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D. Kober · SciRah

Researcher profile · Semantic Scholar

D. Kober

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D. Kober — researcher profile on SciRah

h-index: 11
Works: 42
Citations: 994

Most-cited papers

TREM2-ligand interactions in health and disease
D. Kober, T. Brett
2017Journal of Molecular Biology241 citations Open access
Semantic Scholar
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
D. Kober, Jennifer M. Alexander-Brett, C. Karch, Carlos Cruchaga +3 more
2016eLife210 citations Open access
Semantic Scholar
TREM-2 promotes macrophage survival and lung disease after respiratory viral infection
Kangyun Wu, D. Byers, Xiaohua Jin, E. Agapov +8 more
2015Journal of Experimental Medicine191 citations Open access
Semantic Scholar
Functional insights from biophysical study of TREM2 interactions with ApoE and Aβ1-42
D. Kober, M. D. Stuchell-Brereton, C. Kluender, Hunter B. Dean +10 more
2020bioRxiv81 citations Open access
Semantic Scholar
Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo*
Michelle D. Combs, Russell H Knutsen, T. Broekelmann, Holly M. Toennies +8 more
2013Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Scap Structures Highlight Key Role for Rotation of Intertwined Luminal Loops in Cholesterol Sensing
D. Kober, A. Radhakrishnan, J. Goldstein, Michael S. Brown +3 more
2021Cell36 citations Open access
Semantic Scholar
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
D. Kober, Shimeng Xu, Shili Li, B. Bajaj +3 more
2020Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes
Zeynep Yurtsever, Dhara A. Patel, D. Kober, Alvin Su +4 more
2016Biochimica et Biophysica Acta21 citations Open access
Semantic Scholar
YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria
S. Ohlemacher, Yi-Qiang Xu, D. Kober, Mahnoor Malik +3 more
2018Journal of Biological Chemistry17 citations Open access
Semantic Scholar
Triggering receptor expressed on myeloid cells 2
T. Brett, D. Kober
201617 citations
Semantic Scholar
Preparation, Crystallization, and Preliminary Crystallographic Analysis of Wild-type and Mutant Human TREM-2 Ectodomains Linked to Neurodegenerative and Inflammatory Diseases
D. Kober, Kelsey M Wanhainen, Britney Johnson, David T Randolph +2 more
2014Protein Expression and Purification17 citations Open access
Semantic Scholar
SPRING licenses S1P-mediated cleavage of SREBP2 by displacing an inhibitory pro-domain
S. Hendrix, Vincent Dartigue, Hailee Hall, Shrankhla Bawaria +4 more
2024Nature Communications12 citations Open access
Semantic Scholar
SPRING is a Dedicated Licensing Factor for SREBP-Specific Activation by S1P
S. Hendrix, Josephine M. E. Tan, Klevis Ndoj, Jenina Kingma +7 more
2024Molecular and Cellular Biology8 citations Open access
Semantic Scholar
Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain
Wenbi Wu, Pankaj Kumar, Chad A. Brautigam, S. Tso +3 more
2024bioRxiv6 citations Open access
Semantic Scholar
Limiting respiratory viral infection by targeting antiviral and immunological functions of BST-2/Tetherin: Knowledge and gaps
K. Berry, D. Kober, Alvin Su, T. Brett
2018Bioessays6 citations Open access
Semantic Scholar
Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization.
D. Kober, Zeynep Yurtsever, T. Brett
2015Journal of Visualized Experiments6 citations Open access
Semantic Scholar
SPRINGing off the lock: the role of SPRING in S1P activity and SREBP-regulated lipid metabolism
Ilaria Micallo, Ashley V Bullington, D. Kober, N. Zelcer
2025Current Opinion in Lipidology4 citations Open access
Semantic Scholar
Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap–Insig interaction and SREBP activation
Blake C Williams, D. Kober, Xiao-Chen Bai, D. Rosenbaum +1 more
2025Proceedings of the National Academy of Sciences of the United States of America4 citations
Semantic Scholar
Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis
Shimeng Xu, Linda Donnelly, D. Kober, M. Mak +1 more
2024Journal of Lipid Research3 citations Open access
Semantic Scholar
Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo
D. Kober, Marley C. Caballero Van Dyke, Jennifer L. Eitson, Ian N. Boys +3 more
2024mBio3 citations Open access
Semantic Scholar
Mechanisms of human mitochondrial leaderless mRNA translation initiation
Shuang-Jie Shen, Yinghua Xu, D. Kober, Jin-Fan Wang
2026Nature Communications2 citations Open access
Semantic Scholar
NPC1 trafficking via VPS41-dependent LAMP carriers regulates endosomal cholesterol homeostasis
Klevis Ndoj, Matteo Tantucci, Paolo Sanzà, Kristian Zubak +7 more
2025Proceedings of the National Academy of Sciences of the United States of America2 citations Open access
Semantic Scholar
Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo
D. Kober, Marley C. Caballero Van Dyke, Jennifer L. Eitson, Ian N. Boys +3 more
2023bioRxiv2 citations Open access
Semantic Scholar
YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway
T. Brett, D. Kober, S. Ohlemacher, J. P. Henderson
20182 citations
Semantic Scholar
Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor
Ashley V Bullington, Ilaria Micallo, B. Bajaj, Pankaj Kumar +5 more
2025Proceedings of the National Academy of Sciences of the United States of America1 citations Open access
Semantic Scholar
Structural Studies of TREM-2 Mutants Linked to Neurodegenerative Diseases
D. Kober, T. Brett
20141 citations Open access
Semantic Scholar
Abstract 4425 Cholesterol regulates SREBP activation by displacing a transmembrane helix on Scap and stabilizing the Scap-Insig interaction
Blake C Williams, D. Kober, Xiaochen Bai, A. Radhakrishnan +1 more
2026Journal of Biological Chemistry0 citations Open access
Semantic Scholar
Abstract 2041 Dynamic mechanisms of human mitochondrial leaderless mRNA translation initiation
Jin-Fan Wang, Shuang-Jie Shen, Ying-Hua Xu, D. Kober
2026Journal of Biological Chemistry0 citations Open access
Semantic Scholar
A domain-swapped proPC1/3 structure reveals a conformational checkpoint for ER export
Pankaj Kumar, Phillip A. Hyon, Rishi Nixon, Ashley V Bullington +3 more
2026bioRxiv0 citations Open access
Semantic Scholar
Choreography of human mitochondrial leaderless mRNA translation initiation
Shuang-Jie Shen, Yinghua Xu, D. Kober, Jin-Fan Wang
2025bioRxiv0 citations Open access
Semantic Scholar
A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases
B. Gangadharan, D. Kober, Luke M. Rice
2025bioRxiv0 citations
Semantic Scholar
AD‐Associated Variants Directly Impair Surface Interactions Between the Hydrophobic Site of TREM2 and the Hinge Region of ApoE
Hunter B. Dean, Rory A. Greer, D. Kober, E. Roberson +2 more
2023Alzheimer's & Dementia0 citations Open access
Semantic Scholar
Biophysical analysis of TREM2 interactions reveals a shared binding site for Alzheimer’s disease ligands apoE and oligomeric amyloid beta
J. Greven, Hee-Song Jong, D. Kober, Jennifer M. Alexander-Brett +2 more
2022Alzheimer's & Dementia0 citations
Semantic Scholar
Chicken Scap D435V L1-L7 domain / Fab complex focused map
D. Kober, A. Radhakrishnan, J. Goldstein, M. S. Brown +3 more
20210 citations
Semantic Scholar
WT Chicken Scap L1-L7 / Fab 4G10 complex focused refinement
D. Kober, A. Radhakrishnan, J. Goldstein, M. S. Brown +3 more
20210 citations
Semantic Scholar
P4-172: BIOPHYSICAL INVESTIGATION OF THE TREM2 INTERACTIONS WITH APOE AND AMYLOID BETA1-42 REVEAL TWO DISTINCT BINDING SURFACES AND A POTENTIAL ROLE FOR STREM2 AS AN INHIBITOR OF AMYLOID BETA1-42 POLYMERIZATION
D. Kober, C. Kluender, T. Brett
2019Alzheimer's & Dementia0 citations Open access
Semantic Scholar
Structural, Biophysical, and Functional Studies of TREM2 In Neurodegenerative Disease
D. Kober
20170 citations
Semantic Scholar
Author response: Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
D. Kober, J. Alexander-Brett, C. Karch, C. Cruchaga +3 more
20160 citations Open access
Semantic Scholar
Intercultural Professionalisation in Adult Education
D. Kober
20150 citations
Semantic Scholar
Determinants of Innate Inflammatory Signaling by TREM-2
D. Kober, J. Alexander-Brett, M. Holtzman, T. Brett
20150 citations
Semantic Scholar
Views on Adult Education and Social Movements
D. Kober
20120 citations
Semantic Scholar
Moderation / Präsentation 2012
D. Kober
20120 citations
Semantic Scholar

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