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G. Liang · SciRah

Researcher profile · Semantic Scholar

G. Liang

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G. Liang — researcher profile on SciRah

h-index: 32
Works: 51
Citations: 8,748

Most-cited papers

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
J. Repa, G. Liang, J. Ou, Y. Bashmakov +6 more
20001,594 citations Open access
Semantic Scholar
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.
Jing Yang, Michael S. Brown, G. Liang, N. Grishin +1 more
2008Cell1,187 citations Open access
Semantic Scholar
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
J. Repa, G. Liang, J. Ou, Y. Bashmakov +6 more
2000Genes & Development824 citations
Semantic Scholar
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c*
G. Liang, Jian Yang, J. Horton, R. Hammer +2 more
2002Journal of Biological Chemistry671 citations Open access
Semantic Scholar
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
Tong-Jin Zhao, G. Liang, R. Li, Xuefen Xie +6 more
2010Proceedings of the National Academy of Sciences of the United States of America421 citations Open access
Semantic Scholar
25-hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
A. Reboldi, E. Dang, J. McDonald, G. Liang +2 more
2014Science414 citations Open access
Semantic Scholar
The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals
Young Moon, G. Liang, Xuefen Xie, M. Frank-Kamenetsky +5 more
2012Cell Metabolism322 citations Open access
Semantic Scholar
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
David R. Bauman, A. Bitmansour, J. McDonald, Bonne M. Thompson +2 more
2009Proceedings of the National Academy of Sciences of the United States of America320 citations Open access
Semantic Scholar
Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis
D. Yabe, Ryutaro Komuro, G. Liang, J. Goldstein +1 more
2003Proceedings of the National Academy of Sciences of the United States of America299 citations Open access
Semantic Scholar
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
J. Owen, Yuanyuan Zhang, S. Bae, M. Farooqi +4 more
2012Proceedings of the National Academy of Sciences of the United States of America275 citations Open access
Semantic Scholar
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
Luke Engelking, H. Kuriyama, R. Hammer, J. Horton +3 more
2004Journal of Clinical Investigation271 citations Open access
Semantic Scholar
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.
Guoxun Chen, G. Liang, J. Ou, J. L. Goldstein +1 more
2004Proceedings of the National Academy of Sciences of the United States of America234 citations Open access
Semantic Scholar
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
Luke Engelking, G. Liang, R. Hammer, K. Takaishi +6 more
2005Journal of Clinical Investigation225 citations Open access
Semantic Scholar
Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S]
A. Linden, Shili Li, Hwa-Young Choi, Fei Fang +6 more
2018Journal of Lipid Research208 citations Open access
Semantic Scholar
DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.
Juan Wang, Jian-Wei Hao, Xu Wang, Huiling Guo +14 more
2019Cell Reports176 citations Open access
Semantic Scholar
From the Cover: Ghrelin secretion stimulated by 1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice
Tong-Jin Zhao, Ichiro Sakata, Rui Li, G. Liang +4 more
2010168 citations
Semantic Scholar
LXR-SREBP-1c-Phospholipid Transfer Protein Axis Controls Very Low Density Lipoprotein (VLDL) Particle Size*
H. Okazaki, J. Goldstein, Michael S. Brown, G. Liang
2009Journal of Biological Chemistry102 citations Open access
Semantic Scholar
Intestinal, but not hepatic, ChREBP is required for fructose tolerance.
Misung Kim, I. Astapova, S. Flier, S. Hannou +6 more
2017JCI Insight88 citations Open access
Semantic Scholar
Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
Shun-Xing Rong, V. Cortés, S. Rashid, N. Anderson +5 more
2017eLife87 citations Open access
Semantic Scholar
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.
Luke Engelking, Bret M. Evers, J. Richardson, J. Goldstein +2 more
2006Journal of Clinical Investigation82 citations Open access
Semantic Scholar
Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice*
Hong-Ping Guan, J. Goldstein, Michael S. Brown, G. Liang
2009Journal of Biological Chemistry68 citations Open access
Semantic Scholar
SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1.
C. Crewe, Yi Zhu, V. A. Paschoal, Nolwenn Joffin +6 more
2019JCI Insight67 citations Open access
Semantic Scholar
Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
H. Kuriyama, G. Liang, Luke Engelking, J. Horton +2 more
2005Cell Metabolism66 citations Open access
Semantic Scholar
Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes[S]
Luke Engelking, M. McFarlane, Christina Li, G. Liang
2012Journal of Lipid Research61 citations Open access
Semantic Scholar
Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin
Bret M. Evers, M. Farooqi, J. Shelton, J. Richardson +3 more
2010Journal of Investigative Dermatology56 citations Open access
Semantic Scholar
Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
Luke Engelking, Mary Jo Castro Cantoria, Yanchao Xu, G. Liang
2017Seminars in Cell and Developmental Biology51 citations Open access
Semantic Scholar
Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice
Xuefen Xie, Michael S. Brown, J. Shelton, J. Richardson +2 more
2011Proceedings of the National Academy of Sciences of the United States of America50 citations Open access
Semantic Scholar
Author response: Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
Shun-Xing Rong, V. Cortés, S. Rashid, N. Anderson +5 more
201744 citations Open access
Semantic Scholar
Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine*
M. McFarlane, G. Liang, Luke Engelking
2013Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice
Fei Fang, Xuanming Shi, Michael S. Brown, J. Goldstein +1 more
2019Proceedings of the National Academy of Sciences of the United States of America35 citations Open access
Semantic Scholar
Scap is required for sterol synthesis and crypt growth in intestinal mucosa[S]
M. McFarlane, Mary Jo Castro Cantoria, A. Linden, Brandon A January +2 more
2015Journal of Lipid Research35 citations Open access
Semantic Scholar
Cannabinoid receptor-1 signaling in hepatocytes and stellate cells does not contribute to NAFLD.
Simeng Wang, Qingzhang Zhu, G. Liang, Tania Franks +8 more
2021Journal of Clinical Investigation32 citations Open access
Semantic Scholar
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
D. Kober, Shimeng Xu, Shili Li, B. Bajaj +3 more
2020Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Liver X receptors (LXRs) regulate apolipoprotein AIV-implications of the antiatherosclerotic effect of LXR agonists.
Yu Liang, Xian-Cheng Jiang, Rui-Jie Liu, G. Liang +6 more
2004Molecular Endocrinology32 citations Open access
Semantic Scholar
Unexpected role for IGF-1 in starvation: Maintenance of blood glucose
Fei Fang, J. Goldstein, Xuanming Shi, G. Liang +1 more
2022Proceedings of the National Academy of Sciences of the United States of America23 citations Open access
Semantic Scholar
A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity1
R. Schmidt, J. Ficorilli, Youyan Zhang, K. Bramlett +11 more
2006Journal of Lipid Research22 citations Open access
Semantic Scholar
CAT‐2003: A novel sterol regulatory element‐binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3‐Leiden mice
M. Zimmer, Pradeep Bista, Ericka L. Benson, Diana Lee +15 more
2017Hepatology Communications20 citations Open access
Semantic Scholar
Supplemental Information DHHC 4 and DHHC 5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD 36 to the Plasma Membrane
Juan Wang, Jian-Wei Hao, Huiling Guo, Hui-Hui Sun +7 more
201817 citations
Semantic Scholar
Cartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis
D. Patra, E. Delassus, G. Liang, L. Sandell
2014PLoS ONE17 citations Open access
Semantic Scholar
Critical role of SREBP-1c large-VLDL pathway in environment-induced hypertriglyceridemia of apoA-V deficiency
Mikio Takanashi, Takeshi Kimura, Chengcheng Li, Masaki Tanaka +17 more
2019Arteriosclerosis, Thrombosis and Vascular Biology15 citations Open access
Semantic Scholar
Surviving starvation: essential role of the ghrelin-growth hormone axis.
J. L. Goldstein, T.-J. Zhao, R. Li, Daniel P. Sherbet +2 more
2011Cold Spring Harbor Symposia on Quantitative Biology12 citations Open access
Semantic Scholar
Adipose triglyceride lipase: the first transacylase for FAHFAs
Juan Wang, G. Liang, Tong-Jin Zhao
2022Life Metabolism3 citations Open access
Semantic Scholar
Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease
F. Luo, Chao Xing, Sumeet K. Asrani, Shili Li +3 more
2021Molecular Metabolism1 citations Open access
Semantic Scholar
Reboldi downstream of type I interferon driven inflammation − 25-Hydroxycholesterol suppresses interleukin-1
E. Dang, J. McDonald, G. Liang, D. Russell +1 more
20141 citations
Semantic Scholar
Effects of Corticosterone, cAMP, cGMP, Ca~(2+), and Protein Kinase C on Apoptosis of Mouse Thymocytes Induced by X-ray Irradiation
G. Liang
20081 citations
Semantic Scholar
Response to Kunos et al. and Lotersztajn and Mallat
Simeng Wang, Qingzhang Zhu, G. Liang, Tania Franks +8 more
2022Journal of Clinical Investigation0 citations Open access
Semantic Scholar
1 - Interplay between CHREBP and SREBP-1C Coordinates Postprandial Hepatic Glycolysis and Lipogenesis
Luke Engelking, Shili Li, A. Linden, J. Horton +1 more
20180 citations
Semantic Scholar
Abstract 17671: The Critical Role of Sterol Regulatory Element-binding Protein-1c in Hypertriglyceridemia Caused by Apolipoprotein A5 Deficiency
H. Okazaki, Mikio Takanashi, Takeshi Kimura, Satoru Takase +9 more
20160 citations
Semantic Scholar
942 Insig-Mediated Regulation of Intestinal Lipogenesis
Luke Engelking, M. McFarlane, Christina Li, G. Liang
20130 citations Open access
Semantic Scholar
1102 Pharmacologic Blockage of Cholesterol Absorption With Ezetimibe Reveals a Novel Homeostatic Network in Enterocytes
Luke Engelking, G. Liang, M. McFarlane, Christina Li
20120 citations Open access
Semantic Scholar

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