Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

M. Spetea · SciRah

Researcher profile · Semantic Scholar

M. Spetea

Share profile

M. Spetea — researcher profile on SciRah

h-index: 31
Works: 127
Citations: 2,582

Most-cited papers

Opioid Analgesia and Opioid-Induced Adverse Effects: A Review
A. Paul, Craig M. Smith, M. Rahmatullah, V. Nissapatorn +4 more
2021Pharmaceuticals283 citations Open access
Semantic Scholar
In vivo Brain GPCR Signaling Elucidated by Phosphoproteomics
Jeffrey J. Liu, K. Sharma, Luca Zangrandi, Chong-Guang Chen +6 more
2018Science114 citations Open access
Semantic Scholar
μ Opioid receptor: novel antagonists and structural modeling
T. Kaserer, Aquilino Lantero, H. Schmidhammer, M. Spetea +1 more
2016Scientific Reports75 citations Open access
Semantic Scholar
Peripheral versus Central Antinociceptive Actions of 6-Amino Acid-Substituted Derivatives of 14-O-Methyloxymorphone in Acute and Inflammatory Pain in the Rat
S. Fürst, P. Riba, T. Friedmann, J. Tímár +8 more
2005Journal of Pharmacology and Experimental Therapeutics72 citations
Semantic Scholar
Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice
M. Spetea, S. Eans, Michelle L. Ganno, Aquilino Lantero +4 more
2017British Journal of Pharmacology71 citations Open access
Semantic Scholar
The µ opioid receptor and ligands acting at the µ opioid receptor, as therapeutics and potential therapeutics.
M. Spetea, M. F. Asim, Gerhard Wolber, H. Schmidhammer
2014Current pharmaceutical design63 citations
Semantic Scholar
Modulation of basal and stress‐induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L‐822429
N. Singewald, G. Chicchi, Clemens C. Thurner, Kwei-Lan C. Tsao +6 more
2008Journal of Neurochemistry59 citations Open access
Semantic Scholar
Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat.
I. Obara, W. Makuch, M. Spetea, J. Schütz +3 more
2007European Journal of Pharmacology55 citations
Semantic Scholar
Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor
Edin Muratspahić, Kristine Deibler, Jian-Ming Han, Nataša Tomašević +20 more
2023Nature Communications47 citations Open access
Semantic Scholar
Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.
D. Schuster, M. Spetea, Melisa Music, Silvia Rief +8 more
2010Bioorganic & Medicinal Chemistry43 citations Open access
Semantic Scholar
A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects
Armand Drieu la Rochelle, Karel Guillemyn, Maria Dumitrascuta, C. Martin +12 more
2018Pain38 citations Open access
Semantic Scholar
Discovery and biological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist
M. Spetea, I. Berzetei-Gurske, E. Guerrieri, J. Mallareddy +2 more
2012BMC Pharmacology and Toxicology38 citations Open access
Semantic Scholar
Anti-inflammatory effects of contralateral administration of the kappa-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis.
I. Bileviciute-Ljungar, Tore Saxne, M. Spetea
2006Rheumatology38 citations
Semantic Scholar
Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists
S. M. Noha, H. Schmidhammer, M. Spetea
2017ACS Chemical Neuroscience36 citations Open access
Semantic Scholar
Opioid receptors and their ligands in the musculoskeletal system and relevance for pain control.
M. Spetea
2014Current pharmaceutical design36 citations
Semantic Scholar
Peripherally Mediated Antinociception of the (cid:1) -Opioid Receptor Agonist 2-[(4,5 (cid:2) -Epoxy-3-hydroxy-14 (cid:3) -methoxy-17-methylmorphinan-6 (cid:3) -yl)amino]acetic Acid (HS-731) after Subcutaneous and Oral Administration in Rats with Carrageenan-Induced Hindpaw Inflammation
I. Bileviciute-Ljungar, M. Spetea, Yan Guo, J. Schütz +2 more
200636 citations
Semantic Scholar
Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists
T. Kaserer, Theresa Steinacher, Roman Kainhofer, Filippo Erli +4 more
2020Scientific Reports34 citations Open access
Semantic Scholar
In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel μ opioid analgesic with reduced propensity to alter motor function
M. Spetea, C. Bohotin, M. F. Asim, Kurt Stübegger +1 more
2010European Journal of Pharmaceutical Sciences34 citations Open access
Semantic Scholar
In vitro opioid activity profiles of 6-amino acid substituted derivatives of 14-O-methyloxymorphone.
M. Spetea, T. Friedmann, P. Riba, J. Schütz +4 more
2004European Journal of Pharmacology34 citations Open access
Semantic Scholar
Injectable peptide-based hydrogel formulations for the extended in vivo release of opioids
C. Martin, Edith Oyen, Y. Van Wanseele, Tanila Ben Haddou +10 more
201733 citations
Semantic Scholar
DAMGO and 6β-glycine substituted 14 -O -methyloxymorphone but not morphine show peripheral, preemptive antinociception after systemic administration in a mouse visceral pain model and high intrinsic efficacy in the isolated rat vas deferens
M. Al-Khrasani, M. Spetea, T. Friedmann, P. Riba +3 more
200732 citations
Semantic Scholar
On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance
S. Fürst, Z. Zádori, F. Zádor, K. Király +13 more
2020Molecules31 citations Open access
Semantic Scholar
Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity
Tanila Ben Haddou, S. Béni, S. Hosztafi, D. Malfacini +3 more
2014PLoS ONE31 citations Open access
Semantic Scholar
In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera
Karel Guillemyn, P. Kleczkowska, A. Novoa, Bart Vandormael +8 more
2012Molecular Brain31 citations Open access
Semantic Scholar
Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure–Activity Relationships
Filippo Erli, E. Guerrieri, Tanila Ben Haddou, Aquilino Lantero +3 more
2017Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Variation of the net charge, lipophilicity and side chain flexibility in Dmt1-DALDA: effect on opioid activity and biodistribution
A. Novoa, Sylvia Van Dorpe, E. Wynendaele, M. Spetea +11 more
2012Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Opioid peptides and receptors in joint tissues: Study in the rat
J. Bergström, M. Ahmed, Jian Li, T. Ahmad +2 more
2006Journal of Orthopaedic Research30 citations Open access
Semantic Scholar
Biodegradable Amphipathic Peptide Hydrogels as Extended-Release System for Opioid Peptides.
C. Martin, Maria Dumitrascuta, M. Mannes, Aquilino Lantero +10 more
2018Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.
R. Lattanzi, M. Spetea, F. Schüllner, Silvia Rief +3 more
2005Journal of Medicinal Chemistry29 citations Open access
Semantic Scholar
Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies
S. Gonzalez, Maria Dumitrascuta, Émilie Eiselt, St Louis +12 more
2020Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain
Camille Lagard, L. Chevillard, Karel Guillemyn, P. Risède +4 more
2016Pain26 citations Open access
Semantic Scholar
Injectable peptide hydrogels for controlled-release of opioids
C. Martin, Edith Oyen, Jeroen Mangelschots, Mathieu Bibian +8 more
201625 citations
Semantic Scholar
Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonist cyprodime.
M. Spetea, F. Schüllner, Radu C Moisa, I. Berzetei-Gurske +6 more
2004Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Fundamentals of the Dynorphins / Kappa Opioid Receptor System: From Distribution to Signaling and Function
C. Cahill, H. Tejeda, M. Spetea, Chong-Guang Chen +1 more
2021Handbook of Experimental Pharmacology20 citations Open access
Semantic Scholar
N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists
Maria Dumitrascuta, M. Bermudez, Tanila Ben Haddou, E. Guerrieri +9 more
2020Scientific Reports19 citations Open access
Semantic Scholar
Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor.
E. Guerrieri, J. Mallareddy, G. Tóth, H. Schmidhammer +1 more
2015ACS Chemical Neuroscience19 citations
Semantic Scholar
Immunopharmacology and in fl ammation Anti-in fl ammatory effect of dual nociceptin and opioid receptor agonist , BU 08070 , in experimental colitis in mice
M. Zieli, ska, Tanila Ben Haddou, G. Cami-Kobeci +5 more
201519 citations
Semantic Scholar
Synthesis of 14-alkoxymorphinan derivatives and their pharmacological actions.
H. Schmidhammer, M. Spetea
2011Topics in current chemistry18 citations
Semantic Scholar
Effect of a 6-cyano substituent in 14-oxygenated N-methylmorphinans on opioid receptor binding and antinociceptive potency.
M. Spetea, E. Greiner, M. Aceto, L. Harris +2 more
2005Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists
Maria Dumitrascuta, Tanila Ben Haddou, E. Guerrieri, S. M. Noha +3 more
2017Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening
Johanna K. Kaufmann, N. K. Blum, Falko Nagel, A. Schuler +17 more
2022bioRxiv15 citations Open access
Semantic Scholar
Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt1]DALDA, and KGOP01, Binding to the Mu Opioid Receptor
Maria Dumitrascuta, M. Bermudez, S. Ballet, Gerhard Wolber +1 more
2020Molecules15 citations Open access
Semantic Scholar
Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives
M. Spetea, Silvia Rief, Tanila Ben Haddou, Monika Fink +9 more
2018Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor
Tanila Ben Haddou, D. Malfacini, G. Calo, M. Aceto +5 more
2014Molecular Pain15 citations Open access
Semantic Scholar
Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking
Maria Dumitrascuta, M. Bermudez, Olga Trovato, Jolien De Neve +3 more
2021Molecules14 citations Open access
Semantic Scholar
Current κ opioid receptor ligands and discovery of a new molecular scaffold as a κ opioid receptor antagonist using pharmacophore-based virtual screening.
M. Spetea, M. F. Asim, S. M. Noha, Gerhard Wolber +1 more
2014Current pharmaceutical design14 citations
Semantic Scholar
Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
Kristina Puls, H. Schmidhammer, Gerhard Wolber, M. Spetea
2022Molecules13 citations Open access
Semantic Scholar
Contralateral, ipsilateral and bilateral treatments with the kappa-opioid receptor agonist U-50,488H in mononeuropathic rats.
I. Bileviciute-Ljungar, M. Spetea
2004European Journal of Pharmacology13 citations
Semantic Scholar
Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples
Edin Muratspahić, Andrew M. White, Cosmin I. Ciotu, Nadine Hochrainer +7 more
2023Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Development of Diphenethylamines as Selective Kappa Opioid Receptor Ligands and Their Pharmacological Activities
H. Schmidhammer, Filippo Erli, E. Guerrieri, M. Spetea
2020Molecules12 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

H. Schmidhammer×29
Invite
H. Schmidhammer — researcher profile on SciRah
S. Ballet×10
Invite
S. Ballet — researcher profile on SciRah
Tanila Ben Haddou×9
Invite
Tanila Ben Haddou — researcher profile on SciRah
Gerhard Wolber×7
Invite
Gerhard Wolber — researcher profile on SciRah

Maria Dumitrascuta

×7

Invite

Maria Dumitrascuta — researcher profile on SciRah

E. Guerrieri×7

Invite

E. Guerrieri — researcher profile on SciRah

Aquilino Lantero×5

Invite

Aquilino Lantero — researcher profile on SciRah

Invite

J. Schütz — researcher profile on SciRah

Invite

M. F. Asim — researcher profile on SciRah

Invite

C. Martin — researcher profile on SciRah

Invite

S. Fürst — researcher profile on SciRah

Invite

P. Riba — researcher profile on SciRah