTORS AND LOW TEMPERATURE ANALYZED BY GENE EXPRESSION PROFILING
E. Sondo, Valeria Tomati, E. Caci, A. Esposito +3 more
2011American Journal of Physiology - Cell Physiology92 citations Open access
Semantic Scholar
Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release
G. Gorrieri, P. Scudieri, E. Caci, M. Schiavon +13 more
2016Scientific Reports83 citations Open access
Semantic Scholar
A novel missense mutation in ANO5/TMEM16E is causative for gnathodiaphyseal dyplasia in a large Italian pedigree
C. Marconi, P. B. Binello, G. Badiali, E. Caci +10 more
2012European Journal of Human Genetics65 citations Open access
Semantic Scholar
Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia.
E. Sondo, Federico Falchi, E. Caci, L. Ferrera +9 more
2018Cell Chemical Biology63 citations Open access
Semantic Scholar
The TMEM16A chloride channel as an alternative therapeutic target in cystic fibrosis.
E. Sondo, E. Caci, L. Galietta
2014International Journal of Biochemistry and Cell Biology62 citations
Semantic Scholar
Dual Activity of Aminoarylthiazoles on the Trafficking and Gating Defects of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Caused by Cystic Fibrosis Mutations
N. Pedemonte, Valeria Tomati, E. Sondo, E. Caci +5 more
2011Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations
N. Pedemonte, T. Diena, E. Caci, E. Nieddu +4 more
2005Molecular Pharmacology59 citations
Semantic Scholar
CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds.
E. Caci, C. Folli, O. Zegarra-Moran, T. Ma +6 more
2003American Journal of Physiology - Lung cellular and Molecular Physiology58 citations
Semantic Scholar
Correction of G551D‐CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB‐07
O. Zegarra-Moran, L. Romio, C. Folli, E. Caci +6 more
2002British Journal of Pharmacology58 citations Open access
Semantic Scholar
Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells
P. Scudieri, I. Musante, Arianna Venturini, Daniela Guidone +9 more
2020Cells55 citations Open access
Semantic Scholar
Increased expression of ATP12A proton pump in cystic fibrosis airways.
P. Scudieri, I. Musante, E. Caci, Arianna Venturini +9 more
2018JCI Insight54 citations Open access
Semantic Scholar
TRPV4 and purinergic receptor signalling pathways are separately linked in airway epithelia to CFTR and TMEM16A chloride channels
M. Genovese, Anna Borrelli, Arianna Venturini, Daniela Guidone +6 more
2019Journal of Physiology51 citations
Semantic Scholar
Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation
Valeria Tomati, E. Sondo, A. Armirotti, E. Caci +12 more
2015Scientific Reports51 citations Open access
Semantic Scholar
Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways.
G. Candiano, M. Bruschi, N. Pedemonte, E. Caci +8 more
2005American Journal of Respiratory and Critical Care Medicine50 citations
Semantic Scholar
Functional human CFTR produced by a stable minichromosome
Cristina Auriche, D. Carpani, M. Conese, E. Caci +3 more
2002EMBO Reports46 citations Open access
Semantic Scholar
TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels.
P. Scudieri, E. Sondo, E. Caci, R. Ravazzolo +1 more
2013Biochemical Journal45 citations
Semantic Scholar
IL-12 Can Target Human Lung Adenocarcinoma Cells and Normal Bronchial Epithelial Cells Surrounding Tumor Lesions
I. Airoldi, E. Di Carlo, C. Cocco, E. Caci +11 more
2009PLoS ONE43 citations Open access
Semantic Scholar
Two CFTR mutations within codon 970 differently impact on the chloride channel functionality
F. Amato, P. Scudieri, I. Musante, Valeria Tomati +11 more
2019Human Mutation42 citations Open access
Semantic Scholar
Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel
N. Pedemonte, F. Bertozzi, E. Caci, Federico Sorana +11 more
2020Science Advances41 citations Open access
Semantic Scholar
Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA.
E. Caci, R. Melani, N. Pedemonte, Guelnihal Yueksekdag +4 more
2009American Journal of Respiratory Cell and Molecular Biology41 citations
Semantic Scholar
A minimal isoform of the TMEM16A protein associated with chloride channel activity
L. Ferrera, P. Scudieri, E. Sondo, A. Caputo +4 more
2011Biochimica et Biophysica Acta39 citations Open access
Semantic Scholar
Functional analysis of acid-activated Cl⁻ channels: properties and mechanisms of regulation.
V. Capurro, A. Gianotti, E. Caci, R. Ravazzolo +2 more
2015Biochimica et Biophysica Acta37 citations Open access
Semantic Scholar
Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin
E. Caci, P. Scudieri, E. Di Carlo, P. Morelli +10 more
2015PLoS ONE37 citations Open access
Semantic Scholar
Mutation-Specific Potency and Efficacy of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Potentiators
A. Caputo, A. Hinzpeter, E. Caci, N. Pedemonte +5 more
2009Journal of Pharmacology and Experimental Therapeutics35 citations Open access
Semantic Scholar
Small molecule‐facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis
M. Fiore, C. Cossu, V. Capurro, C. Picco +7 more
2019British Journal of Pharmacology33 citations Open access
Semantic Scholar
In vitro Methods for the Development and Analysis of Human Primary Airway Epithelia
A. Gianotti, L. Delpiano, E. Caci
2018Frontiers in Pharmacology33 citations Open access
Semantic Scholar
CD4+CD25highCD127- regulatory T-cells in COPD: smoke and drugs effect
A. Chiappori, C. Folli, F. Balbi, E. Caci +5 more
2016The World Allergy Organization Journal33 citations Open access
Semantic Scholar
Epithelial sodium channel silencing as a strategy to correct the airway surface fluid deficit in cystic fibrosis.
A. Gianotti, R. Melani, E. Caci, E. Sondo +3 more
2013American Journal of Respiratory Cell and Molecular Biology33 citations
Semantic Scholar
High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel
Valeria Tomati, E. Pesce, E. Caci, E. Sondo +7 more
2017Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Effect of inflammatory stimuli on airway ion transport.
L. Galietta, C. Folli, E. Caci, N. Pedemonte +3 more
2004Proceedings of the American Thoracic Society30 citations
Semantic Scholar
Murine Rankl−/− Mesenchymal Stromal Cells Display an Osteogenic Differentiation Defect Improved by a RANKL‐Expressing Lentiviral Vector
F. Schena, C. Menale, E. Caci, L. Diomede +13 more
2017Stem Cells28 citations Open access
Semantic Scholar
Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
A. Gianotti, V. Capurro, L. Delpiano, Marcin Mielczarek +8 more
2020International Journal of Molecular Sciences27 citations Open access
Semantic Scholar
Thymosin α-1 does not correct F508del-CFTR in cystic fibrosis airway epithelia.
Valeria Tomati, E. Caci, L. Ferrera, E. Pesce +9 more
2018JCI Insight25 citations Open access
Semantic Scholar
Non-canonical translation start sites in the TMEM16A chloride channel
E. Sondo, P. Scudieri, Valeria Tomati, E. Caci +4 more
2014Biochimica et Biophysica Acta25 citations Open access
Semantic Scholar
The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism
E. Pesce, E. Sondo, L. Ferrera, Valeria Tomati +10 more
2018Frontiers in Pharmacology24 citations Open access
Semantic Scholar
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation and reduced inflammation in obstructive airway diseases
A. Ghigo, A. Murabito, V. Sala, A. Pisano +42 more
2022Science Translational Medicine22 citations Open access
Semantic Scholar
Anion-Transport Mechanism of a Triazole-Bearing Derivative of Prodigiosine: A Candidate for Cystic Fibrosis Therapy
C. Cossu, M. Fiore, D. Baroni, V. Capurro +4 more
2018Frontiers in Pharmacology21 citations Open access
Semantic Scholar
SWATH label-free proteomics for cystic fibrosis research.
Clarissa Braccia, Valeria Tomati, E. Caci, N. Pedemonte +1 more
2019Journal of Cystic Fibrosis20 citations Open access
Semantic Scholar
Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.
T. Diena, R. Melani, E. Caci, N. Pedemonte +3 more
2007European Journal of Pharmacology20 citations Open access
Semantic Scholar
Pulmonary , gastrointestinal and urogenital pharmacology Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways
A. Gianotti, L. Ferrera, Amber R. Philp, E. Caci +3 more
201616 citations
Semantic Scholar
Evaluation of a systems biology approach to identify pharmacological correctors of the mutant CFTR chloride channel.
E. Pesce, G. Gorrieri, F. Sirci, F. Napolitano +6 more
2016Journal of Cystic Fibrosis15 citations Open access
Semantic Scholar
Pharmacological analysis of epithelial chloride secretion mechanisms in adult murine airways.
A. Gianotti, L. Ferrera, Amber R. Philp, E. Caci +3 more
2016European Journal of Pharmacology12 citations
Semantic Scholar

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