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P. Lyne · SciRah

Researcher profile · Semantic Scholar

P. Lyne

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P. Lyne — researcher profile on SciRah

h-index: 31
Works: 104
Citations: 4,439

Most-cited papers

Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring.
P. Lyne, M. Lamb, J. Saeh
2006Journal of Medicinal Chemistry669 citations Open access
Semantic Scholar
Structure-based virtual screening: an overview.
P. Lyne
2002Drug Discovery Today624 citations
Semantic Scholar
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.
E. Keeton, K. McEachern, K. Dillman, Sangeetha Palakurthi +17 more
2014Blood241 citations Open access
Semantic Scholar
STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial.
M. Reilley, P. McCoon, C. Cook, P. Lyne +23 more
2018Journal of Immunotherapy for Cancer226 citations Open access
Semantic Scholar
On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors
Hong-Ming Chen, P. Lyne, F. Giordanetto, Timothy Lovell +1 more
2006Journal of Chemical Information and Modeling218 citations
Semantic Scholar
Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
Sarah J. Ross, Alexey S. Revenko, Lyndsey Hanson, Rebecca P A Ellston +13 more
2017Science Translational Medicine158 citations Open access
Semantic Scholar
A Hybrid QM−MM Potential Employing Hartree−Fock or Density Functional Methods in the Quantum Region
P. Lyne, M. Hodošček, M. Karplus
1999134 citations
Semantic Scholar
Self-organizing molecular field analysis: a tool for structure-activity studies.
Daniel D. Robinson, P. Winn, P. Lyne, W. Richards
1999Journal of Medicinal Chemistry133 citations
Semantic Scholar
AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies
G. Rhyasen, M. Hattersley, Yi Yao, A. Dulak +25 more
2016Molecular Cancer Therapeutics132 citations Open access
Semantic Scholar
Insights into Chorismate Mutase Catalysis from a Combined QM/MM Simulation of the Enzyme Reaction
P. Lyne, A. Mulholland, W. Richards
1995112 citations
Semantic Scholar
Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening.
P. Lyne, P. Kenny, David A. Cosgrove, C. Deng +3 more
2004Journal of Medicinal Chemistry109 citations Open access
Semantic Scholar
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.
L. Dakin, M. Block, Huawei Chen, Erin L. Code +14 more
2012Bioorganic & Medicinal Chemistry Letters98 citations Open access
Semantic Scholar
Ab initio QM/MM study of the citrate synthase mechanism. A low-barrier hydrogen bond is not involved
A. Mulholland, P. Lyne, M. Karplus
200094 citations
Semantic Scholar
Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer
A. Revenko, L. Carnevalli, C. Sinclair, Ben Johnson +24 more
2022Journal for ImmunoTherapy of Cancer77 citations Open access
Semantic Scholar
Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.
Vibha B. Oza, S. Ashwell, L. Almeida, P. Brassil +21 more
2012Journal of Medicinal Chemistry72 citations Open access
Semantic Scholar
Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.
Tao Wang, M. Lamb, David A. Scott, Haixia Wang +18 more
2008Journal of Medicinal Chemistry71 citations Open access
Semantic Scholar
Inhibitors of checkpoint kinases: from discovery to the clinic.
J. Janetka, S. Ashwell, S. Zabludoff, P. Lyne
2007Current opinion in drug discovery & development61 citations
Semantic Scholar
Lead Hopping Using SVM and 3D Pharmacophore Fingerprints
J. Saeh, P. Lyne, B. Takasaki, David A. Cosgrove
2005Journal of Chemical Information and Modeling60 citations Open access
Semantic Scholar
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
J. Johannes, L. Almeida, K. Daly, A. Ferguson +23 more
2015Bioorganic & Medicinal Chemistry Letters56 citations Open access
Semantic Scholar
BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors
G. Rhyasen, Yi Yao, Jingwen Zhang, A. Dulak +11 more
2018PLoS ONE55 citations Open access
Semantic Scholar
Discovery of (2R)-N-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a potent and selective Janus Kinase 1 (JAK1) inhibitor.
Qibin Su, E. Banks, G. Bebernitz, Kirsten Bell +23 more
2020Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.
J. Dowling, M. Alimzhanov, Larry Bao, C. Chuaqui +10 more
2016ACS Medicinal Chemistry Letters49 citations Open access
Semantic Scholar
Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.
Tao Wang, M. Lamb, M. Block, Audrey M Davies +15 more
2012ACS Medicinal Chemistry Letters46 citations Open access
Semantic Scholar
Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.
J. Dowling, M. Alimzhanov, Larry Bao, M. Block +14 more
2013ACS Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.
J. Dowling, C. Chuaqui, Timothy W Pontz, P. Lyne +17 more
2012ACS Medicinal Chemistry Letters42 citations Open access
Semantic Scholar
Molecular structure, gas-phase acidity and basicity of N-hydroxyurea
M. Remko, P. Lyne, W. Richards
199941 citations
Semantic Scholar
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.
Ze-Bin Wang, S. Grosskurth, Tony Cheung, P. Petteruti +21 more
2018Cancer Research40 citations Open access
Semantic Scholar
Modelling the catalytic reaction in human aldose reductase
P. Várnai, W. Richards, P. Lyne
1999Proteins: Structure, Function, and Bioinformatics34 citations
Semantic Scholar
COMBINED QUANTUM AND MOLECULAR MECHANICAL STUDY OF DNA CROSS-LINKING BY NITROUS ACID
A. Elcock, P. Lyne, A. Mulholland, A. Nandra +1 more
199533 citations
Semantic Scholar
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
J. Janetka, L. Almeida, S. Ashwell, P. Brassil +17 more
2008Bioorganic & Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
M. Vasbinder, Brian Aquila, M. Augustin, Huawei Chen +21 more
2013Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Determination of the pKaof the 2‘-Hydroxyl Group of a Phosphorylated Ribose: Implications for the Mechanism of Hammerhead Ribozyme Catalysis
P. Lyne, M. Karplus
200030 citations
Semantic Scholar
Investigation of the trans influence in transition-metal nitride complexes
P. Lyne, D. M. Mingos
199527 citations
Semantic Scholar
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
N. Grimster, Erica K. Anderson, M. Alimzhanov, G. Bebernitz +25 more
2018Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Vibha B. Oza, S. Ashwell, P. Brassil, J. Breed +14 more
2012Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors.
Bin Yang, M. Vasbinder, A. Hird, Qibin Su +13 more
2018Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.
E. Hennessy, Vibha B. Oza, Ammar Adam, K. Byth +15 more
2015Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Molecular Orbital Analysis of the Intermediates and Products Generated by the Photooxidation of Iron Pentacarbonyl
P. Lyne, D. M. Mingos, T. Ziegler, A. J. Downs
199322 citations
Semantic Scholar
Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.
David A. Scott, B. Aquila, G. Bebernitz, D. Cook +8 more
2008Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
Molecular modeling of the GM‐CSF and IL‐3 receptor complexes
P. Lyne, P. Bamborough, D. Duncan, W. Richards
1995Protein Science21 citations Open access
Semantic Scholar
The effects of back-bonding to phosphines on the trans influence in [Mo(NH)Cl3(PR3)2]0,±1 (R H, Me and F)
P. Lyne, D. M. Mingos
199420 citations
Semantic Scholar
1135OPhase 1b/2 Study (SCORES) assessing safety, tolerability, and preliminary anti-tumor activity of durvalumab plus AZD9150 or AZD5069 in patients with advanced solid malignancies and squamous cell carcinoma of the head and neck (SCCHN)
E. Cohen, D. Hong, T. Draper, W. William +9 more
201719 citations Open access
Semantic Scholar
Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression
A. Borodovsky, Yanjun Wang, M. Ye, J. Shaw +16 more
201717 citations
Semantic Scholar
Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
L. Gingipalli, M. Block, Larry Bao, E. Cooke +14 more
2018Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
A phase I dose escalation, safety and pharmacokinetic (PK) study of AZD5312 (IONIS-ARRx), a first-in-class Generation 2.5 antisense oligonucleotide targeting the androgen receptor (AR)
S. Chowdhury, H. Burris, Maitray D. Patel, J. Infante +8 more
201615 citations
Semantic Scholar
Partial Molecular Alignment via Local Structure Analysis
Daniel D. Robinson, P. Lyne, W. Richards
2000Journal of chemical information and computer sciences15 citations
Semantic Scholar
A partial model of the erythropoietin receptor complex
Justin A. Caravella, P. Lyne, W. Richards
1996Proteins: Structure, Function, and Bioinformatics15 citations
Semantic Scholar
Alignment of 3D-Structures by the Method of 2D-Projections
Daniel D. Robinson, P. Lyne, W. Richards
1999Journal of chemical information and computer sciences12 citations
Semantic Scholar
A theoretical study of Te64+ and Te4S42+
P. Lyne, D. M. Mingos, T. Ziegler
199212 citations
Semantic Scholar
Population pharmacokinetic analysis of danvatirsen supporting flat dosing switch
Hongmei Xu, Xiao Tong, G. Mugundu, M. Scott +6 more
2019Journal of Pharmacokinetics and Pharmacodynamics11 citations
Semantic Scholar

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