J. Travis

Most-cited papers

1. The anesthetized guinea pig: an effective early cardiovascular derisking and lead optimization model.

   P. Morissette, M. Nishida, E. Trepakova, J. Imredy +10 more

   2013Journal of pharmacological and toxicological methods35 citations

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2. QT interval correction assessment in the anesthetized guinea pig.

   P. Morissette, H. Regan, Kevin Fitzgerald, Sylvain Bernasconi +5 more

   2015Journal of pharmacological and toxicological methods14 citations

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3. Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay

   P. Morissette, S. Polak, A. Chain, Jin Zhai +9 more

   2020Toxicology and Applied Pharmacology8 citations Open access

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4. Impact of in vitro ion channel protocols when assessing cardiac pro-arrhythmic risk with in silico models.

   P. Morissette, J. Imredy, Jin Zhai, J. Travis +7 more

   2019Journal of pharmacological and toxicological methods2 citations

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5. Successful integrative approach of the pro-arrhythmic risk assessment of the multichannel ion channel inhibitor vanoxerine, via combination of in silico human cardiomyocyte models and in vivo guinea-pig electromechanical window assay

   P. Morissette, P. Gerenser, J. Travis, Patrick Fanelli +6 more

   2018Journal of pharmacological and toxicological methods1 citations

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6. Combining an in silico pro-arrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig

   P. Morissette, S. Polak, Anne Chain, Jin Zhai +7 more

   20200 citations

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7. Cardiovascular effects of adenosine transporter (ENT1) inhibition in various preclinical animal models

   C. Regan, P. Morissette, H. Regan, Kevin Fitzgerald +2 more

   20200 citations

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8. Comparative Evaluation of In Silico Models to Assess Cardiac Pro-arrhythmic Risk in Early Drug Development

   P. Morissette, J. Travis, P. Gerenser, Patrick Fanelli +4 more

   20170 citations

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9. Integrated In Vitro Cardiac Safety Assessment of Hepatitis-C Virus Nucleotide Inhibitor (HCV-NI) Drug Interaction with Amiodarone: Translatability to Clinic

   Hao-Yu Zeng, Spencer J. Dech, Bharath Balasubramanian, J. Travis +5 more

   20170 citations

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10. Torsadogenic drugs shorten the cardiac electromechanical window before prolonging the QTc interval in anesthetized guinea pigs

    P. Morissette, J. Travis, P. Gerenser, C. Regan +1 more

    20150 citations

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11. Predictive validity of an integrated preclinical approach combining in vivo rat PK/PD and in vitro rat hippocampal brain slice assays to assess drug-induced seizure risk liability

    Ivy Garfinkel, Jin Zhai, J. Travis, Hao-Yu Zeng +4 more

    20150 citations

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12. QT interval correction assessment in the ketamine/xylazine-anesthetized guinea pig model

    J. Travis, P. Morissette, H. Regan, Kevin Fitzgerald +5 more

    20150 citations

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13. Translation of hemodynamic effects between anesthetized guinea pig and conscious rat models

    P. Gerenser, G. J. Zingaro, J. Travis, Kimberly M. Hoagland +3 more

    20130 citations

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14. Predictive value of the anesthetized guinea pig model to conscious animal models and humans

    P. Morissette, M. Nishida, E. Trepakova, J. Travis +6 more

    20130 citations

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15. Anesthetized guinea pig is an effective and efficient cardiovascular safety pharmacology screening model

    P. Morissette, M. Nishida, J. Travis, D. Steve +5 more

    20110 citations

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