Jean Dam

Most-cited papers

1. Synthesis of copper and zinc 2-(pyridin-2-yl)imidazo[1,2-a]pyridine complexes and their potential anticancer activity.

   Jean Dam, Zeenat Ismail, T. Kurebwa, Nadia Gangat +5 more

   2017European journal of medicinal chemistry68 citations

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2. Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.

   Claire Le Manach, Jean Dam, John G. Woodland, Gurminder Kaur +42 more

   2021Journal of Medicinal Chemistry20 citations Open access

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3. Copper-imidazo[1,2-a]pyridines induce intrinsic apoptosis and modulate the expression of mutated p53, haem-oxygenase-1 and apoptotic inhibitory proteins in HT-29 colorectal cancer cells

   L. Harmse, Nadia Gangat, Carla Martins-Furness, Jean Dam +1 more

   2019Apoptosis16 citations

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4. Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model

   A. Horatscheck, A. Andrijević, Aloysius T. Nchinda, Claire Le Manach +23 more

   2020Journal of Medicinal Chemistry11 citations Open access

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5. Copper-imidazo[1,2-a]pyridines differentially modulate pro- and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death.

   Zeenat Ismail, Jean Dam, C. Penny, C. D. de Koning +1 more

   2021Biochimica et biophysica acta. Molecular cell research10 citations Open access

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6. Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum

   Jean Dam, Grant A Boyle, A. Horatscheck, John G. Woodland +15 more

   2025Journal of Medicinal Chemistry4 citations Open access

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7. Ceric Ammonium Sulfate (CAS) Mediated Oxidations of Benzophenones Possessing a Phenolic Substituent for the Synthesis of Xanthones and Related Products.

   Jean Dam, M. Bode, C. D. de Koning

   2018Journal of Organic Chemistry3 citations Open access

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8. Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model".

   A. Horatscheck, A. Andrijević, Aloysius T. Nchinda, Claire Le Manach +23 more

   2021Journal of Medicinal Chemistry0 citations Open access

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9. Copper-imidazo[1, 2-a]pyridines induce apoptosis in colorectal cancer cell lines

   Nadia Gangat, Jean Dam, C. D. de Koning, L. Harmse

   20180 citations Open access

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10. Copper imidazo[1, 2-a]pyridine complexes induce apoptosis in K562 and HL-60 leukaemic cells

    Zeenat Ismail, C. D. de Koning, Jean Dam, C. Penny +1 more

    20180 citations Open access

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11. Synthetic, mechanistic and biological studies of novel metal-imidazo[1,2-a]pyridines and xanthones

    Jean Dam

    20160 citations

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