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D. Scandella · SciRah

Researcher profile · Semantic Scholar

D. Scandella

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D. Scandella — researcher profile on SciRah

h-index: 35
Works: 80
Citations: 3,714

Most-cited papers

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site.
D. Scandella, G. E. Gilbert, M. Shima, H. Nakai +6 more
1995Blood204 citations
Semantic Scholar
A Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Factor VIII Binding to von Willebrand Factor and to Phosphatidylserine
M. Shima, D. Scandella, A. Yoshioka, H. Nakai +4 more
1993Thrombosis and Haemostasis199 citations
Semantic Scholar
The Acidic Region of the Factor VIII Light Chain and the C2 Domain Together Form the High Affinity Binding Site for von Willebrand Factor*
E. Saenko, D. Scandella
1997Journal of Biological Chemistry194 citations Open access
Semantic Scholar
The inhibitor antibody response is more complex in hemophilia A patients than in most nonhemophiliacs with factor VIII autoantibodies. Recombinate and Kogenate Study Groups.
R. Prescott, H. Nakai, E. Saenko, I. Scharrer +5 more
1997Blood189 citations Open access
Semantic Scholar
Slowed Release of Thrombin-cleaved Factor VIII from von Willebrand Factor by a Monoclonal and a Human Antibody Is a Novel Mechanism for Factor VIII Inhibition*
E. Saenko, M. Shima, G. E. Gilbert, D. Scandella
1996Journal of Biological Chemistry185 citations Open access
Semantic Scholar
A role for the C2 domain of factor VIII in binding to von Willebrand factor.
E. Saenko, M. Shima, K. Rajalakshmi, D. Scandella
1994Journal of Biological Chemistry180 citations
Semantic Scholar
Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII (*)
J. Healey, I. Lubin, H. Nakai, E. Saenko +3 more
1995Journal of Biological Chemistry148 citations Open access
Semantic Scholar
Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization.
D. Scandella, M. Mattingly, S. de Graaf, C. Fulcher
1989Blood146 citations Open access
Semantic Scholar
Transgenic pigs produce functional human factor VIII in milk
R. Paleyanda, W. Velander, Timothy K. Lee, D. Scandella +5 more
1997Nature Biotechnology139 citations
Semantic Scholar
Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules.
R. T. Barrow, J. Healey, D. Gailani, D. Scandella +1 more
2000Blood122 citations
Semantic Scholar
Some human inhibitor antibodies interfere with factor VIII binding to factor IX.
D. Zhong, E. Saenko, M. Shima, M. Felch +1 more
1998Blood111 citations
Semantic Scholar
Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII.
J. Healey, R. T. Barrow, Hiba M. Tamim, I. Lubin +3 more
1998Blood104 citations
Semantic Scholar
A Mechanism for Inhibition of Factor VIII Binding to Phospholipid by von Willebrand Factor (*)
E. Saenko, D. Scandella
1995Journal of Biological Chemistry101 citations Open access
Semantic Scholar
Long-term induction of immune tolerance after blockade of CD40-CD40L interaction in a mouse model of hemophilia A.
G. Rossi, Jolly Sarkar, D. Scandella
2001Blood99 citations Open access
Semantic Scholar
Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A.
K. Peerlinck, M. Jacquemin, J. Arnout, M. Hoylaerts +7 more
1999Blood94 citations
Semantic Scholar
Human Inhibitor Antibodies Specific for the Factor VIII A2 Domain Disrupt the Interaction between the Subunit and Factor IXa*
P. Fay, D. Scandella
1999Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Identification of the binding site for activated protein C on the light chain of factors V and VIII.
F. J. Walker, D. Scandella, P. Fay
1990Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Activation of Factor VIII by Thrombin Increases Its Affinity for Binding to Synthetic Phospholipid Membranes and Activated Platelets*
E. Saenko, D. Scandella, Alexey V. Yakhyaev, N. Greco
1998Journal of Biological Chemistry84 citations Open access
Semantic Scholar
Loss of tolerance to exogenous and endogenous factor VIII in a mild hemophilia A patient with an Arg593 to Cys mutation.
Arthur R. Thompson, M. E. Murphy, Miao-Liang Liu, E. Saenko +3 more
1997Blood84 citations
Semantic Scholar
Factor VIII inhibitors: structure and function in autoantibody and hemophilia A patients.
L. Hoyer, D. Scandella
1994Seminars in hematology (Print)80 citations
Semantic Scholar
Inhibition of human factor VIIIa by anti-A2 subunit antibodies.
Pete Lollar, E. Parker, J. E. Curtis, S. Helgerson +3 more
1994Journal of Clinical Investigation80 citations Open access
Semantic Scholar
An Escherichia coli mutant which inhibits the injection of phage λ DNA
D. Scandella, W. Arber
197473 citations
Semantic Scholar
Common inhibitory effects of human anti‐C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor
M. Shima, H. Nakai, D. Scandella, I. Tanaka +5 more
1995British Journal of Haematology72 citations
Semantic Scholar
Phage λ DNA injection into Escherichia coli pel− mutants is restored by mutations in phage genes V or H
D. Scandella, W. Arber
197667 citations
Semantic Scholar
In hemophilia A and autoantibody inhibitor patients: the factor VIII A2 domain and light chain are most immunogenic.
D. Scandella, H. Nakai, M. Felch, W. Mondorf +3 more
2001Thrombosis Research58 citations
Semantic Scholar
A Soluble Recombinant Factor VIII Fragment Containing the A2 Domain Binds to Some Human Anti-Factor VIII Antibodies that Are not Detected by Immunoblotting
D. Scandella, L. Timmons, M. Mattingly, N. Trabold +1 more
1992Thrombosis and Haemostasis57 citations
Semantic Scholar
Multiple steps during the interaction between coliphage lambda and its receptor protein in vitro.
Michèle Roa, D. Scandella
1976Virology54 citations
Semantic Scholar
Role of factor VIII C2 domain in factor VIII binding to factor Xa.
K. Nogami, M. Shima, K. Hosokawa, T. Suzuki +7 more
1999Journal of Biological Chemistry53 citations Open access
Semantic Scholar
Antibodies to the FVIII light chain that neutralize FVIII procoagulant activity are present in plasma of nonresponder patients with severe hemophilia A and in normal polyclonal human IgG.
A. Moreau, S. Lacroix-Desmazes, Natalie Stieltjes, E. Saenko +5 more
2000Blood50 citations
Semantic Scholar
Role of Factor VIII C2 Domain in Factor VIII Binding to Factor Xa*
K. Nogami, M. Shima, K. Hosokawa, Toyoaki Suzuki +7 more
1999Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Analysis of the Human Factor VIII A2 Inhibitor Epitope by Alanine Scanning Mutagenesis*
I. Lubin, J. Healey, R. T. Barrow, D. Scandella +1 more
1997Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII.
E. N. van den Brink, W. Bril, E. Turenhout, Marleen G. Zuurveld +9 more
2002Blood45 citations Open access
Semantic Scholar
Properties of Anti-Factor VIII Inhibitor Antibodies in Hemophilia A Patients
D. Scandella
2000Seminars in Thrombosis and Hemostasis38 citations
Semantic Scholar
Dominant C2 Domain Epitope Specificity of Inhibitor Antibodies Elicited by a Heat Pasteurized Product, Factor VIII CPS-P, in Previously Treated Hemophilia A Patients without Inhibitors
Y. Sawamoto, R. Prescott, D. Zhong, E. Saenko +4 more
1998Thrombosis and Haemostasis38 citations
Semantic Scholar
Inhibitors in German Hemophilia A Patients Treated with a Double Virus Inactivated Factor VIII Concentrate Bind to the C2 Domain of FVIII Light Chain
R. Laub, Di Giambattista, P. Fondu, H. Brackmann +4 more
1999Thrombosis and Haemostasis37 citations Open access
Semantic Scholar
Human Anti‐Factor VIII Antibodies: Epitope Localization and Inhibitory Function
D. Scandella
1996Vox Sanguinis34 citations
Semantic Scholar
Epitope Specificity and Inactivation Mechanisms of Factor VIII Inhibitor Antibodies
D. Scandella
1999Vox Sanguinis33 citations Open access
Semantic Scholar
Identification of a factor VIII peptide, residues 2315–2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326 and Glu2327 for maximum effect
K. Nogami, M. Shima, H. Nakai, I. Tanaka +7 more
1999British Journal of Haematology32 citations Open access
Semantic Scholar
The natural history of the immune response to exogenous factor VIII in severe haemophilia A
C. A. Lee, C. Kessler, D. Varon, U. Martinowitz +4 more
1998Haemophilia22 citations
Semantic Scholar
An Escherichia coli mutant which inhibits the injection of phage lambda DNA.
D. Scandella, W. Arber
1974Virology20 citations
Semantic Scholar
Phage lambda DNA injection into Escherichia coli pel- mutants is restored by mutations in phage genes V or H.
D. Scandella, W. Arber
1976Virology16 citations
Semantic Scholar
New Characteristics of Anti-Factor VIII Inhibitor Antibody Epitopes and Unusual Immune Responses to Factor VIII
D. Scandella
2002Seminars in Thrombosis and Hemostasis15 citations
Semantic Scholar
Antibodies to the FVIII light chain that neutralize FVIII procoagulant activity are present in plasma of nonresponder patients with severe hemophilia A and in normal polyclonal human IgG
A. Moreau, S. Lacroix-Desmazes, Natalie Stieltjes, E. Saenko +5 more
200015 citations
Semantic Scholar
An Alloantibody Recognizing the FVIII A1 Domain in a Patient with CRM Reduced Haemophilia A due to Deletion of a Large Portion of the A1 Domain DNA Sequence
M. Shibata, M. Shima, S. Morichika, J. McVey +9 more
2000Thrombosis and Haemostasis14 citations
Semantic Scholar
Inhibition by CIPC of mitosis and development in Dictyostelium discoideum and the isolation of CIPC‐resistant mutants
E. White, D. Scandella, E. Katz
198113 citations
Semantic Scholar
Detection of all anti-factor VIII antibodies in haemophilia A patients by the Bethesda assay and a more sensitive immunoprecipitation assay.
J. Klinge, G. Auerswald, U. Budde, H. Klose +3 more
200111 citations
Semantic Scholar
Genetic, biochemical, and developmental studies of nystatin resistant mutants in Dictyostelium discoideum
D. Scandella, R. Rooney, E. Katz
2004Molecular and General Genetics MGG7 citations
Semantic Scholar
ANALYSIS OF CONSUMER PREFERENCES
D. Scandella, S. Vénien, N. Lespinasse, J. Lichou +1 more
20066 citations
Semantic Scholar
Recognizing apple and pear varieties.
P. Vaysse, A. Masseron, M. Trillot, D. Scandella +2 more
20006 citations
Semantic Scholar
Sensory evaluation of Charentais-type melons: an exploratory tool.
C. Guerineau, E. Denis, D. Scandella, B. Navez +1 more
20003 citations
Semantic Scholar

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E. Saenko×19
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M. Shima×11
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H. Nakai×7
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L. Hoyer×7
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I. Tanaka — researcher profile on SciRah

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P. Lollar — researcher profile on SciRah

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S. Kamisue — researcher profile on SciRah

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J. Healey — researcher profile on SciRah

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W. Arber — researcher profile on SciRah

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K. Nogami — researcher profile on SciRah