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D. Graham · SciRah

Researcher profile · Semantic Scholar

D. Graham

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D. Graham — researcher profile on SciRah

h-index: 47
Works: 100
Citations: 12K

Most-cited papers

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
Randall J. Platt, Si-Di Chen, Yang Zhou, Michael J. Yim +17 more
2014Cell1,914 citations Open access
Semantic Scholar
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
John G Doench, E. Hartenian, D. Graham, Z. Tothova +6 more
2014Nature Biotechnology1,567 citations Open access
Semantic Scholar
Cellular and inter-cellular rewiring of the human colon during ulcerative colitis
C. Smillie, Moshe Biton, J. Ordovas-Montañes, Keri M Sullivan +29 more
2019Cell1,195 citations Open access
Semantic Scholar
Pathway Paradigms Revealed from the Genetics of Inflammatory Bowel Disease
D. Graham, R. Xavier
2020Nature626 citations Open access
Semantic Scholar
T helper cell cytokines modulate intestinal stem cell renewal and differentiation
Moshe Biton, Adam L. Haber, Noga Rogel, Grace Burgin +25 more
2018Cell528 citations Open access
Semantic Scholar
Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis
Eduard Ansaldo, Leianna C. Slayden, Krystal L. Ching, M. Koch +7 more
2019Science523 citations Open access
Semantic Scholar
The human and mouse enteric nervous system at single cell resolution
E. Drokhlyansky, C. Smillie, N. V. Wittenberghe, M. Ericsson +13 more
2020Cell499 citations Open access
Semantic Scholar
Bacteroides-derived sphingolipids are critical for maintaining intestinal homeostasis and symbiosis
Eric Michael Brown, Xiaobo Ke, D. Hitchcock, Sarah Jeanfavre +17 more
2019Cell Host and Microbe448 citations Open access
Semantic Scholar
Akkermansia muciniphila phospholipid induces homeostatic immune responses
Munhyung Bae, Chelsi D. Cassilly, Xiaoxi Liu, Sung-Moo Park +11 more
2022Nature367 citations Open access
Semantic Scholar
Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2
S. Acton, Jillian L. Astarita, D. Malhotra, Veronika Lukacs-Kornek +22 more
2012Immunity314 citations Open access
Semantic Scholar
Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships
D. Plichta, D. Graham, S. Subramanian, R. Xavier
2019Cell261 citations Open access
Semantic Scholar
Transcriptional atlas of intestinal immune cells reveals that neuropeptide α-CGRP modulates group 2 innate lymphoid cell responses
He-Ping Xu, Jiarui Ding, Caroline B. M. Porter, Antonia Wallrapp +17 more
2019Immunity248 citations Open access
Semantic Scholar
The landscape of immune dysregulation in Crohn’s Disease revealed through single-cell transcriptomic profiling in the ileum and colon
Ling-Jia Kong, Vladislav Pokatayev, A. Lefkovith, Grace T. Carter +10 more
2023Immunity245 citations Open access
Semantic Scholar
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes
Linda M. Stephenson, Brian C. Miller, A. Ng, Jason Eisenberg +7 more
2009Autophagy217 citations Open access
Semantic Scholar
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility
Aleksejs Sazonovs, Christine R. Stevens, G. Venkataraman, K. Yuan +126 more
2022Nature Genetics159 citations Open access
Semantic Scholar
Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.
D. Graham, C. M. Robertson, J. Bautista, F. Mascarenhas +8 more
2007Journal of Clinical Investigation138 citations Open access
Semantic Scholar
QRICH1 Dictates the Outcome of ER Stress through Transcriptional Control of Proteostasis
Kwontae You, Ling-Fei Wang, Chih-Hung Chou, Kai Liu +10 more
2020Science133 citations Open access
Semantic Scholar
Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics1
D. Graham, M. Cella, Emanuele Giurisato, K. Fujikawa +7 more
2006Journal of Immunology103 citations Open access
Semantic Scholar
Resources for the design of CRISPR gene editing experiments
D. Graham, D. Root
2015Genome Biology102 citations Open access
Semantic Scholar
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing
Guadalupe J. Jasso, A. Jaiswal, M. Varma, Tyler Laszewski +10 more
2022PLoS Biology100 citations Open access
Semantic Scholar
From Genetics of Inflammatory Bowel Disease Towards Mechanistic Insights
D. Graham, R. Xavier
2013Trends in immunology94 citations Open access
Semantic Scholar
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
Thomas B. Sundberg, H. Choi, J. Song, C. Russell +13 more
2014Proceedings of the National Academy of Sciences of the United States of America88 citations Open access
Semantic Scholar
Vav proteins control MyD88-dependent oxidative burst.
Ana V Miletic, D. Graham, Vivianne Montgrain, K. Fujikawa +6 more
2007Blood87 citations Open access
Semantic Scholar
Conditioning of the immune system by the microbiome.
D. Graham, R. Xavier
2023Trends in immunology86 citations Open access
Semantic Scholar
Cellular and inter-cellular rewiring of the human colon during ulcerative colitis
C. Smillie, M. Biton, J. Ordovas-Montañes, M. Keri +32 more
201986 citations
Semantic Scholar
B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
J. Scheid, C. Barnes, B. Eraslan, A. Hudak +32 more
2021Cell85 citations Open access
Semantic Scholar
The Human Cell Atlas White Paper
A. Regev, S. Teichmann, O. Rozenblatt-Rosen, Michael J. T. Stubbington +76 more
201885 citations
Semantic Scholar
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
M. Rivas, B. Avila, J. Koskela, Hai-Liang Huang +53 more
2016bioRxiv83 citations Open access
Semantic Scholar
Antigen Discovery and Specification of Immunodominance Hierarchies for MHCII-Restricted Epitopes
D. Graham, C. Luo, Daniel J. O'Connell, A. Lefkovith +9 more
2018Nature Medicine76 citations Open access
Semantic Scholar
Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo
Thomas B. Sundberg, Yanke Liang, Huixian Wu, H. Choi +13 more
2016ACS Chemical Biology76 citations Open access
Semantic Scholar
Understanding human immune function using the resources from the Human Functional Genomics Project
M. Netea, L. Joosten, Yang Li, Vinod Kumar +41 more
2016Nature Medicine74 citations Open access
Semantic Scholar
An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells
D. Graham, Linda M. Stephenson, Siu K. Lam, K. Brim +6 more
2007Journal of Experimental Medicine69 citations Open access
Semantic Scholar
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells
Liv Johannessen, Thomas B. Sundberg, Daniel J. O'Connell, R. Kolde +16 more
2017Nature Chemical Biology66 citations Open access
Semantic Scholar
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis
M. Rivas, D. Graham, P. Sulem, Christine R. Stevens +86 more
2015Nature Communications66 citations Open access
Semantic Scholar
pH sensing controls tissue inflammation by modulating cellular metabolism and endo-lysosomal function of immune cells
Xiang-Jun Chen, A. Jaiswal, Zachary A. Costliow, Paula Herbst +6 more
2022Nature Immunology64 citations Open access
Semantic Scholar
Selective modulation of autophagy, innate immunity and adaptive immunity by small molecules
S. Shaw, K. Tran, A. Castoreno, Joanna M. Peloquin +11 more
2013ACS Chemical Biology62 citations Open access
Semantic Scholar
Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient Mice1
D. Graham, M. Bell, M. Mccausland, C. Huntoon +4 more
2006Journal of Immunology58 citations Open access
Semantic Scholar
Vav Links the T Cell Antigen Receptor to the Actin Cytoskeleton and T Cell Activation Independently of Intrinsic Guanine Nucleotide Exchange Activity
Ana V Miletic, D. Graham, K. Sakata-Sogawa, M. Hiroshima +7 more
2009PLoS ONE57 citations Open access
Semantic Scholar
Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice.
D. Graham, M. Bell, M. M. McCausland, C. Huntoon +4 more
2006Journal of Immunology56 citations
Semantic Scholar
Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn’s Disease Reveals Tissue-Specific Characteristics and Drug Targets
W. U. Uniken Venema, M. Voskuil, A. V. Vila, Gerben van der Vries +9 more
2018Gastroenterology55 citations Open access
Semantic Scholar
TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation
D. Graham, A. Lefkovith, Patrick Deelen, N. de Klein +13 more
2016Cell Reports55 citations Open access
Semantic Scholar
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease
T. K. Pedersen, Eric Michael Brown, D. Plichta, Joachim Johansen +7 more
2022Immunity52 citations Open access
Semantic Scholar
PKCδ Deficiency Perturbs Bone Homeostasis by Selective Uncoupling of Cathepsin K Secretion and Ruffled Border Formation in Osteoclasts
V. Cremasco, C. Decker, D. Stumpo, Perry J. Blackshear +6 more
2012Journal of Bone and Mineral Research52 citations Open access
Semantic Scholar
Vav/Phospholipase Cγ2–Mediated Control of a Neutrophil-Dependent Murine Model of Rheumatoid Arthritis
V. Cremasco, D. Graham, D. Novack, W. Swat +1 more
2008Arthritis & Rheumatism50 citations Open access
Semantic Scholar
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery
Martin Stražar, Jihye Park, Jennifer G. Abelin, Hannah B. Taylor +10 more
2023Immunity49 citations Open access
Semantic Scholar
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease
Elizaveta S. Leshchiner, J. Rush, M. Durney, Zhi-Fang Cao +13 more
2017Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
A missense variant in SLC39A8 confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrity
Toru Nakata, E. Creasey, Motohiko Kadoki, Helen Lin +6 more
2020Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes
D. Graham, Guadalupe J. Jasso, A. Mok, G. Goel +8 more
2018Cell Reports47 citations Open access
Semantic Scholar
Gut bacterial metabolites modulate endoplasmic reticulum stress
Xiaobo Ke, Kwontae You, M. Pichaud, H. J. Haiser +4 more
2021Genome Biology45 citations Open access
Semantic Scholar
Simultaneous Pathway Activity Inference and Gene Expression Analysis Using RNA Sequencing
Daniel J. O'Connell, R. Kolde, M. Sooknah, D. Graham +4 more
2016Cell Systems44 citations Open access
Semantic Scholar

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C. Smillie — researcher profile on SciRah