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T. Hideshima · SciRah

Researcher profile · Semantic Scholar

T. Hideshima

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T. Hideshima — researcher profile on SciRah

h-index: 124
Works: 876
Citations: 56K

Most-cited papers

Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation
A. Gullà, E. Morelli, M. Samur, C. Botta +14 more
2021Cancer Discovery123 citations Open access
Semantic Scholar
JAK-STAT pathway regulates CD38 on myeloma cells in the bone marrow microenvironment: therapeutic implications.
D. Ogiya, Jiye Liu, H. Ohguchi, K. Kurata +6 more
2020Blood79 citations Open access
Semantic Scholar
Targeting LAG3/GAL-3 to overcome immunosuppression and enhance anti-tumor immune responses in multiple myeloma
J. Bae, F. Accardi, T. Hideshima, Yu-Tzu Tai +7 more
2021Leukemia74 citations Open access
Semantic Scholar
Signaling Pathway Mediating Myeloma Cell Growth and Survival
T. Hideshima, K. Anderson
2021Cancers61 citations Open access
Semantic Scholar
Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways
T. Hideshima, D. Ogiya, Jiye Liu, T. Harada +4 more
2020Leukemia58 citations Open access
Semantic Scholar
Multiple myeloma gammopathies Targeting histone deacetylase 3 ( HDAC 3 ) in the bone marrow microenvironment inhibits multiple myeloma proliferation by modulating exosomes and IL-6 trans-signaling
M. Ho, Tian-Zeng Chen, Jiye Liu, P. Dowling +18 more
201941 citations
Semantic Scholar
Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma
Jiye Liu, L. Xing, Jiang Li, Kenneth Wen +18 more
2024Nature Communications34 citations Open access
Semantic Scholar
The power of proteasome inhibition in multiple myeloma
T. Guerrero-Garcia, Sara Gandolfi, J. Laubach, T. Hideshima +4 more
2018Espert Review of Proteomics32 citations
Semantic Scholar
A MIR17HG-derived Long Noncoding RNA Provides an Essential Chromatin Scaffold for Protein Interaction and Myeloma Growth.
E. Morelli, M. Fulciniti, M. Samur, C. Ribeiro +29 more
2022Blood29 citations Open access
Semantic Scholar
BRD9 degradation disrupts ribosome biogenesis in multiple myeloma
K. Kurata, M. Samur, Priscilla Liow, Kenneth Wen +8 more
2023Clinical Cancer Research28 citations Open access
Semantic Scholar
Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma
H. Ohguchi, Paul M. C. Park, Tingjian Wang, B. Gryder +26 more
2021Cancer Discovery25 citations Open access
Semantic Scholar
Targeting Histone Deacetylase 3 (HDAC3) in the Bone Marrow Microenvironment Inhibits Multiple Myeloma Proliferation by Modulating Exosomes and IL-6 Trans-Signaling
M. Ho, Tian-Zeng Chen, Jiye Liu, P. Dowling +17 more
2019Leukemia25 citations Open access
Semantic Scholar
Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma.
A. Gullà, E. Morelli, Megan Johnstone, M. Turi +25 more
2024Blood22 citations Open access
Semantic Scholar
ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment
Jiye Liu, T. Hideshima, L. Xing, Sui-Zhao Wang +16 more
2021Science Advances22 citations Open access
Semantic Scholar
BCMA-targeted bortezomib nanotherapy improves therapeutic efficacy, overcomes resistance, and modulates the immune microenvironment in multiple myeloma
Debasmita Dutta, Jiye Liu, Kenneth Wen, Keiji Kurata +4 more
2023Blood Cancer Journal21 citations Open access
Semantic Scholar
Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma
K. Kurata, Anna James-Bott, M. Tye, Leona Yamamoto +25 more
2023Blood Cancer Journal19 citations Open access
Semantic Scholar
Heterogeneity of B cell lymphopoiesis in patients with premalignant and active myeloma
J. Jakubikova, D. Cholujová, G. Beke, T. Hideshima +7 more
2023JCI Insight13 citations Open access
Semantic Scholar
A BCMA-mRNA vaccine is a promising therapeutic for multiple myeloma
Debasmita Dutta, Jiye Liu, Kenneth Wen, A. Ray +6 more
2025Blood12 citations
Semantic Scholar
Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma
Sophia Adamia, S. Bhatt, Kenneth Wen, Z. Chyra +8 more
2022Leukemia11 citations Open access
Semantic Scholar
Randomized, placebo‐controlled, phase 3 study of perifosine combined with bortezomib and dexamethasone in patients with relapsed, refractory multiple myeloma previously treated with bortezomib
P. Richardson, A. Nagler, D. Ben-yehuda, A. Badros +20 more
2020eJHaem11 citations Open access
Semantic Scholar
Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase
T. Harada, H. Ohguchi, Asuka Oda, Michiyasu Nakao +15 more
2022Blood Advances9 citations Open access
Semantic Scholar
Dysfunctions of innate and adaptive immune tumor microenvironment in Waldenström Macroglobulinemia
D. Cholujová, G. Beke, Z. Hunter, T. Hideshima +11 more
2022International Journal of Cancer8 citations Open access
Semantic Scholar
Dual BCL-2/BCL-XL Inhibitor Pelcitoclax (APG-1252) Overcomes Intrinsic and Acquired Resistance to Venetoclax in Multiple Myeloma Cells
Leona Yamamoto, Sanika Derebail, Anil Aktas-Samur, T. Hideshima +12 more
2021Blood5 citations Open access
Semantic Scholar
Bortezomib Induces Anti-Multiple Myeloma Immune Response Mediated By Cgas/Sting Pathway Activation, Type I Interferon Secretion, and Immunogenic Cell Death: Clinical Application
A. Gullà, E. Morelli, M. Samur, C. Botta +13 more
2020Blood5 citations
Semantic Scholar
Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics
D. Ogiya, Z. Chyra, S. Verselis, Morgan O'Keefe +11 more
2023Blood Cancer Journal4 citations Open access
Semantic Scholar
Optimizing Mechanisms for Induction of Immunogenic Cell Death to Improve Patient Outcome in Multiple Myeloma
A. Gullà, E. Morelli, T. Hideshima, M. Samur +4 more
2018Blood4 citations
Semantic Scholar
BCMA-Targeted Bortezomib Nanotherapy (BCMA-BTZ-Nps) Targets Tumor, Enhances Therapeutic Efficacy, Triggers Immunogenic Cell Death, Overcomes Drug Resistance, and Reduces Off-Target Toxicity in Multiple Myeloma (MM)
Debasmita Dutta, Jiye Liu, Kenneth Wen, Keiji Kurata +4 more
2023Blood3 citations Open access
Semantic Scholar
Correction: Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma
C. Fabre, N. Mimura, Kathryn L. Bobb, Sun-Young Kong +12 more
2019Clinical Cancer Research3 citations
Semantic Scholar
Author Correction: Oncolytic adenoviral therapy plus pembrolizumab in BCG-unresponsive non-muscle-invasive bladder cancer: the phase 2 CORE-001 trial
Di Zhu, Zhong-Qiu Wang, Jian-Jun Zhao, Teresa Calimeri +19 more
2024Nature Medicine2 citations Open access
Semantic Scholar
Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma
K. Kurata, Anna James-Bott, M. Tye, Leona Yamamoto +25 more
2023Blood Cancer Journal2 citations Open access
Semantic Scholar
Identification a Novel Molecular Mechanism Underlying the Anti-CD38-Based Treatment Resistance in Multiple Myeloma Patients
Sophia Adamia, D. Ogiya, E. Hatjiharissi, Michael P. Chu +6 more
2022Blood2 citations
Semantic Scholar
Gabarap Loss Mediates Immune Escape in High Risk Multiple Myeloma
A. Gullà, E. Morelli, M. Samur, C. Botta +12 more
2021Blood2 citations Open access
Semantic Scholar
High-Dimensional Heterogeneity of Waldenström Macroglobulinemia within Its Immune Tumor Microenvironment
J. Jakubikova, D. Cholujová, G. Beke, Z. Hunter +8 more
2019Blood2 citations Open access
Semantic Scholar
Mechanisms, biologic sequelae and clinical benefits of bortezomib-induced immunogenic cell death in multiple myeloma
A. Gullà, E. Morelli, M. Samur, T. Hideshima +9 more
2019Clinical Lymphoma, Myeloma & Leukemia2 citations
Semantic Scholar
The Critical Role of HDAC1-IRF4-Pim-2 Axis in Myeloma Cell Growth and Survival: Therapeutic Impacts of Targeting the HDAC1-IRF4-Pim-2 Axis
T. Harada, Asuka Oda, Y. Grondin, J. Teramachi +13 more
2018Blood2 citations Open access
Semantic Scholar
Lipid Nanoparticle-Mediated Combinational mRNA Vaccine for Multiple Myeloma: The Next Stage of Cancer Immunotherapy
Debasmita Dutta, Jiye Liu, Kenneth Wen, A. Gullà +2 more
2024Blood1 citations
Semantic Scholar
Editorial Expression of Concern: p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
T. Hideshima, K. Podar, D. Chauhan, K. Ishitsuka +12 more
2024Oncogene1 citations Open access
Semantic Scholar
Retraction: Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage.
Yu-Tzu Tai, G. Teoh, B. Lin, F. Davies +7 more
2024Journal of Immunology1 citations
Semantic Scholar
Exploring the anti-myeloma potential of composite nanoparticles As4S4/Fe3O4: Insights from in vitro, ex vivo and in vivo studies.
Danka Cholujová, Z. Bujňáková, E. Dutková, Zuzana Valuskova +9 more
2024Nanomedicine: Nanotechnology, Biology and Medicine1 citations Open access
Semantic Scholar
Multiple myeloma–associated DIS3 gene is essential for hematopoiesis, but loss of DIS3 is insufficient for myelomagenesis
Hiroto Ohguchi, Yasuyo Ohguchi, Sho Kubota, Kan Etoh +12 more
2024Blood neoplasia1 citations Open access
Semantic Scholar
The Spop/BRD4/c-Myc Axis Modulates IMiDs Sensitivity in Multiple Myeloma
Li-Jie Xing, Jiye Liu, Kenneth Wen, T. Hideshima +2 more
2023Blood1 citations Open access
Semantic Scholar
OA-46 Epigenetic regulation of CD38/48 by KDM6A mediates NK cell response in multiple myeloma
Jiye Liu, L. Xing, Jiang Li, Kenneth Wen +9 more
2023Clinical Lymphoma, Myeloma & Leukemia1 citations
Semantic Scholar
Bioprocessing of MIR17HG Results in Long and Short Noncoding RNAs with Targetable Tumor-Promoting Activity in Multiple Myeloma
E. Morelli, A. Gullà, N. Liu, Domenico Maisano +22 more
2022Blood1 citations Open access
Semantic Scholar
Genome-Wide CRISPR-Cas9 Screen Identifies KDM6A As a Modulator of Daratumumab Sensitivity in Multiple Myeloma
Jiye Liu, L. Xing, T. Hideshima, K. Kurata +5 more
2022Blood1 citations Open access
Semantic Scholar
Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703
F. Garbicz, Sonia Dębek, A. Szumera-Ciećkiewicz, J. Barankiewicz +24 more
2022Blood1 citations Open access
Semantic Scholar
Enhanced CD138 peptide-specific cytotoxic T lymphocyte activities against breast, colon and pancreatic cancers in combination with pembrolizumab (anti-PD1).
J. Bae, T. Hideshima, Yu-Tzu Tai, N. Munshi +1 more
2019Journal of Clinical Oncology1 citations
Semantic Scholar
Whole-genome bisulfite sequencing identifies HDAC3-mediated DNA methylation in multiple myeloma
D. Ogiya, H. Ohguchi, Jiye Liu, K. Kurata +3 more
2019Clinical Lymphoma, Myeloma & Leukemia1 citations
Semantic Scholar
Abstract B100: Development of fargeted multiple myeloma cancer vaccine and antigen-specific T-cell immunotherapy using novel Immunogenic-engineered heteroclitic BCMA peptides
J. Bae, T. Hideshima, Yu-Tzu Tai, N. Munshi +1 more
2019Novel Vaccine Platforms and Combinations1 citations
Semantic Scholar
Novel Therapeutic Rationale for Targeting HDAC1 and PIM2 in Multiple Myeloma
T. Harada, Asuka Oda, H. Ohguchi, Y. Grondin +13 more
2019Blood1 citations Open access
Semantic Scholar
Immunomodulatory Drugs Suppress mTORC1 Signaling to Induce Direct Cytotoxicity and Enhance Antitumor Immunity in Multiple Myeloma
Jiye Liu, Jing-Yu Xu, T. Hideshima, Kenneth Wen +6 more
2025Clinical Lymphoma, Myeloma & Leukemia0 citations
Semantic Scholar

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Yu-Tzu Tai×23
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Yu-Tzu Tai — researcher profile on SciRah
K. Anderson×23
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Kenneth Wen×20
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Kenneth Wen — researcher profile on SciRah
M. Samur×18
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M. Samur — researcher profile on SciRah

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A. Gullà — researcher profile on SciRah

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Jiye Liu — researcher profile on SciRah

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E. Morelli — researcher profile on SciRah

M. Fulciniti×12

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M. Fulciniti — researcher profile on SciRah

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Kenneth C. Anderson×11

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D. Chauhan — researcher profile on SciRah