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Alykhan F. Shamji · SciRah

Researcher profile · Semantic Scholar

Alykhan F. Shamji

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Alykhan F. Shamji — researcher profile on SciRah

h-index: 45
Works: 84
Citations: 21K

Most-cited papers

Regulation of Ferroptotic Cancer Cell Death by GPX4
W. Yang, Rohitha SriRamaratnam, Matthew E. Welsch, K. Shimada +11 more
2014Cell7,048 citations Open access
Semantic Scholar
A Next Generation Connectivity Map: L1000 platform and the first 1,000,000 profiles
A. Subramanian, R. Narayan, Steven M. Corsello, David Peck +52 more
2017bioRxiv3,160 citations Open access
Semantic Scholar
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
V. Viswanathan, M. Ryan, Harshil Dhruv, S. Gill +36 more
2017Nature1,813 citations Open access
Semantic Scholar
Selective killing of cancer cells with a small molecule targeting stress response to ROS
Lakshmi Raj, T. Ide, Aditi U. Gurkar, Michael Foley +10 more
2011Nature965 citations Open access
Semantic Scholar
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
M. Rees, B. Seashore-Ludlow, Jaime H. Cheah, Drew J. Adams +23 more
2015Nature Chemical Biology822 citations Open access
Semantic Scholar
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules
A. Basu, Nicole E. Bodycombe, Jaime H. Cheah, Edmund Price +25 more
2013Cell787 citations Open access
Semantic Scholar
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Brinton Seashore-Ludlow, M. Rees, Jaime H. Cheah, Murat Cokol +22 more
2015Cancer Discovery714 citations Open access
Semantic Scholar
Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins.
James S. Hardwick, F. Kuruvilla, J. Tong, Alykhan F. Shamji +1 more
1999Proceedings of the National Academy of Sciences of the United States of America579 citations Open access
Semantic Scholar
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
K. Lassen, Petric Kuballa, K. Conway, Khushbu K. Patel +20 more
2014Proceedings of the National Academy of Sciences of the United States of America375 citations Open access
Semantic Scholar
Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays
F. Kuruvilla, Alykhan F. Shamji, S. Sternson, P. Hergenrother +1 more
2002Nature317 citations
Semantic Scholar
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
Chan-Ning Yu, Aristotle M. Mannan, Griselda M. Yvone, K. Ross +17 more
2016Nature Biotechnology299 citations Open access
Semantic Scholar
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
P. Clemons, Nicole E. Bodycombe, Hyman A. Carrinski, J. A. Wilson +4 more
2010Proceedings of the National Academy of Sciences of the United States of America296 citations Open access
Semantic Scholar
Multiplex Cytological Profiling Assay to Measure Diverse Cellular States
S. Gústafsdóttir, V. Ljosa, K. Sokolnicki, J. A. Wilson +9 more
2013PLoS ONE260 citations Open access
Semantic Scholar
Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins.
Alykhan F. Shamji, F. Kuruvilla, S. Schreiber
2000Current Biology252 citations Open access
Semantic Scholar
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection
K. Conway, Petric Kuballa, J. Song, Khushbu K. Patel +19 more
2013Gastroenterology241 citations Open access
Semantic Scholar
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
Drew J. Adams, M. Dai, G. Pellegrino, B. Wagner +3 more
2012Proceedings of the National Academy of Sciences of the United States of America216 citations Open access
Semantic Scholar
Integration of growth factor and nutrient signaling: implications for cancer biology.
Alykhan F. Shamji, P. Nghiem, S. Schreiber
2003Molecules and Cells193 citations Open access
Semantic Scholar
A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay
M. Bray, S. Gústafsdóttir, M. Rohban, Shantanu Singh +16 more
2017GigaScience182 citations Open access
Semantic Scholar
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling
M. Wawer, Kejie Li, S. Gústafsdóttir, V. Ljosa +21 more
2014Proceedings of the National Academy of Sciences of the United States of America177 citations Open access
Semantic Scholar
A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma
Yuan Yuan, Qiu Wang, Joshiawa Paulk, S. Kubicek +5 more
2012ACS Chemical Biology170 citations Open access
Semantic Scholar
A genetic basis for the variation in the vulnerability of cancer to DNA damage
B. Yard, Drew J. Adams, E. Chie, P. Tamayo +15 more
2016Nature Communications168 citations Open access
Semantic Scholar
Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.
A. Koehler, Alykhan F. Shamji, S. Schreiber
2003Journal of the American Chemical Society156 citations
Semantic Scholar
Advancing Biological Understanding and Therapeutics Discovery with Small Molecule Probes
S. Schreiber, J. Kotz, Min Li, J. Aubé +51 more
2015Cell147 citations Open access
Semantic Scholar
The Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-Fungal Immunity and Intestinal Inflammation
Zhi-Fang Cao, K. Conway, Robert J. W. Heath, J. Rush +14 more
2015Immunity126 citations Open access
Semantic Scholar
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells
Kimberly A. Hartwell, P. Miller, S. Mukherjee, Alissa R. Kahn +33 more
2013Nature Chemical Biology108 citations Open access
Semantic Scholar
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
Lakshmi Raj, T. Ide, Aditi U. Gurkar, Michael Foley +10 more
2012Nature99 citations Open access
Semantic Scholar
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells
B. Khor, John D. Gagnon, G. Goel, M. Roche +19 more
2015eLife96 citations Open access
Semantic Scholar
Identification of cancer cytotoxic modulators of PDE3A by predictive chemogenomics
L. de Waal, T. Lewis, M. Rees, Aviad Tsherniak +18 more
2015Nature Chemical Biology89 citations Open access
Semantic Scholar
Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors
F. Kuruvilla, Alykhan F. Shamji, S. Schreiber
2001Proceedings of the National Academy of Sciences of the United States of America89 citations Open access
Semantic Scholar
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
Thomas B. Sundberg, H. Choi, J. Song, C. Russell +13 more
2014Proceedings of the National Academy of Sciences of the United States of America88 citations Open access
Semantic Scholar
Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.
Emily L. Humphrey, Alykhan F. Shamji, B. Bernstein, S. Schreiber
2004Chemistry and Biology79 citations Open access
Semantic Scholar
Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function In Vivo
Thomas B. Sundberg, Yanke Liang, Huixian Wu, H. Choi +13 more
2016ACS Chemical Biology76 citations Open access
Semantic Scholar
NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes
Drew J. Adams, D. Ito, M. Rees, Brinton Seashore-Ludlow +8 more
2014ACS Chemical Biology74 citations Open access
Semantic Scholar
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics
Szu-Yu Kuo, A. Castoreno, L. Aldrich, K. Lassen +12 more
2015Proceedings of the National Academy of Sciences of the United States of America71 citations Open access
Semantic Scholar
Towards patient-based cancer therapeutics
S. Schreiber, Alykhan F. Shamji, P. Clemons, Cindy S. Hon +35 more
2010Nature Biotechnology67 citations Open access
Semantic Scholar
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells
Liv Johannessen, Thomas B. Sundberg, Daniel J. O'Connell, R. Kolde +16 more
2017Nature Chemical Biology66 citations Open access
Semantic Scholar
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map
M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi +17 more
2014Cancer Discovery66 citations Open access
Semantic Scholar
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death
Drew J. Adams, Z. Boskovic, J. Thériault, Alex J. Wang +4 more
2013ACS Chemical Biology64 citations Open access
Semantic Scholar
Selective modulation of autophagy, innate immunity and adaptive immunity by small molecules
S. Shaw, K. Tran, A. Castoreno, Joanna M. Peloquin +11 more
2013ACS Chemical Biology62 citations Open access
Semantic Scholar
DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets
Allison R. Hanaford, Tenley C. Archer, Antoinette C. Price, U. Kahlert +18 more
2016Clinical Cancer Research60 citations Open access
Semantic Scholar
Integrated genetic and pharmacologic interrogation of rare cancers
A. Hong, Yuen-Yi Tseng, G. Cowley, O. Jonas +29 more
2016Nature Communications52 citations Open access
Semantic Scholar
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease
Elizaveta S. Leshchiner, J. Rush, M. Durney, Zhi-Fang Cao +13 more
2017Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells
S. Kubicek, Joshua C. Gilbert, Dina Fomina-Yadlin, Alexander D. Gitlin +11 more
2012Proceedings of the National Academy of Sciences of the United States of America48 citations Open access
Semantic Scholar
Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway
G. I. Schaefer, J. Pérez, Jeremy R. Duvall, Benjamin Z. Stanton +2 more
2013Journal of the American Chemical Society45 citations Open access
Semantic Scholar
Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening.
Jiong Yang, Alykhan F. Shamji, Sirinya Matchacheep, S. Schreiber
2007Chemistry and Biology45 citations Open access
Semantic Scholar
Discovery of a Small-Molecule Probe for V-ATPase Function
L. Aldrich, Szu-Yu Kuo, A. Castoreno, G. Goel +8 more
2015Journal of the American Chemical Society43 citations Open access
Semantic Scholar
KRAS genomic status predicts the sensitivity of ovarian cancer cells to decitabine
Michelle L. Stewart, P. Tamayo, A. Wilson, Stephanie W. Wang +5 more
2015Cancer Research42 citations Open access
Semantic Scholar
Small-molecule and CRISPR screening converge to reveal RTK dependencies in pediatric rhabdoid tumors
Elaine M. Oberlick, M. Rees, Brinton Seashore-Ludlow, F. Vazquez +24 more
2019Cell Reports40 citations Open access
Semantic Scholar
Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses
Vlado Dancík, Hyman A. Carrel, Nicole E. Bodycombe, K. Seiler +6 more
2014Journal of biomolecular screening32 citations Open access
Semantic Scholar
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors
S. Chattopadhyay, Alison L. Stewart, S. Mukherjee, Cherrie Huang +29 more
2015Cell Reports30 citations Open access
Semantic Scholar

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