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N. Grimster · SciRah

Researcher profile · Semantic Scholar

N. Grimster

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N. Grimster — researcher profile on SciRah

h-index: 18
Works: 51
Citations: 2,828

Most-cited papers

Cu(II)-catalyzed direct and site-selective arylation of indoles under mild conditions.
Robert J. Phipps, N. Grimster, M. Gaunt
2008Journal of the American Chemical Society647 citations
Semantic Scholar
Palladium-catalyzed intermolecular alkenylation of indoles by solvent-controlled regioselective C-H functionalization.
N. Grimster, Carolyn Gauntlett, C. R. A. Godfrey, M. Gaunt
2005Angewandte Chemie508 citations
Semantic Scholar
Toward the Molecular Mechanism(s) by which EGCG Treatment Remodels Mature Amyloid Fibrils
F. Palhano, Ji-Yong Lee, N. Grimster, J. Kelly
2013Journal of the American Chemical Society330 citations Open access
Semantic Scholar
Mild aerobic oxidative palladium (II) catalyzed C-H bond functionalization: regioselective and switchable C-H alkenylation and annulation of pyrroles.
E. Beck, N. Grimster, R. Hatley, M. Gaunt
2006Journal of the American Chemical Society277 citations
Semantic Scholar
Synthesis and Reactivity of Rhodium(II) N-Triflyl Azavinyl Carbenes
N. Grimster, Li Zhang, V. Fokin
2010Journal of the American Chemical Society176 citations Open access
Semantic Scholar
Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.
Gizem Akçay, M. Belmonte, B. Aquila, C. Chuaqui +7 more
2016Nature Chemical Biology166 citations Open access
Semantic Scholar
Catalytic Asymmetric Transannulation of NH-1,2,3-Triazoles with Olefins
S. Kwok, Li Zhang, N. Grimster, V. Fokin
2014Angewandte Chemie135 citations Open access
Semantic Scholar
A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.
Herschel Mukherjee, J. Debreczeni, J. Breed, Sharon Tentarelli +4 more
2017Organic and biomolecular chemistry81 citations
Semantic Scholar
Beyond cysteine: recent developments in the area of targeted covalent inhibition.
Herschel Mukherjee, N. Grimster
2018Current Opinion in Chemical Biology80 citations
Semantic Scholar
Discovery of (2R)-N-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a potent and selective Janus Kinase 1 (JAK1) inhibitor.
Qibin Su, E. Banks, G. Bebernitz, Kirsten Bell +23 more
2020Journal of Medicinal Chemistry50 citations Open access
Semantic Scholar
Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease
S. D. Orwig, Y. Tan, N. Grimster, Zhan-Qian Yu +3 more
2011Biochemistry37 citations Open access
Semantic Scholar
Alkynes to (E)-enolates using tandem catalysis: stereoselective anti-aldol and syn-[3,3]-rearrangement reactions
N. Grimster, D. Wilton, L. M. Chan, Godfrey Christopher Richard Ay +3 more
201037 citations
Semantic Scholar
Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1
J. Kettle, A. Åstrand, M. Catley, N. Grimster +3 more
2017Expert Opinion on Therapeutic Patents34 citations
Semantic Scholar
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
N. Grimster, Erica K. Anderson, M. Alimzhanov, G. Bebernitz +25 more
2018Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Covalent PROTACs: the best of both worlds?
N. Grimster
2021RSC Medicinal Chemistry22 citations Open access
Semantic Scholar
Parallel synthesis of 1,2,4-trisubstituted imidazoles via N-alkyl-N-(β-keto)amides using a carbazate linker
James M. Cobb, N. Grimster, N. Khan, Justine Y. Q. Lai +4 more
200221 citations
Semantic Scholar
Synthesis of Selective Agonists for the α7 Nicotinic Acetylcholine Receptor with In Situ Click-Chemistry on Acetylcholine-Binding Protein Templates
John G. Yamauchi, Kimberly Gomez, N. Grimster, Mikael Dufouil +7 more
2012Molecular Pharmacology20 citations Open access
Semantic Scholar
Expedient synthesis of MLN1251, a CCR5 antagonist for treatment of HIV
M. Ronn, Q. Mccubbin, Steve Winter, Melanie K. Veige +3 more
200718 citations
Semantic Scholar
Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2
J. Kettle, A. Åstrand, M. Catley, N. Grimster +3 more
2017Expert Opinion on Therapeutic Patents17 citations
Semantic Scholar
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.
Jeffrey A. Boerth, Alex J Chinn, M. Schimpl, Gayathri Bommakanti +24 more
2023ACS Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.
Jason D. Shields, David Baker, Amber Y. S. Balazs, Gayathri Bommakanti +61 more
2025Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
M. Nilsson, Kristina Berggren, Susanne Berglund, S. Cerboni +16 more
2023Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils.
Luiza Fernandes, N. Moraes, F. S. Sagrillo, A. Magalhães +6 more
2017ACS Chemical Neuroscience14 citations
Semantic Scholar
Selective Janus kinase 1 inhibition resolves inflammation and restores hair growth offering a viable treatment option for alopecia areata
J. Mattsson, E. Israelsson, Karin Björhall, L. Yrlid +16 more
2023Skin Health and Disease13 citations Open access
Semantic Scholar
Discovery and optimization of covalent Bcl-xL antagonists.
Herschel Mukherjee, Nancy Su, M. Belmonte, D. Hargreaves +4 more
2019Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
Adelphe M. Mfuh, Jeffrey A. Boerth, Gayathri Bommakanti, Christina Chan +33 more
2024Journal of Medicinal Chemistry12 citations Open access
Semantic Scholar
Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors.
N. Grimster, L. Gingipalli, B. Barlaam, Qibin Su +29 more
2009Bioorganic & Medicinal Chemistry Letters11 citations
Semantic Scholar
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.
Taylor R. Quinn, K. Giblin, Clare Thomson, Jeffrey A. Boerth +22 more
2024Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Fluorogenic Small Molecules Requiring Reaction with a Specific Protein to Create a Fluorescent Conjugate for Biological Imaging–What we Know and What we Need to Learn
Aleksandra Baranczak, S. Connelly, Yu Liu, Sungwook Choi +4 more
2014Biopolymers10 citations Open access
Semantic Scholar
Preparation of kinase‐biased compounds in the search for lead inhibitors of kinase targets
Justine Y. Q. Lai, S. Langston, Ruth Adams, R. Beevers +30 more
2005Medicinal research reviews (Print)9 citations
Semantic Scholar
Optimization of a Series of Novel, Potent and Selective Macrocyclic SYK Inhibitors.
N. Grimster, L. Gingipalli, Amber Y. S. Balazs, B. Barlaam +33 more
2023Bioorganic & Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Abstract 979: Discovery of the JAK1 selective kinase inhibitor AZD4205
J. Kettle, Qibin Su, N. Grimster, Sameer Kawatkar +11 more
20174 citations
Semantic Scholar
Generative AI-Assisted Discovery of HPK1 Inhibitors.
K. Giblin, Kun Song, Hong-Ming Chen, Weijie Chen +19 more
2026Journal of Medicinal Chemistry2 citations
Semantic Scholar
Abstract 3453: First disclosure of a highly potent and selective HPK1 inhibitor that rescues T cell exhaustion
Deanna A. Mele, N. Grimster, Gayathri Bommakanti, Jason Shields +13 more
2023Cancer Research2 citations
Semantic Scholar
Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.
A. J. Metrano, Lucas A Morrill, Gayathri Bommakanti, Robert Casella +30 more
2025RSC Medicinal Chemistry1 citations
Semantic Scholar
Freeze‐Frame Click‐Chemistry Synthesis on a Soluble Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR) Ligand Binding Domain
Á. Nemecz, T. Talley, Joseph R. Fotsing, Timo Weide +5 more
20081 citations
Semantic Scholar
Palladium-Catalyzed Regioselective Direct C-2 and C-3 Functionalization of Indoles
N. Grimster, Carolyn Gauntlett, C. R. A. Godfrey, M. Gaunt
20051 citations
Semantic Scholar
The Design of Covalent-Based Inhibitors: Preface
Richard A Ward, N. Grimster
2021The Design of Covalent-Based Inhibitors0 citations
Semantic Scholar
Abstract A56: Releasing the brake on T-cell activation through inhibition of HPK1
N. Grimster, L. Drew, S. Fawell, Deanna A. Mele +8 more
20200 citations
Semantic Scholar
Human FGF in complex with a covalent inhibitor
J. Debreczeni, J. Breed, Herschel Mukherjee, B. Aquila +4 more
20180 citations
Semantic Scholar
Abstract C40: Inhibition of Mcl-1 through covalent modification of a non-catalytic lysine side chain
Qibin Su, Gizem Akçay, N. Grimster, M. Belmonte +4 more
20150 citations
Semantic Scholar
Synthesizing Selective Agonists for the α 7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates
John G. Yamauchi, Kimberly Gomez, N. Grimster, Mikael Dufouil +7 more
20120 citations
Semantic Scholar
Generation of selective ligands for nicotinic acetylcholine receptors
John G. Yamauchi, Á. Nemecz, Kimberly Gomez, Kwok-yiu Ho +8 more
20120 citations
Semantic Scholar
Ligand design for human nicotinic acetylcholine receptors using in situ freeze‐frame click chemistry
John G. Yamauchi, Á. Nemecz, Kwok-yiu Ho, Joseph R. Fotsing +7 more
20100 citations
Semantic Scholar
Rhodium-Catalyzed Asymmetric Cyclopropanation via AzavinylCarbenoids
N. Grimster, Li Zhang, V. Fokin
20100 citations
Semantic Scholar
Alkynes to (E)‐Enolates Using Tandem Catalysis: Stereoselective anti‐Aldol and syn‐[3,3]‐Rearrangement Reactions.
N. Grimster, D. Wilton, L. M. Chan, C. R. A. Godfrey +3 more
20100 citations
Semantic Scholar
A structure‐guided design strategy to develop ligands with subtype selectivity for human nicotinic acetylcholine receptors
John G. Yamauchi, Á. Nemecz, Kwok-yiu Ho, Joseph R. Fotsing +9 more
20090 citations
Semantic Scholar
Soluble templates for drug design: the acetylcholine binding proteins and freeze‐frame, “click” chemistry for in situ synthesis of nicotinic ligands
T. Talley, Joseph R. Fosting, Timo Weide, N. Grimster +3 more
20080 citations
Semantic Scholar
Direct Cu(II)-Catalyzed Arylation of Indoles: SwitchableRegioselectivity
Robert J. Phipps, N. Grimster, M. Gaunt
20080 citations
Semantic Scholar
Mild Aerobic Oxidative Palladium (II) Catalyzed C—H Bond Functionalization: Regioselective and Switchable C—H Alkenylation and Annulation of Pyrroles.
E. Beck, N. Grimster, R. Hatley, M. Gaunt
20060 citations
Semantic Scholar

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