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A. Schmidt · SciRah

Researcher profile · Semantic Scholar

A. Schmidt

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A. Schmidt — researcher profile on SciRah

h-index: 28
Works: 94
Citations: 4,655

Most-cited papers

Association analyses based on false discovery rate implicate new loci for coronary artery disease
C. Nelson, A. Goel, A. Butterworth, S. Kanoni +58 more
2017Nature Genetics638 citations Open access
Semantic Scholar
Linear regression and the normality assumption.
A. Schmidt, C. Finan
2017Journal of Clinical Epidemiology632 citations Open access
Semantic Scholar
Genetic drug target validation using Mendelian randomisation
A. Schmidt, C. Finan, M. Gordillo-Marañón, F. Asselbergs +7 more
2020Nature Communications482 citations Open access
Semantic Scholar
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
L. Lotta, R. Scott, S. Sharp, S. Burgess +24 more
2016PLoS Medicine398 citations Open access
Semantic Scholar
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
A. Schmidt, D. Swerdlow, M. Holmes, R. Patel +129 more
2017The Lancet Diabetes and Endocrinology344 citations Open access
Semantic Scholar
Mendelian randomization for studying the effects of perturbing drug targets
D. Gill, Marios K. Georgakis, V. Walker, A. Schmidt +14 more
2021Wellcome Open Research226 citations Open access
Semantic Scholar
PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease.
A. Schmidt, L. Pearce, J. Wilkins, John P. Overington +2 more
2017Cochrane Database of Systematic Reviews220 citations Open access
Semantic Scholar
Associations Between Measures of Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Cohort Study and Mendelian Randomization Analysis Using the UK Biobank
R. Farmer, R. Mathur, A. Schmidt, K. Bhaskaran +6 more
2019Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease125 citations Open access
Semantic Scholar
Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease
A. Schmidt, N. Hunt, M. Gordillo-Marañón, P. Charoen +19 more
2021Nature Communications114 citations Open access
Semantic Scholar
Adjustment for index event bias in genome-wide association studies of subsequent events
F. Dudbridge, R. Allen, N. Sheehan, A. Schmidt +5 more
2018Nature Communications100 citations Open access
Semantic Scholar
Lipid Lowering and Alzheimer Disease Risk: A Mendelian Randomization Study
Dylan M. Williams, C. Finan, A. Schmidt, S. Burgess +1 more
2019Annals of Neurology95 citations Open access
Semantic Scholar
Cardiovascular risk prediction in type 2 diabetes: a comparison of 22 risk scores in primary care settings
K. Dziopa, F. Asselbergs, J. Gratton, N. Chaturvedi +1 more
2020Diabetologia77 citations Open access
Semantic Scholar
Dissecting the IL‐6 pathway in cardiometabolic disease: A Mendelian randomization study on both IL6 and IL6R
Arjen J. Cupido, F. Asselbergs, P. Natarajan, P. Ridker +2 more
2021British Journal of Clinical Pharmacology72 citations Open access
Semantic Scholar
Prevalence and Disease Expression of Pathogenic and Likely Pathogenic Variants Associated with Inherited Cardiomyopathies in the General Population
M. Bourfiss, M. van Vugt, A. Alasiri, B. Ruijsink +9 more
2022Circulation Genomic and Precision Medicine67 citations Open access
Semantic Scholar
Exploring interaction effects in small samples increases rates of false-positive and false-negative findings: results from a systematic review and simulation study.
A. Schmidt, R. Groenwold, M. Knol, A. Hoes +4 more
2014Journal of Clinical Epidemiology63 citations
Semantic Scholar
Prognostic factors of early metastasis and mortality in dogs with appendicular osteosarcoma after receiving surgery: an individual patient data meta-analysis.
A. Schmidt, M. Nielen, O. Klungel, A. Hoes +3 more
2013Preventive Veterinary Medicine61 citations Open access
Semantic Scholar
Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study.
A. Cupido, L. Reeskamp, A. Hingorani, C. Finan +3 more
2022JAMA cardiology59 citations Open access
Semantic Scholar
Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta‐Analysis in Up to 16 126 Participants
M. Borges, A. Schmidt, B. Jefferis, S. Wannamethee +14 more
2020Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease50 citations Open access
Semantic Scholar
Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients
I. Losenkov, N. Mulder, L. Levchuk, N. Vyalova +9 more
2020Frontiers in Psychiatry41 citations Open access
Semantic Scholar
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
A. Schmidt, M. Holmes, D. Preiss, D. Swerdlow +163 more
2018bioRxiv39 citations Open access
Semantic Scholar
An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors
J. M. I. H. Gho, A. Schmidt, L. Pasea, S. Koudstaal +9 more
2018BMJ Open38 citations Open access
Semantic Scholar
Human Genomics and Drug Development.
A. Schmidt, A. Hingorani, C. Finan
2021Cold Spring Harbor Perspectives in Medicine36 citations Open access
Semantic Scholar
Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity
A. Schmidt, M. Bourfiss, A. Alasiri, E. Puyol-Antón +17 more
2023Science Advances34 citations Open access
Semantic Scholar
Penetrance and Prognosis of MYH7 Variant-Associated Cardiomyopathies: Results From a Dutch Multicenter Cohort Study.
M. Jansen, R. de Brouwer, Fahima Hassanzada, Angela Schoemaker +16 more
2023JACC. Heart failure33 citations Open access
Semantic Scholar
Individualized Family Screening for Arrhythmogenic Right Ventricular Cardiomyopathy.
S. Muller, A. Gasperetti, L. Bosman, A. Schmidt +14 more
2023Journal of the American College of Cardiology32 citations Open access
Semantic Scholar
Justification of exclusion criteria was underreported in a review of cardiovascular trials.
A. Schmidt, R. Groenwold, J. V. van Delden, Y. van der Does +4 more
2014Journal of Clinical Epidemiology32 citations Open access
Semantic Scholar
The median and the mode as robust meta‐analysis estimators in the presence of small‐study effects and outliers
F. Hartwig, G. Davey Smith, A. Schmidt, J. Sterne +2 more
2020Research Synthesis Methods30 citations Open access
Semantic Scholar
Polygenic risk scores for coronary artery disease and subsequent event risk amongst established cases
Laurence J. Howe, F. Dudbridge, A. Schmidt, C. Finan +4 more
2020Human Molecular Genetics29 citations Open access
Semantic Scholar
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis
J. Mensah-Kane, A. Schmidt, A. Hingorani, C. Finan +8 more
2021Frontiers in Genetics28 citations Open access
Semantic Scholar
Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults
R. Joshi, S. Wannamethee, J. Engmann, Tom R. Gaunt +14 more
2020European Journal of Preventive Cardiology28 citations Open access
Semantic Scholar
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics
M. Gordillo-Marañón, M. Zwierzyna, P. Charoen, F. Drenos +18 more
2020Nature Communications28 citations Open access
Semantic Scholar
The Impact of Selection Bias on Estimation of Subsequent Event Risk
Yi-Juan Hu, A. Schmidt, F. Dudbridge, M. Holmes +169 more
2017Circulation: Cardiovascular Genetics28 citations Open access
Semantic Scholar
Biomedical consequences of elevated cholesterol-containing lipoproteins and apolipoproteins on cardiovascular and non-cardiovascular outcomes
A. Schmidt, R. Joshi, M. Gordillo-Marañón, F. Drenos +14 more
2023Communications Medicine25 citations Open access
Semantic Scholar
Differences in interaction and subgroup-specific effects were observed between randomized and nonrandomized studies in three empirical examples.
A. Schmidt, M. Rovers, O. Klungel, A. Hoes +4 more
2013Journal of Clinical Epidemiology25 citations Open access
Semantic Scholar
Low‐Density Lipoprotein Cholesterol Attributable Cardiovascular Disease Risk Is Sex Specific
A. Cupido, F. Asselbergs, A. Schmidt, G. Hovingh
2022Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease23 citations Open access
Semantic Scholar
Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium
Riyaz S. Patel, V. Tragante, A. Schmidt, R. McCubrey +177 more
2019Circulation Genomic and Precision Medicine20 citations Open access
Semantic Scholar
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
A. Schmidt, D. Swerdlow, M. Holmes, R. Patel +2 more
201620 citations
Semantic Scholar
Unravelling the Difference Between Men and Women in Post-CABG Survival
A. Schmidt, S. Haitjema, U. Sartipy, M. Holzmann +13 more
2022Frontiers in Cardiovascular Medicine18 citations Open access
Semantic Scholar
Prospective associations between diet quality, dietary components, and risk of cardiometabolic multimorbidity in older British men
Qiaoye Wang, A. Schmidt, L. Lennon, O. Papacosta +2 more
2023European Journal of Nutrition17 citations Open access
Semantic Scholar
The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study
M. Borges, P. Haycock, Jie Zheng, G. Hemani +11 more
2022medRxiv17 citations Open access
Semantic Scholar
Association between 8 P‐glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug‐induced hyperprolactinaemia
L. Geers, I. Pozhidaev, S. Ivanova, M. Freidin +11 more
2020British Journal of Clinical Pharmacology17 citations Open access
Semantic Scholar
Tailoring treatments using treatment effect modification
A. Schmidt, O. Klungel, M. Nielen, A. de Boer +2 more
2016Pharmacoepidemiology and Drug Safety17 citations Open access
Semantic Scholar
Prioritising genetic findings for drug target identification and validation.
N. Hukerikar, A. Hingorani, F. Asselbergs, C. Finan +1 more
2024Atherosclerosis16 citations Open access
Semantic Scholar
Untargeted Metabolomics Identifies Potential Hypertrophic Cardiomyopathy Biomarkers in Carriers of MYBPC3 Founder Variants
M. Jansen, M. Schuldt, B. V. van Driel, A. Schmidt +14 more
2023International Journal of Molecular Sciences16 citations Open access
Semantic Scholar
PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease.
A. Schmidt, J. Carter, L. Pearce, J. Wilkins +3 more
2020Cochrane Database of Systematic Reviews16 citations
Semantic Scholar
Sex-specific Mendelian randomisation to assess the causality of sex differences in the effects of risk factors and treatment: spotlight on hypertension
S. C. de Ruiter, A. Schmidt, D. Grobbee, H. D. den Ruijter +1 more
2023Journal of Human Hypertension12 citations Open access
Semantic Scholar
Assessment of practical applicability and clinical relevance of a commonly used LDL-C polygenic score in patients with severe hypercholesterolemia.
T. Tromp, A. Cupido, L. Reeskamp, E. Stroes +4 more
2021Atherosclerosis12 citations Open access
Semantic Scholar
Which dogs with appendicular osteosarcoma benefit most from chemotherapy after surgery? Results from an individual patient data meta-analysis.
A. Schmidt, R. Groenwold, P. Amsellem, N. Bacon +7 more
2016Preventive Veterinary Medicine12 citations Open access
Semantic Scholar
Adjusting for Confounding in Early Postlaunch Settings: Going Beyond Logistic Regression Models
A. Schmidt, O. Klungel, R. Groenwold
2016Epidemiology12 citations Open access
Semantic Scholar
A Machine Learning Model to Aid Detection of Familial Hypercholesterolemia
J. Gratton, M. Futema, S. Humphries, A. Hingorani +2 more
2023JACC: Advances11 citations Open access
Semantic Scholar

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