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L. Carnevalli · SciRah

Researcher profile · Semantic Scholar

L. Carnevalli

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L. Carnevalli — researcher profile on SciRah

h-index: 21
Works: 47
Citations: 1,566

Most-cited papers

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
R. Scognamiglio, Nina Cabezas-Wallscheid, M. Thier, S. Altamura +18 more
2016Cell259 citations Open access
Semantic Scholar
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
L. Carnevalli, K. Masuda, F. Frigerio, O. Le Bacquer +6 more
2010Developmental Cell203 citations Open access
Semantic Scholar
Combined inhibition of mTOR and CDK4/6 is required for optimal blockade of E2F function and long term growth inhibition in estrogen receptor positive breast cancer
C. Michaloglou, C. Crafter, Rasmus Siersbæk, O. Delpuech +10 more
2018Molecular Cancer Therapeutics153 citations Open access
Semantic Scholar
Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery
Molly A. Taylor, Adina M. Hughes, Joseph Walton, A. Coenen-Stass +9 more
2019Journal of Immunotherapy for Cancer83 citations Open access
Semantic Scholar
Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer
A. Revenko, L. Carnevalli, C. Sinclair, Ben Johnson +24 more
2022Journal for ImmunoTherapy of Cancer77 citations Open access
Semantic Scholar
PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity
L. Carnevalli, C. Sinclair, Molly A. Taylor, P. Gutierrez +11 more
2018Journal of Immunotherapy for Cancer77 citations Open access
Semantic Scholar
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment
Elizabeth L Hardaker, E. Sanseviero, Ankur Karmokar, Devon Taylor +52 more
2024Nature Communications65 citations
Semantic Scholar
The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER+ Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance
M. Lawson, Natalie Cureton, S. Ros, Azadeh Cheraghchi-Bashi +33 more
2023Cancer Research61 citations Open access
Semantic Scholar
Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity
Sophie Langdon, Adina M. Hughes, Molly A. Taylor, E. Kuczynski +7 more
2018Oncoimmunology57 citations Open access
Semantic Scholar
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response
Dimitra Georgopoulou, Maurizio Callari, O. Rueda, A. Shea +19 more
2021Nature Communications52 citations Open access
Semantic Scholar
Translation initiation at non-AUG codons mediated by weakened association of eukaryotic initiation factor (eIF) 2 subunits.
N. N. Hashimoto, L. Carnevalli, B. A. Castilho
2002Biochemical Journal50 citations Open access
Semantic Scholar
STAT3 Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1
T. Proia, Maneesh Singh, R. Woessner, L. Carnevalli +19 more
2020Clinical Cancer Research48 citations Open access
Semantic Scholar
Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer
Álvaro Avivar-Valderas, R. McEwen, Amir Taheri-Ghahfarokhi, L. Carnevalli +5 more
2018OncoTarget48 citations Open access
Semantic Scholar
Genome Engineering For Estrogen Receptor Mutations Reveals Differential Responses To Anti-Estrogens And New Prognostic Gene Signatures For Breast Cancer
Alison Harrod, C. Lai, Isabella Goldsbrough, Georgia M. Simmons +16 more
2022Oncogene37 citations Open access
Semantic Scholar
Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer
F. C. Martins, D. Couturier, I. de Santiago, Carolin M. Sauer +29 more
2022Nature Communications36 citations Open access
Semantic Scholar
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
Silvia Basilico, Xiao-Nan Wang, A. Kennedy, K. Tzelepis +10 more
2020Nature Communications35 citations Open access
Semantic Scholar
Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.
L. Carnevalli, Cátia Pereira, Carolina B. Jaqueta, V. S. Alves +5 more
2006Biochemical Journal31 citations Open access
Semantic Scholar
Metabolic Control by S6 Kinases Depends on Dietary Lipids
T. Castaňeda, William Abplanalp, S. Um, P. Pfluger +13 more
2012PLoS ONE28 citations Open access
Semantic Scholar
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B
L. Carnevalli, R. Scognamiglio, Nina Cabezas-Wallscheid, Susann Rahmig +10 more
2014Journal of Experimental Medicine25 citations Open access
Semantic Scholar
Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach
T. I. Johnson, Christopher Minteer, Daniel Kottmann, Charles R. Dunlop +6 more
2021EBioMedicine22 citations Open access
Semantic Scholar
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.
L. Carnevalli, Cátia Pereira, B. Longo, Carolina B. Jaqueta +3 more
2004Neuroscience Letters21 citations
Semantic Scholar
Modeling Dose and Schedule Effects of AZD2811 Nanoparticles Targeting Aurora B Kinase for Treatment of Diffuse Large B-cell Lymphoma
Nicolas Floc’h, S. Ashton, Douglas Ferguson, P. Taylor +11 more
2019Molecular Cancer Therapeutics20 citations Open access
Semantic Scholar
Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models
Lorna Hopcroft, E. Wigmore, S. Williamson, S. Ros +17 more
2023npj Breast Cancer17 citations Open access
Semantic Scholar
Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition
L. Carnevalli, Molly A. Taylor, M. King, A. Coenen-Stass +15 more
2021Molecular Cancer Therapeutics17 citations Open access
Semantic Scholar
Therapeutic Approaches Targeting the Natural Killer-Myeloid Cell Axis in the Tumor Microenvironment
L. Carnevalli, H. Ghadially, S. Barry
2021Frontiers in Immunology11 citations Open access
Semantic Scholar
A phase 1/2 study of the combination of acalabrutinib and vistusertib in patients with relapsed/refractory B-cell malignancies
G. Collins, Tracy N Clevenger, K. Burke, Bu-Yue Yang +24 more
2021Leukemia and Lymphoma7 citations Open access
Semantic Scholar
Tuning mTORC1 activity for balanced self-renewal and differentiation.
L. Carnevalli, A. Trumpp
2010Developmental Cell7 citations Open access
Semantic Scholar
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability
E. Kuczynski, Giulia Morlino, A. Peter, A. Coenen-Stass +8 more
2022EMBO Molecular Medicine6 citations Open access
Semantic Scholar
Abstract 1207: Reversing lactate-driven immunosuppression using the novel, potent and selective MCT4 inhibitor AZD0095
S. Critchlow, G. Hughes, Anna D. Staniszewska, M. King +9 more
2019Experimental and Molecular Therapeutics6 citations
Semantic Scholar
Abstract P3-07-13: The next generation oral selective estrogen receptor degrader (SERD) camizestrant (AZD9833) is active against wild type and mutant estrogen receptor α
Christopher Morrow, L. Carnevalli, R. Baird, T. Brier +35 more
2023Cancer Research4 citations Open access
Semantic Scholar
Longitudinal tracking of T cell lymphomas in mice using flow cytometry
E. Kuczynski, L. Carnevalli, C. Sinclair
2023STAR Protocols3 citations Open access
Semantic Scholar
Abstract 100: Novel selective PI3Kγ inhibitor AZD3458 promotes anti-tumor immune responses and reverts resistance to immunotherapy in checkpoint blockade refractory preclinical models
L. Carnevalli, Danielle Carrol, M. Moschetta, P. Gutierrez +7 more
2019Tumor Biology2 citations Open access
Semantic Scholar
Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer
F. C. Martins, D. Couturier, I. de Santiago, Carolin M. Sauer +28 more
2020bioRxiv1 citations Open access
Semantic Scholar
Abstract PD4-04: Combined inhibition of mTOR and CDK4/6 is required for optimal blockade of E2F function and long term growth inhibition in estrogen receptor positive breast cancer
E. Oelmann, C. Michaloglou, C. Crafter, Rasmus Siersbæk +11 more
20181 citations
Semantic Scholar
Abstract LB195: Immunotherapies that repolarize macrophages and CD4 T cells enhance the effect of chemotherapy in high-grade serous ovarian cancer
Samar Elorbany, Chiara Berlato, L. Carnevalli, E. Maniati +5 more
2023Cancer Research0 citations
Semantic Scholar
Abstract PD10-04: PD10-04 Combination of the next generation oral SERD camizestrant (AZD9833) with CDK4/6 and mTOR/AKT inhibitors delivers robust efficacy in a broad range of ER+ breast tumors
L. Carnevalli, S. Ros, J. Urosevic, Natalie Cureton +9 more
2023Cancer Research0 citations
Semantic Scholar
877 Intermittent dosing of the ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib promotes antitumor immunity by remodelling the tumor immune microenvironment in pre-clinical models
E. Hardaker, Ankur Karmokar, Marta Milo, C. Michaloglou +19 more
2023Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
Author Correction: Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models
Lorna Hopcroft, E. Wigmore, Stuart C Williamson, S. Ros +17 more
2023npj Breast Cancer0 citations Open access
Semantic Scholar
Author Correction: Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models
Lorna Hopcroft, E. Wigmore, S. Williamson, S. Ros +17 more
2023npj Breast Cancer0 citations Open access
Semantic Scholar
3114 – FROM MECHANISMS OF LEUKAEMOGENIC DYSREGULATION TO NEW CANDIDATE THERAPEUTICS
A. Kennedy, F. Nieto, L. Carnevalli, B. Gottgens +2 more
2022Experimental Hematology0 citations
Semantic Scholar
Abstract PO-20: Molecular characterization of a mouse model of peripheral T-cell lymphoma with Tfh and Th2 features
E. Kuczynski, Giulia Morlino, A. Peter, D. Calado +2 more
20200 citations
Semantic Scholar
Modelling dose and schedule effects of AZD2811 nanoparticles targeting Aurora B kinase for treatment of diffuse large B-cell lymphoma
S. Ashton, Douglas Ferguson, P. Taylor, L. Carnevalli +10 more
20190 citations
Semantic Scholar
Abstract 104: Mechanistic insights and dose optimization for AZD3458, a novel selective PI3Kg immuno-modulator, using a quantitative systems approach
P. Gutierrez, Yuri Kosinsky, K. Peskov, Ivan Azarov +9 more
2019Tumor Biology0 citations Open access
Semantic Scholar
PO-491 Single-cell phenotypic profiling of breast cancerpatient-derived tumour xenografts using mass cytometry
Dimitra Georgopoulou, Maurizio Callari, Alistair G Martin, O. Rueda +6 more
2018ESMO Open0 citations Open access
Semantic Scholar
Additional file 8: of PI3KÎą/Î´ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity
L. Carnevalli, C. Sinclair, Molly A. Taylor, P. Gutierrez +11 more
20180 citations
Semantic Scholar
Combined Inhibition of mTOR and BTK Signaling Is Required for Optimal Long Term Growth Inhibition in DLBCL Models
W. Brugger, M. Hattersley, A. Bussey, C. Reimer +14 more
20170 citations
Semantic Scholar
Thomas and Autophagy in Hepatocellular Carcinoma mTOR Inhibitors Synergize on Regression , Reversal of Gene Expression
H. E. Thomas, C. Mercer, L. Carnevalli, Jongsun Park +12 more
20120 citations
Semantic Scholar

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