Researcher profile · Semantic Scholar

Alfredo C Castro

h-index: 13
Works: 28
Citations: 2,852

Most-cited papers

NF-κB as a Therapeutic Target in Multiple Myeloma*
T. Hideshima, D. Chauhan, P. Richardson, C. Mitsiades +8 more
2002Journal of Biological Chemistry868 citations Open access
Semantic Scholar
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine
L. Campesato, S. Budhu, J. Tchaicha, Chien-Huan Weng +14 more
2020Nature Communications472 citations Open access
Semantic Scholar
NF-kappa B as a therapeutic target in multiple myeloma.
T. Hideshima, D. Chauhan, P. Richardson, C. Mitsiades +8 more
2002Journal of Biological Chemistry439 citations
Semantic Scholar
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
M. Tremblay, André Lescarbeau, M. Grogan, Eddy Tan +24 more
2009Journal of Medicinal Chemistry254 citations Open access
Semantic Scholar
Novel IKK inhibitors: β-carbolines
Alfredo C Castro, L. C. Dang, F. Soucy, L. Grenier +6 more
2003223 citations Open access
Semantic Scholar
Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.
Catherine A. Evans, Tao Liu, André Lescarbeau, S. Nair +21 more
2016ACS Medicinal Chemistry Letters138 citations Open access
Semantic Scholar
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
M. Tremblay, Marta Nevalainen, S. Nair, J. R. Porter +18 more
2008Journal of Medicinal Chemistry109 citations
Semantic Scholar
Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.
Tao Liu, S. Nair, André Lescarbeau, Jitendra D. Belani +17 more
2012Journal of Medicinal Chemistry74 citations Open access
Semantic Scholar
Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy
M. Tremblay, Michael J. Nesler, Robin A Weatherhead, Alfredo C Castro
2009Expert Opinion on Therapeutic Patents73 citations
Semantic Scholar
Novel IKK inhibitors: beta-carbolines.
Alfredo C Castro, L. C. Dang, F. Soucy, L. Grenier +6 more
2003Bioorganic & Medicinal Chemistry Letters59 citations
Semantic Scholar
Discovery and characterization of a novel aryl hydrocarbon receptor inhibitor, IK-175, and its inhibitory activity on tumor immune suppression.
Karen McGovern, Alfredo C Castro, Jillian D. Cavanaugh, S. Coma +7 more
2022Molecular Cancer Therapeutics40 citations Open access
Semantic Scholar
New developments in the discovery of small molecule Hedgehog pathway antagonists.
M. Tremblay, Karen McGovern, M. Read, Alfredo C Castro
2010Current Opinion in Chemical Biology36 citations
Semantic Scholar
Abstract 2156: IK-930 is a novel TEAD inhibitor for the treatment of cancers harboring mutations in the Hippo signal transduction pathway
B. Amidon, M. Sanchez-Martin, W. Bartolini, Sakeena Syed +6 more
2022Cancer Research16 citations
Semantic Scholar
Abstract 1646: IK-930, a paralog-selective TEAD inhibitor for treating YAP/TAZ-TEAD dependent cancers
Nathan Young, G. Punkosdy, Jillian D. Cavanaugh, Collin Bantle +9 more
2023Cancer Research12 citations
Semantic Scholar
Abstract P216: IK-930 mediated TEAD inhibition decreases and delays tumor growth and enhances targeted apoptosis in lung and colon cancer xenografts when combined with MEK or EGFR inhibitors
B. Amidon, Hyejin Frosch, Sakeena Syed, Jillian D. Cavanaugh +6 more
2021Poster Presentations - Proffered Abstracts8 citations
Semantic Scholar
Development of a Multi Kilogram-Scale, Tandem Cyclopropanation Ring-Expansion Reaction en Route to Hedgehog Antagonist IPI-926
Brian C. Austad, Andrew B. Hague, Priscilla L. White, S. Peluso +21 more
20168 citations Open access
Semantic Scholar
Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119.
Erin E Brophy, James M. Conley, Patrick J O'Hearn, M. Douglas +14 more
20136 citations
Semantic Scholar
Novel IKK Inhibitors: β‐Carbolines.
Alfredo C Castro, L. C. Dang, F. Soucy, L. Grenier +6 more
20035 citations
Semantic Scholar
CYT01B, a Novel RAD51 Inhibitor, Act Synergistically with Both Targeted and Chemotherapeutic Anti-Cancer Agents
Tyler Maclay, J. Vacca, C. McComas, Alfredo C Castro +2 more
2018Blood4 citations Open access
Semantic Scholar
The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway
Sherri A. Smith, J. Hoyt, Nigel Whitebread, J. Manna +22 more
2013Xenobiotica; the fate of foreign compounds in biological systems4 citations
Semantic Scholar
448 Discovery of clinical candidate IK-175, a selective orally active AHR antagonist
Karen McGovern, Alfredo C Castro, Jillian D. Cavanaugh, M. Sanchez-Martin +8 more
20203 citations Open access
Semantic Scholar
Abstract 4131: Overcoming aryl hydrocarbon receptor mediated tumor immunosuppression
J. Tchaicha, S. Coma, M. Walsh, Jillian D. Cavanaugh +6 more
2019Immunology2 citations
Semantic Scholar
Abstract B029: The potent and selective phosphoinositide-3-kinase-gamma inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment
J. Kutok, Janid A. Ali, Erin E Brophy, Alfredo C Castro +22 more
20161 citations
Semantic Scholar
Abstract A192: The potent and selective phosphoinositide-3-kinase-γ inhibitor, IPI-549, inhibits tumor growth in murine syngeneic solid tumor models through alterations in the immune suppressive microenvironment
Karen McGovern, Janid A. Ali, Erin E Brophy, Alfredo C Castro +21 more
20151 citations
Semantic Scholar
Abstract 2474: Potent small molecule TEAD inhibitors targeting the Hippo pathway exhibit antiproliferation in vitro and anti-tumor effect in vivo
B. Amidon, Sakeena Syed, Jillian D. Cavanaugh, Hyejin Frosch +4 more
2020Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
A Novel RAD51 Inhibitor, CYT01B, Shows Anti-Cancer Activity in Preclinical Models of Aid Expressing Lymphomas
M. Hasham, D. Patrick, L. Bedard, J. Vacca +4 more
2018Blood0 citations Open access
Semantic Scholar
Phosphoproteomics in Drug Discovery and Development
M. Moran, J. Marto, C. Brame, O. Ornatsky +11 more
20060 citations
Semantic Scholar
Substituted beta-carboline with ikb kinase inhibitory effect
O. Ritzeler, Alfredo C Castro, L. Grenier, F. Soucy +4 more
20010 citations
Semantic Scholar

Jillian D. Cavanaugh

×7

J. Adams×7

J. Ecsedy×7

J. Tchaicha×6

André Lescarbeau×6

L. Grenier×6

Sakeena Syed×5

Kerry F White×4