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D. Eggleston · SciRah

Researcher profile · Semantic Scholar

D. Eggleston

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D. Eggleston — researcher profile on SciRah

h-index: 31
Works: 220
Citations: 5,248

Most-cited papers

Type IIA topoisomerase inhibition by a new class of antibacterial agents
B. Bax, P. Chan, D. Eggleston, A. Fosberry +21 more
2010Nature802 citations
Semantic Scholar
Crystal Structure of Human Cytochrome P450 2D6*
P. Rowland, F. Blaney, M. Smyth, Joanna J. Jones +8 more
2005Journal of Biological Chemistry398 citations Open access
Semantic Scholar
DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
D. A. Holt, J. Luengo, D. Yamashita, H. Oh +11 more
1994180 citations
Semantic Scholar
New roles for structure in biology and drug discovery
R. Russell, D. Eggleston
2000Nature Structural Biology173 citations
Semantic Scholar
Structure determination of racemic trichogin A IV using centrosymmetric crystals
C. Toniolo, C. Peggion, M. Crisma, F. Formaggio +2 more
1994Nature Structural Biology127 citations Open access
Semantic Scholar
Synthesis and recognition properties of aromatic amide oligomers: Molecular zippers
Adrian P. Bisson, Fiona J. Carver, D. Eggleston, R. Haltiwanger +5 more
2000125 citations
Semantic Scholar
1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.
S. Christensen, A. Guider, C. Forster, J. G. Gleason +18 more
1998Journal of Medicinal Chemistry124 citations Open access
Semantic Scholar
Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor.
J. Darker, Rod A. Porter, D. Eggleston, D. Smart +3 more
2001Bioorganic & Medicinal Chemistry Letters70 citations Open access
Semantic Scholar
Elucidation of vancomycin's enantioselective binding site using its copper complex
U. B. Nair, Samuel S Chang, D. Armstrong, Yasir Y. Rawjee +2 more
199662 citations
Semantic Scholar
Chelation control in metal-assisted aldol addition reactions of .alpha.-N-halogenated imide enolates leading to predominantly anti stereoselectivity. An example of a stereocontrolled Darzens reaction
L. N. Pridgen, A. Abdelmagid, I. Lantos, S. Shilcrat +1 more
199355 citations
Semantic Scholar
The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one.
P. Baures, D. Eggleston, Karl F. Erhard, L. Cieslinski +2 more
1993Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
Lipopeptide substrates for SpsB, the Staphylococcus aureus type I signal peptidase: design, conformation and conversion to alpha-ketoamide inhibitors.
G. Bruton, A. Huxley, P. O'hanlon, B. Orlek +10 more
2003European journal of medicinal chemistry50 citations
Semantic Scholar
Cellular uptake and spread of the cell‐permeable peptide penetratin in adult rat brain
Sarah J. Bolton, Declan Jones, John G. Darker, D. Eggleston +2 more
2000European Journal of Neuroscience50 citations
Semantic Scholar
Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists.
Richard M. Keenan, J. Callahan, James M. Samanen, William E. Bondinell +18 more
1999Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Defining and maintaining a high quality screening collection: the GSK experience.
S. Lane, D. Eggleston, Keith A. Brinded, J. Hollerton +2 more
2006Drug Discovery Today44 citations
Semantic Scholar
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept.
Giulio Dondio, S. Ronzoni, D. Eggleston, M. Artico +6 more
1997Journal of Medicinal Chemistry44 citations Open access
Semantic Scholar
Artabotrine: A novel bioactive alkaloid from Artabotrys zeylanicus
E. M. Kithsiri Wijeratne, A. A. Leslie Gunatilaka, D. Kingston, R. Haltiwanger +1 more
199534 citations
Semantic Scholar
Non-thiazolidinedione antihyperglycaemic agents. Part 3 : The effects of stereochemistry on the potency of α-methoxy-β-phenylpropanoic acids
D. Haigh, G. Allen, H. Birrell, D. Buckle +10 more
199929 citations
Semantic Scholar
Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.
J. Berge, Royston C. B. Copley, D. Eggleston, Dieter W. Hamprecht +4 more
2000Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
SB-204900, a novel oxirane carboxamide from Clausena lansium
P. Milner, N. Coates, M. Gilpin, S. R. Spear +1 more
199628 citations
Semantic Scholar
ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.
A. D. Gribble, R. Ife, Antony Shaw, David McNair +13 more
1998Journal of Medicinal Chemistry27 citations Open access
Semantic Scholar
STEREOCONTROLLED CONSTRUCTION OF CONDENSED GAMMA-LACTAM RING-SYSTEMS BY CATIONIC CYCLIZATIONS - REARRANGEMENT OF A GAMMA-LACTAM TO A DELTA-LACTAM
C. M. Marson, Urszula Grabowska, T. Walsgrove, D. Eggleston +1 more
199426 citations
Semantic Scholar
Stereoselective syntheses of substituted 5,6-dihydro-2(1H)-pyridinones in polyphosphate media
C. M. Marson, Urszula Grabowska, A. Fallah, T. Walsgrove +2 more
199425 citations
Semantic Scholar
New Halogenated Sesquiterpenes from South African Specimens of the Circumtropical Sea Hare Aplysia dactylomela
Kerry L. MPhail, M. Davies-Coleman, Royston C. B. Copley, D. Eggleston
199923 citations
Semantic Scholar
Daleformis, a new phytoalexin from the roots fo Dalea filiciformis: an inhibitor of endothelin converting enzyme.
A. Patil, A. Freyer, D. Eggleston, R. Haltiwanger +3 more
1997Journal of Natural Products23 citations
Semantic Scholar
Metal-drug interactions: synthesis and crystal structure of dichlorodithiabendazolecobalt(II) monohydrate
B. Umadevi, P. Muthiah, Xiu-Qi Shui, D. Eggleston
199522 citations
Semantic Scholar
Facile biocatalytic reduction of the carbon–carbon double bond of 5-benzylidenethiazolidine-2,4-diones. Synthesis of (±)-5-(4-{2-[methyl(2-pyridyl)amino]ethoxy}benzyl)thiazolidine-2,4-dione (BRL 49653), its (R)-(+)-enantiomer and analogues
B. Cantello, D. Eggleston, D. Haigh, R. Haltiwanger +5 more
199422 citations
Semantic Scholar
Substituent effects on aromatic interactions in the solid state
H. Adams, P. Bernad, D. Eggleston, R. Haltiwanger +6 more
200121 citations
Semantic Scholar
Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.
P. Brown, D. Eggleston, R. Haltiwanger, R. L. Jarvest +3 more
2001Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist.
William E. Bondinell, Richard M. Keenan, William H. Miller, F. Ali +19 more
1994Bioorganic & Medicinal Chemistry19 citations
Semantic Scholar
Non-thiazolidinedione antihyperglycaemic agents. Part 5: Asymmetric aldol synthesis of (S)-(−)-2-oxy-3-arylpropanoic acids
D. Haigh, H. Birrell, B. Cantello, D. Eggleston +4 more
199918 citations
Semantic Scholar
Cycloadditions of Cephalosporins. A Comprehensive Study of the Reaction of Cephalosporin Triflates with Olefins, Acetylenes, and Dienes To Form [2 + 2] and [4 + 2] Adducts
R. Elliott, N. Nicholson, Fiona E. Peaker, Andrew K. Takle +6 more
199718 citations
Semantic Scholar
Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based inhibitors of ATP citrate lyase.
Roland E. Dolle, A. Gribble, Tracey Wilkes, L. Kruse +4 more
1995Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Crystallographic structure of a multiple beta-turn containing, glycine-rich heptapeptide: a synthetic precursor of the lipopeptaibol antibiotic trichodecenin I.
V. Monaco, F. Formaggio, M. Crisma, Claudio Toniolo +2 more
1998Biopolymers17 citations
Semantic Scholar
Synthesis of a 2-benzazepine analog of a potent, nonpeptide GPIIb/IIIa antagonist
W. Miller, K. Newlander, D. Eggleston, R. Haltiwanger
199514 citations
Semantic Scholar
Discrimination in resolving systems. II: Ephedrine-substituted mandelic acids.
E. J. Valente, Christopher W. Miller, Jeffrey D. Zubkowski, D. Eggleston +1 more
1995Chirality13 citations
Semantic Scholar
Synthesis of conformationally restricted analogues of the tryptophanyl tRNA synthetase inhibitor indolmycin
D. Witty, G. Walker, J. Bateson, P. O'hanlon +2 more
199612 citations
Semantic Scholar
Nonpeptide HIV protease inhibitors designed to replace a bound water
B. Chenera, R. DesJarlais, J. Finkelstein, D. Eggleston +3 more
199312 citations
Semantic Scholar
(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid and related compounds: high affinity leukotriene B4 receptor antagonists.
R. A. Daines, P. A. Chambers, D. Eggleston, J. Foley +6 more
1994Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Heterochiral N-formyl methionyl peptides. Molecular conformation and crystal structures of N-f-L-Met-D-Phe and N-f-L-Met-D-Phe-OtBu.
D. Eggleston
2009International journal of peptide & protein research10 citations
Semantic Scholar
Hydrogen bonding patterns in trimethoprim sulfate trihydrate [trimethoprim = 2,4-diamino-5-(3,4,5-methoxybenzyl)pyrimidine]
Packianathan Thomas Muthiah, B. Umadevi, N. Stanley, Xiu-Qi Shui +1 more
200110 citations
Semantic Scholar
5,5-Dimethylthiazolidine-4-carboxylic acid (DTC) as a proline analog with restricted conformation.
J. Samanen, G. Zuber, J. W. Bean, D. Eggleston +4 more
2009International journal of peptide & protein research9 citations
Semantic Scholar
Conformational influences of N2-methylation in chemotactic peptides.
Peter W. Jeffs, Sarah L. Headl, Daniel F. Chodosh, D. Eggleston
2009International journal of peptide & protein research9 citations
Semantic Scholar
Conformation and structure of acidic dipeptides. Crystal structures of L-alanyl-L-aspartic acid and alpha-L-glutamyl-L-aspartic acid.
D. Eggleston, D. Hodgson
2009International journal of peptide & protein research9 citations
Semantic Scholar
New polyhydroxylated pregnadienes from the South African soft coral Pieterfaurea unilobata
D. Beukes, M. Davies-Coleman, D. Eggleston, R. Haltiwanger +1 more
19979 citations
Semantic Scholar
A screen for inhibitors of DNA recombination: identification of two new spirostanol glycosides from Chamaedorea linearis.
A. Patil, Paul W. Baures, D. Eggleston, Leo F. Faucette +3 more
1993Journal of Natural Products9 citations
Semantic Scholar
Guanidyl-carboxylate interactions: crystal structures of arginine dipeptides*
D. Eggleston, D. Hodgson
20098 citations
Semantic Scholar
Conformation and structure of acidic dipeptides. Crystal structure of glycyl-L-aspartic acid dihydrate.
D. Eggleston, D. Hodgson
2009International journal of peptide & protein research8 citations
Semantic Scholar
Synthesis of 6-Hydroxy-2-methyl-3-thioxo-2H-1,2,4-triazin-5-one
C. Branch, D. Eggleston, R. Haltiwanger, A. C. Kaura +1 more
19968 citations
Semantic Scholar
Synthesis and structure-activity relationships of macrocyclic FKBP ligands
J. Luengo, A. Konialian-Beck, M. Levy, M. Brandt +2 more
19947 citations
Semantic Scholar

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