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P. Kenny · SciRah

Researcher profile · Semantic Scholar

P. Kenny

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P. Kenny — researcher profile on SciRah

h-index: 29
Works: 68
Citations: 2,641

Most-cited papers

Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.
A. Leach, Huw D. Jones, David A. Cosgrove, P. Kenny +5 more
2006Journal of Medicinal Chemistry254 citations
Semantic Scholar
Hydrogen-Bond Donors in Drug Design.
P. Kenny
2021Journal of Medicinal Chemistry208 citations
Semantic Scholar
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
Melissa L. Boby, D. Fearon, Matteo P. Ferla, Mihajlo Filep +208 more
2020bioRxiv167 citations Open access
Semantic Scholar
Structure Modification in Chemical Databases
P. Kenny, J. Sadowski
2005165 citations
Semantic Scholar
Hydrogen Bonding, Electrostatic Potential, and Molecular Design
P. Kenny
2009Journal of Chemical Information and Modeling147 citations
Semantic Scholar
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.
J. Albert, N. Blomberg, A. Breeze, Alastair J. H. Brown +10 more
2007Current Topics in Medicinal Chemistry119 citations
Semantic Scholar
Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening.
P. Lyne, P. Kenny, David A. Cosgrove, C. Deng +3 more
2004Journal of Medicinal Chemistry109 citations Open access
Semantic Scholar
The nature of ligand efficiency
P. Kenny
2018Journal of Cheminformatics95 citations Open access
Semantic Scholar
Pharmacophoric pattern matching in files of three-dimensional chemical structures: Comparison of conformational-searching algorithms for flexible searching
D. Clark, Gareth Jones, P. Willett, P. Kenny +1 more
1994Journal of chemical information and computer sciences94 citations
Semantic Scholar
Inflation of correlation in the pursuit of drug-likeness
P. Kenny, C. Montanari
2013Journal of Computer-Aided Molecular Design75 citations
Semantic Scholar
Structure-based design of protein tyrosine phosphatase-1B inhibitors.
Emma Black, J. Breed, A. Breeze, K. Embrey +12 more
2005Bioorganic & Medicinal Chemistry Letters74 citations Open access
Semantic Scholar
Design of compound libraries for fragment screening
N. Blomberg, David A. Cosgrove, P. Kenny, K. Kolmodin
2009J. Comput. Aided Mol. Des.70 citations
Semantic Scholar
Ligand efficiency metrics considered harmful
P. Kenny, A. Leitão, C. Montanari
2014Journal of Computer-Aided Molecular Design56 citations
Semantic Scholar
Hydrogen Bond Basicity Prediction for Medicinal Chemistry Design.
P. Kenny, C. Montanari, I. M. Prokopczyk, J. Ribeiro +1 more
2016Journal of Medicinal Chemistry55 citations
Semantic Scholar
Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors
L. Avelar, Cristian Camilo, S. de Albuquerque, W. B. Fernandes +10 more
2015PLoS Neglected Tropical Diseases54 citations Open access
Semantic Scholar
Toward prediction of alkane/water partition coefficients.
A. Toulmin, J. M. Wood, P. Kenny
2008Journal of Medicinal Chemistry52 citations
Semantic Scholar
Prediction of hydrogen bond basicity from computed molecular electrostatic properties: implications for comparative molecular field analysis
P. Kenny
199449 citations
Semantic Scholar
Dipeptidyl nitrile inhibitors of Cathepsin L.
Nabil Asaad, Paul A. Bethel, M. Coulson, J. Dawson +18 more
2009Bioorganic & Medicinal Chemistry Letters48 citations Open access
Semantic Scholar
Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.
R. Ducray, Iain Simpson, F. Jung, J. M. Nissink +5 more
2011Bioorganic & Medicinal Chemistry Letters44 citations Open access
Semantic Scholar
Pharmacophoric pattern matching in files of three-dimensional chemical structures: use of bounded distance matrices for the representation and searching of conformationally flexible molecules.
David E. Clark, P. Willett, P. Kenny
1992Journal of Molecular Graphics43 citations
Semantic Scholar
Comment on The Ecstasy and Agony of Assay Interference Compounds
P. Kenny
2017Journal of Chemical Information and Modeling41 citations
Semantic Scholar
Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.
A. M. Birch, P. Kenny, N. Oikonomakos, L. Otterbein +3 more
2007Bioorganic & Medicinal Chemistry Letters37 citations Open access
Semantic Scholar
A comparative study of warheads for design of cysteine protease inhibitors.
D. G. Silva, J. Ribeiro, D. de Vita, Lorenzo Cianni +8 more
2017Bioorganic & Medicinal Chemistry Letters35 citations Open access
Semantic Scholar
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritis.
A. Dossetter, H. Beeley, J. Bowyer, C. Cook +21 more
2012Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors.
A. M. Birch, P. Kenny, Iain Simpson, P. Whittamore
2009Bioorganic & Medicinal Chemistry Letters33 citations
Semantic Scholar
Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors
A. Burtoloso, S. de Albuquerque, M. Furber, J. Gomes +7 more
2017PLoS Neglected Tropical Diseases32 citations Open access
Semantic Scholar
ClogPalk: a method for predicting alkane/water partition coefficient
P. Kenny, C. Montanari, I. M. Prokopczyk
2013Journal of Computer-Aided Molecular Design32 citations
Semantic Scholar
Comment on: Rich and Myszka, Grading the commercial optical biosensor literature—Class of 2008: ‘The Mighty Binders’. J. Mol. Recognit. 2010, 23, 1–64.
P. Kenny
2010Journal of Molecular Recognition30 citations
Semantic Scholar
Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
P. R. Whittamore, M. Addie, S. Bennett, A. M. Birch +17 more
2006Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
High throughput solubility determination with application to selection of compounds for fragment screening.
N. Colclough, A. Hunter, P. Kenny, R. S. Kittlety +3 more
2008Bioorganic & Medicinal Chemistry28 citations
Semantic Scholar
Design of selective Cathepsin inhibitors.
Paul A. Bethel, S. Gerhardt, E. V. Jones, P. Kenny +8 more
2009Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
The influence of hydrogen bonding on partition coefficients
N. Borges, P. Kenny, C. Montanari, I. M. Prokopczyk +3 more
2017Journal of Computer-Aided Molecular Design25 citations
Semantic Scholar
Use of Ir/sub 4/(CO)/sub 11/ to measure the lengths of organic molecules with a scanning transmission electron microscope
F. Furuya, L. Miller, J. Hainfeld, W. Christopfel +1 more
198821 citations
Semantic Scholar
BOOMSLANG: a program for combinatorial structure generation.
David A. Cosgrove, P. Kenny
1996Journal of Molecular Graphics20 citations
Semantic Scholar
Pharmacophoric pattern matching in files of three-dimensional chemical structures: implementation of flexible searching.
David E. Clark, P. Willett, P. Kenny
1993Journal of Molecular Graphics20 citations
Semantic Scholar
Organized monolayers of polycyclic aromatic quinones
P. Kenny, L. Miller, S. Rak, T. Jozefiak +3 more
198820 citations
Semantic Scholar
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors.
J. Crawford, P. Kenny, J. Bowyer, C. Cook +18 more
2012Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement.
J. Gomes, Lorenzo Cianni, J. Ribeiro, Fernanda dos Reis Rocho +10 more
2019Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
Assessment of Reversibility for Covalent Cysteine Protease Inhibitors Using Quantum Mechanics/Molecular Mechanics Free Energy Surfaces
A. M. dos Santos, A. R. S. Oliveira, Clauber H. S. da Costa, P. Kenny +3 more
2022Journal of Chemical Information and Modeling15 citations
Semantic Scholar
Cycloaddition reactions of a bisisobenzofuran leading to linear polyacenequinones and a quadruply bridged cyclophane
T. Chiba, P. Kenny, L. Miller
198715 citations
Semantic Scholar
Construction of the CSIRO Fragment Library
C. Francis, P. Kenny, O. Dolezal, S. Saubern +4 more
201312 citations
Semantic Scholar
Pharmacophoric pattern matching in files of three-dimensional chemical structures: use of smoothed bounded distances for incompletely specified query patterns.
David E. Clark, P. Willett, P. Kenny
1991Journal of Molecular Graphics12 citations
Semantic Scholar
Properties of a tetracyanopentacenequinone and its tetracyanoquinodimethane derivative
P. Kenny, T. Jozefiak, L. Miller
198812 citations
Semantic Scholar
Crystal structure of Leishmania mexicana cysteine protease B in complex with a high-affinity azadipeptide nitrile inhibitor.
J. Ribeiro, Lorenzo Cianni, Chan Li, Thomas G. Warwick +9 more
2020Bioorganic & Medicinal Chemistry11 citations Open access
Semantic Scholar
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
A. Morley, P. Kenny, Brenda Burton, R. Heald +8 more
2009Bioorganic & Medicinal Chemistry Letters11 citations Open access
Semantic Scholar
Synthesis of a 5-alkoxypyrido[4,3-d]pyrimidin-4(3H)-one derivative via a regioselective Meisenheimer N-oxide rearrangement
Emma J. Williams, P. Kenny, J. Kettle, Paul G. Mwashimba
200411 citations
Semantic Scholar
Synthesis of molecular lines, rigid linear molecules with nanometer scale dimensions
P. Kenny, L. Miller
198811 citations
Semantic Scholar
Automated molecule editing in molecular design
P. Kenny, C. Montanari, I. M. Prokopczyk, F. A. Sala +1 more
2013Journal of Computer-Aided Molecular Design9 citations
Semantic Scholar
New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives.
R. Bradbury, C. Allott, M. Dennis, J. Girdwood +6 more
1993Journal of Medicinal Chemistry9 citations
Semantic Scholar
Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors.
S. Bennett, A. Campbell, A. Hancock, C. Johnstone +8 more
2010Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar

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