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G. Friedrichs · SciRah

Researcher profile · Semantic Scholar

G. Friedrichs

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G. Friedrichs — researcher profile on SciRah

h-index: 15
Works: 59
Citations: 829

Most-cited papers

Benchmarking safety pharmacology regulatory packages and best practice.
S. Lindgren, A. Bass, R. Briscoe, K. Bruse +5 more
2008Journal of pharmacological and toxicological methods105 citations
Semantic Scholar
Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart.
G. Friedrichs, K. Kilgore, P. J. Manley, M. Gralinski +1 more
1994Circulation Research87 citations
Semantic Scholar
Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury.
S. Black, M. Gralinski, G. Friedrichs, K. Kilgore +2 more
1995Cardiovascular Research86 citations
Semantic Scholar
Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies.
G. Friedrichs, L. Patmore, A. Bass
2005Journal of pharmacological and toxicological methods66 citations
Semantic Scholar
Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis.
F. Markland, G. Friedrichs, Shawn R. Pewitt, B. Lucchesi
1994Circulation52 citations Open access
Semantic Scholar
Evaluation of PAI-039 [{1-Benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic Acid], a Novel Plasminogen Activator Inhibitor-1 Inhibitor, in a Canine Model of Coronary Artery Thrombosis
J. Hennan, H. Elokdah, M. Leal, A. Ji +6 more
2005Journal of Pharmacology and Experimental Therapeutics44 citations
Semantic Scholar
The anesthetized guinea pig: an effective early cardiovascular derisking and lead optimization model.
P. Morissette, M. Nishida, E. Trepakova, J. Imredy +10 more
2013Journal of pharmacological and toxicological methods35 citations
Semantic Scholar
The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys
T. M. Haushalter, G. Friedrichs, D. L. Reynolds, Mary Barecki-Roach +3 more
2008British Journal of Pharmacology35 citations Open access
Semantic Scholar
Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms.
S. Spence, M. Deurinck, H. Ju, M. Traebert +7 more
2016Toxicological Sciences33 citations
Semantic Scholar
Protective Effects of Ranolazine on Ventricular Fibrillation Induced by Activation of the ATP-Dependent Potassium Channel in the Rabbit Heart
M. Gralinski, L. Chi, James L. Park, G. Friedrichs +3 more
1996Journal of Cardiovascular Pharmacology and Therapeutics33 citations
Semantic Scholar
Sphingosine Modulates Myocyte Electrophysiology, Induces Negative Inotropy, and Decreases Survival After Myocardial Ischemia
G. Friedrichs, R. Swillo, B. Jow, T. Bridal +4 more
2002Journal of Cardiovascular Pharmacology31 citations Open access
Semantic Scholar
MS‐551 Protects Against Ventricular Fibrillation in a Chronic Canine Model of Sudden Cardiac Death
G. Friedrichs, L. Chi, M. Gralinski, S. Black +5 more
1995Journal of Cardiovascular Pharmacology23 citations Open access
Semantic Scholar
Adenosine deaminase and adenosine attenuate ventricular arrhythmias caused by norepinephrine.
G. Friedrichs, G. Merrill
1991American Journal of Physiology21 citations
Semantic Scholar
Experimental models of atrial fibrillation/flutter.
G. Friedrichs
2000Journal of pharmacological and toxicological methods18 citations
Semantic Scholar
Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.
A. Gopalsamy, S. Kincaid, J. Ellingboe, T. M. Groeling +5 more
2004Bioorganic & Medicinal Chemistry Letters16 citations Open access
Semantic Scholar
Antiarrhythmic Agent, MS‐551, Protects Against Pinacidil + Hypoxia‐Induced Ventricular Fibrillation in Langendorff‐Perfused Rabbit Isolated Heart
G. Friedrichs, L. Chi, S. Black, P. J. Manley +1 more
1994Journal of Cardiovascular Pharmacology15 citations Open access
Semantic Scholar
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium
Emmanuel Boulay, M. Abernathy, R. Chui, G. Friedrichs +14 more
2018International journal of toxicology14 citations Open access
Semantic Scholar
Translational assessment of cardiac contractility by echocardiography in the telemetered rat.
Hai-ming Tang, H. Ju, Shu-Fang Q. Zhao, Carrie LaDuke +4 more
2016Journal of pharmacological and toxicological methods14 citations
Semantic Scholar
Plasma lipid concentrations in college students performing self-selected exercise.
G. Merrill, G. Friedrichs
1990Journal of the American College of Nutrition14 citations
Semantic Scholar
Coronary vasodilation caused by intravenous cocaine in the anesthetized beagle.
G. Friedrichs, H. Wei, G. Merrill
1990Canadian Journal of Physiology and Pharmacology13 citations
Semantic Scholar
Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events.
S. Paglialunga, B. Morimoto, M. Clark, G. Friedrichs
2019Journal of pharmacological and toxicological methods10 citations
Semantic Scholar
The Pathway-selective Estrogen Receptor Ligand WAY-169916 Displays Differential Activity in Ischemia-Reperfusion Injury Models
D. C. Harnish, Xiao-Rong Liu, T. Kenney, R. Winneker +3 more
2006Journal of Cardiovascular Pharmacology10 citations Open access
Semantic Scholar
Adenosine deaminase and BW A1433U attenuate hypoxia-induced ventricular ectopy.
R. Leone, G. Friedrichs, G. Merrill
1993Journal of applied physiology9 citations
Semantic Scholar
An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation
S. Authier, M. Abernathy, Krystle G. Correll, R. Chui +12 more
2020International journal of toxicology8 citations
Semantic Scholar
5-hydroxydecanoate fails to attenuate ventricular fibrillation in a conscious canine model of sudden cardiac death.
G. Friedrichs, J. Abreu, S. Black, L. Chi +1 more
1996European Journal of Pharmacology8 citations
Semantic Scholar
Reduction of Myocardial Necrosis after Glycosaminoglycan Administration: Effects of a Single Intravenous Administration of Heparin or N-Acetylheparin 2 Hours before Regional Ischemia and Reperfusion
M. Gralinski, E. Driscoll, G. Friedrichs, M. Denardis +1 more
19967 citations
Semantic Scholar
Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.
H. Elokdah, G. Friedrichs, S. Chai, B. Harrison +3 more
2002Bioorganic & Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
EEG telemetry models in the rodent and non-human primate
Erik Deboer, G. Friedrichs
20093 citations
Semantic Scholar
Route dependent effects of 2-chloroadenosine and theophylline in isolated perfused guinea pig hearts.
H.-W. Wei, G. Friedrichs, G. Merrill
1991Cardiovascular Research3 citations
Semantic Scholar
Respiratory Rates Derived From Arterial Blood Pressure Waveforms in Telemetered Dogs
Hai-ming Tang, Carrie LaDuke, D. Reynolds, Cynthia Carey +2 more
2020International journal of toxicology2 citations Open access
Semantic Scholar
Adrenergic-dependent Effect of Adenosine-induced Ventricular Fibrillation in the Isolated Rabbit Heart
G. Friedrichs, L. Chi, James L. Park, B. Lucchesi
1997Journal of Cardiovascular Pharmacology and Therapeutics2 citations
Semantic Scholar
Flow-dependent antiarrhythmic properties of ammonia during catecholamine-driven ventricular tachycardia.
A. Malootian, G. Friedrichs, G. Merrill
1992Canadian Journal of Physiology and Pharmacology2 citations
Semantic Scholar
Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation.
E. Rossman, F. Cools, Jason S. Cordes, D. Dhuyvetter +8 more
2020Journal of pharmacological and toxicological methods1 citations Open access
Semantic Scholar
Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluation
E. Rossman, F. Cools, Jason S. Cordes, D. Dhuyvetter +6 more
2018Journal of pharmacological and toxicological methods1 citations
Semantic Scholar
Compound X increases heart weight: Ultrasound and telemetry evaluation in the rat
H. Ju, K. Hershman, Shu-Fang Q. Zhao, Carrie LaDuke +3 more
20151 citations
Semantic Scholar
Antifibrillatory effects ofclofilium intherabbit isolated heart
G. Friedrichs, A. L. Green, B. Lucchesi
19941 citations
Semantic Scholar
Thrombolytic effects of fibrolase in a canine model of carotid artery thrombosis
F. Markland, G. Friedrichs, S. .. Pewitt, B. Lucchesi
19941 citations
Semantic Scholar
Cardiovascular data acquisition and analysis: An SPS industry survey
S. Authier, M. Abernathy, Krystle G. Correll, R. Chui +12 more
20200 citations
Semantic Scholar
Investigation of hemodynamic changes induced by CompoundX in Wistar Han rats
Hai-ming Tang, M. Flaherty, D. I. Aibo, D. Walker +5 more
20160 citations
Semantic Scholar
Decreased ejection fraction induced by a MEK inhibitor in spontaneously hypertensive and Wistar rats: Reversibility following co-administration of lisinopril
H. Ju, Shu-Fang Q. Zhao, Lori A. Martin, E. Wolak +5 more
20160 citations
Semantic Scholar
Hypertensive rat model induced by iv infusion of phenylephrine via programmable pump
Carrie LaDuke, H. Ju, Suzette Hahn, Cynthia Carey +2 more
20150 citations
Semantic Scholar
Preclinical investigation of blood pressure elevation induced by DEB025 in spontaneously hypertensive rats (SHR)
Hai-ming Tang, H. Ju, Carrie LaDuke, D. Brees +3 more
20150 citations
Semantic Scholar
Functional and genetic characterization of human iPS cardiomyocytes for cardiac safety screening
M. Traebert, M. Delmotte, K. Zimmermann, Valerie Weber +2 more
20150 citations
Semantic Scholar
Species-specific ERG effects: hERG vs dERG vs cERG
M. Traebert, Anina von Planta, G. Guillemain, Enrico Funhoff +2 more
20150 citations
Semantic Scholar
Predictive value of nonclinical QT data to man: Retrospective database of TQT studies with noncardiovascular drugs
B. Dumotier, M. Traebert, G. Friedrichs
20150 citations
Semantic Scholar
Evaluation of cardiac contractility in a telemetered rat model: Compare to a translational assessment by echocardiography
Hai-ming Tang, H. Ju, Shu-Fang Q. Zhao, Carrie LaDuke +4 more
20150 citations
Semantic Scholar
Application of an in vitro model for early detection of cardiac sodium channel blocking liabilities
H. Ju, Gan-Xin Yan, Де Коспаро Марк, Cynthia Carey +1 more
20140 citations
Semantic Scholar
FK506 (tacrolimus) shows non-IKr related QT prolongation and proarrhythmogenicity in in vitro electrophysiological systems
B. Dumotier, M. Traebert, G. Friedrichs, H. Peter
20140 citations
Semantic Scholar
Reducing animal use by refining experimental paradigms and colony management in a conscious rat telemetry model
Ivy Garfinkel, Martha Hasbun-Manning, Jude Ferraro, Patrick Fanelli +7 more
20130 citations
Semantic Scholar
Translation of hemodynamic effects between anesthetized guinea pig and conscious rat models
P. Gerenser, G. J. Zingaro, J. Travis, Kimberly M. Hoagland +3 more
20130 citations
Semantic Scholar

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B. Lucchesi×11
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