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N. Rioux · SciRah

Researcher profile · Semantic Scholar

N. Rioux

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N. Rioux — researcher profile on SciRah

h-index: 22
Works: 68
Citations: 3,012

Most-cited papers

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Elayne Chan-Penebre, Kristy G. Kuplast, C. Majer, P. Boriack-Sjodin +26 more
2015Nature Chemical Biology507 citations
Semantic Scholar
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
A. Fedoriw, Satyajit R. Rajapurkar, S. O'Brien, Sarah V. Gerhart +43 more
2019Cancer Cell290 citations Open access
Semantic Scholar
Epidemiologic data of primary glomerular diseases in western France.
P. Simon, M. Ramée, Rehouni Boulahrouz, Corina Stănescu +7 more
2004Kidney International215 citations Open access
Semantic Scholar
Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398.
N. Rioux, A. Castonguay
1998Cancer Research211 citations
Semantic Scholar
Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents.
N. Rioux, A. Castonguay
1998Carcinogenesis204 citations
Semantic Scholar
Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.
K. Duncan, N. Rioux, P. Boriack-Sjodin, M. Munchhof +13 more
2016ACS Medicinal Chemistry Letters142 citations Open access
Semantic Scholar
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
J. Campbell, K. Kuntz, S. Knutson, N. Warholic +15 more
2015ACS Medicinal Chemistry Letters126 citations Open access
Semantic Scholar
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Allison E. Drew, O. Moradei, S. Jacques, N. Rioux +20 more
2017Scientific Reports122 citations Open access
Semantic Scholar
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
L. Mitchell, Allison E. Drew, S. Ribich, N. Rioux +14 more
2015ACS Medicinal Chemistry Letters121 citations Open access
Semantic Scholar
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
J. J. Joshi, H. Coffey, E. Corcoran, J. Tsai +28 more
2017Cancer Research106 citations Open access
Semantic Scholar
Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
C. Fenwick, M. Amad, M. Bailey, R. Bethell +23 more
2014Antimicrobial Agents and Chemotherapy92 citations Open access
Semantic Scholar
Results of a Clinical Trial of H3B-8800, a Splicing Modulator, in Patients with Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML)
D. Steensma, M. Wermke, V. Klimek, Peter L. Greenberg +32 more
2019Blood81 citations Open access
Semantic Scholar
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.
X. Puyang, Craig Furman, Guo-Zhu Zheng, Z. Wu +49 more
2018Cancer Discovery80 citations Open access
Semantic Scholar
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
L. Mitchell, P. Boriack-Sjodin, Sherri A. Smith, M. Thomenius +17 more
2016ACS Medicinal Chemistry Letters79 citations Open access
Semantic Scholar
CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice
A. Poissonnier, Doriane Sanséau, Matthieu Le Gallo, M. Malleter +20 more
2016Immunity78 citations Open access
Semantic Scholar
Evidence of selection on the orange allele in the domestic cat Felis catus: the role of social structure
D. Pontier, N. Rioux, A. Heizmann
199562 citations
Semantic Scholar
Tumoral CD105 is a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma
A. Saroufim, Y. Messai, M. Hasmim, N. Rioux +8 more
2014British Journal of Cancer59 citations Open access
Semantic Scholar
Regulatory T Cells in Kidney Allograft Infiltrates Correlate With Initial Inflammation and Graft Function
Cécile Taflin, D. Nochy, G. Hill, T. Frouget +4 more
2010Transplantation56 citations Open access
Semantic Scholar
Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation
M. Thomenius, Jennifer Totman, D. Harvey, L. Mitchell +30 more
2018PLoS ONE47 citations Open access
Semantic Scholar
Quantification of the expression and inducibility of 12 rat cytochrome P450 isoforms by quantitative RT–PCR
E. Caron, N. Rioux, O. Nicolas, Hugo Lebel-Talbot +1 more
2006Journal of biochemical and molecular toxicology43 citations
Semantic Scholar
Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development
N. Rioux, N. Waters
2016Drug Metabolism And Disposition34 citations
Semantic Scholar
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
P. Beaulieu, R. Coulombe, J. Duan, G. Fazal +12 more
2013Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
L. Fader, M. Bailey, Eric Beaulieu, F. Bilodeau +26 more
2016ACS Medicinal Chemistry Letters22 citations Open access
Semantic Scholar
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone modulation of cytokine release in U937 human macrophages
N. Rioux, A. Castonguay
2001Cancer Immunology and Immunotherapy22 citations
Semantic Scholar
A high throughput in vitro mrp2 assay to predict in vivo biliary excretion
F. Colombo, C. Armstrong, J. Duan, N. Rioux
2012Xenobiotica; the fate of foreign compounds in biological systems17 citations
Semantic Scholar
Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor
N. Rioux, K. Duncan, R. Lantz, Xiu-Sheng Miao +6 more
2016Xenobiotica; the fate of foreign compounds in biological systems16 citations
Semantic Scholar
Assessment of CYP3A‐mediated drug–drug interaction potential for victim drugs using an in vivo rat model
N. Rioux, É. Bellavance, S. Bourg, Michel Garneau +2 more
2013Biopharmaceutics & drug disposition16 citations
Semantic Scholar
Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA)
N. Rioux, Sherri A. Smith, M. Korpal, M. O'Shea +4 more
2018Cancer Chemotherapy and Pharmacology15 citations
Semantic Scholar
H3B-8800-G0001-101: A first in human phase I study of a splicing modulator in patients with advanced myeloid malignancies.
D. Steensma, M. Maris, Jay Yang, W. Donnellan +15 more
201715 citations
Semantic Scholar
A membrane vesicle-based assay to enable prediction of human biliary excretion
F. Colombo, H. Poirier, N. Rioux, Maria Arias Montecillo +2 more
2013Xenobiotica; the fate of foreign compounds in biological systems11 citations
Semantic Scholar
Systemic light chain amyloidosis and Sjogren syndrome: an uncommon association
A. Perlat, O. Decaux, R. Gervais, N. Rioux +1 more
2009Amyloid: Journal of Protein Folding Disorders11 citations
Semantic Scholar
A phase I study of H3B-6527 in hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC) patients (pts).
T. M. Mercade, V. Moreno, Binu V. John, J. Morris +14 more
2019Journal of Clinical Oncology10 citations
Semantic Scholar
Induction of COX expression by a tobacco carcinogen: Implication in lung cancer chemoprevention
N. Rioux, A. Castonguay
1999Inflammation Research9 citations
Semantic Scholar
Phase I dose escalation of H3B-6545, a first-in-class highly Selective ERα Covalent Antagonist (SERCA), in women with ER-positive, HER2-negative breast cancer (HR+ BC).
E. Hamilton, E. Dees, Judy S. Wang, A. Kim +5 more
2019Journal of Clinical Oncology8 citations
Semantic Scholar
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Allison E. Drew, O. Moradei, S. Jacques, N. Rioux +20 more
2017Scientific Reports7 citations Open access
Semantic Scholar
Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans
N. Rioux, Sherri A. Smith, F. Colombo, A. Kim +5 more
2020Xenobiotica; the fate of foreign compounds in biological systems6 citations Open access
Semantic Scholar
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652
N. Rioux, L. Mitchell, P. Tiller, Katie Plant +7 more
2015Drug Metabolism And Disposition6 citations Open access
Semantic Scholar
Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma
Elayne Penebre, Kristy G. Kuplast, C. Majer, L. Johnston +21 more
20146 citations
Semantic Scholar
[Selective COX-2 inhibitor-associated colitis: two case reports].
P. d'Halluin, B. Turlin, É. Polard, M. Dinasquet +5 more
2003Gastroentérologie Clinique et Biologique6 citations
Semantic Scholar
Abstract P5-08-05: Preclinical activity of KB-0742, an oral, highly selective, CDK9 inhibitor, in cell lines and in MYC-high expressing, patient-derived models of multiple breast cancer subtypes
D. Saffran, M. Day, N. Rioux, Tom Chen +7 more
2022Cancer Research5 citations
Semantic Scholar
Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers
N. Rioux, A. Kim, D. Nix, T. Bowser +3 more
2018Cancer Chemotherapy and Pharmacology4 citations
Semantic Scholar
Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer
Peter C. Smith, X. Puyang, Craig Furman, Zheng-Guo Zhu +31 more
20174 citations
Semantic Scholar
A simplified approach to predict CYP3A-mediated drug–drug interactions at early drug discovery: validation with clinical data
N. Rioux, J. Batonga, F. Colombo, Jonathan Massé +4 more
2013Xenobiotica; the fate of foreign compounds in biological systems4 citations
Semantic Scholar
Abstract P228: Preclinical pharmacokinetics and pharmacodynamics of KB-0742, a selective, oral CDK9 inhibitor
M. Day, D. Saffran, N. Rioux, Tom Chen +9 more
2021Poster Presentations - Proffered Abstracts3 citations
Semantic Scholar
Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWTand ERaMUTbreast cancer
M. Korpal, Craig Furman, X. Puyang, Zhaojie Zhang +34 more
20213 citations
Semantic Scholar
Abstract 3126: H3B6527, a selective and potent FGFR4 inhibitor for FGF19-driven hepatocellular carcinoma
Anand Selvaraj, E. Corcoran, H. Coffey, P. Sudeep +24 more
20172 citations
Semantic Scholar
Abstract A135: Physiologically-based pharmacokinetic modeling to support clinical investigation of the EZH2 inhibitor, tazemetostat (EPZ-6438) in INI1-deficient pediatric tumors
N. Rioux, H. Keilhack, B. Thomson, R. Chesworth +4 more
20152 citations
Semantic Scholar
A strategy to reduce biliary clearance in early drug discovery.
N. Rioux, É. Bellavance, H. Poirier, Mariève Dupuis +3 more
2013Journal of pharmacological and toxicological methods2 citations
Semantic Scholar
Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study
Federico Colombo, Sherri A. Smith, G. Lai, D. Nix +3 more
2020Xenobiotica; the fate of foreign compounds in biological systems1 citations
Semantic Scholar
In vitro-in vivo correlation of clearance for H3B-5942, a novel selective erα covalent antagonist (SERCA)
F. Colombo, Sherri A. Smith, M. Korpal, Mingtian Hao +7 more
2019Drug Metabolism and Pharmacokinetics1 citations
Semantic Scholar

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