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Karel Guillemyn · SciRah

Researcher profile · Semantic Scholar

Karel Guillemyn

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Karel Guillemyn — researcher profile on SciRah

h-index: 12
Works: 22
Citations: 519

Most-cited papers

Structural basis for bifunctional peptide recognition at human δ-Opioid receptor
G. Fenalti, N. Zatsepin, Cecilia Betti, P. Giguère +32 more
2015Nature Structural &Molecular Biology180 citations Open access
Semantic Scholar
Bifunctional Peptide-Based Opioid Agonist–Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain
Karel Guillemyn, Joanna Sarnowska, Camille Lagard, J. Dyniewicz +15 more
2016Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects
Armand Drieu la Rochelle, Karel Guillemyn, Maria Dumitrascuta, C. Martin +12 more
2018Pain38 citations Open access
Semantic Scholar
Nanobody-Enabled Reverse Pharmacology on G-Protein-Coupled Receptors.
E. Pardon, Cecilia Betti, T. Laeremans, Florent Chevillard +4 more
2018Angewandte Chemie36 citations
Semantic Scholar
In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera
Karel Guillemyn, P. Kleczkowska, A. Novoa, Bart Vandormael +8 more
2012Molecular Brain31 citations Open access
Semantic Scholar
Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice
Joanna Starnowska, Roberto Costante, Karel Guillemyn, K. Popiołek-Barczyk +12 more
2017ACS Chemical Neuroscience30 citations Open access
Semantic Scholar
Structure Revision of N-Mercapto-4-formylcarbostyril Produced by Pseudomonas fluorescens G308 to 2-(2-Hydroxyphenyl)thiazole-4-carbaldehyde [aeruginaldehyde]
L. Ye, P. Cornelis, Karel Guillemyn, S. Ballet +2 more
2014Natural Product Communications30 citations Open access
Semantic Scholar
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Karel Guillemyn, Patrycia Kleczkowska, A. Leśniak, J. Dyniewicz +18 more
2015European journal of medicinal chemistry27 citations Open access
Semantic Scholar
Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain
Camille Lagard, L. Chevillard, Karel Guillemyn, P. Risède +4 more
2016Pain26 citations Open access
Semantic Scholar
A combinatorial approach to the structure elucidation of a pyoverdine siderophore produced by a Pseudomonas putida isolate and the use of pyoverdine as a taxonomic marker for typing P. putida subspecies
L. Ye, S. Ballet, F. Hildebrand, G. Laus +5 more
2013Biometals20 citations
Semantic Scholar
Stabilisation of a short α‐helical VIP fragment by side chain to side chain cyclisation: a comparison of common cyclisation motifs by circular dichroism
Lukasz P. Frankiewicz, Cecilia Betti, Karel Guillemyn, D. Tourwé +2 more
2013Journal of Peptide Science15 citations
Semantic Scholar
T3P-Promoted, Mild, One-Pot Syntheses of Constrained Polycyclic Lactam Dipeptide Analogues via Stereoselective Pictet-Spengler and Meyers Lactamization Reactions.
M. Jida, O. Van der Poorten, Karel Guillemyn, Z. Urbańczyk-Lipkowska +2 more
2015Organic Letters13 citations
Semantic Scholar
Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain‐related behaviour in a rat model of neuropathy
Joanna Starnowska, Karel Guillemyn, W. Makuch, J. Mika +2 more
2017European Journal of Pharmaceutical Sciences11 citations
Semantic Scholar
Efficient one-pot synthesis of amino-benzotriazolodiazocinone scaffolds via catalyst-free tandem Ugi-Huisgen reactions.
T. Barlow, M. Jida, Karel Guillemyn, D. Tourwé +2 more
2016Organic and biomolecular chemistry10 citations
Semantic Scholar
χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.
O. Van der Poorten, R. Van Den Hauwe, Émilie Eiselt, Cecilia Betti +9 more
2017ACS Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Azepinone-Constrained Amino Acids in Peptide and Peptidomimetic Design
S. Ballet, Karel Guillemyn, O. Van der Poorten, Ben Schurgers +2 more
20153 citations
Semantic Scholar
In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera
Karel Guillemyn, P. Kleczkowska, A. Novoa, Bart Vandormael +8 more
2012Molecular Brain1 citations Open access
Semantic Scholar
T3P‐Promoted, Mild, One‐Pot Syntheses of Constrained Polycyclic Lactam Dipeptide Analogues via Stereoselective Pictet—Spengler and Meyers Lactamization Reactions.
M. Jida, O. Van der Poorten, Karel Guillemyn, Z. Urbańczyk-Lipkowska +2 more
20160 citations
Semantic Scholar
Synchrotron structure of the human delta opioid receptor in complex with a bifunctional peptide (PSI community target)
G. Fenalti, N. Zatsepin, Cecilia Betti, P. Giguère +32 more
20150 citations
Semantic Scholar
XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide
G. Fenalti, N. Zatsepin, Cecilia Betti, P. Giguère +32 more
20150 citations
Semantic Scholar
Synthesis and biological evaluation of a compact, conformationally constrained bifunctional opioid agonist-neurokin-1 antagonist
D. Tourwé, Karel Guillemyn, P. Kleczkowska, O. Van der Poorten +14 more
20140 citations
Semantic Scholar
Evaluation of constrained amino acids in the design of neurokinin 1 receptor- and bifunctional opioid – neurokinin 1 receptor ligands
S. Ballet, Lukasz P. Frankiewicz, Karel Guillemyn, Isabelle Van den Eynde +9 more
20110 citations
Semantic Scholar

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