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M. Pugsley · SciRah

Researcher profile · Semantic Scholar

M. Pugsley

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M. Pugsley — researcher profile on SciRah

h-index: 28
Works: 186
Citations: 3,399

Most-cited papers

Safety pharmacology investigations on the nervous system: An industry survey.
S. Authier, J. Arezzo, M. Delatte, M. Kallman +9 more
2016Journal of pharmacological and toxicological methods68 citations Open access
Semantic Scholar
Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative.
Hai Huang, M. Pugsley, B. Fermini, M. Curtis +3 more
2017Journal of pharmacological and toxicological methods67 citations Open access
Semantic Scholar
Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance
H. Vargas, A. Bass, J. Koerner, Sherri Matis-Mitchell +6 more
2015British Journal of Pharmacology56 citations Open access
Semantic Scholar
The emerging role of in vitro electrophysiological methods in CNS safety pharmacology.
M. Accardi, M. Pugsley, R. Forster, É. Troncy +2 more
2016Journal of pharmacological and toxicological methods52 citations Open access
Semantic Scholar
The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.
B. Guth, Alan Y. Chiang, J. Doyle, M. Engwall +10 more
2015Journal of pharmacological and toxicological methods49 citations Open access
Semantic Scholar
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
H. Prior, P. Baldrick, S. Beken, H. Booler +36 more
2020Regulatory toxicology and pharmacology : RTP34 citations Open access
Semantic Scholar
Proarrhythmia liability assessment and the comprehensive in vitro Proarrhythmia Assay (CiPA): An industry survey on current practice.
S. Authier, M. Pugsley, J. Koerner, B. Fermini +6 more
2017Journal of pharmacological and toxicological methods34 citations Open access
Semantic Scholar
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
E. Rossman, Todd A. Wisialowski, H. Vargas, J. Valentin +13 more
2023Journal of pharmacological and toxicological methods31 citations
Semantic Scholar
Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates
S. Polak, M. Pugsley, N. Stockbridge, C. Garnett +1 more
2015AAPS Journal27 citations Open access
Semantic Scholar
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
H. Vargas, E. Rossman, Todd A. Wisialowski, Jill Nichols +7 more
2023Journal of pharmacological and toxicological methods25 citations Open access
Semantic Scholar
An overview of drug‐induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety
K. Chaudhary, Colleen E. Clancy, Pei-Chi Yang, Jennifer B. Pierson +11 more
2024Clinical and Translational Science23 citations Open access
Semantic Scholar
Biophysics and Molecular Biology of Cardiac Ion Channels for the Safety Pharmacologist.
M. Pugsley, M. Curtis, E. Hayes
2015Handbook of Experimental Pharmacology19 citations
Semantic Scholar
A pharmacological characterization of Cannabis sativa chemovar extracts
Alykhan Devsi, Brett Kiyota, Theophile Ouellette, A. Hegle +5 more
2020Journal of Cannabis Research15 citations Open access
Semantic Scholar
A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium
Emmanuel Boulay, M. Abernathy, R. Chui, G. Friedrichs +14 more
2018International journal of toxicology14 citations Open access
Semantic Scholar
An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs.
M. Pugsley, B. Guth, Alan Y. Chiang, J. M. Doyle +9 more
2017Journal of pharmacological and toxicological methods14 citations Open access
Semantic Scholar
Reevaluating Safety Pharmacology Respiratory studies within the ICH S7A Core Battery: A multi-company evaluation of preclinical utility and clinical translation.
G. S. Friedrichs, M. Abernathy, D. Ackley, M. Clark +14 more
2024Regulatory toxicology and pharmacology : RTP10 citations
Semantic Scholar
Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats.
P. J. Pereira, M. Pugsley, É. Troncy, Wendy Tan +11 more
2019Journal of pharmacological and toxicological methods9 citations Open access
Semantic Scholar
The Challenges of Predicting Drug-Induced QTc Prolongation in Humans
J. Valentin, P. Hoffmann, Catherine Ortemann‐Renon, J. Koerner +8 more
2022Toxicological Sciences8 citations Open access
Semantic Scholar
Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy.
M. Pugsley, M. Brooks, C. Fishman, P. Katavolos +4 more
2020Journal of pharmacological and toxicological methods8 citations Open access
Semantic Scholar
An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation
S. Authier, M. Abernathy, Krystle G. Correll, R. Chui +12 more
2020International journal of toxicology8 citations
Semantic Scholar
Ventricular arrhythmia incidence in the rat is reduced by naloxone.
M. Pugsley, Eric S. Hayes, W.-Q. Wang, Michael J. A. Walker
2015Pharmacological Research8 citations
Semantic Scholar
Safety pharmacology methods and models in an evolving regulatory environment.
M. Pugsley, T. de Korte, S. Authier, Hai Huang +2 more
2017Journal of pharmacological and toxicological methods7 citations
Semantic Scholar
GLP in safety pharmacology studies: Report card after 15years.
B. Guth, M. Pugsley
2017Journal of pharmacological and toxicological methods7 citations Open access
Semantic Scholar
The Diplomate in Safety Pharmacology (DSP) certification scheme.
S. Authier, M. Curtis, M. Soloviev, W. Redfern +9 more
2015Journal of pharmacological and toxicological methods7 citations
Semantic Scholar
The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system.
Loïs S Miraucourt, M. Accardi, K. Asin, M. Pugsley +2 more
2020Journal of pharmacological and toxicological methods6 citations Open access
Semantic Scholar
Confounders and Pharmacological Characterization When Using the QT, JTp, and Tpe Intervals in Beagle Dogs
Emmanuel Boulay, É. Troncy, M. Accardi, M. Pugsley +9 more
2020International journal of toxicology6 citations
Semantic Scholar
Cardiac contractility: Correction strategies applied to telemetry data from a HESI-sponsored consortium.
Emmanuel Boulay, M. Pugsley, V. Jacquemet, A. Vinet +6 more
2017Journal of pharmacological and toxicological methods6 citations Open access
Semantic Scholar
Haemodynamic Assessment in Safety Pharmacology.
S. Authier, M. Pugsley, M. Curtis
2015Handbook of Experimental Pharmacology6 citations
Semantic Scholar
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis.
Emmanuel Boulay, Loïs S Miraucourt, M. Pugsley, M. Abernathy +18 more
2023Journal of pharmacological and toxicological methods5 citations Open access
Semantic Scholar
The northeast regional SPS meeting update: Safety pharmacology innovations and applications.
Malarvannan Pannirselvam, T. Brabham, Alfred Botchway, D. Hodges +2 more
2017Journal of pharmacological and toxicological methods5 citations
Semantic Scholar
Current practices on the measurement of electrocardiogram and hemodynamic parameters in non-rodent species in regulatory safety assessment studies.
J. Valentin, Todd Bourcier, Xuan Chi, A. Delaunois +17 more
2025Journal of pharmacological and toxicological methods4 citations
Semantic Scholar
Toxicology and safety pharmacology investigations on the nervous system: 2024 industry survey.
S. Authier, Marcus S. Delatte, Alison Wakeford, Wendy G. Halpern +7 more
2025Journal of pharmacological and toxicological methods4 citations
Semantic Scholar
Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity.
D. De Alwis, C. M. Foley, Eugene Herman, Adam P. Hill +8 more
2024Journal of pharmacological and toxicological methods4 citations Open access
Semantic Scholar
Combined Cardiopulmonary Assessments Using Impedance and Digital Implants in Conscious Freely Moving Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs: Pharmacological Characterization and Social Housing Effects
Emmanuel Boulay, É. Troncy, M. Pugsley, J. St-Pierre +5 more
2021International journal of toxicology4 citations
Semantic Scholar
The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.
Alan Y. Chiang, B. Guth, M. Pugsley, C. M. Foley +5 more
2018Journal of pharmacological and toxicological methods4 citations Open access
Semantic Scholar
The Safety Pharmacology Society salary survey.
M. Pugsley, S. Authier, T. Brabham, M. Soloviev +9 more
2017Journal of pharmacological and toxicological methods4 citations
Semantic Scholar
Gastroinstestinal motility: Motility and motor migrating complex (MMC) evaluations in rats, dogs and non-human primates
S. Authier, Hai-ming Tang, S. Abtout, A. Ascah +5 more
20164 citations
Semantic Scholar
Evaluation of Biomarkers to Detect Early Prothrombotic Imbalance in Rat Models of Hypercoagulability Induced by Thromboplastin Infusion and Hypofibrinolysis Induced by Tranexamic Acid
Marjory B Brooks, Cindy Fishman, M. Kamalakannan, Paula Katavolos +7 more
2025Toxicologic pathology (Print)3 citations
Semantic Scholar
In Silico Human Cardiomyocyte Action Potential Modeling: Exploring Ion Channel Input Combinations
Emmanuel Boulay, É. Troncy, V. Jacquemet, Hai Huang +4 more
2024International journal of toxicology3 citations Open access
Semantic Scholar
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document.
M. Pugsley, Y. Koshman, C. M. Foley, Brett R. Winters +2 more
2023Journal of pharmacological and toxicological methods3 citations Open access
Semantic Scholar
The Spontaneous Incidence of Neurological Clinical Signs in Preclinical Species Using Cage-side Observations or High-definition Video Monitoring: A Retrospective Analysis
Chiara Orciani, Cristina Ballesteros, É. Troncy, Clémence Berthomé +7 more
2023International journal of toxicology3 citations
Semantic Scholar
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment
M. Pugsley, Y. Koshman, T. de Korte, S. Authier +2 more
2022Journal of pharmacological and toxicological methods3 citations Open access
Semantic Scholar
Current Trends of Practices in Nonclinical Toxicology: An Industry Survey
S. Authier, W. J. Brock, W. Halpern, Stephanie N Harris +4 more
2021International journal of toxicology3 citations
Semantic Scholar
Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry.
A. Bass, M. Pugsley, F. Sannajust, T. Yoshinaga +1 more
2019Journal of pharmacological and toxicological methods3 citations
Semantic Scholar
Safety pharmacology methods and regulatory considerations evolve together.
M. Pugsley, Marci Harter, T. de Korte, Chantelle E. Connaughton +2 more
2018Journal of pharmacological and toxicological methods3 citations
Semantic Scholar
Non-clinical cardiovascular safety testing: Current status, gaps and emerging trends.
Peter Hoffmann, M. Pugsley
2025Journal of pharmacological and toxicological methods2 citations
Semantic Scholar
Innovative approaches to cardiovascular safety pharmacology assessment.
M. Pugsley, Brett R. Winters, Y. Koshman, S. Authier +3 more
2024Journal of pharmacological and toxicological methods2 citations
Semantic Scholar
Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker
Michael J. A. Walker, Eric S. Hayes, David A. Saint, G. Adaikan +6 more
2018Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2 citations Open access
Semantic Scholar
An overview of the safety pharmacology career of Dr. C.R. Hassler.
Michael A. Hawk, M. Pugsley, Thomas M. Vinci, J. Wallery +2 more
2017Journal of pharmacological and toxicological methods2 citations
Semantic Scholar
An Overview of the Safety Pharmacology Society (SPS) Strategic Plan (2016-2018)
M. Pugsley, S. Authier, J. Koerner, W. Redfern +13 more
20172 citations
Semantic Scholar

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