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C. Lemieux · SciRah

Researcher profile · Semantic Scholar

C. Lemieux

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C. Lemieux — researcher profile on SciRah

h-index: 28
Works: 109
Citations: 2,666

Most-cited papers

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.
P. W. Schiller, Thi M.-D. Nguyen, G. Weltrowska, B. Wilkes +3 more
1992Proceedings of the National Academy of Sciences of the United States of America193 citations Open access
Semantic Scholar
The Opioid μ Agonist/δ Antagonist DIPP-NH2[Ψ] Produces a Potent Analgesic Effect, No Physical Dependence, and Less Tolerance than Morphine in Rats
P. Schiller, M. Fundytus, L. Merovitz, G. Weltrowska +4 more
1999159 citations Open access
Semantic Scholar
Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity.
P. Schiller, Thi M.-D. Nguyen, N. Chung, C. Lemieux
1989Journal of Medicinal Chemistry156 citations Open access
Semantic Scholar
Synthesis and in vitro opioid activity profiles of DALDA analogues.
P. Schiller, Thi M.-D. Nguyen, I. Berezowska, Sébastien Dupuis +3 more
2000European journal of medicinal chemistry139 citations Open access
Semantic Scholar
TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.
P. W. Schiller, G. Weltrowska, Thi M.-D. Nguyen, B. Wilkes +2 more
1993Journal of Medicinal Chemistry121 citations Open access
Semantic Scholar
The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists.
P. W. Schiller, Grazyna Weltrowska, Irena Berezowska, Thi M.-D. Nguyen +3 more
1999Biopolymers86 citations
Semantic Scholar
Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.
P. W. Schiller, G. Weltrowska, Thi My Dieu Nguyen, C. Lemieux +3 more
1991Journal of Medicinal Chemistry75 citations Open access
Semantic Scholar
Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.
Michael Keller, C. Boissard, Luc Patiny, N. Chung +3 more
2001Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.
Yi-Xin Lu, Thi M.-D. Nguyen, G. Weltrowska, I. Berezowska +3 more
2001Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.
I. Berezowska, N. Chung, C. Lemieux, B. Wilkes +1 more
2007Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats.
P. Schiller, M. Fundytus, L. Merovitz, G. Weltrowska +4 more
1999Journal of Medicinal Chemistry48 citations
Semantic Scholar
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.
R. Schmidt, D. Vogel, C. Mrestani‐Klaus, Wolfgang Brandt +4 more
1994Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.
P. W. Schiller, Thi M.-D. Nguyen, L. Maziak, B. Wilkes +1 more
1987Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Novel ligands lacking a positive charge for the δ- and μ-opioid receptors
P. Schiller, I. Berezowska, Thi M.-D. Nguyen, R. Schmidt +8 more
200043 citations Open access
Semantic Scholar
Synthesis and Characterization of Potent and Selective μ-Opioid Receptor Antagonists, [Dmt1, d-2-Nal4]endomorphin-1 (Antanal-1) and [Dmt1, d-2-Nal4]endomorphin-2 (Antanal-2)
J. Fichna, J. Do Régo, N. Chung, C. Lemieux +5 more
200742 citations Open access
Semantic Scholar
Design of novel neurokinin 1 receptor antagonists based on conformationally constrained aromatic amino acids and discovery of a potent chimeric opioid agonist-neurokinin 1 receptor antagonist
S. Ballet, D. Feytens, K. Buysse, N. Chung +10 more
2011Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.
P. W. Schiller, Thi M.-D. Nguyen, C. Lemieux, Louise A. Maziak
1985Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Structure-activity relationships of dermorphin analogues containing N-substituted amino acids in the 2-position of the peptide sequence.
R. Schmidt, A. Kálmán, N. Chung, C. Lemieux +2 more
2009International journal of peptide & protein research39 citations
Semantic Scholar
Conformationally restricted deltorphin analogues.
P. W. Schiller, Grazyna Weltrowska, Thi M.-D. Nguyen, B. Wilkes +2 more
1992Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
A novel cyclic opioid peptide analog showing high preference for mu-receptors.
P. W. Schiller, Thi M.-D. Nguyen, Louise Maziak, C. Lemieux
1985Biochemical and Biophysical Research Communications - BBRC39 citations
Semantic Scholar
Evidence of a peptide backbone contribution toward selective receptor recognition for leucine enkephalin thioamide analogs.
K. Clausen, A. Spatola, C. Lemieux, P. W. Schiller +1 more
1984Biochemical and Biophysical Research Communications - BBRC39 citations
Semantic Scholar
Synthesis and biological activity of [Leu5]enkephalin derivatives containing D-glucose.
J. Horvat, Š. Horvat, C. Lemieux, P. W. Schiller
2009International journal of peptide & protein research31 citations
Semantic Scholar
Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice
Joanna Starnowska, Roberto Costante, Karel Guillemyn, K. Popiołek-Barczyk +12 more
2017ACS Chemical Neuroscience30 citations Open access
Semantic Scholar
Variation of the net charge, lipophilicity and side chain flexibility in Dmt1-DALDA: effect on opioid activity and biodistribution
A. Novoa, Sylvia Van Dorpe, E. Wynendaele, M. Spetea +11 more
2012Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
‘Carba’-Analogues of Fentanyl are Opioid Receptor Agonists
G. Weltrowska, N. Chung, C. Lemieux, Jianxin Guo +3 more
2010Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.
S. Ballet, A. Misicka, P. Kosson, C. Lemieux +4 more
2008Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Karel Guillemyn, Patrycia Kleczkowska, A. Leśniak, J. Dyniewicz +18 more
2015European journal of medicinal chemistry27 citations Open access
Semantic Scholar
Highly potent fluorescent analogues of the opioid peptide [Dmt1] DALDA.
I. Berezowska, N. Chung, C. Lemieux, B. Zelent +2 more
2003Peptides24 citations
Semantic Scholar
Conversion of δ-, κ- and μ-receptor selective opioid peptide agonists into δ-, κ- and μ-selective antagonists
P. Schiller, G. Weltrowska, Thi M.-D. Nguyen, C. Lemieux +2 more
200324 citations Open access
Semantic Scholar
Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics.
P. Schiller, Grazyna Weltrowska, R. Schmidt, Irena Berezowska +5 more
1999Journal of Receptor and Signal Transduction Research24 citations
Semantic Scholar
Cyclic dermorphin tetrapeptide analogues obtained via ring-closing metathesis.
I. Berezowska, N. Chung, C. Lemieux, B. Wilkes +1 more
2006Acta Biochimica Polonica23 citations Open access
Semantic Scholar
A chimeric opioid peptide with mixed μ agonist/δ antagonist properties
G. Weltrowska, C. Lemieux, N. Chung, P. Schiller
200423 citations
Semantic Scholar
Synthesis and biological activity of some glucose-enkephalin conjugates.
L. Varga, Š. Horvat, C. Lemieux, P. W. Schiller
2009International journal of peptide & protein research22 citations
Semantic Scholar
Cyclic Opioid Peptide Agonists and Antagonists Obtained Via Ring-Closing Metathesis
I. Berezowska, C. Lemieux, N. Chung, B. Wilkes +1 more
2009Chemical Biology and Drug Design22 citations Open access
Semantic Scholar
Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide.
Yi-Xin Lu, G. Weltrowska, C. Lemieux, N. Chung +1 more
2001Bioorganic & Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
FOUR DIFFERENT TYPES OF OPIOID PEPTIDES WITH MIXED μ AGONIST/δ ANTAGONIST PROPERTIES
P. Schiller, G. Weltrowska, R. Schmidt, T.m.-D Nguyen +5 more
199521 citations
Semantic Scholar
Hybrid bivalent ligands with opiate and enkephalin pharmacophores.
P. S. Portoghese, David L. Larson, Giuseppe Ronsisvalle, P. W. Schiller +3 more
1987Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Structural modifications of the N-terminal tetrapeptide segment of [D-Ala2]deltorphin I: effects on opioid receptor affinities and activities in vitro and on antinociceptive potency.
R. Schmidt, D. Ménard, C. Mrestani‐Klaus, N. Chung +2 more
1997Peptides19 citations
Semantic Scholar
[Aladan3]TIPP: A fluorescent δ‐opioid antagonist with high δ‐receptor binding affinity and δ selectivity
He-Ru Chen, N. Chung, C. Lemieux, B. Zelent +4 more
2005Biopolymers18 citations
Semantic Scholar
Synthesis and opioid activity profiles of cyclic dynorphin analogs
P. Schiller, Thi M.-D. Nguyen, C. Lemieux
198818 citations
Semantic Scholar
Agonist vs Antagonist Behavior of δ Opioid Peptides Containing Novel Phenylalanine Analogues in Place of Tyr1
I. Berezowska, N. Chung, C. Lemieux, B. Wilkes +1 more
2009Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
A novel cyclic enkephalin analogue with potent opioid antagonist activity.
G. Weltrowska, Yi-Xin Lu, C. Lemieux, N. Chung +1 more
2004Bioorganic & Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
N-Methylated Cyclic Enkephalin Analogues Retain High Opioid Receptor Binding Affinity
G. Weltrowska, I. Berezowska, C. Lemieux, N. Chung +2 more
2009Chemical Biology and Drug Design14 citations Open access
Semantic Scholar
The receptor-bound conformation of H-Tyr-Tic-(Phe-Phe)-OH-related delta-opioid antagonists contains all trans peptide bonds.
B. Wilkes, Thi M.-D. Nguyen, Grazyna Weltrowska, K. A. Carpenter +3 more
2009Journal of Peptide Research13 citations
Semantic Scholar
Cyclic enkephalin analogs containing various para-substituted phenylalanine derivatives in place of Tyr1 are potent opioid agonists.
Grazyna Weltrowska, C. Lemieux, N. Chung, P. W. Schiller
2008Journal of Peptide Research13 citations
Semantic Scholar
Type and location of fluorescent probes incorporated into the potent mu-opioid peptide [Dmt]DALDA affect potency, receptor selectivity and intrinsic efficacy.
P. W. Schiller, Irena Berezowska, Grazyna Weltrowska, He-Ru Chen +2 more
2005Journal of Peptide Research12 citations
Semantic Scholar
A novel side‐chain‐linked antiparallel cyclic dimer of enkephalin
P. W. Schiller, Thi M.-D. Nguyen, C. Lemieux, Louise A. Maziak
1985FEBS Letters12 citations
Semantic Scholar
Reverse turn mimics
W. Huffman, J. Callahan, D. Eggleston, K. Newlander +7 more
198811 citations
Semantic Scholar
‘Carba’-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode
G. Weltrowska, C. Lemieux, N. Chung, J. Guo +2 more
2014Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
Formation Pathways and Opioid Activity Data for 3‐Hydroxypyridinium Compounds Derived from Glucuronic Acid and Opioid Peptides by Maillard Processes
Š. Horvat, M. Roščić, C. Lemieux, Thi M.-D. Nguyen +1 more
2007Chemical Biology and Drug Design10 citations
Semantic Scholar

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P. Schiller×26
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P. W. Schiller×24
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Thi M.-D. Nguyen×18
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G. Weltrowska×15

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