Researcher profile · Semantic Scholar

Sarah J. Ross

h-index: 12
Works: 30
Citations: 950

Most-cited papers

Acquired resistance to mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models
C. Eberlein, Daniel B. Stetson, A. Markovets, K. Al-Kadhimi +19 more
2015Cancer Research296 citations Open access
Semantic Scholar
Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
Sarah J. Ross, Alexey S. Revenko, Lyndsey Hanson, Rebecca P A Ellston +13 more
2017Science Translational Medicine158 citations Open access
Semantic Scholar
Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines
E. Linnane, Paul R. J. Davey, P. Zhang, Sanyogitta Puri +6 more
2019Nucleic Acids Research95 citations Open access
Semantic Scholar
AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo
Sarah A. Loddick, Sarah J. Ross, A. Thomason, David M Robinson +21 more
2013Molecular Cancer Therapeutics70 citations Open access
Semantic Scholar
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations
J. Boumelha, S. de Carné Trécesson, Emily K Law, P. Romero-Clavijo +22 more
2022Cancer Research62 citations Open access
Semantic Scholar
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C.
J. Kettle, S. Bagal, Sue Bickerton, M. Bodnarchuk +38 more
2022Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
D. Jenkins, Sarah J. Ross, Margaret H Veldman-Jones, I. Foltz +14 more
2012Molecular Cancer Therapeutics55 citations
Semantic Scholar
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
J. Kettle, S. Bagal, D. Barratt, M. Bodnarchuk +41 more
2023Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Emerging approaches to target tumor metabolism.
Sarah J. Ross, S. Critchlow
2014Current opinion in pharmacology (Print)24 citations
Semantic Scholar
Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition
Tereza Vaclová, A. Chakraborty, James L Sherwood, Sarah J. Ross +4 more
2022Scientific Reports20 citations Open access
Semantic Scholar
Specific targeting of the KRAS mutational landscape in myeloma as a tool to unveil the elicited anti-tumor activity.
A. Sacco, C. Federico, K. Todoerti, B. Ziccheddu +30 more
2021Blood20 citations Open access
Semantic Scholar
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling
A. Kapustin, Paul R. J. Davey, D. Longmire, Carl Matthews +12 more
2021Communications Biology15 citations Open access
Semantic Scholar
Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer
H. Khawaja, Rebecca Briggs, C. Latimer, Mustasin Rassel +15 more
2022bioRxiv11 citations Open access
Semantic Scholar
AZD4625 is a Potent and Selective Inhibitor of KRASG12C
A. Chakraborty, Lyndsey Hanson, David M Robinson, H. Lewis +18 more
2022Molecular Cancer Therapeutics6 citations Open access
Semantic Scholar
An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations
J. Boumelha, S. de Carné Trécesson, Emily K Law, P. Romero-Clavijo +22 more
2020bioRxiv6 citations Open access
Semantic Scholar
Abstract 3848: Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
Sarah A. Loddick, R. Bradbury, Nicola Broadbent, H. Campbell +14 more
20126 citations
Semantic Scholar
Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases
C. Hurd, P. Brear, J. Revell, Sarah J. Ross +2 more
2020Journal of Biological Chemistry5 citations Open access
Semantic Scholar
Specific Targeting of KRAS Using a Novel High-Affinity KRAS Antisense Oligonucleotide in Multiple Myeloma
A. Sacco, C. Federico, K. Todoerti, B. Ziccheddu +25 more
2019Blood4 citations Open access
Semantic Scholar
Ras proteins as therapeutic targets.
A. Chakraborty, E. Linnane, Sarah J. Ross
2018Biochemical Society Transactions4 citations
Semantic Scholar
Combinatorial approaches for mitigating resistance to KRAS-targeted therapies
H. R. Warren, Sarah J. Ross, Paul D. Smith, J. Coulson +1 more
2022Biochemical Journal3 citations Open access
Semantic Scholar
Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases.
C. Hurd, P. Brear, J. Revell, Sarah J. Ross +2 more
2020Journal of Biological Chemistry1 citations Open access
Semantic Scholar
Abstract 558: Targeting tumour heparanase activity using fully human monoclonal antibodies
P. Rathanaswami, Oscar Pan, Sarah J. Ross, C. King +2 more
20111 citations
Semantic Scholar
Bcl-xL and association with apoptosis following KRASG12C inhibition in KRASG12C mutant colorectal cancer.
H. Khawaja, Rebecca Briggs, C. Latimer, Md A.M.B. Rassel +15 more
2022Journal of Clinical Oncology0 citations
Semantic Scholar
Abstract 1619: Characterising the in vivo response of lung tumors to KrasG12C inhibition
C. Martins, A. Bidar, Lillevi Karrberg, M. Porritt +10 more
2020Prevention, Early Detection, and Interception0 citations
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Abstract 5095: Development of a pharmacodynamic biomarker assay for AZD4785, an antisense oligonucleotide targeting KRAS
C. Rooney, Sarah J. Ross, Anna D. Staniszewska, Sabine Lennarz +7 more
20170 citations
Semantic Scholar
Abstract PR05: ERK pathway activation is associated with acquired resistance to AZD9291, a third-generation irreversible inhibitor targeting EGFR sensitizing (EGFRm+) and resistance (T790M) mutations in NSCLC
C. Eberlein, K. Al-Kadhimi, Sarah J. Ross, Henry Brown +7 more
20150 citations
Semantic Scholar
Abstract PR12: Discovery and preclinical evaluation of cEt-modified KRAS antisense oligonucleotide inhibitors
A. Revenko, Sarah J. Ross, Lyndsey Hanson, Rebecca P A Ellston +10 more
20150 citations
Semantic Scholar
Abstract A152: Novel autotaxin inhibitory antibodies block lysophosphatidic acid production in plasma and tumour cell proliferation in vitro
Sarah J. Ross, S. Collins, J. Jovanovic, J. Kendrew +4 more
20150 citations
Semantic Scholar
Small Molecule Therapeutics AZD 3514 : A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo
Sarah A. Loddick, Sarah J. Ross, A. Thomason, David M Robinson +21 more
20130 citations
Semantic Scholar
Abstract B127: Establishment and characterization of in vitro co-culture assays comprising tumor and fibroblast cells that more closely model the cell/stroma interactions of human tumors.
C. Eberlein, Sarah J. Ross, C. Rooney, M. Farren +2 more
20110 citations
Semantic Scholar

David M Robinson

×5

C. Eberlein×4

Anna D. Staniszewska×4

A. Chakraborty×4

A. Macleod×4

P. Lyne×3

E. Linnane×3

Sarah A. Loddick×3