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E. Winzeler · SciRah

Researcher profile · Semantic Scholar

E. Winzeler

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E. Winzeler — researcher profile on SciRah

h-index: 79
Works: 299
Citations: 35K

Most-cited papers

Antimalarial drug discovery: progress and approaches
Jair L. Siqueira-Neto, K. Wicht, K. Chibale, J. Burrows +2 more
2023Nature reviews. Drug discovery214 citations Open access
Semantic Scholar
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
B. Baragaña, B. Forte, Ryan Choi, Stephen Nakazawa-Hewitt +73 more
2019Proceedings of the National Academy of Sciences of the United States of America126 citations Open access
Semantic Scholar
The genomic architecture of antimalarial drug resistance
A. Cowell, E. Winzeler
2019Briefings in Functional Genomics88 citations Open access
Semantic Scholar
Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery
James M. Murithi, Edward Owen, E. Istvan, Marcus C. S. Lee +7 more
2019Cell Chemical Biology87 citations Open access
Semantic Scholar
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
J. Reader, Mariëtte E. van der Watt, D. Taylor, Claire Le Manach +29 more
2021Nature Communications79 citations Open access
Semantic Scholar
MalDA, Accelerating Malaria Drug Discovery
Tuo Yang, Sabine Ottilie, E. Istvan, Karla P. Godinez-Macias +19 more
2021Trends in Parasitology79 citations Open access
Semantic Scholar
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity
M. Vanaerschot, James M. Murithi, C. Pasaje, Sonja Ghidelli-Disse +27 more
2020Cell Chemical Biology79 citations Open access
Semantic Scholar
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents
Barbara H. Stokes, Euna Yoo, James M. Murithi, M. Luth +6 more
2019PLoS Pathogens76 citations Open access
Semantic Scholar
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
Mahmood M. Alam, A. Sánchez-Azqueta, Omar Janha, E. Flannery +31 more
2019Science72 citations Open access
Semantic Scholar
Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections
A. Cowell, E. Winzeler
2019Genome Medicine70 citations Open access
Semantic Scholar
Prioritization of Molecular Targets for Antimalarial Drug Discovery
B. Forte, Sabine Ottilie, A. Plater, B. Campo +17 more
2021ACS Infectious Diseases69 citations Open access
Semantic Scholar
Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis
E. Istvan, Sudipta Das, Suyash Bhatnagar, J. Beck +7 more
2019eLife60 citations Open access
Semantic Scholar
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
R. Summers, C. Pasaje, J. P. Pisco, Josefine Striepen +30 more
2021Cell Chemical Biology55 citations Open access
Semantic Scholar
Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection
Gregory M. LaMonte, Pamela Orjuela-Sanchez, Jaeson Calla, Lawrence T Wang +11 more
2019Nature Communications47 citations Open access
Semantic Scholar
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig +22 more
2019Nature Communications47 citations Open access
Semantic Scholar
The antimalarial resistome – finding new drug targets and their modes of action
Krypton Carolino, E. Winzeler
2020Current Opinion in Microbiology44 citations Open access
Semantic Scholar
Reaction hijacking of tyrosine tRNA synthetase as a whole-of-life-cycle antimalarial strategy
S. Xie, R. D. Metcalfe, Elyse Dunn, C. Morton +33 more
2022Science43 citations Open access
Semantic Scholar
Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series
M. J. Palmer, Xiao-Yi Deng, Shawn Watts, Goran Krilov +40 more
2021Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages
L. Arendse, James M. Murithi, Tarrick Qahash, C. Pasaje +26 more
2022Science Translational Medicine39 citations Open access
Semantic Scholar
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model
Rebecca E. K. Mandt, M. Lafuente-Monasterio, Tomoyo Sakata-Kato, M. Luth +9 more
2019Science Translational Medicine38 citations Open access
Semantic Scholar
Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials
Matthew Abraham, Kerstin Gagaring, Marisa L. Martino, M. Vanaerschot +12 more
2020ACS Infectious Diseases37 citations Open access
Semantic Scholar
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
Krittikorn Kumpornsin, T. Kochakarn, Tomas Yeo, John Okombo +21 more
2022bioRxiv36 citations Open access
Semantic Scholar
A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
N. Beutler, T. Pholcharee, D. Oyen, Yevel Flores-Garcia +18 more
2022PLoS Pathogens35 citations Open access
Semantic Scholar
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome
S. Xie, R. D. Metcalfe, Hirotake Mizutani, Tanya Puhalovich +36 more
2021Proceedings of the National Academy of Sciences of the United States of America33 citations Open access
Semantic Scholar
Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance
M. Tye, N. Payne, C. Johansson, Kritika Singh +14 more
2022Nature Communications30 citations Open access
Semantic Scholar
Structure-Activity and Structure-Toxicity Relationships of Novel Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity
Marcel K. W. Mackwitz, Eva Hesping, Yevgeniya Antonova-Koch, D. Diedrich +10 more
2019ChemMedChem30 citations Open access
Semantic Scholar
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
S. Bopp, C. Pasaje, R. Summers, P. Magistrado-Coxen +26 more
2023Nature Communications29 citations Open access
Semantic Scholar
Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development.
S. Xie, M. Griffin, E. Winzeler, Lluís Ribas de Pouplana +1 more
2023Annual Review of Microbiology27 citations Open access
Semantic Scholar
7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex
William Nguyen, Madeline G. Dans, Iain Currie, Jon Kyle Awalt +22 more
2023ACS Infectious Diseases27 citations Open access
Semantic Scholar
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone
T. Skinner-Adams, G. Fisher, A. Riches, Oliver E. Hutt +12 more
2019Communications Biology27 citations Open access
Semantic Scholar
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
James M. Murithi, Ioanna Deni, C. Pasaje, John Okombo +29 more
2021Cell Chemical Biology26 citations Open access
Semantic Scholar
Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases
B. Morahan, Clarissa Abrie, K. Al-Hasani, Mitchell B. Batty +7 more
2020Communications Biology25 citations Open access
Semantic Scholar
Cytoplasmic Isoleucyl tRNA synthetase as an attractive Multi-stage antimalarial drug target
E. Istvan, Francisco Guerra, Matthew Abraham, Kuo-Sen Huang +23 more
2023Science Translational Medicine24 citations Open access
Semantic Scholar
Genomic Approaches to Drug Resistance in Malaria.
Frances Rocamora, E. Winzeler
2020Annual Review of Microbiology24 citations
Semantic Scholar
Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance
M. Luth, Karla P. Godinez-Macias, Daisy Chen, John Okombo +44 more
2024Science23 citations Open access
Semantic Scholar
In vivo screen of Plasmodium targets for mosquito-based malaria control
Alexandra S. Probst, D. Paton, Federico Appetecchia, S. Bopp +23 more
2025Nature22 citations
Semantic Scholar
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites
D. Dorjsuren, Richard T. Eastman, K. Wicht, D. Jansen +26 more
2021Scientific Reports22 citations Open access
Semantic Scholar
Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance
Sabine Ottilie, M. Luth, Erich Hellemann, Gregory M. Goldgof +28 more
2022Communications Biology20 citations Open access
Semantic Scholar
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Claire Le Manach, Jean Dam, John G. Woodland, Gurminder Kaur +42 more
2021Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Development of Potent and Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors
J. Almaliti, Pavla Fajtová, Jaeson Calla, Gregory M. LaMonte +11 more
2023Chemistry19 citations Open access
Semantic Scholar
Novel Antimalarial Tetrazoles and Amides Active Against the Hemoglobin Degradation Pathway in Plasmodium falciparum
Aloysus K. Lawong, Suraksha Gahalawat, John Okombo, Josefine Striepen +20 more
2021Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum
Frances Rocamora, Purva Gupta, E. Istvan, M. Luth +12 more
2021ACS Infectious Diseases19 citations Open access
Semantic Scholar
Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites
H. Wong, V. Padín-Irizarry, Mariëtte E. van der Watt, J. Reader +9 more
2020Frontiers in Chemistry17 citations Open access
Semantic Scholar
Whole-genome surveillance identifies markers of Plasmodium falciparum drug resistance and novel genomic regions under selection in Mozambique
E. Coonahan, Hunter Gage, Daisy Chen, E. Noormahomed +7 more
2023mBio16 citations Open access
Semantic Scholar
A consensus-based and readable extension of Linear Code for Reaction Rules (LiCoRR)
Benjamin P. Kellman, Yujie Zhang, Emma Logomasini, Eric Meinhardt +16 more
2020bioRxiv13 citations Open access
Semantic Scholar
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase
S. Xie, Yi-Nuo Wang, C. J. Morton, R. D. Metcalfe +40 more
2024Nature Communications12 citations Open access
Semantic Scholar
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2
B. Laleu, Kelly Rubiano, Tomas Yeo, I. Hallyburton +16 more
2022ChemMedChem12 citations Open access
Semantic Scholar
A novel antiparasitic compound kills ring-stage Plasmodium falciparum and retains activity against artemisinin-resistant parasites.
Rebecca L. Clements, Vincent A. Streva, Peter C. Dumoulin, Wei-Gang Huang +7 more
2020Journal of Infectious Diseases12 citations Open access
Semantic Scholar
Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty
Snigdha Singh, Nelly El-Sakkary, Danielle Skinner, P. Sharma +7 more
2020Pharmaceuticals12 citations Open access
Semantic Scholar
Identification of fungal natural products with potent inhibition in Toxoplasma gondii
Tiantian Jiang, Karla P. Godinez-Macias, Jennifer E. Collins, Jin Woo Lee +5 more
2024Microbiology spectrum11 citations Open access
Semantic Scholar

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